Human gastric carcinogenesis: a multistep and multifactorial process--First American Cancer Society Award Lecture on Cancer Epidemiology and Prevention.

abstract：:To define transcriptional dependencies of triple-negative breast cancer (TNBC), we identified transcription factors highly and specifically expressed in primary TNBCs and tested their requirement for cell growth in a panel of breast cancer cell lines. We found that EN1 (engrailed 1) is overexpressed in TNBCs and its d...

journal_title：Cancer research

authors： Peluffo G,Subedee A,Harper NW,Kingston N,Jovanović B,Flores F,Stevens LE,Beca F,Trinh A,Chilamakuri CSR,Papachristou EK,Murphy K,Su Y,Marusyk A,D'Santos CS,Rueda OM,Beck AH,Caldas C,Carroll JS,Polyak K

更新日期：2019-08-15 00:00:00

abstract：:Vascular permeability factor (VPF) is one of the most potent known inducers of microvascular hyperpermeability; in addition, it is a selective endothelial cell growth factor, hence its alternate name, vascular endothelial growth factor. VPF exerts its actions on the microvasculature by interacting with specific endoth...

journal_title：Cancer research

authors： Brown LF,Berse B,Jackman RW,Tognazzi K,Manseau EJ,Senger DR,Dvorak HF

更新日期：1993-10-01 00:00:00

abstract：:The binding of the papillomavirus E6 protein to E6AP and the induction of p53 degradation are common features of high-risk genital human papillomaviruses (HPV); cutaneous HPVs, on the other hand, lack these capacities. Nevertheless, several cutaneous HPV types of the beta-genus, such as HPV38 are associated with tumor...

journal_title：Cancer research

authors： Muench P,Probst S,Schuetz J,Leiprecht N,Busch M,Wesselborg S,Stubenrauch F,Iftner T

更新日期：2010-09-01 00:00:00

abstract：:To evaluate the role of the human T-cell-specific tyrosine kinase lck (YT16), we measured the levels of lck expression in thymocytes, peripheral T-cells, and leukemia T-cell lines which are arrested at different stages of thymic differentiation. The results indicate that higher levels of the lck message can be found i...

journal_title：Cancer research

authors： Koga Y,Kimura N,Minowada J,Mak TW

更新日期：1988-02-15 00:00:00

abstract：:An estrogen receptor immunocytochemical assay which uses monoclonal antibodies to the estrogen receptor protein [Nature (Lond.), 307: 745-747, 1984] was applied to several human tissues, including human breast tumors, and the results were compared to those of steroid-binding assays performed on cytosol extracts of the...

journal_title：Cancer research

authors： King WJ,DeSombre ER,Jensen EV,Greene GL

更新日期：1985-01-01 00:00:00

abstract：:An undifferentiated status and the epigenetic inactivation of tumor-suppressor genes are hallmarks of transformed cells. Promoter CpG island hypermethylation of differentiating genes, however, has rarely been reported. The Groucho homologue Transducin-like Enhancer of Split 1 (TLE1) is a multitasked transcriptional co...

journal_title：Cancer research

authors： Fraga MF,Berdasco M,Ballestar E,Ropero S,Lopez-Nieva P,Lopez-Serra L,Martín-Subero JI,Calasanz MJ,Lopez de Silanes I,Setien F,Casado S,Fernandez AF,Siebert R,Stifani S,Esteller M

更新日期：2008-06-01 00:00:00

abstract：:A 16,500 molecular weight fraction of maleic vinyl ether (MVE-2) induced tumoristatic and tumoricidal activity in peritoneal macrophages of BALB/c and C57BL/6 mice following i.p. administration. Growth of B16 melanoma cells in vitro was inhibited up to 85% by MVE-2-activated, but not resident, peritoneal macrophages. ...

journal_title：Cancer research

authors： Loveless SE,Munson AE

更新日期：1981-10-01 00:00:00

abstract：:1-Nitropyrene, a direct-acting mutagenic component of extracts of diesel exhaust and ambient air particulates, is one of the major nitroarenes found in products of incomplete combustion. Injection of this compound into newborn Sprague-Dawley-derived CD rats at 100 mumol/kg body weight s.c. once a week for 8 weeks indu...

journal_title：Cancer research

authors： Hirose M,Lee MS,Wang CY,King CM

更新日期：1984-03-01 00:00:00

abstract：:A major challenge in treating cancer is the difficulty of bringing therapy to poorly perfused areas of solid tumors, which are often most resistant to chemotherapy and radiation. GRP94 is a chaperone protein localized in the endoplasmic reticulum with antiapoptotic properties. We report here that in vitro the proximal...

journal_title：Cancer research

authors： Reddy RK,Dubeau L,Kleiner H,Parr T,Nichols P,Ko B,Dong D,Ko H,Mao C,DiGiovanni J,Lee AS

更新日期：2002-12-15 00:00:00

abstract：:The level of steroid receptors in target cells affects the responsiveness of the cell to the hormone. In mouse AtT-20 cells, it has been shown that chronic glucocorticoid treatment causes a down-regulation of glucocorticoid receptor (GR) levels (F. Svec and M. Rudis, J. Biol. Chem., 256:5984-5987, 1981). The current s...

journal_title：Cancer research

authors： Vedeckis WV,Ali M,Allen HR

更新日期：1989-04-15 00:00:00

abstract：:General anesthesia was used to facilitate 259 whole-body hyperthermia treatments in 90 patients. These patients fell into American Society of Anesthesiologists Classifications 3 (moderate to severe systemic disease) and 4 (severe systemic disease with life-threatening potential). Whole-body hyperthermia imposes severe...

journal_title：Cancer research

authors： Cronau LH Jr,Bourke DL,Bull JM

更新日期：1984-10-01 00:00:00

abstract：:There is a preclinical evidence that the oral administration of d,l-sulforaphane (SFN) can decrease the incidence or burden of early-stage prostate cancer [prostatic intraepithelial neoplasia (PIN)] and well-differentiated cancer (WDC) but not late-stage poorly differentiated cancer (PDC). Because SFN treatment induce...

journal_title：Cancer research

authors： Vyas AR,Hahm ER,Arlotti JA,Watkins S,Stolz DB,Desai D,Amin S,Singh SV

更新日期：2013-10-01 00:00:00

abstract：:Some, but not all, epidemiological studies have suggested that dichlorodiphenyltrichloroethane (DDT) may play a role in the development of breast cancer. These investigations have been conducted in countries where this substance has been banned for at least 20 years. We conducted a study in Mexico, a country in which ...

journal_title：Cancer research

authors： López-Carrillo L,Blair A,López-Cervantes M,Cebrián M,Rueda C,Reyes R,Mohar A,Bravo J

更新日期：1997-09-01 00:00:00

abstract：:Vascular thermotolerance in SCK tumors of A/J mice was studied by comparing the changes in blood flow, as measured by the 86Rb uptake method, from a single heating with those from two heatings. The heat-induced decline in 86Rb uptake in tumors could be substantially inhibited when the tumors were preheated, indicating...

journal_title：Cancer research

authors： Lin JC,Song CW

更新日期：1993-05-01 00:00:00

abstract：:Mitomycin C (MMC) is an anticancer drug that requires reductive activation to exert its toxicity. MMC is known to cross-link DNA that contributes significantly to the cytotoxicity and consequent cell death. Cytosolic NADPH:quinone oxidoreductase 1 (NQO1) and microsomal enzymes have been shown to mediate MMC-induced DN...

journal_title：Cancer research

authors： Celli CM,Jaiswal AK

更新日期：2003-09-15 00:00:00

abstract：:In vitro cell-mediated cytotoxicity (CMC) assays have been carried out in human melanoma system with blood effector lymphocytes on [3H]proline-labeled target cells in a 48-hr microcytotoxicity technique. Three lymphocyte purification procedures (Ficoll:Hypaque gradient, plasma gel sedimentation followed by nylon colum...

journal_title：Cancer research

authors： Mukherji B,Vassos D,Flowers A,Binder SC,Nathanson L

更新日期：1975-12-01 00:00:00

abstract：:BD-40, a pyridopyrroloisoquinoline analogue of ellipticines, has dose-dependent cytostatic and cytotoxic effects on cultures of Saccharomyces cerevisiae. These inhibitory effects take place only in growing cells and are enhanced in the presence of oxygen. Among the different repair-deficient mutants examined, a mutant...

journal_title：Cancer research

authors： Moustacchi E,Favaudon V,Bisagni E

更新日期：1983-08-01 00:00:00

abstract：:Recombinant immunotoxins (RIT) have been highly successful in cancer therapy due, in part, to the high cancer-specific expression of cell surface antigens such as mesothelin, which is overexpressed in mesothelioma, ovarian, lung, breast, and pancreatic cancers, but is limited in normal cells. RG7787 is a clinically op...

journal_title：Cancer research

authors： Ali-Rahmani F,FitzGerald DJ,Martin S,Patel P,Prunotto M,Ormanoglu P,Thomas C,Pastan I

更新日期：2016-03-15 00:00:00

abstract：:A genome-wide computational screen was performed to identify tumor-associated alternative RNA splicing isoforms. A BLAST algorithm was used to compare 11,014 genes from RefSeq with 3,471,822 human expressed sequence tag sequences. The screen identified 26,258 alternative splicing isoforms of which 845 were significant...

journal_title：Cancer research

authors： Wang Z,Lo HS,Yang H,Gere S,Hu Y,Buetow KH,Lee MP

更新日期：2003-02-01 00:00:00

abstract：:A tetracosapeptide (peptide-24) corresponding to the amino-terminal sequence of the carcinoembryonic antigen (CEA) was synthesized and characterized. Antisera were produced to the peptide-24, and a radioimmunoassay was developed utilizing peptide-24 with a tyrosine residue on the amino-terminal end (Tyr-peptide-24). I...

journal_title：Cancer research

authors： Paul D,Flouret G,Tomita JT,Ranney K,Schenck J,Anderson B

更新日期：1981-06-01 00:00:00

abstract：:The specific binding of labeled porcine insulin, human prolactin, and human growth hormone was studied in 63 human breast tumors and 15 nonmalignant breast tissues. Most (90%) of the tumors demonstrated significant binding of insulin, as did 80% of nonmalignant tissues. Autoradiographic studies indicated that insulin ...

journal_title：Cancer research

authors： Holdaway IM,Friesen HG

更新日期：1977-07-01 00:00:00

abstract：:Energy restriction (ER) inhibits mammary carcinogenesis and results in a marked reduction in tumor size, effects likely to be explained by ER-mediated induction of apoptosis. The goal of this study was to investigate the molecular mechanism(s) accounting for apoptosis induction. To do this, chemically induced mammary ...

journal_title：Cancer research

authors： Thompson HJ,Zhu Z,Jiang W

更新日期：2004-02-15 00:00:00

abstract：:Development of novel approaches for quantitative analysis of gene expression in intact tumor cells should provide new means for cancer detection and for studying the response of cancer cells to biological and therapeutic reagents. We developed procedures for detecting the levels of expression of multiple genes in fixe...

journal_title：Cancer research

authors： Peng XH,Cao ZH,Xia JT,Carlson GW,Lewis MM,Wood WC,Yang L

更新日期：2005-03-01 00:00:00

abstract：:Recent technologic advances have permitted higher resolution and more rapid analysis of individual cancer genomes at the single-nucleotide level. Such advances have shown bewildering intertumor heterogeneity with limited somatic alterations shared between tumors of the same histopathologic subtype. Exacerbating such c...

journal_title：Cancer research

authors： Swanton C

更新日期：2012-10-01 00:00:00

abstract：:Despite strong evidence of an association between Helicobacter pylori and gastric cancer, the benefit of eradicating H. pylori infection is unknown. Our aim was to test the hypothesis that exposure to high doses of antibiotics reduces risk for gastric cancer via possible eradication of H. pylori We conducted a nationw...

journal_title：Cancer research

authors： Akre K,Signorello LB,Engstrand L,Bergström R,Larsson S,Eriksson BI,Nyrén O

更新日期：2000-11-15 00:00:00

abstract：:Dietary genistein, a natural flavone compound found in soy, has been proposed to be responsible for the low rate of breast cancer in Asian women. The cellular mechanisms of genistein's chemopreventive effects in vio have been largely unexplored. In our previous studies, we found that genistein exerted pronounced antip...

journal_title：Cancer research

authors： Shao ZM,Wu J,Shen ZZ,Barsky SH

更新日期：1998-11-01 00:00:00

abstract：:A number of studies have shown that the extracellular pH (pHe) in cancers is typically lower than that in normal tissue and that an acidic pHe promotes invasive tumor growth in primary and metastatic cancers. Here, we investigate the hypothesis that increased systemic concentrations of pH buffers reduce intratumoral a...

journal_title：Cancer research

authors： Silva AS,Yunes JA,Gillies RJ,Gatenby RA

更新日期：2009-03-15 00:00:00

abstract：:alphaVbeta3 integrin complexes are overexpressed in the growing, invading margins of human glioblastoma multiforme (GBM) and in the GBM vasculature, suggesting a key role for alphaVbeta3 in GBM growth and invasion. The function of alphaVbeta3 complexes in tumor formation, however, has been challenged by studies showin...

journal_title：Cancer research

authors： Kanamori M,Vanden Berg SR,Bergers G,Berger MS,Pieper RO

更新日期：2004-04-15 00:00:00

abstract：:Recently, we have shown that prostate epithelium-specific deficiency for p53 and Rb tumor suppressors leads to metastatic cancer, exhibiting features of both luminal and neuroendocrine differentiation. Using stage-by-stage evaluation of carcinogenesis in this model, we report that all malignant neoplasms arise from th...

journal_title：Cancer research

authors： Zhou Z,Flesken-Nikitin A,Nikitin AY

更新日期：2007-06-15 00:00:00

abstract：:The tachykinin family of neuropeptides, including substance P and neurokinins A and B, induce a transient increase in intracellular free calcium concentration in human small cell lung carcinoma (SCLC) cells, as measured with a calcium indicator fura-2. The effects are dose dependent and even greater than that of bombe...

journal_title：Cancer research

authors： Takuwa N,Takuwa Y,Ohue Y,Mukai H,Endoh K,Yamashita K,Kumada M,Munekata E

更新日期：1990-01-15 00:00:00