Abstract：
:Gene expression signatures for a basal-like breast cancer (BLBC) subtype have been associated with poor clinical outcomes, but a molecular basis for this disease remains unclear. Here, we report overexpression of the transcription factor FOXC1 as a consistent feature of BLBC compared with other molecular subtypes of breast cancer. Elevated FOXC1 expression predicted poor overall survival in BLBC (P = 0.0001), independently of other clinicopathologic prognostic factors including lymph node status, along with a higher incidence of brain metastasis (P = 0.02) and a shorter brain metastasis-free survival in lymph node-negative patients (P < 0.0001). Ectopic overexpression of FOXC1 in breast cancer cells increased cell proliferation, migration, and invasion, whereas shRNA-mediated FOXC1 knockdown yielded opposite effects. Our findings identify FOXC1 as a theranostic biomarker that is specific for BLBC, offering not only a potential prognostic candidate but also a potential molecular therapeutic target in this breast cancer subtype.
journal_name
Cancer Resjournal_title
Cancer researchauthors
Ray PS,Wang J,Qu Y,Sim MS,Shamonki J,Bagaria SP,Ye X,Liu B,Elashoff D,Hoon DS,Walter MA,Martens JW,Richardson AL,Giuliano AE,Cui Xdoi
10.1158/0008-5472.CAN-09-4120subject
Has Abstractpub_date
2010-05-15 00:00:00pages
3870-6issue
10eissn
0008-5472issn
1538-7445pii
0008-5472.CAN-09-4120journal_volume
70pub_type
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