Abstract：
:A role for proteolysis during chemical induction of endogenous xenotropic Type C virus from Kirsten sarcoma virus-transformed mouse cells was examined. Two distinct classes of protease inhibitors, the trypsin inhibitor, alpha-N-tosyl-L-lysine chloromethyl ketone, and two naturally occurring oligopeptide inhibitors, antipain and leupeptin, were found to inhibit induction of virus by cycloheximide and histidinol. Virus activation by 5-iododeoxyuridine was inhibited to a lesser degree. During the time cells were exposed to these compounds, there was little inhibition of [3H]uridine incorporation into total cellular RNA or polyadenylic acid cytoplasmic messenger RNA, suggesting that inhibition of proteolysis, and not RNA transcription, was responsible for blocking virus induction.
journal_name
Cancer Resjournal_title
Cancer researchauthors
Long CW,Bruszewski JA,Christensen WL,Suk WAsubject
Has Abstractpub_date
1979-08-01 00:00:00pages
2995-9issue
8eissn
0008-5472issn
1538-7445journal_volume
39pub_type
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