Sphingosine kinase 1: a new modulator of hypoxia inducible factor 1alpha during hypoxia in human cancer cells.

abstract：:DNA mismatch repair (MMR) plays a key role in the cytotoxic response of human cells to methylating agents, however, the cascade of events leading to cell cycle arrest and cell death has yet to be characterized. We studied the role of MMR in the transcriptional response to DNA methylation damage in two human cellular m...

journal_title：Cancer research

authors： di Pietro M,Marra G,Cejka P,Stojic L,Menigatti M,Cattaruzza MS,Jiricny J

更新日期：2003-12-01 00:00:00

abstract：:The relatively recent clinical success of bortezomib, particularly in multiple myeloma, has established the validity of the proteasome as a viable target for anticancer drug development. This highly cited 1999 Cancer Research article from Adams and colleagues was published during the period when this drug was transiti...

journal_title：Cancer research

authors： Tew KD

更新日期：2016-09-01 00:00:00

abstract：:Carcinoembryonic antigen (CEA) is a glycoprotein metabolized primarily by the liver. Subcellular fractions of rat liver were examined for CEA binding activity. Hepatocyte plasma membrane and microsome fractions bound CEA, and this binding shared the calcium requirement, neuraminidase sensitivity, and carbohydrate spec...

journal_title：Cancer research

authors： Byrn RA,Medrek P,Thomas P,Jeanloz RW,Zamcheck N

更新日期：1985-07-01 00:00:00

abstract：:Dog and rat animal models have been developed for repeated intravascular administrations to the liver. However, mice have generally been considered too small to use for these models. This study describes the development of mouse models that permit the establishment of liver metastases that can be subsequently treated ...

journal_title：Cancer research

authors： Kasuya H,Kuruppu DK,Donahue JM,Choi EW,Kawasaki H,Tanabe KK

更新日期：2005-05-01 00:00:00

abstract：:Drug sensitivity assays were performed using a variation of a colorimetric [3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT)] assay on V79, CHO-AuxB1, CHRC5, NCI-H460, and NCI-H249 cell lines following optimization of experimental conditions for each cell line. Results from this assay were compared w...

journal_title：Cancer research

authors： Carmichael J,DeGraff WG,Gazdar AF,Minna JD,Mitchell JB

更新日期：1987-02-15 00:00:00

abstract：:Alkylating agents, such as temozolomide, are among the most effective cytotoxic agents used for malignant gliomas, but responses remain very poor. The DNA repair protein O6-methylguanine-DNA methyltransferase (MGMT) plays an important role in cellular resistance to alkylating agents. IFN-beta can act as a drug sensiti...

journal_title：Cancer research

authors： Natsume A,Ishii D,Wakabayashi T,Tsuno T,Hatano H,Mizuno M,Yoshida J

更新日期：2005-09-01 00:00:00

abstract：:Rapid or accelerated tumor cell repopulation after significant tumor cell killing induced by various cytotoxic agents often compromises the expected therapeutic benefit of such tumor responses. Here, we discuss the concept that tumor cell repopulation after certain cytotoxic therapies, using vascular disrupting agents...

journal_title：Cancer research

authors： Shaked Y,Kerbel RS

更新日期：2007-08-01 00:00:00

abstract：:The reactivity of normal and tumor host lymphocytes incubated with normal serum or with serum or malignant ascites fluid from tumor hosts was measured by the ability of the lymphocytes to synthesize ornithine decarboxylase after phytohemagglutinin stimulation. Each of three tumors tested (a solid fibrosarcoma, an asci...

journal_title：Cancer research

authors： Vaage J,Agarwal S,Reinertsen JL

更新日期：1978-08-01 00:00:00

abstract：:SOX9 [sex-determining region Y (SRY)-box 9 protein], a high mobility group box transcription factor, plays critical roles during embryogenesis and its activity is required for development, differentiation, and lineage commitment in various tissues including the intestinal epithelium. Here, we present functional and cl...

journal_title：Cancer research

authors： Matheu A,Collado M,Wise C,Manterola L,Cekaite L,Tye AJ,Canamero M,Bujanda L,Schedl A,Cheah KS,Skotheim RI,Lothe RA,López de Munain A,Briscoe J,Serrano M,Lovell-Badge R

更新日期：2012-03-01 00:00:00

abstract：:Plasmacytoid dendritic cells (pDC) are the main producers of a key T-cell-stimulatory cytokine, IFNα, and critical regulators of antiviral immunity. Chronic myeloid leukemia (CML) is caused by BCR-ABL, which is an oncogenic tyrosine kinase that can be effectively inhibited with ABL-selective tyrosine kinase inhibitors...

journal_title：Cancer research

authors： Inselmann S,Wang Y,Saussele S,Fritz L,Schütz C,Huber M,Liebler S,Ernst T,Cai D,Botschek S,Brendel C,Calogero RA,Pavlinic D,Benes V,Liu ET,Neubauer A,Hochhaus A,Burchert A

更新日期：2018-11-01 00:00:00

abstract：:8-Chloroadenosine 3',5'-monophosphate has been reported to inhibit growth of various mammalian cell lines at micromolar concentrations. We have used Chinese hamster ovary cell lines with mutated cyclic AMP-dependent protein kinase or altered cyclic nucleotide metabolism to show that a metabolite, 8-chloroadenosine, is...

journal_title：Cancer research

authors： Van Lookeren Campagne MM,Villalba Díaz F,Jastorff B,Kessin RH

更新日期：1991-03-15 00:00:00

abstract：:Thirty-six wild-caught woodchucks (Marmota monax) were characterized according to sex, weight, trapping locality, liver pathology, and serum or hepatic markers of woodchuck hepatitis virus. Liver subcellular fractions were assayed for microsomal cytochromes P-450, aryl hydrocarbon hydroxylase, glutathione, cytosolic e...

journal_title：Cancer research

authors： De Flora S,Camoirano A,Romano M,Astengo M,Cesarone CF,Millman I

更新日期：1987-08-01 00:00:00

abstract：:Although immunotherapies of tumors have demonstrated promise for altering the progression of malignancies, immunotherapies have been limited by an immunosuppressive tumor microenvironment (TME) that prevents infiltrating immune cells from performing their anticancer functions. Prominent among immunosuppressive cells a...

journal_title：Cancer research

authors： Cresswell GM,Wang B,Kischuk EM,Broman MM,Alfar RA,Vickman RE,Dimitrov DS,Kularatne SA,Sundaram CP,Singhal S,Eruslanov EB,Crist SA,Elzey BD,Ratliff TL,Low PS

更新日期：2020-11-17 00:00:00

abstract：:The inactivation of the tumor suppressor gene p53 has been demonstrated in a variety of human tumors. In this study, we present a p53 gene analysis of 13 uterine carcinoma cell lines. Sequencing analysis of the entire coding region revealed mutations changing the p53 amino acid composition in all six endometrial carci...

journal_title：Cancer research

authors： Yaginuma Y,Westphal H

更新日期：1991-12-15 00:00:00

abstract：:The RNA-binding protein PNO1 is critical for ribosome biogenesis, but its potential role in cancer remains unknown. In this study, online data mining, cDNA, and tissue microarrays indicated that PNO1 expression was higher in colorectal cancer tissue than in noncancerous tissue, and its overexpression was associated wi...

journal_title：Cancer research

authors： Shen A,Chen Y,Liu L,Huang Y,Chen H,Qi F,Lin J,Shen Z,Wu X,Wu M,Li Q,Qiu L,Yu N,Sferra TJ,Peng J

更新日期：2019-05-01 00:00:00

abstract：:Using a microcytotoxicity assay we have studied the immune responses to the preneoplastic, hyperplastic alveolar nodule (HAN) lines D1 and D2 and to the mammary tumors arising spontaneously from them in BALB/c mice. Lymph node cells (LNC) from mice bearing HAN implants, or from mice whose implants had been removed gre...

journal_title：Cancer research

authors： Heppner GH,Kopp JS,Medina D

更新日期：1976-02-01 00:00:00

abstract：:Gene expression signatures for a basal-like breast cancer (BLBC) subtype have been associated with poor clinical outcomes, but a molecular basis for this disease remains unclear. Here, we report overexpression of the transcription factor FOXC1 as a consistent feature of BLBC compared with other molecular subtypes of b...

journal_title：Cancer research

authors： Ray PS,Wang J,Qu Y,Sim MS,Shamonki J,Bagaria SP,Ye X,Liu B,Elashoff D,Hoon DS,Walter MA,Martens JW,Richardson AL,Giuliano AE,Cui X

更新日期：2010-05-15 00:00:00

abstract：:The cyclin-dependent kinase (Cdk)-associated protein phosphatase (KAP) is a human dual specificity protein phosphatase that dephosphorylates Cdk2 on threonine 160 in a cyclin-dependent manner. To investigate whether mutations of this enzyme occur in hepatocellular carcinoma (HCC), KAP mRNA was analyzed by reverse tran...

journal_title：Cancer research

authors： Yeh CT,Lu SC,Chen TC,Peng CY,Liaw YF

更新日期：2000-09-01 00:00:00

abstract：:CD99 is a Mr 32,000 transmembrane molecule that shows a high level of expression on cells of the hemopoietic system as well as on Ewing tumor cells. Within the hematopoietic system, CD99 has been implicated in cell adhesion and cell death, participating in this way in the differentiation of T-cell precursors. In this ...

journal_title：Cancer research

authors： Scotlandi K,Baldini N,Cerisano V,Manara MC,Benini S,Serra M,Lollini PL,Nanni P,Nicoletti G,Bernard G,Bernard A,Picci P

更新日期：2000-09-15 00:00:00

abstract：:Low income, poor diet, obesity, and a lack of exercise are interrelated lifestyle factors that can profoundly alter our biologic make up to increase cancer risk, growth, and development. We recently reported a potential mechanistic link between carbohydrate-derived metabolites and cancer, which may provide a biologic ...

journal_title：Cancer research

authors： Turner DP

更新日期：2015-05-15 00:00:00

abstract：:The induction, accumulation, and persistence of sister chromatid exchanges (SCEs) and high SCE frequency cells (HFCs) was measured in peripheral blood lymphocytes of women with breast cancer before chemotherapy and on multiple occasions during and after therapy. Chemotherapy consisted of i.v. infusion of cyclophospham...

journal_title：Cancer research

authors： Tucker JD,Wyrobek AJ,Ashworth LK,Christensen ML,Burton GV,Carrano AV,Everson RB

更新日期：1990-08-15 00:00:00

abstract：:Pregnant Sprague-Dawley rats were X-irradiated on the 16th day of gestation with 5 to 250 rads and given i.p. injections 4 days later with 10 mg ethylnitrosourea per kg. The offspring were observed over their life span for the appearance of neurogenic tumors. The frequency of animals surviving beyond 4 weeks of age th...

journal_title：Cancer research

authors： Kalter H,Mandybur TI,Ormsby I,Warkany J

更新日期：1980-11-01 00:00:00

abstract：:The presence of a non-small cell lung carcinoma (NSCLC)-related gene or genes on chromosome band 11p15.5 is of particular interest, given the specific loss of heterozygosity (LOH) measured in this region for lung as well as many other pediatric and adult neoplasms. We have undertaken high-density polymorphic marker an...

journal_title：Cancer research

authors： Tran YK,Newsham IF

更新日期：1996-07-01 00:00:00

abstract：:A hormone-dependent subline of the transplantable rat mammary tumor MTW9 contains binding sites for both prolactin and estrogen. Prolactin binding is saturable (K-d similar to 2 times 10-9 M), hormone specific, and destroyed by proteases. By contrast, an autonomous subline derived from the same parent tumor has lost m...

journal_title：Cancer research

authors： Costlow ME,Buschow RA,Richert NJ,McGuire WL

更新日期：1975-04-01 00:00:00

abstract：:The transformation of murine BALB/c embryonic fibroblasts by murine sarcoma virus, Moloney strain, followed by prolonged treatment with murine interferon, resulted in the appearance of a new cell population (MSV-IF+). These MSV-IF+ cells are characterized by the recovery of a normal phenotype, contact inhibition, and ...

journal_title：Cancer research

authors： Gerfaux J,Rousset S,Chany-Fournier F,Chany C

更新日期：1981-09-01 00:00:00

abstract：:We have examined the properties of the estrogen receptor and progesterone receptor in MDA-MB-134 human breast cells and have evaluated the effects of estrogen on cell proliferation and progesterone receptor levels in these cells as indices of hormonal sensitivity. These cells contain high levels of estrogen receptor (...

journal_title：Cancer research

authors： Reiner GC,Katzenellenbogen BS

更新日期：1986-03-01 00:00:00

abstract：:The effects on Leydig cell tumorigenesis of surgical cryptorchidy, parabiotic union with a castrate male partner, and a combination on the two procedures as well as of the continuous exposure to a high level of diethylstilbestrol stimulation were studied in the high-tumor Fischer rat. Localized foci of adenomatous hyp...

journal_title：Cancer research

authors： Huseby RA

更新日期：1981-08-01 00:00:00

abstract：:Types I and II cyclic adenosine 3':5'-monophosphate (cAMP)-dependent protein kinases were compared in extracts from untransformed rat 3Y1 cells and 3Y1 cells transformed by the highly oncogenic human adenovirus type 12. Analysis of the kinases through diethylaminoethyl Sepharose column chromatography showed a signific...

journal_title：Cancer research

authors： Ledinko N,Chan IJ

更新日期：1984-06-01 00:00:00

abstract：:We previously reported that amino acids 20 to 50 of nuclear receptor interacting factor-3 mediates rapid apoptosis in breast cancer cell lines but not in cells derived from other tissues. We refer to this short region as death domain-1 (DD1). Small interfering RNA studies indicated that DD1-mediated apoptosis is caspa...

journal_title：Cancer research

authors： Das S,Nwachukwu JC,Li D,Vulin AI,Martinez-Caballero S,Kinnally KW,Samuels HH

更新日期：2007-02-15 00:00:00

abstract：:Tumor hypoxia is associated clinically with therapeutic resistance and poor patient outcomes. One feature of tumor hypoxia is activated expression of carbonic anhydrase IX (CA9), a regulator of pH and tumor growth. In this study, we investigated the hypothesis that impeding the reuptake of bicarbonate produced extrace...

journal_title：Cancer research

authors： McIntyre A,Hulikova A,Ledaki I,Snell C,Singleton D,Steers G,Seden P,Jones D,Bridges E,Wigfield S,Li JL,Russell A,Swietach P,Harris AL

更新日期：2016-07-01 00:00:00