Cell-mediated antitumor immunity in breast cancer patients evaluated by antigen-induced leukocyte adherence inhibition in test tubes.

abstract：:The polyglutamylation of aminopterin and methotrexate (N10-methylaminopterin) was compared in the Ehrlich ascites tumor in vitro. Three poly-gamma-glutamyl conjugates of methotrexate and aminopterin were detected, although at an equal (1 microM) extracellular drug concentration, the net accumulation of aminopterin pol...

journal_title：Cancer research

authors： Matherly LH,Voss MK,Anderson LA,Fry DW,Goldman ID

更新日期：1985-03-01 00:00:00

abstract：:Experiments were performed to assess the role of liver cell necrosis in the induction of early steps in liver carcinogenesis with diethylnitrosamine, as measured by the appearance of foci of resistant hepatocytes that stain for gamma-glutamyl transpeptidase and that are presumptive preneoplastic lesions in the rat. Wi...

journal_title：Cancer research

authors： Ying TS,Sarma DS,Farber E

更新日期：1981-06-01 00:00:00

abstract：:Tetracyclines, a class of antibiotics that target bacterial translation, are commonly used in research for inducible gene expression using Tet-ON/Tet-OFF systems. However, such tetracycline-inducible systems carry a risk. Given that mitochondria have a "bacterial" ancestry, these antibiotics also target mitochondrial ...

journal_title：Cancer research

authors： Chatzispyrou IA,Held NM,Mouchiroud L,Auwerx J,Houtkooper RH

更新日期：2015-11-01 00:00:00

abstract：:Accumulating evidence suggests that the p53 gene is a good target for molecular epidemiological studies to search for risk factors in carcinogenic events. The lung cancer incidence for females in Hong Kong is unusually high, ranking among the highest in the world despite a low percentage with a history of smoking. To ...

journal_title：Cancer research

authors： Takagi Y,Koo LC,Osada H,Ueda R,Kyaw K,Ma CC,Suyama M,Saji S,Takahashi T,Tominaga S

更新日期：1995-11-15 00:00:00

abstract：:To improve the immunogenicity of melanoma self-antigens, we used a novel strategy of nonviral genetic vaccination coupled with muscle electroporation. Electroporation-enhanced immunization with plasmids encoding either human gp100 or mouse TRP-2 antigens induced only partial rejection of B16 melanoma challenge. Howeve...

journal_title：Cancer research

authors： Mendiratta SK,Thai G,Eslahi NK,Thull NM,Matar M,Bronte V,Pericle F

更新日期：2001-02-01 00:00:00

abstract：:The murine monoclonal antibody OC125 reacts with an antigenic determinant (CA 125) found on a high-molecular-weight glycoprotein complex present in the serum of greater than 80% of women with epithelial ovarian cancer. The antigen expressing CA 125 (CA 125 antigen) isolated from the sera of ovarian carcinoma patients ...

journal_title：Cancer research

authors： Davis HM,Zurawski VR Jr,Bast RC Jr,Klug TL

更新日期：1986-12-01 00:00:00

abstract：:Phosphatidylinositol 3-kinase (PI3K)/AKT pathway aberrations are common in cancer. By applying mass spectroscopy-based sequencing and reverse-phase protein arrays to 547 human breast cancers and 41 cell lines, we determined the subtype specificity and signaling effects of PIK3CA, AKT, and PTEN mutations and the effect...

journal_title：Cancer research

authors： Stemke-Hale K,Gonzalez-Angulo AM,Lluch A,Neve RM,Kuo WL,Davies M,Carey M,Hu Z,Guan Y,Sahin A,Symmans WF,Pusztai L,Nolden LK,Horlings H,Berns K,Hung MC,van de Vijver MJ,Valero V,Gray JW,Bernards R,Mills GB,Hennes

更新日期：2008-08-01 00:00:00

abstract：:The rat pancreatic carcinoma cell line AR4-2J was screened for growth-associated genes linked to the mitogenic effect of the novel gut brain hormone, pituitary adenylate cyclase activating polypeptide (PACAP). Using the mRNA differential display technique, we identified and sequenced an unknown rat gene, PACAP-respons...

journal_title：Cancer research

authors： Schäfer H,Trauzold A,Siegel EG,Fölsch UR,Schmidt WE

更新日期：1996-06-01 00:00:00

abstract：:Similarly to p53, p73alpha and p73beta induce growth arrest and/or apoptosis in response to DNA damage or when exogenously expressed. However, how they trigger apoptosis remains unresolved. After stable transduction of either p73alpha or p73beta, a greater apoptotic response was observed for p73beta in both primary an...

journal_title：Cancer research

authors： Gonzalez S,Perez-Perez MM,Hernando E,Serrano M,Cordon-Cardo C

更新日期：2005-03-15 00:00:00

abstract：:Topotecan (SK&F 104864, hycamptamine, NSC 609699) is believed to exert its cytotoxic effects through inhibition of topoisomerase I, the activity of which recovers rapidly on removal of the drug in vitro. In vivo studies show that the activity of topotecan is schedule dependent, favoring repeated doses. Early human stu...

journal_title：Cancer research

authors： Haas NB,LaCreta FP,Walczak J,Hudes GR,Brennan JM,Ozols RF,O'Dwyer PJ

更新日期：1994-03-01 00:00:00

abstract：:Treatment of rats with either intermittent bolus i.v. injections or continuous i.v. infusions of the same sublethal daily dose of tumor necrosis factor (TNF) results in decreased food intake and decreased nitrogen balance compared to saline-treated control rats. After 4 days of treatment, rats treated with intermitten...

journal_title：Cancer research

authors： Darling G,Fraker DL,Jensen JC,Gorschboth CM,Norton JA

更新日期：1990-07-01 00:00:00

abstract：:In 1956, Otto Warburg proposed that the origin of cancer cells was closely linked to a permanent respiratory defect that bypassed the Pasteur effect (i.e., the inhibition of anaerobic fermentation by oxygen). Since then, permanent defects in oxygen consumption that could explain the dependence of cancer cells on aerob...

journal_title：Cancer research

authors： Samudio I,Fiegl M,McQueen T,Clise-Dwyer K,Andreeff M

更新日期：2008-07-01 00:00:00

abstract：:Organization of cancer cells into endothelial-like cell-lined structures to support neovascularization and to fuel solid tumors is a hallmark of progression and poor outcome. In triple-negative breast cancer (TNBC), PDGFRβ has been identified as a key player of this process and is considered a promising target for bre...

journal_title：Cancer research

authors： D'Ippolito E,Plantamura I,Bongiovanni L,Casalini P,Baroni S,Piovan C,Orlandi R,Gualeni AV,Gloghini A,Rossini A,Cresta S,Tessari A,De Braud F,Di Leva G,Tripodo C,Iorio MV

更新日期：2016-09-15 00:00:00

abstract：:In order to characterize the promoting activity of the peroxisome proliferator [4-chloro-6-(2,3-xylidino)-2-pyrimidinylthio]acetic acid (WY-14,463), male F344 rats which received a single 150-mg/kg dose of diethylnitrosamine (DEN) were fed 0.1% WY-14,643 or 0.05% phenobarbital in the diet for 11, 22, or 54 wk. WY-14,6...

journal_title：Cancer research

authors： Cattley RC,Popp JA

更新日期：1989-06-15 00:00:00

abstract：:TEL-AML1 gene fusion derived by chromosomal translocation is a common acquired genetic lesion in pediatric cancer that is present in approximately 25% of B-cell precursor acute lymphoblastic leukemias, and recent evidence suggests that this recombination event may initiate leukemogenesis prenatally during fetal hemopo...

journal_title：Cancer research

authors： Wiemels JL,Greaves M

更新日期：1999-08-15 00:00:00

abstract：:Oncomir-1 is an oncogenic cluster of microRNAs (miRNA) located on chromosome 13. Previous in vitro studies showed that it is transcriptionally regulated by the transcription factor E2F3. In this report, we combine expression profiling of both mRNA and miRNAs in Wilms' tumor (WT) samples to provide the first evidence t...

journal_title：Cancer research

authors： Kort EJ,Farber L,Tretiakova M,Petillo D,Furge KA,Yang XJ,Cornelius A,Teh BT

更新日期：2008-06-01 00:00:00

abstract：:Cigarette smoke contains low levels of agonists for the aryl hydrocarbon receptor (AhR; also called the dioxin receptor). However, little is understood about the whole potential of cigarette smoke for activating AhR. In this report, we evaluated the total "dioxin-like" activity of cigarette smoke using in vitro and in...

journal_title：Cancer research

authors： Kasai A,Hiramatsu N,Hayakawa K,Yao J,Maeda S,Kitamura M

更新日期：2006-07-15 00:00:00

abstract：:The ErbB2 receptor tyrosine kinase is overexpressed in approximately 25% of breast tumors and contributes to poor patient prognosis and therapeutic resistance. Here, we examine the role of the recently discovered ErbB negative regulator LRIG1 in ErbB2(+) breast cancer. We observe that LRIG1 protein levels are signific...

journal_title：Cancer research

authors： Miller JK,Shattuck DL,Ingalla EQ,Yen L,Borowsky AD,Young LJ,Cardiff RD,Carraway KL 3rd,Sweeney C

更新日期：2008-10-15 00:00:00

abstract：:Sézary syndrome is the leukemic form of cutaneous T-cell lymphoma characterized by circulating neoplastic CD4+ T-cells. Although peripheral blood mononuclear cells from patients with Sézary syndrome have been shown to respond poorly to mitogens, we found that mitogen-activated peripheral blood mononuclear cells from f...

journal_title：Cancer research

authors： Abrams JT,Ghosh SK,DeFreitas E

更新日期：1993-11-15 00:00:00

abstract：:Induction of T-cell activation requires multiple signals provided by cell surface receptor interactions and/or cytokines. T-cell stimulation via the T-cell receptor/CD3 complex provides an important initial activation event which, when combined with the proper costimulatory signals, results in an activated effector T ...

journal_title：Cancer research

authors： Kroesen BJ,Bakker A,van Lier RA,The HT,de Leij L

更新日期：1995-10-01 00:00:00

abstract：:A historical cohort of 68 female breast cancer patients from one institution who were enrolled in a multicenter randomized controlled trial between 1971 and 1973 were followed up to the beginning of 1986. Weight and height at the time of mastectomy were transformed into two indices of body size, namely the Quetelet In...

journal_title：Cancer research

authors： Suissa S,Pollak M,Spitzer WO,Margolese R

更新日期：1989-06-01 00:00:00

abstract：:Available evidence suggests that, among hematological malignancies, p53 is most often mutated in Burkitt's lymphoma (BL). However, much of the published data is based on cell lines. We have, therefore, analyzed BL biopsies to determine more accurately the frequency and pattern of p53 mutations in primary tumors and to...

journal_title：Cancer research

authors： Bhatia KG,Gutiérrez MI,Huppi K,Siwarski D,Magrath IT

更新日期：1992-08-01 00:00:00

abstract：:A transplantable bladder tumor (Chapman R-4909) of the rat, when first received in our laboratory, grew with a complex histopathology. The predominant component was transitional cell carcinoma, but there were foci of keratinization, including pearl formation, and foci of a less well-defined cystic appearance. We repor...

journal_title：Cancer research

authors： Toyoshima K,Abaza N,Leighton J

更新日期：1976-08-01 00:00:00

abstract：:Transforming growth factor-beta (TGF-beta) promotes a multitude of diverse biological processes, including growth arrest of epithelial cells and proliferation of fibroblasts. Although the TGF-beta signaling pathways that promote inhibition of epithelial cell growth are well characterized, less is known about the mecha...

journal_title：Cancer research

authors： Rahimi RA,Andrianifahanana M,Wilkes MC,Edens M,Kottom TJ,Blenis J,Leof EB

更新日期：2009-01-01 00:00:00

abstract：:The majority of advanced prostate cancer therapies aim to inhibit androgen receptor (AR) signaling. However, AR reactivation inevitably drives disease progression to castration-resistant prostate cancer (CRPC). Here we demonstrate that protein arginine methyltransferase 5 (PRMT5) functions as an epigenetic activator o...

journal_title：Cancer research

authors： Beketova E,Fang S,Owens JL,Liu S,Chen X,Zhang Q,Asberry AM,Deng X,Malola J,Huang J,Li C,Pili R,Elzey BD,Ratliff TL,Wan J,Hu CD

更新日期：2020-11-15 00:00:00

abstract：:The evolution of immune blockades in tumors limits successful antitumor immunity, but the mechanisms underlying this process are not fully understood. Depletion of regulatory T cells (Treg), a T-cell subset that dampens excessive inflammatory and autoreactive responses, can allow activation of tumor-specific T cells. ...

journal_title：Cancer research

authors： Hindley JP,Jones E,Smart K,Bridgeman H,Lauder SN,Ondondo B,Cutting S,Ladell K,Wynn KK,Withers D,Price DA,Ager A,Godkin AJ,Gallimore AM

更新日期：2012-11-01 00:00:00

abstract：:Cell-cycle inhibition has yet to offer a generally effective approach to cancer treatment, but a full evaluation of different combinations of cell-cycle inhibitors has not been evaluated. Cyclin A2, a core component of the cell cycle, is often aberrantly expressed in cancer where it may impact cell proliferation. In t...

journal_title：Cancer research

authors： Gopinathan L,Tan SL,Padmakumar VC,Coppola V,Tessarollo L,Kaldis P

更新日期：2014-07-15 00:00:00

abstract：:We recently reported the transcription patterns of human papillomavirus (HPV) type 18 sequences in human cervical carcinoma cell lines. The open reading frames (ORFs) E6* and E6 represent the 5'-terminal cistrons in HPV18 mRNAs. ORF E6* was assumed to be specific for HPV types associated with genital carcinomas. To id...

journal_title：Cancer research

authors： Schneider-Gädicke A,Kaul S,Schwarz E,Gausepohl H,Frank R,Bastert G

更新日期：1988-06-01 00:00:00

abstract：:A monoclonal antibody (5E8) has been used to identify and structurally characterize a previously unreported macromolecule present on the surface of human lung tumors. This antibody was derived from a hybrid clone that was produced using spleen cells of mice immunized with a surgically excised squamous cell carcinoma. ...

journal_title：Cancer research

authors： Zylstra S,Chen FA,Ghosh SK,Repasky EA,Rao U,Takita H,Bankert RB

更新日期：1986-12-01 00:00:00

abstract：:Ovarian and testicular tumors were induced in the offspring (F1 generation) of MRC rats that received single or multiple doses of N-nitrosobis(2-oxopropyl)amine on the 14th, 18th, and/or 20th days of pregnancy. The ovarian tumor incidence was significantly higher (46%) in the F1 generation exposed to the carcinogen a ...

journal_title：Cancer research

authors： Pour PM

更新日期：1986-08-01 00:00:00