Abstract：
:SWI/SNF chromatin remodeling complexes regulate critical cellular processes, including cell-cycle control, programmed cell death, differentiation, genomic instability, and DNA repair. Inactivation of this class of chromatin remodeling complex has been associated with a variety of malignancies, including lung, ovarian, renal, liver, and pediatric cancers. In particular, approximately 10% of primary human lung non-small cell lung cancers (NSCLC) display attenuations in the BRG1 ATPase, a core factor in SWI/SNF complexes. To evaluate the role of BRG1 attenuation in NSCLC development, we examined the effect of BRG1 silencing in primary and established human NSCLC cells. BRG1 loss altered cellular morphology and increased tumorigenic potential. Gene expression analyses showed reduced expression of genes known to be associated with progression of human NSCLC. We demonstrated that BRG1 losses in NSCLC cells were associated with variations in chromatin structure, including differences in nucleosome positioning and occupancy surrounding transcriptional start sites of disease-relevant genes. Our results offer direct evidence that BRG1 attenuation contributes to NSCLC aggressiveness by altering nucleosome positioning at a wide range of genes, including key cancer-associated genes.
journal_name
Cancer Resjournal_title
Cancer researchauthors
Orvis T,Hepperla A,Walter V,Song S,Simon J,Parker J,Wilkerson MD,Desai N,Major MB,Hayes DN,Davis IJ,Weissman Bdoi
10.1158/0008-5472.CAN-14-0061subject
Has Abstractpub_date
2014-11-15 00:00:00pages
6486-6498issue
22eissn
0008-5472issn
1538-7445journal_volume
74pub_type
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