Abstract：
:Concanavalin A-induced blastogenesis of spleen lymphocytes was significantly inhibited when lymphocytes from rats on a high-polyunsaturated-fat diet were compared to lymphocytes from rats on a low-fat diet. Responsiveness was dependent on source of serum since lymphocytes from rats fed a low-fat diet were suppressed in serum from rats fed a high-polyunsaturated-fat diet. Alternatively, lymphocytes from rats on a high-polyunsaturated-fat diet were more responsive in serum from low-fat-fed rats compared to their response in autologous serum. One of the inhibiting factors in serum was the lipoprotein fraction; however, rats on a high-polyunsaturated-fat diet probably had additional inhibitors in their serum. While tumor incidence was highest in rats with the least responsive lymphocytes was highest in rats with the least responsive lymphocytes and lowest in rats with the most responsive lymphocytes, the significance of the observation is not known.
journal_name
Cancer Resjournal_title
Cancer researchauthors
Kollmorgen GM,Sansing WA,Lehman AA,Fischer G,Longley RE,Alexander SS Jr,King MM,McCay PBsubject
Has Abstractpub_date
1979-09-01 00:00:00pages
3458-62issue
9eissn
0008-5472issn
1538-7445journal_volume
39pub_type
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