Oncogene-Induced Senescence Limits the Progression of Pancreatic Neoplasia through Production of Activin A.

abstract：:The role of hereditary polymorphisms of the arylamine N-acetyltransferase 1 (NAT1) gene in the etiology of urinary bladder cancer is controversial. NAT1 is expressed in the urothelium and may O-acetylate hydroxyl amines, particularly in subjects with low NAT2 activity. Thus, NAT1 polymorphisms may affect the individua...

journal_title：Cancer research

authors： Cascorbi I,Roots I,Brockmöller J

更新日期：2001-07-01 00:00:00

abstract：:Clinical efficacy of PD-1/PD-L1 targeting relies upon the reactivation of tumor-specific but functionally impaired PD-1+ T cells present before therapy. Thus, analyzing early-stage primary tumors may reveal the presence of T cells that are not yet functionally impaired. In this study, we report that activated (HLA-DR+...

journal_title：Cancer research

authors： Tassi E,Grazia G,Vegetti C,Bersani I,Bertolini G,Molla A,Baldassari P,Andriani F,Roz L,Sozzi G,Pastorino U,Mortarini R,Anichini A

更新日期：2017-02-15 00:00:00

abstract：:Chemotherapeutic agents may damage gastrointestinal epithelium and thereby impair the mucosal barrier to bacteria and their products. In order to obtain an objective measurement of gastrointestinal permeability to large molecules, we measured urinary excretion of [14C]polyvinylpyrrolidone administered p.o. (mean molec...

journal_title：Cancer research

authors： Siber GR,Mayer RJ,Levin MJ

更新日期：1980-10-01 00:00:00

abstract：:Epidemiologic studies linking high serum iron with cancer risks are limited and inconclusive, despite evidence implicating body iron in human carcinogenesis. A cohort of 309,443 adults in Taiwan who had no history of cancer had serum iron levels tested at the time of recruitment (1997-2008). Initially measured iron le...

journal_title：Cancer research

authors： Wen CP,Lee JH,Tai YP,Wen C,Wu SB,Tsai MK,Hsieh DP,Chiang HC,Hsiung CA,Hsu CY,Wu X

更新日期：2014-11-15 00:00:00

abstract：:Deoxycytidine kinase (DCK) is a key enzyme for the activation of a broad spectrum of nucleoside-based chemotherapy drugs (e.g., gemcitabine); low DCK activity is one of the most important causes of cancer drug-resistance. Noninvasive imaging methods that can quantify DCK activity are invaluable for assessing tumor res...

journal_title：Cancer research

authors： Han Z,Li Y,Zhang J,Liu J,Chen C,van Zijl PC,Liu G

更新日期：2019-05-15 00:00:00

abstract：:WT1 encodes a zinc finger transcription factor that is expressed in the developing kidney and the inactivation of which leads to Wilms' tumor, a pediatric kidney cancer. We have recently shown that inducible expression of WT1 in osteosarcoma cells triggers programmed cell death, an effect that is associated with trans...

journal_title：Cancer research

authors： Englert C,Maheswaran S,Garvin AJ,Kreidberg J,Haber DA

更新日期：1997-04-15 00:00:00

abstract：:Notch signaling is an area of great interest in oncology. RO4929097 is a potent and selective inhibitor of gamma-secretase, producing inhibitory activity of Notch signaling in tumor cells. The RO4929097 IC50 in cell-free and cellular assays is in the low nanomolar range with >100-fold selectivity with respect to 75 ot...

journal_title：Cancer research

authors： Luistro L,He W,Smith M,Packman K,Vilenchik M,Carvajal D,Roberts J,Cai J,Berkofsky-Fessler W,Hilton H,Linn M,Flohr A,Jakob-Røtne R,Jacobsen H,Glenn K,Heimbrook D,Boylan JF

更新日期：2009-10-01 00:00:00

abstract：:Cross-coupling of active protein-1 (AP-1) and nuclear factor (NF)-kappaB has been reported. In the present study, we investigated the possibility that both of these two transcription factors might contribute to the process of tumor promoter-induced transformation. To establish a stable reporter cell system, two report...

journal_title：Cancer research

authors： Li JJ,Westergaard C,Ghosh P,Colburn NH

更新日期：1997-08-15 00:00:00

abstract：:Karyotypic and molecular genetic evidence has indicated that deletion or rearrangement of both chromosomes 3 and 13 may be important in the pathology of human small cell lung cancer (SCLC). The retinoblastoma susceptibility gene, RB, on chromosome 13 band q14, has previously been shown to be altered in SCLC [J. W. Har...

journal_title：Cancer research

authors： Hensel CH,Hsieh CL,Gazdar AF,Johnson BE,Sakaguchi AY,Naylor SL,Lee WH,Lee EY

更新日期：1990-05-15 00:00:00

abstract：:Prostate tumor cells, which characteristically metastasize to bone, initiate binding interactions with bone marrow endothelium under blood flow conditions through binding interactions with E-selectin. We hypothesized that E-selectin ligands on prostate tumor cells are directly associated with bone-metastatic potential...

journal_title：Cancer research

authors： Dimitroff CJ,Descheny L,Trujillo N,Kim R,Nguyen V,Huang W,Pienta KJ,Kutok JL,Rubin MA

更新日期：2005-07-01 00:00:00

abstract：:Cancer is associated with a prothrombogenic state capable of platelet activation. Platelets, on the other hand, can support angiogenesis, a process involved in the progression of tumor growth and metastasis. However, it is unclear whether platelet/tumor interactions substantially contribute to tumor physiology. We inv...

journal_title：Cancer research

authors： Ho-Tin-Noé B,Goerge T,Cifuni SM,Duerschmied D,Wagner DD

更新日期：2008-08-15 00:00:00

abstract：:Cell culture studies have been performed to compare the mutagenic potential and the induction of sister chromatid exchanges for hematoporphyrin derivative photoradiation, ionizing radiation, and UV radiation. The mutation frequency in Chinese hamster ovary cells at the hypoxanthine-guanine phosphoribosyltransferase lo...

journal_title：Cancer research

authors： Gomer CJ,Rucker N,Banerjee A,Benedict WF

更新日期：1983-06-01 00:00:00

abstract：:The high frequency of loss of heterozygosity (LOH) in epithelial cells of mammary ductal carcinoma in situ (DCIS) and IDC is a well known phenomenon, whereas the genetic abnormalities in the mammary stroma and its influence on the epithelial component have not been sufficiently studied. Using the PCR, we examined DNA ...

journal_title：Cancer research

authors： Moinfar F,Man YG,Arnould L,Bratthauer GL,Ratschek M,Tavassoli FA

更新日期：2000-05-01 00:00:00

abstract：:Rats were fed sodium saccharin as 5 or 7.5% of the diet by weight, and proliferation of the bladder epithelium was assessed by autoradiography, histology, and scanning electron microscopy. In Experiment 1, male F344 rats, 5 weeks old, were placed on a diet of 0, 5, or 7.5% NaS mixed in Prolab 3200, NIH-07, or AIN-76A ...

journal_title：Cancer research

authors： Garland EM,Sakata T,Fisher MJ,Masui T,Cohen SM

更新日期：1989-07-15 00:00:00

abstract：:Aflatoxicol, R0, was isolated from Mt. Shasta strain rainbow trout (Salmo gairdneri), and liver homogenates were incubated with aflatoxin B1. Its identity was confirmed by mass, infrared, and ultraviolet spectrometry. The structure was identical to one of the diastereomers prepared by chemical reduction of aflatoxin B...

journal_title：Cancer research

authors： Schoenhard GL,Lee DJ,Howell SE,Pawlowski NE,Libbey LM,Sinnhuber RO

更新日期：1976-06-01 00:00:00

abstract：:There are many animal models of glioma, but few that represent the biology of low-grade tumors and allow the study of the genetic mechanisms of glial oncogenesis. We report the in vivo transformation of astrocytic cells in transgenic mice by the SV40 T antigen under the control of the 5'-flanking sequence of the murin...

journal_title：Cancer research

authors： Danks RA,Orian JM,Gonzales MF,Tan SS,Alexander B,Mikoshiba K,Kaye AH

更新日期：1995-10-01 00:00:00

abstract：:Liposome formulations of camptothecins have been actively pursued because of the potential for significant pharmacologic advantages from successful drug delivery of this important class of anticancer drugs. We describe nanoliposomal CPT-11, a novel nanoparticle/liposome construct containing CPT-11 (irinotecan) with un...

journal_title：Cancer research

authors： Drummond DC,Noble CO,Guo Z,Hong K,Park JW,Kirpotin DB

更新日期：2006-03-15 00:00:00

abstract：:We have used a series of bifunctional chelating agents to prepare 206Bi-labeled monoclonal antibody and have assessed the in vivo stability and tumor targeting of these conjugates in the Rauscher murine erythroleukemia model. Several derivatives of diethylenetriaminepentaacetic acid [the dicyclic dianhydride of diethy...

journal_title：Cancer research

authors： Ruegg CL,Anderson-Berg WT,Brechbiel MW,Mirzadeh S,Gansow OA,Strand M

更新日期：1990-07-15 00:00:00

abstract：:Bortezomib (PS-341), a selective inhibitor of proteasome, induces apoptosis in various tumor cells, but its mechanism of action is unclear. Treatment with PS-341 induces apoptosis in SUDHL6 (DHL6), but not SUDHL4 (DHL4), lymphoma cells. Microarray analysis shows high RNA levels of heat shock protein-27 (Hsp27) in DHL4...

journal_title：Cancer research

authors： Chauhan D,Li G,Shringarpure R,Podar K,Ohtake Y,Hideshima T,Anderson KC

更新日期：2003-10-01 00:00:00

abstract：:MTH1 helps prevent misincorporation of ROS-damaged dNTPs into genomic DNA; however, there is little understanding of how MTH1 itself is regulated. Here, we report that MTH1 is regulated by polyubiquitination mediated by the E3 ligase Skp2. In melanoma cells, MTH1 was upregulated commonly mainly due to its improved sta...

journal_title：Cancer research

authors： Wang JY,Liu GZ,Wilmott JS,La T,Feng YC,Yari H,Yan XG,Thorne RF,Scolyer RA,Zhang XD,Jin L

更新日期：2017-11-15 00:00:00

abstract：:We have evaluated immunohistochemical characteristics of tumors and the infiltrating cells in patients treated with various immunotherapy regimens. Forty-eight patients with advanced malignancies were treated with high dose i.v. recombinant interleukin-2 alone or in combination with cyclophosphamide, recombinant tumor...

journal_title：Cancer research

authors： Rubin JT,Elwood LJ,Rosenberg SA,Lotze MT

更新日期：1989-12-15 00:00:00

abstract：:Surgical resection followed by radiation therapy is the mainstay of treatment for glioblastoma multiforme (GBM), the most aggressive of the malignant gliomas. The poor clinical response of GBM and the intrinsic radiation resistance of this tumor type have prompted clinical investigations seeking to define the role of ...

journal_title：Cancer research

authors： Yount GL,Haas-Kogan DA,Levine KS,Aldape KD,Israel MA

更新日期：1998-09-01 00:00:00

abstract：:To better understand immune responses to brain tumors and to develop possible approaches for immunotherapy, we have investigated the leukocyte populations infiltrating the rat 9L gliosarcoma. By immunocytochem-ical analyses of the cells infiltrating the tumor, we observed a substantial number of cells expressing natur...

journal_title：Cancer research

authors： Chambers WH,Bozik ME,Brissette-Storkus SC,Basse P,Redgate E,Watkins S,Boggs SS

更新日期：1996-08-01 00:00:00

abstract：:Dysregulation of Wnt/β-catenin signaling is frequently observed in human gastric cancer. Elucidation of the tumor immune microenvironment is essential for understanding tumorigenesis and for the development of immunotherapeutic strategies. However, it remains unclear how β-catenin signaling regulates the tumor immune ...

journal_title：Cancer research

authors： Ji L,Qian W,Gui L,Ji Z,Yin P,Lin GN,Wang Y,Ma B,Gao WQ

更新日期：2020-05-15 00:00:00

abstract：:The antitumoral effects of oncolytic viruses have generally been limited by inefficient spread of the viruses within infected tumors and by inefficient systemic delivery, particularly in preimmunized hosts. Tumor-selective poxviruses have biological characteristics that may overcome these limitations. Nevertheless, ph...

journal_title：Cancer research

authors： Kirn DH,Wang Y,Liang W,Contag CH,Thorne SH

更新日期：2008-04-01 00:00:00

abstract：:Mouse myeloma cells were fused with spleen cells from BALB/c mice immunized with a cell line derived from human small cell carcinoma (SCC) of the lung. The cloned hybridoma SM1 produced antibody that was reactive with the surface membrane of SCC cell lines and SCC tumors but not with the membrane of several non-SCC ce...

journal_title：Cancer research

authors： Bernal SD,Speak JA

更新日期：1984-01-01 00:00:00

abstract：:APCL, a central nervous system-specific sequence homologue of the adenomatous polyposis coli tumor suppressor, can regulate the cytoplasmic level of beta-catenin as the adenomatous polyposis coli tumor suppressor does, but its overall biological function remains unclear. Using a yeast two-hybrid system, we attempted t...

journal_title：Cancer research

authors： Nakagawa H,Koyama K,Murata Y,Morito M,Akiyama T,Nakamura Y

更新日期：2000-01-01 00:00:00

abstract：:Astrocytoma, the most common brain tumor in humans, is usually malignant and virtually incurable. Two types of malignant astrocytomas can be distinguished histopathologically: anaplastic astrocytoma and glioblastoma multiforme. Studies using DNA markers that detect restriction fragment length polymorphisms have shown ...

journal_title：Cancer research

authors： Fults D,Pedone CA,Thomas GA,White R

更新日期：1990-09-15 00:00:00

abstract：:About two thirds of laryngeal cancers originate at the vocal cords. Early-stage detection of malignant vocal fold alterations, including a discrimination of premalignant lesions, represents a major challenge in laryngology as precancerous vocal fold lesions and small carcinomas are difficult to distinguish by means of...

journal_title：Cancer research

authors： Unger J,Lohscheller J,Reiter M,Eder K,Betz CS,Schuster M

更新日期：2015-01-01 00:00:00

abstract：:We have established two new epithelial cell lines (NRP-152, NRP-154), with markedly different properties, from the dorsal-lateral prostate of Lobund/Wistar rats treated with N-methyl-N-nitrosourea and testosterone propionate. NRP-152 cells do not form tumors in athymic mice and retain many of the properties of normal ...

journal_title：Cancer research

authors： Danielpour D,Kadomatsu K,Anzano MA,Smith JM,Sporn MB

更新日期：1994-07-01 00:00:00