Cell surface membrane antigen present on neuroblastoma cells but not fetal neuroblasts recognized by a monoclonal antibody (KP-NAC8).

abstract：:We have demonstrated previously that the immunomodulator AS101 can protect mice from acute lethal toxicity mediated by high doses of radiation or chemotherapy. The compound was shown to rescue mice from toxic effects of cyclophosphamide or 5-fluorouracil. The results presented herein demonstrate that pretreatment of m...

journal_title：Cancer research

authors： Kalechman Y,Shani A,Sotnik-Barkai I,Albeck M,Sredni B

更新日期：1993-12-15 00:00:00

abstract：:Multiple cytokines stimulate hepatic lipogenesis in rodents. We have previously shown that lipogenic cytokines can be divided into 2 classes by their mechanism of action and their synergistic interactions. We now report the effects of interleukin 4, a cytokine known to inhibit the synthesis and action of other cytokin...

journal_title：Cancer research

authors： Grunfeld C,Soued M,Adi S,Moser AH,Fiers W,Dinarello CA,Feingold KR

更新日期：1991-06-01 00:00:00

abstract：:The mechanism of albumin biosynthesis was studied in Morris hepatoma 5123tc in vivo and in hepatoma cell suspensions obtained by solubilizing the intercellular matrix with collagenase and hyaluronidase. In the in vivo experiments, L-[-14C]leucine was injected i.v. into rats bearing hepatomas in the muscles of both hin...

journal_title：Cancer research

authors： Edwards K,Schreiber G,Dryburgh H,Millership A,Urban J

更新日期：1976-09-01 00:00:00

abstract：:Aberrant cholesterol metabolism is increasingly appreciated to be essential for prostate cancer initiation and progression. Transcript expression of the high-density lipoprotein-cholesterol receptor scavenger receptor B1 (SR-B1) is elevated in primary prostate cancer. Hypothesizing that SR-B1 expression may help facil...

journal_title：Cancer research

authors： Gordon JA,Noble JW,Midha A,Derakhshan F,Wang G,Adomat HH,Tomlinson Guns ES,Lin YY,Ren S,Collins CC,Nelson PS,Morrissey C,Wasan KM,Cox ME

更新日期：2019-07-01 00:00:00

abstract：:Antiangiogenic therapy is efficacious in metastatic renal cell carcinoma (mRCC). However, the ability of antiangiogenic drugs to delay tumor progression and extend survival is limited, due to either innate or acquired drug resistance. Furthermore, there are currently no validated biomarkers that predict which mRCC pat...

journal_title：Cancer research

authors： Robinson SP,Boult JKR,Vasudev NS,Reynolds AR

更新日期：2017-08-01 00:00:00

abstract：:Polo-like kinase 1 (Plk1) is a key regulator of progression through mitosis. Although Plk1 seems to be dispensable for entry into mitosis, its role in spindle formation and exit from mitosis is crucial. Recent evidence suggests that a major role of Plk1 in exit from mitosis is the regulation of inhibitors of the anaph...

journal_title：Cancer research

authors： Eckerdt F,Strebhardt K

更新日期：2006-07-15 00:00:00

abstract：:In 2002, the National Cancer Institute created the Initiative for Chemical Genetics (ICG), to enable public research using small molecules to accelerate the discovery of cancer-relevant small-molecule probes. The ICG is a public-access research facility consisting of a tightly integrated team of synthetic and analytic...

journal_title：Cancer research

authors： Tolliday N,Clemons PA,Ferraiolo P,Koehler AN,Lewis TA,Li X,Schreiber SL,Gerhard DS,Eliasof S

更新日期：2006-09-15 00:00:00

abstract：:Collagenase-3 (matrix metalloproteinase 13; MMP-13), a protease originally identified in breast carcinoma, is characterized by a potent degrading activity against a wide spectrum of extracellular matrix proteins. The aims of this study were to localize and identify the MMP-13-expressing cells in invasive human breast ...

journal_title：Cancer research

authors： Nielsen BS,Rank F,López JM,Balbin M,Vizoso F,Lund LR,Danø K,López-Otín C

更新日期：2001-10-01 00:00:00

abstract：:Lectin-affinity electrophoretic separation of serum alpha-fetoprotein (AFP) was carried out using AFP Differentiation Kits, which used Lens culinaris agglutinin-A (Kit L) and erythroagglutinating phytohemagglutinin (Kit P). Separated AFP bands were detected with a sensitive antibody-affinity blotting technique and det...

journal_title：Cancer research

authors： Taketa K,Endo Y,Sekiya C,Tanikawa K,Koji T,Taga H,Satomura S,Matsuura S,Kawai T,Hirai H

更新日期：1993-11-15 00:00:00

abstract：:Pancreatic ductal adenocarcinoma (PDAC) is a deadly and aggressive cancer. Understanding mechanisms that drive preneoplastic pancreatic lesions is necessary to improve early diagnostic and therapeutic strategies. Mutations and inactivation of activin-like kinase (ALK4) have been demonstrated to favor PDAC onset. Surpr...

journal_title：Cancer research

authors： Zhao Y,Wu Z,Chanal M,Guillaumond F,Goehrig D,Bachy S,Principe M,Ziverec A,Flaman JM,Collin G,Tomasini R,Pasternack A,Ritvos O,Vasseur S,Bernard D,Hennino A,Bertolino P

更新日期：2020-08-15 00:00:00

abstract：:The mutational spectrum of the p53 gene was analyzed in 53 hepatocellular carcinomas. Somatic mutations of the p53 gene were detected in 17 cases (32%). Among these 17 mutations, 9 were missense mutations; the mutations in the other 8 cases were nonsense mutations, deletions, or mutations at the intron-exon junctions....

journal_title：Cancer research

authors： Nishida N,Fukuda Y,Kokuryu H,Toguchida J,Yandell DW,Ikenega M,Imura H,Ishizaki K

更新日期：1993-01-15 00:00:00

abstract：:Overexpression of interleukin 6, a downstream target of the GBX2 homeobox gene, has been linked to the progression of prostate cancer. The Janus kinase-signal transducers and activators of transcription signaling pathway transmits interleukin 6-mediated signals from cell surface receptors to the target genes in the nu...

journal_title：Cancer research

authors： Ni Z,Lou W,Leman ES,Gao AC

更新日期：2000-03-01 00:00:00

abstract：:CTLs were generated in vitro from two healthy donors and one melanoma patient by stimulation of CD8+ T cells with autologous dendritic cells pulsed with natural melanoma peptides (NMPs), obtained by acid treatment of HLA-matched melanoma cells. CTLs showed MHC class I-restricted melanoma-specific cytolytic activity. I...

journal_title：Cancer research

authors： Imro MA,Manici S,Russo V,Consogno G,Bellone M,Rugarli C,Traversari C,Protti MP

更新日期：1999-05-15 00:00:00

abstract：:Indirect immunofluorescence staining with a large battery of monoclonal antibodies of primary and autologous metastatic lesions removed from seven patients with melanoma has detected heterogeneity in the expression of various types of melanoma-associated antigens (MAAs), of distinct determinants of the high molecular ...

journal_title：Cancer research

authors： Natali P,Bigotti A,Cavaliere R,Liao SK,Taniguchi M,Matsui M,Ferrone S

更新日期：1985-06-01 00:00:00

abstract：:Recently, we developed a nutritionally optimal medium for rapid clonal growth (greater than 1 population doubling/day) of normal human bronchial epithelial (NHBE) cells. Adding fetal bovine or adult human blood-derived serum to this medium depresses the clonal growth rate of NHBE cells in a dose-dependent fashion. In ...

journal_title：Cancer research

authors： Lechner JF,McClendon IA,LaVeck MA,Shamsuddin AM,Harris CC

更新日期：1983-12-01 00:00:00

abstract：:The Rb/E2F pathway is deregulated in most human brain tumors, and the finding that loss of E2F1 reduced pituitary tumorigenesis in Rb(+/-) mice suggests that loss of pRb induces brain tumors by activating E2F1. We therefore investigated the role of E2F1 in the development and maintenance of brain cancer using a transg...

journal_title：Cancer research

authors： Olson MV,Johnson DG,Jiang H,Xu J,Alonso MM,Aldape KD,Fuller GN,Bekele BN,Yung WK,Gomez-Manzano C,Fueyo J

更新日期：2007-05-01 00:00:00

abstract：:Inflammation has increasingly been recognized as a critical component influencing tumor growth. Recent reports have revealed conflicting evidence for the role of Toll-like receptors (TLR) in modulating tumorigenesis. In our study, we implicate TLR3 in mediating immune surveillance with increased growth of implanted tr...

journal_title：Cancer research

authors： Chin AI,Miyahira AK,Covarrubias A,Teague J,Guo B,Dempsey PW,Cheng G

更新日期：2010-04-01 00:00:00

abstract：:The C3H/10T1/2 CL8 cell line (10T1/2) is being widely used as a quantitative assay system for chemical and physical carcinogens. 10T1/2 cells, but not their transformed counterparts, exhibit a decreased final saturation density with decreasing serum concentration. Exposure of carcinogen-treated cultures to 5% serum 8 ...

journal_title：Cancer research

authors： Bertram JS

更新日期：1977-02-01 00:00:00

abstract：:A series of linkage studies was previously conducted to identify quantitative trait loci associated with chemically induced lung tumors. However, little is known of genetic susceptibility to spontaneously occurring lung tumorigenesis (SLT) in mice. In this study, we did a whole-genome linkage disequilibrium analysis f...

journal_title：Cancer research

authors： Wang D,You M

更新日期：2005-09-15 00:00:00

abstract：:The pathogenetic relationship between high-grade prostatic intraepithelial neoplasia (PIN), prostatic carcinoma, and metastases is poorly understood. We used fluorescence in situ hybridization (FISH) with centromere-specific probes for chromosomes 7, 8, 10, 12, and Y to evaluate numeric chromosomal anomalies in PIN (6...

journal_title：Cancer research

authors： Qian J,Bostwick DG,Takahashi S,Borell TJ,Herath JF,Lieber MM,Jenkins RB

更新日期：1995-11-15 00:00:00

abstract：:This study was designed to answer the question, do molecules with carcinoembryonic antigen (CEA) activity from colon, breast, and ovarian cancer differ? Extracts of two breast and three ovarian cancers with CEA activity were compared to three colon cancer CEA preparations and to the related antigen, colon carcinoma an...

journal_title：Cancer research

authors： Chism SE,Warner NL,Wells JV,Crewther P,Hunt S,Marchalonis JJ,Fudenberg HH

更新日期：1977-09-01 00:00:00

abstract：:To improve tumor:tissue ratios in immunoscintigraphy, a three-step targeting method has been developed. The reagents used were (a) a radioactive, low molecular weight chelate prepared from ionic gallium and a phenolic polyaminocarboxylic acid, which can be labeled either with the single-photon emitter 67Ga or with the...

journal_title：Cancer research

authors： Schuhmacher J,Klivényi G,Matys R,Stadler M,Regiert T,Hauser H,Doll J,Maier-Borst W,Zöller M

更新日期：1995-01-01 00:00:00

abstract：:A simple technique is described for fixing colony-containing layers of soft agar and drying them onto microscopic slides. The method is extrapolated from techniques used in immunology for permanent preservation of immunodiffusion or immunoelectrophoresis plates. Slides prepared in this fashion are eminently suitable f...

journal_title：Cancer research

authors： Salmon SE,Buick RN

更新日期：1979-03-01 00:00:00

abstract：:Triple-negative breast cancers (TNBC) are especially refractory to treatment due to their negative hormone receptor and ErbB2/HER2 status. Therefore, the identification of cancer-associated deregulated signaling pathways is necessary to develop improved targeted therapies. Here, we show that expression of the ceramide...

journal_title：Cancer research

authors： Heering J,Weis N,Holeiter M,Neugart F,Staebler A,Fehm TN,Bischoff A,Schiller J,Duss S,Schmid S,Korte T,Herrmann A,Olayioye MA

更新日期：2012-06-01 00:00:00

abstract：:The development of colon carcinomas is associated with allelic deletions on chromosomes 5q, 17p, and 18q. The DCC gene located on chromosome 18q21.3 codes for a potential tumor suppressor gene related to cellular adhesion receptors. We investigated the expression of this gene in several pancreatic carcinoma cell lines...

journal_title：Cancer research

authors： Höhne MW,Halatsch ME,Kahl GF,Weinel RJ

更新日期：1992-05-01 00:00:00

abstract：:Astrocytoma, the most common brain tumor in humans, is usually malignant and virtually incurable. Two types of malignant astrocytomas can be distinguished histopathologically: anaplastic astrocytoma and glioblastoma multiforme. Studies using DNA markers that detect restriction fragment length polymorphisms have shown ...

journal_title：Cancer research

authors： Fults D,Pedone CA,Thomas GA,White R

更新日期：1990-09-15 00:00:00

abstract：:A radioimmunoassay for transforming growth factor alpha (TGF-alpha) using synthetic rat sarcoma transforming growth factor and its rabbit polyclonal antibody has been developed. Using radioimmunoassays, the urinary TGF-alpha and epidermal growth factor (EGF) concentrations in 31 patients with hepatocellular carcinoma ...

journal_title：Cancer research

authors： Yeh YC,Tsai JF,Chuang LY,Yeh HW,Tsai JH,Florine DL,Tam JP

更新日期：1987-02-01 00:00:00

abstract：:Two monoclonal antibodies, OC 125 and OC 133, bind to distinct determinants on the surface of human epithelial ovarian carcinoma cell lines. OC 125 and OC 133 recognize determinants on molecules with molecular weights greater than 200,000 and 80,000, respectively. When binding to four different cell lines was compared...

journal_title：Cancer research

authors： Masuho Y,Zalutsky M,Knapp RC,Bast RC Jr

更新日期：1984-07-01 00:00:00

abstract：:The migration of three human prostate tumor epithelial cell lines (TSU-pr1, PC-3, DU-145) in response to secreted protein from a human prostate stromal cell line was investigated by using the modified blind-well Boyden chamber assay. Migrated cells were quantified by spectrophotometrically measuring the concentration ...

journal_title：Cancer research

authors： Djakiew D,Pflug BR,Delsite R,Onoda M,Lynch JH,Arand G,Thompson EW

更新日期：1993-03-15 00:00:00

abstract：:The relative amounts of HLA-A,B,C antigens, beta 2-microglobulin (beta 2m), and trophoblast antigens (Trop-1 and Trop-2) were determined on nine choriocarcinoma cell lines including seven lines of gestational origin and two lines of nongestational origin (from ovary and stomach) by quantitative immunofluorescence anal...

journal_title：Cancer research

authors： Kawata M,Sizer K,Sekiya S,Parnes JR,Herzenberg LA

更新日期：1984-09-01 00:00:00