Calcium/calmodulin-dependent kinase I and calcium/calmodulin-dependent kinase kinase participate in the control of cell cycle progression in MCF-7 human breast cancer cells.

abstract：:Myc oncoproteins exert tumorigenic effects by regulating expression of target oncogenes. Histone H3 lysine 79 (H3K79) methylation at Myc-responsive elements of target gene promoters is a strict prerequisite for Myc-induced transcriptional activation, and DOT1L is the only known histone methyltransferase that catalyzes...

journal_title：Cancer research

authors： Wong M,Tee AEL,Milazzo G,Bell JL,Poulos RC,Atmadibrata B,Sun Y,Jing D,Ho N,Ling D,Liu PY,Zhang XD,Hüttelmaier S,Wong JWH,Wang J,Polly P,Perini G,Scarlett CJ,Liu T

更新日期：2017-05-01 00:00:00

abstract：:Sunitinib is an antiangiogenic therapy given as a first-line treatment for renal cell carcinoma (RCC). While treatment improves progression-free survival, most patients relapse. We hypothesized that patient relapse can stem from the development of a lymphatic network driven by the production of the main growth factor ...

journal_title：Cancer research

authors： Dufies M,Giuliano S,Ambrosetti D,Claren A,Ndiaye PD,Mastri M,Moghrabi W,Cooley LS,Ettaiche M,Chamorey E,Parola J,Vial V,Lupu-Plesu M,Bernhard JC,Ravaud A,Borchiellini D,Ferrero JM,Bikfalvi A,Ebos JM,Khabar KS,Grép

更新日期：2017-03-01 00:00:00

abstract：:A widely held tenet of present day oncology is that tumor cells treated with anticancer agents die from apoptosis, and that cells resistant to apoptosis are resistant to cancer treatment. We suggest, in this review, that this tenet may need to be reexamined for human tumors of nonhematological origin, for two principa...

journal_title：Cancer research

authors： Brown JM,Wouters BG

更新日期：1999-04-01 00:00:00

abstract：:The Xeroderma pigmentosum group D (XPD) protein is an essential participant in nucleotide excision repair and basal transcription. There is evidence that three common polymorphisms of the XPD gene (C156A, Asp312Asn, and Lys751Gln) may be associated with differential DNA repair activity. Because increased DNA repair pl...

journal_title：Cancer research

authors： Park DJ,Stoehlmacher J,Zhang W,Tsao-Wei DD,Groshen S,Lenz HJ

更新日期：2001-12-15 00:00:00

abstract：:Ras associated with diabetes (Rad) is a Ras-related GTPase that promotes cell growth by accelerating cell cycle transitions. Rad knockdown induced cell cycle arrest and premature senescence without additional cellular stress in multiple cancer cell lines, indicating that Rad expression might be critical for the cell c...

journal_title：Cancer research

authors： Lee I,Yeom SY,Lee SJ,Kang WK,Park C

更新日期：2010-06-01 00:00:00

abstract：:An epitope region, located at amino acid residues 173-180 (EAAA-GIQW), of a human cell proliferation-associated nucleolar antigen, P120, has been defined by mutational analysis and competition assays. A synthetic peptide corresponding to this epitope region completely blocks the binding of the anti-P120 antibody to Es...

journal_title：Cancer research

authors： Valdez BC,Busch RK,Larson RG,Busch H

更新日期：1990-05-01 00:00:00

abstract：:Primary melanocytes attach poorly to collagen type IV and laminin, in contrast to their firm attachment to collagen type I/III and fibronectin [Gilchrest et al., In vitro (Rockville), 21: 114-120, 1985]. We have now found that metastatic B16 melanoma cells attach well to collagen type IV, laminin, vitronectin, and fib...

journal_title：Cancer research

authors： Rieber M,Gross A,Rieber MS

更新日期：1987-10-01 00:00:00

abstract：:Colorectal and lung cancers account for one-third of all cancer-related deaths worldwide. Previous studies suggested that Metadherin (MTDH) is involved in the development of colorectal and lung cancers. However, how MTDH regulates the pathogenesis of these cancers remains largely unknown. Using genetically modified mo...

journal_title：Cancer research

authors： Shen M,Xie S,Rowicki M,Michel S,Wei Y,Hang X,Wan L,Lu X,Yuan M,Jin JF,Jaschinski F,Zhou T,Klar R,Kang Y

更新日期：2020-11-25 00:00:00

abstract：:Deoxycytidine kinase (DCK) is a key enzyme for the activation of a broad spectrum of nucleoside-based chemotherapy drugs (e.g., gemcitabine); low DCK activity is one of the most important causes of cancer drug-resistance. Noninvasive imaging methods that can quantify DCK activity are invaluable for assessing tumor res...

journal_title：Cancer research

authors： Han Z,Li Y,Zhang J,Liu J,Chen C,van Zijl PC,Liu G

更新日期：2019-05-15 00:00:00

abstract：:MYC exerts both positive and negative functions in cancer cells, such that its procancerous effects are unmasked only after its anticancer effects are blocked. Here we used multiple mouse models of lung adenocarcinoma to identify genetic events that can cooperate with MYC activation to promote the genesis of non-small...

journal_title：Cancer research

authors： Allen TD,Zhu CQ,Jones KD,Yanagawa N,Tsao MS,Bishop JM

更新日期：2011-03-15 00:00:00

abstract：:To understand the biological basis of resistance to endocrine therapy is of utmost importance in patients with steroid hormone receptor-positive breast cancer. Not only will this allow us prediction of therapy success, it may also lead to novel therapies for patients resistant to current endocrine therapy. DNA methyla...

journal_title：Cancer research

authors： Martens JW,Nimmrich I,Koenig T,Look MP,Harbeck N,Model F,Kluth A,Bolt-de Vries J,Sieuwerts AM,Portengen H,Meijer-Van Gelder ME,Piepenbrock C,Olek A,Höfler H,Kiechle M,Klijn JG,Schmitt M,Maier S,Foekens JA

更新日期：2005-05-15 00:00:00

abstract：:Twenty-eight cervicovaginal tracts from approximately 2-year-old female BALB/cCrgl mice neonatally exposed to ovarian steroids were cut into small segments and transplanted into syngeneic hosts. Within six months, six of 28 host animals developed tumors. Three tumors were from progesterone-exposed mice, two were from ...

journal_title：Cancer research

authors： Jones LA,Pacillas-Verjan R

更新日期：1979-07-01 00:00:00

abstract：:Energy restriction (ER) inhibits mammary carcinogenesis and results in a marked reduction in tumor size, effects likely to be explained by ER-mediated induction of apoptosis. The goal of this study was to investigate the molecular mechanism(s) accounting for apoptosis induction. To do this, chemically induced mammary ...

journal_title：Cancer research

authors： Thompson HJ,Zhu Z,Jiang W

更新日期：2004-02-15 00:00:00

abstract：:Death receptor Fas-mediated apoptosis not only eliminates nonspecific and autoreactive B cells but also plays a major role in antitumor immunity. However, the possible mechanisms underlying impairment of Fas-mediated induction of apoptosis during lymphomagenesis remain unknown. In this study, we employed our developed...

journal_title：Cancer research

authors： Sugihara E,Hashimoto N,Osuka S,Shimizu T,Ueno S,Okazaki S,Yaguchi T,Kawakami Y,Kosaki K,Sato TA,Okamoto S,Saya H

更新日期：2020-10-15 00:00:00

abstract：:Inhibition of angiogenesis has emerged as a key focus for the treatment of cancer, necessitating a better understanding of the downstream molecular targets of angiogenesis inhibitors. Endostatin, thrombospondin-1, fumagillin, and its synthetic derivative, TNP-470, are potent inhibitors of endothelial cell proliferatio...

journal_title：Cancer research

authors： Keezer SM,Ivie SE,Krutzsch HC,Tandle A,Libutti SK,Roberts DD

更新日期：2003-10-01 00:00:00

abstract：:Induction of an apoptotic cell death was studied in a mouse T-cell hybridoma. Apoptosis was induced in these cells following exposure to dexamethasone, X-radiation, 43 degrees C heat shock, A254 light, and hydrogen peroxide. In 5-Gy-exposed cells, a radiation-induced G2 phase cell cycle progression block was maximum b...

journal_title：Cancer research

authors： Warters RL

更新日期：1992-02-15 00:00:00

abstract：:Identification of human melanoma-associated peptide antigens for CTLs has opened unprecedented opportunities for active specific immunotherapy for melanoma with synthetic peptide. We have shown that immunization with a MAGE-1 gene encoded nonapeptide (EADPT-GHSY)-pulsed autologous antigen presenting cell-based vaccine...

journal_title：Cancer research

authors： Hu X,Chakraborty NG,Sporn JR,Kurtzman SH,Ergin MT,Mukherji B

更新日期：1996-06-01 00:00:00

abstract：:Bloom syndrome is an autosomal recessive disorder whose characteristics include an increased risk for many types of cancers. In contrast to the homozygous mutations of Bloom syndrome, heterozygous carriers of BLM mutations may be at increased risk for developing colorectal cancer. We have screened 2,333 Jewish individ...

journal_title：Cancer research

authors： Cleary SP,Zhang W,Di Nicola N,Aronson M,Aube J,Steinman A,Haddad R,Redston M,Gallinger S,Narod SA,Gryfe R

更新日期：2003-04-15 00:00:00

abstract：:A gastric choriocarcinoma cell line synthesizing human chorionic gonadotropin (HCG) was established in 1971 by Oboshi et al. and was found to possess human placental alkaline phosphatase. The present paper also deals with the relationship between the cell growth and HCG secretion and with cellular localization of HCG ...

journal_title：Cancer research

authors： Kameya T,Kuramoto H,Suzuki K,Kenjo T,Oshikiri T,Hayashi H,Itakura M

更新日期：1975-08-01 00:00:00

abstract：:Alkaline phosphatase was monitored in 17 mice with s.c.-implanted tumors to relate the total circulating alkaline phosphatase to the total number of tumor cells in each mouse. There was a semilogarithmic relationship between the alkaline phosphatase units and the number of tumor cells. A time-independent standard plot...

journal_title：Cancer research

authors： Hiramoto RN,Ghanta VK,Soong SJ,Hurst DC

更新日期：1977-02-01 00:00:00

abstract：:Muscle-invasive bladder cancer (MIBC) generally responds poorly to treatment and tends to exhibit significant mortality. Here we show that expression of the tumor suppressor p14ARF (ARF) is upregulated in aggressive subtypes of MIBC. Accumulation of ARF in the nucleolus is associated with poor outcome and attenuated r...

journal_title：Cancer research

authors： Owczarek TB,Kobayashi T,Ramirez R,Rong L,Puzio-Kuter AM,Iyer G,Teo MY,Sánchez-Vega F,Wang J,Schultz N,Zheng T,Solit DB,Al-Ahmadie HA,Abate-Shen C

更新日期：2017-02-15 00:00:00

abstract：:E-cadherin loss is frequently associated with ovarian cancer metastasis. Given that adhesion to the abdominal peritoneum is the first step in ovarian cancer dissemination, we reasoned that down-regulation of E-cadherin would affect expression of cell matrix adhesion receptors. We show here that inhibition of E-cadheri...

journal_title：Cancer research

authors： Sawada K,Mitra AK,Radjabi AR,Bhaskar V,Kistner EO,Tretiakova M,Jagadeeswaran S,Montag A,Becker A,Kenny HA,Peter ME,Ramakrishnan V,Yamada SD,Lengyel E

更新日期：2008-04-01 00:00:00

abstract：:Transfer RNA methylase (tRNA methylase) activity and capacity were monitored in whole-rat-liver preparations during the induction of hepatocellular carcinomas by an 8-week aflatoxin B1 dosing regimen that produced minimal toxic effects. Significant phases of elevated tRNA methylase capacity occurred at 6 to 9 weeks (2...

journal_title：Cancer research

authors： Busby WF Jr,Paglialunga S,Newberne PM,Wogan GN

更新日期：1976-06-01 00:00:00

abstract：:The protein tyrosine phosphatase gamma (PTP gamma) gene has recently been suggested as a candidate tumor suppressor gene involved in the oncogenesis of human lung and renal cancers, although no direct evidence for PTP gamma mutations has been demonstrated thus far. We explored the status of PTP gamma in 31 human lung ...

journal_title：Cancer research

authors： Tsukamoto T,Takahashi T,Ueda R,Hibi K,Saito H,Takahashi T

更新日期：1992-06-15 00:00:00

abstract：:Fibroblast growth factor (FGF) 8, also known as androgen-induced growth factor, was originally isolated from an androgen-dependent mouse mammary Shionogi carcinoma SC-3 cell line, in which it was shown to have androgen-regulated properties. We previously demonstrated that Fgf 8 transcripts were detected in several hum...

journal_title：Cancer research

authors： Tanaka A,Furuya A,Yamasaki M,Hanai N,Kuriki K,Kamiakito T,Kobayashi Y,Yoshida H,Koike M,Fukayama M

更新日期：1998-05-15 00:00:00

abstract：:Preincubation of murine colon 26 colon adenocarcinoma cells with gamma-interferon (IFN-gamma), but not alpha-interferon, produced a significant increase in experimental pulmonary metastases in syngeneic BALB/c and T-cell-deficient BALB/c nude mice. The enhancement was seen after as little as 1 h of exposure to 1 unit/...

journal_title：Cancer research

authors： Kelly SA,Gschmeissner S,East N,Balkwill FR

更新日期：1991-08-01 00:00:00

abstract：:The olfactory marker protein (OMP) is a M(r) 19,000 polypeptide originally considered a selective marker for differentiated olfactory receptor neurons. In an attempt to induce neoplastic proliferation in the olfactory cells, we made mice transgenic for the simian virus 40 large T-antigen gene linked to the OMP gene pr...

journal_title：Cancer research

authors： Servenius B,Vernachio J,Price J,Andersson LC,Peterson PA

更新日期：1994-10-01 00:00:00

abstract：:Local chemotherapy with biodegradable polymers prolongs survival with minimal morbidity in patients with intracranial high-grade gliomas. However, use of local chemotherapy for metastatic brain tumors has not been defined. We studied the safety and the efficacy of locally delivered chemotherapy with and without concur...

journal_title：Cancer research

authors： Ewend MG,Williams JA,Tabassi K,Tyler BM,Babel KM,Anderson RC,Pinn ML,Brat DJ,Brem H

更新日期：1996-11-15 00:00:00

abstract：:Evidence from pathology and epidemiology studies has been provided for a human model of gastric carcinogenesis with the following sequential stages: chronic gastritis; atrophy; intestinal metaplasia; and dysplasia. The initial stages of gastritis and atrophy have been linked to excessive salt intake and infection with...

journal_title：Cancer research

authors： Correa P

更新日期：1992-12-15 00:00:00

abstract：:Epidemiological studies have shown a positive association of colon cancer with hyperlipidemia. Furthermore, signaling generated by peroxisome proliferator-activated receptor (PPAR) alpha and gamma ligands, suggested to be candidate tumor preventive agents, has been shown to lower serum triglyceride levels. In the pres...

journal_title：Cancer research

authors： Niho N,Takahashi M,Kitamura T,Shoji Y,Itoh M,Noda T,Sugimura T,Wakabayashi K

更新日期：2003-09-15 00:00:00