Inflammation-mediated cytosine damage: a mechanistic link between inflammation and the epigenetic alterations in human cancers.

abstract：:Previous studies have shown that PC12 cells undergo apoptosis (programmed cell death) when deprived of serum. In the present study, we examined the relationship of this death process to the cell cycle. PC12 cell populations synchronized at different, specific phases of the cell cycle exhibit similar kinetics of cell d...

journal_title：Cancer research

authors： Lindenboim L,Diamond R,Rothenberg E,Stein R

更新日期：1995-03-15 00:00:00

abstract：:Salvage of preformed nucleosides requires transport across the plasma membrane by sodium-dependent (concentrative) and sodium-independent (equilibrative) mechanisms. These transport systems are also the route of cellular uptake for nucleoside analogues, including gemcitabine (2',2'-difluorodeoxycytidine), a deoxycytid...

journal_title：Cancer research

authors： Rauchwerger DR,Firby PS,Hedley DW,Moore MJ

更新日期：2000-11-01 00:00:00

abstract：:Although the concept that cancers originate from stem cells (SC) is becoming scientifically accepted, mechanisms by which SC contribute to tumor initiation and progression are largely unknown. For colorectal cancer (CRC), investigation of this problem has been hindered by a paucity of specific markers for identificati...

journal_title：Cancer research

authors： Huang EH,Hynes MJ,Zhang T,Ginestier C,Dontu G,Appelman H,Fields JZ,Wicha MS,Boman BM

更新日期：2009-04-15 00:00:00

abstract：:We cloned mouse ING1 homologue (mINGh), an A1/Bfl-1-interacting protein, from mouse mammary glands using a yeast two-hybrid assay and unexpectedly found four splicing variants of mINGh by reverse transcription-PCR assay and sequence analysis. The alternative splicing variants were mINGh-S, mINGh-M, mINGh-L, and mINGh-...

journal_title：Cancer research

authors： Ha S,Lee S,Chung M,Choi Y

更新日期：2002-03-01 00:00:00

abstract：:Human mammary and other carcinoma cells secrete and express on their cell surfaces complex, mucin-like glycoproteins (Mr greater than 10(6] that are recognized as tumor-associated antigens by a variety of monoclonal antibodies (MAbs). One such MAb, B72.3, has been extensively studied as to range of reactivity for a va...

journal_title：Cancer research

authors： Sheer DG,Schlom J,Cooper HL

更新日期：1988-12-01 00:00:00

abstract：:Discovery of somatically mutated cells in human tissues has been less frequent than would be predicted by in vitro mutational rates. We analyzed the PTEN tumor suppressor gene as an early marker for endometrial carcinogenesis, and we show that 43% of histologically normal premenopausal endometria contain rare glands t...

journal_title：Cancer research

authors： Mutter GL,Ince TA,Baak JP,Kust GA,Zhou XP,Eng C

更新日期：2001-06-01 00:00:00

abstract：:Carcinoma cells can transition from an epithelial-to-mesenchymal differentiation state through a process known as epithelial-mesenchymal transition (EMT). The process of EMT is characterized by alterations in the pattern of gene expression and is associated with a loss of cell polarity, an increase in invasiveness, an...

journal_title：Cancer research

authors： Bogachek MV,De Andrade JP,Weigel RJ

更新日期：2015-01-01 00:00:00

abstract：:Docetaxel tolerance and antitumor efficacy could be enhanced if drug administration was adapted to circadian rhythms. This hypothesis was investigated in seven experiments involving a total of 626 male B6D2F1 mice, synchronized with an alternation of 12 h of light and 12 h of darkness (12:12), after i.v. administratio...

journal_title：Cancer research

authors： Tampellini M,Filipski E,Liu XH,Lemaigre G,Li XM,Vrignaud P,François E,Bissery MC,Lévi F

更新日期：1998-09-01 00:00:00

abstract：:Overexpression of ABCB1 (MDR1) P-glycoprotein, a multidrug efflux pump, is one mechanism by which tumor cells may develop multidrug resistance (MDR), preventing the successful chemotherapeutic treatment of cancer. Sesquiterpenes from Celastraceae family are natural compounds shown previously to reverse MDR in several ...

journal_title：Cancer research

authors： Muñoz-Martínez F,Lu P,Cortés-Selva F,Pérez-Victoria JM,Jiménez IA,Ravelo AG,Sharom FJ,Gamarro F,Castanys S

更新日期：2004-10-01 00:00:00

abstract：:Cellular motility is a critical function in embryonic development, tissue repair, and tumor invasion. We used assays of scattering (epithelial colony dispersion), cell migration, and cell invasion to study cytokine-regulated motility in epithelial and carcinoma cell lines. Tumor necrosis factor (TNF) stimulated motili...

journal_title：Cancer research

authors： Rosen EM,Goldberg ID,Liu D,Setter E,Donovan MA,Bhargava M,Reiss M,Kacinski BM

更新日期：1991-10-01 00:00:00

abstract：:Cultured normal and malignant human lung cells were examined for their different sensitivities to the cytocidal action of nine antitumor and three non-antitumor agents. The malignant cells were killed preferentially at lower concentrations and in a shorter time with each antitumor agent, Adriamycin, neocarzinostatin, ...

journal_title：Cancer research

authors： Tsukeda H,Mizuno S,Nitta K

更新日期：1978-08-01 00:00:00

abstract：:Various chemical compounds have been described to induce photosensitization of tumor cells resulting in cell death. We studied the effect of merocyanine-540 (MC-540) on both leukemic and normal bone marrow (BM) cells. Acute promyelocytic leukemia (HL-60) and common acute lymphoblastic leukemia antigen-positive non-T, ...

journal_title：Cancer research

authors： Atzpodien J,Gulati SC,Clarkson BD

更新日期：1986-10-01 00:00:00

abstract：:Barrett's esophagus, a columnar metaplasia of the lower esophagus epithelium related to gastroesophageal reflux disease, is the strongest known risk factor for the development of esophageal adenocarcinoma (EAC). Understanding the signal transduction events involved in esophageal epithelium carcinogenesis may provide i...

journal_title：Cancer research

authors： Yen CJ,Izzo JG,Lee DF,Guha S,Wei Y,Wu TT,Chen CT,Kuo HP,Hsu JM,Sun HL,Chou CK,Buttar NS,Wang KK,Huang P,Ajani J,Hung MC

更新日期：2008-04-15 00:00:00

abstract：:We have demonstrated previously that the immunomodulator AS101 can protect mice from acute lethal toxicity mediated by high doses of radiation or chemotherapy. The compound was shown to rescue mice from toxic effects of cyclophosphamide or 5-fluorouracil. The results presented herein demonstrate that pretreatment of m...

journal_title：Cancer research

authors： Kalechman Y,Shani A,Sotnik-Barkai I,Albeck M,Sredni B

更新日期：1993-12-15 00:00:00

abstract：:Neonatal and adult BALB/c mice were investigated in a longitudinal study for the acquisition of leukemia-associated inhibitory activity (LIA) interactions after inoculation with Abelson virus in vivo. Within 2 to 4 days after virus infection, the granulocyte-macrophage colony-forming cells from the bone marrow and spl...

journal_title：Cancer research

authors： Broxmeyer HE,Ralph P,Gilbertson S,Margolis VB

更新日期：1980-11-01 00:00:00

abstract：:Degradation and invasion of basement membrane by tumor cells involves the cooperative hydrolysis of proteoglycans, collagens, and glycoproteins mediated by a number of enzymes including proteases, collagenases, and glycosidases. In order to study these processes in vitro, a tissue culture system was developed in which...

journal_title：Cancer research

authors： Woynarowska B,Wikiel H,Bernacki RJ

更新日期：1989-10-15 00:00:00

abstract：:We analyzed the epidermal growth factor receptor gene using a complementary DNA probe of the epidermal growth factor receptor gene in 21 uncultured primary breast carcinomas and found that the gene was amplified in three of these tumors. We further demonstrated by immunohistochemistry using a monoclonal antibody to th...

journal_title：Cancer research

authors： Ro J,North SM,Gallick GE,Hortobagyi GN,Gutterman JU,Blick M

更新日期：1988-01-01 00:00:00

abstract：:Stathmin is a p53-regulated protein known to influence microtubule dynamics. Because several chemotherapeutic agents used to treat breast cancer alter the dynamic equilibrium of tubulin polymerization, stathmin may play an important role in determining the sensitivity to these drugs. Therefore, we evaluated the effect...

journal_title：Cancer research

authors： Alli E,Bash-Babula J,Yang JM,Hait WN

更新日期：2002-12-01 00:00:00

abstract：:Rhabdomyosarcoma (RMS) is a common soft-tissue sarcoma of childhood in need of more effective therapeutic options. The expression of p53 in RMS is heterogeneous such that some tumors are wild-type whereas others are p53 mutant. The small molecule CP-31398 modulates both the wild-type and the mutant p53 proteins. Here,...

journal_title：Cancer research

authors： Xu J,Timares L,Heilpern C,Weng Z,Li C,Xu H,Pressey JG,Elmets CA,Kopelovich L,Athar M

更新日期：2010-08-15 00:00:00

abstract：:Glutamine supplementation has been advocated for patients requiring parenteral nutritional support. However, the direct effect of glutamine on neoplastic cells is poorly understood. We therefore investigated the effects of glutamine on the proliferation, differentiation, and cell-matrix interactions of two human colon...

journal_title：Cancer research

authors： Turowski GA,Rashid Z,Hong F,Madri JA,Basson MD

更新日期：1994-11-15 00:00:00

abstract：:Lectin-affinity electrophoretic separation of serum alpha-fetoprotein (AFP) was carried out using AFP Differentiation Kits, which used Lens culinaris agglutinin-A (Kit L) and erythroagglutinating phytohemagglutinin (Kit P). Separated AFP bands were detected with a sensitive antibody-affinity blotting technique and det...

journal_title：Cancer research

authors： Taketa K,Endo Y,Sekiya C,Tanikawa K,Koji T,Taga H,Satomura S,Matsuura S,Kawai T,Hirai H

更新日期：1993-11-15 00:00:00

abstract：:Calcium is universally required for cell growth and proliferation. Calmodulin is the main intracellular receptor for calcium. Although calcium and calmodulin are well known to be required for cell cycle regulation, the target pathways for their action remain poorly defined. Potential targets include the calcium/calmod...

journal_title：Cancer research

authors： Rodriguez-Mora OG,LaHair MM,McCubrey JA,Franklin RA

更新日期：2005-06-15 00:00:00

abstract：:The majority of BRCA1-associated breast cancers are basal cell-like, which is associated with a poor outcome. Using a spontaneous mouse mammary tumor model, we show that platinum compounds, which generate DNA breaks during the repair process, are more effective than doxorubicin in Brca1/p53-mutated tumors. At 0.5 mg/k...

journal_title：Cancer research

authors： Shafee N,Smith CR,Wei S,Kim Y,Mills GB,Hortobagyi GN,Stanbridge EJ,Lee EY

更新日期：2008-05-01 00:00:00

abstract：:Oncogenic K-Ras mutation occurs frequently in several types of cancers, including pancreatic and lung cancers. Tumors with K-Ras mutation are resistant to chemotherapeutic drugs as well as molecular targeting agents. Although numerous approaches are ongoing to find effective ways to treat these tumors, there are still...

journal_title：Cancer research

authors： Fujita-Sato S,Galeas J,Truitt M,Pitt C,Urisman A,Bandyopadhyay S,Ruggero D,McCormick F

更新日期：2015-07-15 00:00:00

abstract：:Dysregulated signal transduction from receptor tyrosine kinases to phosphatidylinositol 3-kinase (PI3K), AKT (protein kinase B), and its effector FKBP-rapamycin-associated protein (FRAP) occurs via autocrine stimulation or inactivation of the tumor suppressor PTEN in many cancers. Here we demonstrate that in human pro...

journal_title：Cancer research

authors： Zhong H,Chiles K,Feldser D,Laughner E,Hanrahan C,Georgescu MM,Simons JW,Semenza GL

更新日期：2000-03-15 00:00:00

abstract：:cis-Diammine(1,1-cyclobutanedicarboxylato)platinum (CBDCA) is a nonnephrotoxic but myelosuppressive analogue of cisplatin (DDP) with greatly reduced protein binding and greatly increased renal excretion. Thus, CBDCA might produce undue toxicity in patients with decreased renal function. Twenty-two patients [14 females...

journal_title：Cancer research

authors： Egorin MJ,Van Echo DA,Tipping SJ,Olman EA,Whitacre MY,Thompson BW,Aisner J

更新日期：1984-11-01 00:00:00

abstract：:Mice that are genetically engineered to mimic the human hereditary cancer-prone DNA repair-defective disease xeroderma pigmentosum (XP) are highly predisposed to UV radiation-induced skin cancer. It is not clear, however, whether XP mice or humans are predisposed to cancers in other tissues associated with exposure to...

journal_title：Cancer research

authors： Cheo DL,Burns DK,Meira LB,Houle JF,Friedberg EC

更新日期：1999-02-15 00:00:00

abstract：:Cancer stem-like cells (CSC) in hepatocellular carcinoma (HCC) are thought to mediate therapeutic resistance and poor survival outcomes, but their intrinsic and extrinsic control is not well understood. In this study, we found that the chromatin modification factor LSD1 is highly expressed in HCC CSC where it decrease...

journal_title：Cancer research

authors： Liu C,Liu L,Chen X,Cheng J,Zhang H,Zhang C,Shan J,Shen J,Qian C

更新日期：2018-02-15 00:00:00

abstract：:Successful treatment of many patients with osteosarcoma requires more effective chemotherapy. Since new agents are needed, we have developed an immunotoxin using TP-3, an IgG2b mAb which recognizes human and canine osteosarcomas and budding capillaries of tumors. The plant hemitoxin, pokeweed antiviral protein (PAP), ...

journal_title：Cancer research

authors： Anderson PM,Meyers DE,Hasz DE,Covalcuic K,Saltzman D,Khanna C,Uckun FM

更新日期：1995-03-15 00:00:00

abstract：:Vascular endothelial growth factor (VEGF) expression correlates with microvessel density, stage, malignant ascites, metastasis, and survival in ovarian cancer. By transducing VEGF165 into a nontumorigenic rat ovarian surface epithelial cell line (ROSE199), we investigated the direct effect of an angiogenic phenotype o...

journal_title：Cancer research

authors： Schumacher JJ,Dings RP,Cosin J,Subramanian IV,Auersperg N,Ramakrishnan S

更新日期：2007-04-15 00:00:00