Prostaglandin H synthase-catalyzed metabolism and DNA binding of 2-naphthylamine.

abstract：:The cultivated mushroom of commerce in the Western hemisphere, Agaricus bisporus, was given p.o. to randomly bred Swiss mice for 3 days and was followed by semisynthetic diet for 4 days each week for life. The mice were 6 weeks old at the beginning of the experiment. As a result of treatment, tumors were induced in th...

journal_title：Cancer research

authors： Toth B,Erickson J

更新日期：1986-08-01 00:00:00

abstract：:Gliomas are primary brain tumors with high mortality and heterogeneous biology that is insufficiently understood. In this study, we performed a systematic analysis of the intrinsic organization of complex glioma transcriptome to gain deeper knowledge of the tumor biology. Gene coexpression relationships were explored ...

journal_title：Cancer research

authors： Ivliev AE,'t Hoen PA,Sergeeva MG

更新日期：2010-12-15 00:00:00

abstract：:Testicular germ cell cancer is one of the very few cancers that are highly sensitive to and curable by cisplatin-based chemotherapy even in an advanced stage. However, in a few cases resistance to cisplatin occurs and patients subsequently die from progressive disease. The molecular basis for this resistance remains t...

journal_title：Cancer research

authors： Mueller T,Voigt W,Simon H,Fruehauf A,Bulankin A,Grothey A,Schmoll HJ

更新日期：2003-01-15 00:00:00

abstract：:KRAS-activating mutations drive human non-small cell lung cancer and initiate lung tumorigenesis in genetically engineered mouse (GEM) models. However, in a GEM model of KRAS(G12D)-induced lung cancer, tumors arise stochastically following a latency period, suggesting that additional events are required to promote ear...

journal_title：Cancer research

authors： Green S,Trejo CL,McMahon M

更新日期：2015-12-15 00:00:00

abstract：:Iodine-131-labeled anti-CD45 antibody has been added to conventional hematopoietic stem cell transplant preparative regimens to deliver targeted radiation to hematopoietic tissues, with the goal of decreasing relapse rates without increasing toxicity. However, higher radiation doses could be delivered to leukemia cell...

journal_title：Cancer research

authors： Ruffner KL,Martin PJ,Hussell S,Nourigat C,Fisher DR,Bernstein ID,Matthews DC

更新日期：2001-07-01 00:00:00

abstract：:The molecular hallmark of Philadelphia chromosome-positive acute lymphoblastic leukemia (ALL) is the expression of 1 of 2 alternate forms of the aberrant BCR-ABL protein-p210BCR-ABL or p190BCR-ABL. The presence of BCR-ABL message provides a target for analyzing the lineage derivation of this disease. We, therefore, st...

journal_title：Cancer research

authors： Estrov Z,Talpaz M,Kantarjian HM,Zipf TF,McClain KL,Kurzrock R

更新日期：1993-07-15 00:00:00

abstract：:Estrogen independence and progression to a metastatic phenotype are hallmarks of therapeutic resistance and mortality in breast cancer patients. Metastasis has been associated with chemokine signaling through the SDF-1-CXCR4 axis. Thus, the development of estrogen independence and endocrine therapy resistance in breas...

journal_title：Cancer research

authors： Rhodes LV,Short SP,Neel NF,Salvo VA,Zhu Y,Elliott S,Wei Y,Yu D,Sun M,Muir SE,Fonseca JP,Bratton MR,Segar C,Tilghman SL,Sobolik-Delmaire T,Horton LW,Zaja-Milatovic S,Collins-Burow BM,Wadsworth S,Beckman BS,Wood CE

更新日期：2011-01-15 00:00:00

abstract：:Each tumor harbors unique repertoire of mutated antigenic peptides that are immunogenic and potentially can induce tumor-specific immune responses. Because heat shock proteins (HSPs) have the promiscuous ability to chaperone and present a broad repertoire of tumor antigens to antigen presenting cells, HSP tumor vaccin...

journal_title：Cancer research

authors： Huang XF,Ren W,Rollins L,Pittman P,Shah M,Shen L,Gu Q,Strube R,Hu F,Chen SY

更新日期：2003-11-01 00:00:00

abstract：:There is increasing evidence that high doses of radiotherapy, like those delivered in stereotactic body radiotherapy (SBRT), trigger indirect mechanisms of cell death. Such effect seems to be two-fold. High doses may trigger an immune response and may cause vascular damage, leading to cell starvation and death. Develo...

journal_title：Cancer research

authors： Rodríguez-Barbeito P,Díaz-Botana P,Gago-Arias A,Feijoo M,Neira S,Guiu-Souto J,López-Pouso Ó,Gómez-Caamaño A,Pardo-Montero J

更新日期：2019-12-01 00:00:00

abstract：:The lymphoid tissue in the omentum, at the so-called milky spots, is known as an initial place for disseminated cancer cells to develop into solid tumors. In the present study, i.p. macrophages significantly took up oligomannose-coated liposomes (OMLs) that were injected into the peritoneal cavity, and then gradually ...

journal_title：Cancer research

authors： Ikehara Y,Niwa T,Biao L,Ikehara SK,Ohashi N,Kobayashi T,Shimizu Y,Kojima N,Nakanishi H

更新日期：2006-09-01 00:00:00

abstract：:Pharmacokinetic studies of 5-fluorouracil (5-FUra) were performed on 18 patients divided into three groups: seven patients were given 5-FUra i.v. by rapid injection; five patients received the drug p.o.; and six patients were treated by continuous i.v. infusion for 96 hr. The results showed rapid i.v. injection to be ...

journal_title：Cancer research

authors： Fraile RJ,Baker LH,Buroker TR,Horwitz J,Vaitkevicius VK

更新日期：1980-07-01 00:00:00

abstract：:Traditionally, non-small cell lung cancer (NSCLC) has been evaluated as a unique entity in genotyping studies. However, recent biological data suggest that different NSCLC subtypes, specifically adenocarcinomas (AC) and squamous cell carcinomas (SCC), differentially alter cancer behavior. Several studies have associat...

journal_title：Cancer research

authors： Liu G,Miller DP,Zhou W,Thurston SW,Fan R,Xu LL,Lynch TJ,Wain JC,Su L,Christiani DC

更新日期：2001-12-15 00:00:00

abstract：:A role for proteolysis during chemical induction of endogenous xenotropic Type C virus from Kirsten sarcoma virus-transformed mouse cells was examined. Two distinct classes of protease inhibitors, the trypsin inhibitor, alpha-N-tosyl-L-lysine chloromethyl ketone, and two naturally occurring oligopeptide inhibitors, an...

journal_title：Cancer research

authors： Long CW,Bruszewski JA,Christensen WL,Suk WA

更新日期：1979-08-01 00:00:00

abstract：:Despite the apparent similarity of the dexamethasone-receptor concentration in the rat liver and Novikoff hepatoma cytoplasms, the in vitro translocation of the dexamethasone-receptor complex into liver or hepatoma nuclei was three times greater from liver as compared to hepatoma cytosol; both cytosols showed an appar...

journal_title：Cancer research

authors： Liu SL,Webb TE

更新日期：1977-06-01 00:00:00

abstract：:Cells lacking the tumor suppressor gene LKB1/STK11 alter their metabolism to match the demands of accelerated growth, leaving them highly vulnerable to stress. However, targeted therapy for LKB1-deficient cancers has yet to be reported. In both Kras/p53/Lkb1 cell lines and a genetically engineered mouse model of Kras/...

journal_title：Cancer research

authors： Liu Y,Li Y,Wang X,Liu F,Gao P,Quinn MM,Li F,Merlino AA,Benes C,Liu Q,Gray NS,Wong KK

更新日期：2017-09-15 00:00:00

abstract：:Previously, we identified an amplified gene in a stomach cancer cell line, KATO-III, and designated it K-sam. This gene was later found to be identical with a gene for a receptor tyrosine kinase, bek/FGFR2. One of the characteristics of the K-sam gene is structural diversity of its transcripts; K-sam complementary DNA...

journal_title：Cancer research

authors： Ishii H,Hattori Y,Itoh H,Kishi T,Yoshida T,Sakamoto H,Oh H,Yoshida S,Sugimura T,Terada M

更新日期：1994-01-15 00:00:00

abstract：:In an attempt to identify phytochemicals contributing to the well-documented preventive effect of plant-based diets on cancer incidence and mortality, we have previously shown that certain flavonoids inhibit in vitro angiogenesis. Here, we show that the flavonoid luteolin inhibited tumor growth and angiogenesis in a m...

journal_title：Cancer research

authors： Bagli E,Stefaniotou M,Morbidelli L,Ziche M,Psillas K,Murphy C,Fotsis T

更新日期：2004-11-01 00:00:00

abstract：:We developed a novel approach for conducting multisample, multigene, ultradeep bisulfite sequencing analysis of DNA methylation patterns in clinical samples. A massively parallel sequencing-by-synthesis method (454 sequencing) was used to directly sequence >100 bisulfite PCR products in a single sequencing run without...

journal_title：Cancer research

authors： Taylor KH,Kramer RS,Davis JW,Guo J,Duff DJ,Xu D,Caldwell CW,Shi H

更新日期：2007-09-15 00:00:00

abstract：:Bloom syndrome is an autosomal recessive disorder whose characteristics include an increased risk for many types of cancers. In contrast to the homozygous mutations of Bloom syndrome, heterozygous carriers of BLM mutations may be at increased risk for developing colorectal cancer. We have screened 2,333 Jewish individ...

journal_title：Cancer research

authors： Cleary SP,Zhang W,Di Nicola N,Aronson M,Aube J,Steinman A,Haddad R,Redston M,Gallinger S,Narod SA,Gryfe R

更新日期：2003-04-15 00:00:00

abstract：:Neuroblastoma cells accumulate ascorbic acid and iron. It was hypothesized that these features could be exploited for sensitizing neuroblastoma cells for therapy in combination with reactive oxygen intermediates. In the present study the effects of 6-hydroxydopamine (6-OHDA) and H2O2 on metabolic parameters critical f...

journal_title：Cancer research

authors： Bruchelt G,Schraufstätter IU,Niethammer D,Cochrane CG

更新日期：1991-11-15 00:00:00

abstract：:TGF-β has limited effects on ovarian cancer cells, but its contributions to ovarian tumor growth might be mediated through elements of the tumor microenvironment. In the present study, we tested the hypothesis that TGF modulates ovarian cancer progression by modulating the contribution of cancer-associated fibroblasts...

journal_title：Cancer research

authors： Yeung TL,Leung CS,Wong KK,Samimi G,Thompson MS,Liu J,Zaid TM,Ghosh S,Birrer MJ,Mok SC

更新日期：2013-08-15 00:00:00

abstract：:The lack of markers to predict chemotherapy responses in patients poses a major handicap in cancer treatment. We searched for gene expression patterns that correlate with docetaxel or cisplatin response in a mouse model for breast cancer associated with BRCA1 deficiency. Array-based expression profiling did not identi...

journal_title：Cancer research

authors： Rottenberg S,Vollebergh MA,de Hoon B,de Ronde J,Schouten PC,Kersbergen A,Zander SA,Pajic M,Jaspers JE,Jonkers M,Lodén M,Sol W,van der Burg E,Wesseling J,Gillet JP,Gottesman MM,Gribnau J,Wessels L,Linn SC,Jonkers J,

更新日期：2012-05-01 00:00:00

abstract：:In this study of breast cancer specimens, the relationship between cytosolic estrogen (ER) and progesterone receptor (PR) content to the size of the respective growth fraction (GF) (expressed as percentage of proliferating tumor cells) was investigated. We applied the recently developed ligand-binding assay for extrac...

journal_title：Cancer research

authors： Vollmer G,Gerdes J,Knuppen R

更新日期：1989-07-15 00:00:00

abstract：:Cancer chemotherapy may be improved by increasing antineoplastic drug specificity for tumor cells. We have synthesized a glucuronide prodrug that can be enzymatically converted to an antineoplastic agent at tumor cells that are able to bind beta-glucuronidase-monoclonal antibody conjugates. The glucuronide prodrug BHA...

journal_title：Cancer research

authors： Wang SM,Chern JW,Yeh MY,Ng JC,Tung E,Roffler SR

更新日期：1992-08-15 00:00:00

abstract：:As recently characterized, following s.c. implantation into syngeneic C57BL/6 mice, E0771 tumor invades locally into dermal layers and peritoneum, metastasizes to the lung, and induces a nonspecific immunosuppression in the host. Using this breast medullar adenocarcinoma model, a therapy consisting of a single moderat...

journal_title：Cancer research

authors： Ewens A,Luo L,Berleth E,Alderfer J,Wollman R,Hafeez BB,Kanter P,Mihich E,Ehrke MJ

更新日期：2006-05-15 00:00:00

abstract：:Dendritic cells (DCs) are attractive candidates for innovative cancer immunotherapy by virtue of their potential to function as professional antigen-presenting cells for initiating cellular immune responses. In this study, we evaluated a possible synergy of conventional chemotherapy together with intratumoral injectio...

journal_title：Cancer research

authors： Tong Y,Song W,Crystal RG

更新日期：2001-10-15 00:00:00

abstract：:Thrombin-mediated proteolysis is a major determinant of metastasis, but is not universally important for primary tumor growth. Here, we report that colorectal adenocarcinoma represents one important exception whereby thrombin-mediated functions support both primary tumor growth and metastasis. In contrast with studies...

journal_title：Cancer research

authors： Adams GN,Rosenfeldt L,Frederick M,Miller W,Waltz D,Kombrinck K,McElhinney KE,Flick MJ,Monia BP,Revenko AS,Palumbo JS

更新日期：2015-10-01 00:00:00

abstract：:The supply of oxygen and nutrients to solid tumors is inefficient because cancer tissues have an inadequate number of microvessels, thus inducing the selective growth of the most aggressive cancer cells. This explains why many of the factors underlying a poor prognosis are induced in hypoxic/hypoglycemic conditions. A...

journal_title：Cancer research

authors： Raspaglio G,De Maria I,Filippetti F,Martinelli E,Zannoni GF,Prislei S,Ferrandina G,Shahabi S,Scambia G,Ferlini C

更新日期：2010-07-15 00:00:00

abstract：:The effect of i.v. administration of the nitric oxide synthase (NOS) inhibitor N(omega)-nitro-L-arginine (L-NNA) on tumor blood flow compared with normal tissue blood flow was studied in anesthetized BD9 rats bearing subcutaneous P22 carcinosarcomas. Blood flow was measured by the tissue uptake of radiolabeled iodoant...

journal_title：Cancer research

authors： Tozer GM,Prise VE,Chaplin DJ

更新日期：1997-03-01 00:00:00

abstract：:Multifunctional cytokines play important and only partially defined roles in mammary tumor development and progression. Normal human mammary epithelia] cells (MECs) constitutively produce interleukin (IL) 6, IL8, and a nonsecreted form of tumor necrosis factor. MEC transformation by different oncogenes is frequently a...

journal_title：Cancer research

authors： Basolo F,Fiore L,Fontanini G,Conaldi PG,Calvo S,Falcone V,Toniolo A

更新日期：1996-07-01 00:00:00