Differential Effects of IL6 and Activin A in the Development of Cancer-Associated Cachexia.

abstract：:The mechanism of in vitro cytotoxicity by tumor necrosis serum (TNS) and a purified fraction was examined using sensitive L-M cells. Cell death was assessed by uptake of the dye trypan blue and/or by release of radiolabeled chromium. Cell killing was time and dose dependent. Cell survival was assessed by counting the ...

journal_title：Cancer research

authors： Kull FC Jr,Cuatrecasas P

更新日期：1981-12-01 00:00:00

abstract：:Gene-targeted mice that contain a His6-tagged mouse c-Myc cDNA, Myc(His), inserted head to head into different sites of the mouse immunoglobulin heavy-chain locus, Igh, mimic the chromosomal T(12;15)(Igh-Myc) translocation that results in the activation of Myc in the great majority of mouse plasmacytomas. Mice carryin...

journal_title：Cancer research

authors： Park SS,Shaffer AL,Kim JS,duBois W,Potter M,Staudt LM,Janz S

更新日期：2005-09-01 00:00:00

abstract：:The human cytomegalovirus (HCMV), potentially associated with the development of malignancies, encodes the constitutively active chemokine receptor US28. Previously, we have shown that US28 expression induces an oncogenic phenotype both in vitro and in vivo. Microarray analysis revealed differential expression of gene...

journal_title：Cancer research

authors： Maussang D,Langemeijer E,Fitzsimons CP,Stigter-van Walsum M,Dijkman R,Borg MK,Slinger E,Schreiber A,Michel D,Tensen CP,van Dongen GA,Leurs R,Smit MJ

更新日期：2009-04-01 00:00:00

abstract：:The human glioma-derived cell line D-54 MG and the human medulloblastoma-derived cell line TE-671 have been shown to be sensitive in culture to the pharmacological interference with glutamine metabolism by acivicin, 6-diazo-5-oxo-L-norleucine, and methionine sulfoximine. Using as a guide the multiple contributions of ...

journal_title：Cancer research

authors： Dranoff G,Elion GB,Friedman HS,Bigner DD

更新日期：1985-09-01 00:00:00

abstract：:Elevated oxidative stress is observed more frequently in cancer cells than in normal cells. It is therefore expected that additional exposure to a low level of reactive oxygen species (ROS) will push cancer cells toward death, whereas normal cells might maintain redox homeostasis through adaptive antioxidant responses...

journal_title：Cancer research

authors： Xu Y,Fang F,Miriyala S,Crooks PA,Oberley TD,Chaiswing L,Noel T,Holley AK,Zhao Y,Kiningham KK,Clair DK,Clair WH

更新日期：2013-07-15 00:00:00

abstract：:Inflammatory pathways may mediate preparation of the "metastatic soil" in the lungs. Some of these pathways--activation and/or the recruitment of certain inflammatory cells--might depend on vascular endothelial growth factor receptor 1 (VEGFR1) activity. Thus, blocking the activity of VEGFR1 (or the interaction with i...

journal_title：Cancer research

authors： Duda DG,Jain RK

更新日期：2010-07-15 00:00:00

abstract：:We have examined the effects of protein kinase C (PK-C) stimulation and cytosolic Ca2+ elevation on the in vitro induction of non-histocompatibility-restricted tumoricidal activity from human peripheral blood lymphocytes. The tumor cytolytic activity, as well as the number of cells recovered from interleukin 2 (IL-2)-...

journal_title：Cancer research

authors： McCrady CW,Li F,Grant AJ,Merchant RE,Carchman RA

更新日期：1988-02-01 00:00:00

abstract：:The aim of this study was to evaluate to what extent tumor necrosis factor alpha (TNF-alpha) and interleukin 1 may explain the development of experimental cancer cachexia. For this purpose, C57BL/6J mice bearing a transplantable low differentiated rapidly growing tumor were passively immunized every other day with rab...

journal_title：Cancer research

authors： Gelin J,Moldawer LL,Lönnroth C,Sherry B,Chizzonite R,Lundholm K

更新日期：1991-01-01 00:00:00

abstract：:Cyclooxygenase-2 (Cox-2) expression can induce mammary tumorigenesis in transgenic mice, and selective Cox-2 inhibitors are both chemopreventive and chemotherapeutic in rat models of breast cancer. We analyzed the expression of Cox-2 protein by immunohistochemistry in tissue array specimens of 1576 invasive breast can...

journal_title：Cancer research

authors： Ristimäki A,Sivula A,Lundin J,Lundin M,Salminen T,Haglund C,Joensuu H,Isola J

更新日期：2002-02-01 00:00:00

abstract：:Estrogen-related receptor alpha (ERRalpha) was identified as a gene related to estrogen receptor alpha (ERalpha) and belongs to a class of nuclear orphan receptors. ERRalpha binds to estrogen responsive element(s) (ERE) and is considered to be involved in modulation of estrogenic actions. However, biological significa...

journal_title：Cancer research

authors： Suzuki T,Miki Y,Moriya T,Shimada N,Ishida T,Hirakawa H,Ohuchi N,Sasano H

更新日期：2004-07-01 00:00:00

abstract：:Members of the phosphatidylinositol 3-kinase-related kinase family, in particular the ataxia-telangiectasia mutated (ATM) kinase and the catalytic subunit of the DNA-dependent protein kinase (DNA-PKcs), regulate cellular responses to DNA double-strand breaks. Increased sensitivity to ionizing radiation (IR) in DNA-PKc...

journal_title：Cancer research

authors： Arlander SJ,Greene BT,Innes CL,Paules RS

更新日期：2008-01-01 00:00:00

abstract：:The objective of this study is to elucidate the association between high-arsenic artesian well water and cancers in endemic area of blackfoot disease, a unique peripheral vascular disease related to continuous arsenic exposure. As compared with the general population in Taiwan, both the standardized mortality ratio (S...

journal_title：Cancer research

authors： Chen CJ,Chuang YC,Lin TM,Wu HY

更新日期：1985-11-01 00:00:00

abstract：:The possibility that the female sex steroid progesterone plays a role in meningioma proliferation has been suggested by a number of investigators; and it had been shown that many meningiomas have high affinity progesterone binding sites. The aim of this study was to examine the expression of progesterone receptor mRNA...

journal_title：Cancer research

authors： Carroll RS,Glowacka D,Dashner K,Black PM

更新日期：1993-03-15 00:00:00

abstract：:Chicken chondrocytes isolated from 11-day-old chicken vertebrate cartilage were transformed by Rous sarcoma virus ts LA24 of the Prague strain as well as by the wild-type Prague strain of Rous sarcoma virus. The morphology of chondrocytes transformed by Rous sarcoma virus ts LA 24 was dependent on the temperature, and...

journal_title：Cancer research

authors： Okayama M,Yoshimura M,Muto M,Chi J,Roth S,Kaji A

更新日期：1977-03-01 00:00:00

abstract：:Blood tests to detect circulating tumor cells (CTC) offer great potential to monitor disease status, gauge prognosis, and guide treatment decisions for patients with cancer. For patients with brain tumors, such as aggressive glioblastoma multiforme, CTC assays are needed that do not rely on expression of cancer cell s...

journal_title：Cancer research

authors： Macarthur KM,Kao GD,Chandrasekaran S,Alonso-Basanta M,Chapman C,Lustig RA,Wileyto EP,Hahn SM,Dorsey JF

更新日期：2014-04-15 00:00:00

abstract：:Combinatorial strategies are needed to overcome the resistance of pancreatic cancer to immune checkpoint blockade (ICB). DNA damage activates the innate immune response and improves ICB efficacy. Because ATM is an apical kinase in the radiation-induced DNA damage response, we investigated the effects of ATM inhibition...

journal_title：Cancer research

authors： Zhang Q,Green MD,Lang X,Lazarus J,Parsels JD,Wei S,Parsels LA,Shi J,Ramnath N,Wahl DR,Pasca di Magliano M,Frankel TL,Kryczek I,Lei YL,Lawrence TS,Zou W,Morgan MA

更新日期：2019-08-01 00:00:00

abstract：:In Sarcoma 180 and L1210 ascites tumor models, the initial rate of methotrexate accumulation in tumor cells in the peritoneal cavity and in small intestine (intracellularly) after s.c. doses up to 800 mg/kg, showed saturation kinetics. These results and the fact that initial uptake in these tissues within this dosage ...

journal_title：Cancer research

authors： Sirotnak FM,Donsbach RC,Dorick DM,Moccio DM

更新日期：1976-12-01 00:00:00

abstract：:Extracellular signal-regulated kinases (ERK) regulate cellular functions in response to a variety of external signals. However, the specific functions of individual ERK isoforms are largely unknown. Hence, we have investigated the specific function of ERK1 in skin homeostasis and tumorigenesis in ERK1 knockout mice. T...

journal_title：Cancer research

authors： Bourcier C,Jacquel A,Hess J,Peyrottes I,Angel P,Hofman P,Auberger P,Pouysségur J,Pagès G

更新日期：2006-03-01 00:00:00

abstract：:N,N-Dimethylformamide treatment of cell cultures established from a transplantable murine rhabdomyosarcoma-induced morphological differentiation and a marked reduction in the tumorigenicity of the sarcoma cells. Fourteen of 17 CE/J mice receiving injections of inducer-treated cells did not develop tumors after 6 month...

journal_title：Cancer research

authors： Dexter DL

更新日期：1977-09-01 00:00:00

abstract：:Gene targeting studies in mice have shown that the transcription factor Ikaros plays an essential role in lymphoid development and as a tumor suppressor in T cells, whereas the related gene Aiolos functions as a tumor suppressor in B cells. We analyzed the expression levels of the Ikaros gene family, Ikaros and Aiolos...

journal_title：Cancer research

authors： Nakase K,Ishimaru F,Avitahl N,Dansako H,Matsuo K,Fujii K,Sezaki N,Nakayama H,Yano T,Fukuda S,Imajoh K,Takeuchi M,Miyata A,Hara M,Yasukawa M,Takahashi I,Taguchi H,Matsue K,Nakao S,Niho Y,Takenaka K,Shinagawa K,

更新日期：2000-08-01 00:00:00

abstract：:Cyclins and cyclin-dependent kinases regulate the cell cycle. Cyclin A has a dual role in cell proliferation. It is essential in the S phase for DNA replication, and it is also involved in G2-M-phase transition, signifying actively dividing cells. The expression of cyclin A was determined by immunohistochemistry in pa...

journal_title：Cancer research

authors： Huuhtanen RL,Blomqvist CP,Böhling TO,Wiklund TA,Tukiainen EJ,Virolainen M,Tribukait B,Andersson LC

更新日期：1999-06-15 00:00:00

abstract：:Despite their extensive clinical and pathologic heterogeneity, all malignant germ cell tumors (GCT) are thought to originate from primordial germ cells. However, no common biological abnormalities have been identified to date. We profiled 615 microRNAs (miRNA) in pediatric malignant GCTs, controls, and GCT cell lines ...

journal_title：Cancer research

authors： Palmer RD,Murray MJ,Saini HK,van Dongen S,Abreu-Goodger C,Muralidhar B,Pett MR,Thornton CM,Nicholson JC,Enright AJ,Coleman N,Children's Cancer and Leukaemia Group.

更新日期：2010-04-01 00:00:00

abstract：:Mitogen-activated protein kinase (MAPK) kinase 4 (MKK4) is a component of a stress and cytokine-induced signal transduction pathway involving MAPK proteins. The MKK4 protein has been implicated in activation of JNK1 and p38 MAPK on phosphorylation by conserved kinase pathways. A recent report on the deletion and mutat...

journal_title：Cancer research

authors： Su GH,Hilgers W,Shekher MC,Tang DJ,Yeo CJ,Hruban RH,Kern SE

更新日期：1998-06-01 00:00:00

abstract：:Commercially available St. John's wort (Hypericum perforatum) preparations and some of their main constituents (hypericin, pseudohypericin, hyperforin, rutin, and quercetin) were examined for their potential to inhibit carcinogen activation by human cytochrome P450 1A1 (CYP1A1). We used a reconstituted system consisti...

journal_title：Cancer research

authors： Schwarz D,Kisselev P,Roots I

更新日期：2003-11-15 00:00:00

abstract：:Aberrant genome-wide hypomethylation has been thought to be related to tumorigenesis. However, its mechanism and implications in hepatocellular carcinogenesis remain to be elucidated. Samples of hepatoma (hepatocellular carcinoma, HCC) and paired non-HCC liver tissues were obtained from 17 HCC patients. Normal liver t...

journal_title：Cancer research

authors： Lin CH,Hsieh SY,Sheen IS,Lee WC,Chen TC,Shyu WC,Liaw YF

更新日期：2001-05-15 00:00:00

abstract：:Tumor suppressor p53-dependent apoptosis is thought to be one of the most important tumor-suppressive functions in human tumorigenesis. However, whether the major mechanism underlying the p53-dependent apoptosis is transactivation dependent or independent remains unclear. Using 179 mutant p53s with diverse transcripti...

journal_title：Cancer research

authors： Kakudo Y,Shibata H,Otsuka K,Kato S,Ishioka C

更新日期：2005-03-15 00:00:00

abstract：:Determination of estrogen receptor content in 82 breast cancer specimens with immunocytochemical estrogen receptor assay (ER-EIA) (Abbott) was compared with our routinely used binding assay using 125I-estradiol as radioligand with Scatchard plot analysis of the binding data. Although the estrogen receptor content meas...

journal_title：Cancer research

authors： Heubner A,Beck T,Grill HJ,Pollow K

更新日期：1986-08-01 00:00:00

abstract：:The chemopreventive activity of two synthetic retinamides of relatively low toxicity against N-butyl-N-(4-hydroxybutyl)nitrosamine (OH-BBN)-induced urinary bladder cancer was studied in F344 rats and C57BL/6 X DBA/2 F1 mice. Female and male rats were given a total dose of either 1800 or 3200 mg OH-BBN over a period of...

journal_title：Cancer research

authors： Thompson HJ,Becci PJ,Grubbs CJ,Shealy YF,Stanek EJ,Brown CC,Sporn MB,Moon RC

更新日期：1981-03-01 00:00:00

abstract：:We reported that NK4, composed of the N-terminal hairpin and subsequent four kringle domains of hepatocyte growth factor (HGF), acts as the competitive antagonist for HGF. We now provide the first evidence that NK4 inhibits tumor growth and metastasis as an angiogenesis inhibitor as well as an HGF antagonist. Administ...

journal_title：Cancer research

authors： Kuba K,Matsumoto K,Date K,Shimura H,Tanaka M,Nakamura T

更新日期：2000-12-01 00:00:00

abstract：:Inhibition of the survival kinase Akt can trigger apoptosis, and also has been found to activate autophagy, which may confound tumor attack. In this study, we investigated regulatory mechanisms through which apoptosis and autophagy were modulated in tumor cells subjected to Akt inhibition by MK-2206, the first alloste...

journal_title：Cancer research

authors： Cheng Y,Ren X,Zhang Y,Patel R,Sharma A,Wu H,Robertson GP,Yan L,Rubin E,Yang JM

更新日期：2011-04-01 00:00:00