Differential regulation of expression of three transforming growth factor beta species in human breast cancer cell lines by estradiol.

abstract：:Because of their short range and high linear energy transfer, alpha-particles may be particularly effective in the treatment of neoplastic meningitis. Monoclonal antibody 81C6 was labeled with alpha-particle-emitting 211At using N-succinimidyl3-[211At]astatobenzoate, and the efficacy and toxicity of this immunoconjuga...

journal_title：Cancer research

authors： Zalutsky MR,McLendon RE,Garg PK,Archer GE,Schuster JM,Bigner DD

更新日期：1994-09-01 00:00:00

abstract：:Primary cell cultures derived from human skin epithelium metabolized benzo(a)pyrene to three classes of compounds: phenols, quinones, and dihydrodiols. The relative proportions of metabolites varied according to the skin donor but differed from the pattern of metabolites in rat liver microsome preparations. While appr...

journal_title：Cancer research

authors： Fox CH,Selkirk JK,Price FM,Croy RG,Sanford KK,Cottler-Fox M

更新日期：1975-12-01 00:00:00

abstract：:The correlation between the clinical outcome in patients with esophageal squamous cell carcinoma and coamplification of the proto-oncogenes int-2 and hst-1, which are partially homologous to angiogenesis-inducing fibroblast growth factor, was analyzed retrospectively. Coamplification of these genes was examined by slo...

journal_title：Cancer research

authors： Kitagawa Y,Ueda M,Ando N,Shinozawa Y,Shimizu N,Abe O

更新日期：1991-03-01 00:00:00

abstract：:MicroRNAs (miRNA) are a recently discovered class of noncoding RNAs that negatively regulate gene expression. Recent evidence indicates that miRNAs may play an important role in cancer. However, the mechanism of their deregulation in neoplastic transformation has only begun to be understood. To elucidate the role of t...

journal_title：Cancer research

authors： Corney DC,Flesken-Nikitin A,Godwin AK,Wang W,Nikitin AY

更新日期：2007-09-15 00:00:00

abstract：:Focal adhesion kinase (FAK) functions downstream of integrins and growth factor receptors to promote tumor cell motility and invasion. In colorectal cancer, FAK is activated by amidated gastrin, a protumorigenic hormone. However, it is unclear how FAK receives signals from the gastrin receptor or other G-protein-coupl...

journal_title：Cancer research

authors： Yu HG,Nam JO,Miller NL,Tanjoni I,Walsh C,Shi L,Kim L,Chen XL,Tomar A,Lim ST,Schlaepfer DD

更新日期：2011-01-15 00:00:00

abstract：:Prostate cancer is highly sensitive to hormone therapy because androgens are essential for prostate cancer cell growth. However, with the nearly invariable progression of this disease to androgen independence, endocrine therapy ultimately fails to control prostate cancer in most patients. Androgen-independent acquisit...

journal_title：Cancer research

authors： Cerasuolo M,Paris D,Iannotti FA,Melck D,Verde R,Mazzarella E,Motta A,Ligresti A

更新日期：2015-08-01 00:00:00

abstract：:Hypoxia is considered to be a major cause of tumor radioresistance. Reoxygenation of previously hypoxic areas after a priming dose of radiation is associated with an increase in tumor radiosensitivity. In a study of a hypoxic mammary carcinoma, 31P nuclear magnetic resonance spectra showed statistically significant in...

journal_title：Cancer research

authors： Koutcher JA,Alfieri AA,Devitt ML,Rhee JG,Kornblith AB,Mahmood U,Merchant TE,Cowburn D

更新日期：1992-09-01 00:00:00

abstract：:Resistance to chemotherapy predicts an unfavorable outcome for patients with radioiodine-insensitive thyroid cancer. To investigate the mechanisms underlying this resistance, we evaluated the expression of four different inhibitor of apoptosis proteins, and their antagonist, Smac, in thyroid cancer cells that survived...

journal_title：Cancer research

authors： Tirrò E,Consoli ML,Massimino M,Manzella L,Frasca F,Sciacca L,Vicari L,Stassi G,Messina L,Messina A,Vigneri P

更新日期：2006-04-15 00:00:00

abstract：:Although ethanol has generally not been found to induce cancer in experimental animals, the consumption of alcoholic beverages has been linked to increased risks of several cancers in humans. Risks of oral, pharyngeal, laryngeal, esophageal, and liver cancer are elevated among drinkers, typically in proportion to the ...

journal_title：Cancer research

authors： Blot WJ

更新日期：1992-04-01 00:00:00

abstract：:After 5 or 20 mg cyclophosphamide per kg body weight, given once i.v., the output in thoracic duct lymph of small and large lymphoid cells, cells incorporating [3H]lymidine in vitro, mitotic cells, pyknotic cells, and/or the number of lymphocytes and neutrophils in peripheral blood were measured in six calves. The med...

journal_title：Cancer research

authors： Wagner JP,Chanana AD,Cottier H,Cronkite EP,Gassmann A,Joel DD,Laissue JA

更新日期：1976-09-01 00:00:00

abstract：:Proteolysis-inducing factor (PIF) is a sulfated glycoprotein produced by cachexia-inducing tumors, which induces atrophy of skeletal muscle. PIF has been shown to bind specifically with high affinity (K(d), in nanomolar) to sarcolemma membranes from skeletal muscle of both the mouse and the pig, as well as murine myob...

journal_title：Cancer research

authors： Todorov PT,Wyke SM,Tisdale MJ

更新日期：2007-12-01 00:00:00

abstract：:Cyclin G1 was identified as a transcriptional target of p53 that encodes a protein with strong homology to the cyclin family of cell cycle regulators. We show that either ectopically expressed or endogenous cyclin G1 protein is very unstable, undergoes modification with ubiquitin, and is likely degraded by the proteas...

journal_title：Cancer research

authors： Piscopo DM,Hinds PW

更新日期：2008-07-15 00:00:00

abstract：:The thiopurines 6-thioguanine (6TG) and 6-mercaptopurine (6MP) are cytotoxic to proliferating cells by a mechanism involving incorporation into DNA via the purine salvage pathway, and resistance to these agents can be conferred by lack of the salvage pathway enzyme hypoxanthine-guanine phosphoribosyltransferase. Howev...

journal_title：Cancer research

authors： Morgan CJ,Chawdry RN,Smith AR,Siravo-Sagraves G,Trewyn RW

更新日期：1994-10-15 00:00:00

abstract：:To identify molecular alterations involved in the initiation and progression of breast carcinomas, we analyzed the global gene expression profiles of normal mammary epithelial cells and in situ, invasive, and metastatic breast carcinomas using serial analysis of gene expression (SAGE). We identified sets of genes expr...

journal_title：Cancer research

authors： Porter DA,Krop IE,Nasser S,Sgroi D,Kaelin CM,Marks JR,Riggins G,Polyak K

更新日期：2001-08-01 00:00:00

abstract：:The tobacco-specific nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) is a potent carcinogen in adult laboratory rodents. Our previous studies have shown that NNK crosses the placenta in pregnant hamsters and is metabolized into DNA-methylating and clastogenic intermediates by fetal respiratory tract t...

journal_title：Cancer research

authors： Correa E,Joshi PA,Castonguay A,Schüller HM

更新日期：1990-06-01 00:00:00

abstract：:Sequence alterations of mitotic checkpoint genes, hBUB1 and hBUBR1, were examined, and their gene transcripts were quantified using on-line, real-time quantitative reverse transcription-PCR in surgically resected human colorectal cancers and their neighboring normal tissues. Our results reveal a new hBUB1 missense mut...

journal_title：Cancer research

authors： Shichiri M,Yoshinaga K,Hisatomi H,Sugihara K,Hirata Y

更新日期：2002-01-01 00:00:00

abstract：:Insulin receptor (IR) exists as two isoforms resulting from the alternative splicing of IR pre-mRNA. IR-B promotes the metabolic effects of insulin, whereas IR-A rather signals proliferative effects. IR-B is predominantly expressed in the adult liver. Here, we show that the alternative splicing of IR pre-mRNA is dysre...

journal_title：Cancer research

authors： Chettouh H,Fartoux L,Aoudjehane L,Wendum D,Clapéron A,Chrétien Y,Rey C,Scatton O,Soubrane O,Conti F,Praz F,Housset C,Rosmorduc O,Desbois-Mouthon C

更新日期：2013-07-01 00:00:00

abstract：:Monoclonal antibodies (MoAbs) against human osteosarcoma cells were obtained by the fusion of NS/1 mouse myeloma cells with spleen cells from the human osteosarcoma cell line-immunized BALB/c mice. Two hybrid clones were established and designated as 2H10 and 2D3. Both MoAbs reacted strongly with all osteosarcoma tiss...

journal_title：Cancer research

authors： Wada T,Uede T,Ishii S,Matsuyama K,Yamawaki S,Kikuchi K

更新日期：1988-04-15 00:00:00

abstract：:We have investigated the effect of a combined chemoimmunotherapy protocol with liposomal muramyl tripeptide phosphatidylethanolamine (MTP-PE), 5-fluorouracil (5-FU), and 5-formyltetrahydrofolate (leucovorin) on the growth of hepatic metastases using carcinoma H-59, a liver-homing subline of the Lewis lung carcinoma (P...

journal_title：Cancer research

authors： Asao T,Shibata HR,Batist G,Brodt P

更新日期：1992-11-15 00:00:00

abstract：:Hepatocellular carcinoma (HCC) typically develops in cirrhosis, a condition characterized by Hedgehog (Hh) pathway activation and accumulation of Hh-responsive myofibroblasts. Although Hh signaling generally regulates stromal-epithelial interactions that support epithelial viability, the role of Hh-dependent myofibrob...

journal_title：Cancer research

authors： Chan IS,Guy CD,Chen Y,Lu J,Swiderska-Syn M,Michelotti GA,Karaca G,Xie G,Krüger L,Syn WK,Anderson BR,Pereira TA,Choi SS,Baldwin AS,Diehl AM

更新日期：2012-12-15 00:00:00

abstract：:Angiogenesis is a hallmark of cancer that promotes tumor progression and metastasis. However, antiangiogenic agents have limited efficacy in cancer therapy due to the development of resistance. In clear cell renal cell carcinoma (ccRCC), AXL expression is associated with antiangiogenic resistance and poor survival. He...

journal_title：Cancer research

authors： Xiao Y,Zhao H,Tian L,Nolley R,Diep AN,Ernst A,Fuh KC,Miao YR,von Eyben R,Leppert JT,Brooks JD,Peehl DM,Giaccia AJ,Rankin EB

更新日期：2019-11-15 00:00:00

abstract：:Expression of the alpha6beta4 integrin is associated with poor patient prognosis and reduced survival in a variety of human cancers. In recent years, a limited number of in vivo studies have examined the contribution of this integrin receptor to cancer progression and they have revealed that the alpha6beta4 integrin p...

journal_title：Cancer research

authors： Dutta U,Shaw LM

更新日期：2008-11-01 00:00:00

abstract：:The translation initiation factor eIF4E is an oncogene that is commonly overexpressed in primary breast cancers and metastases. In this article, we report that a pharmacologic inhibitor of eIF4E function, ribavirin, safely and potently suppresses breast tumor formation. Ribavirin administration blocked the growth of p...

journal_title：Cancer research

authors： Pettersson F,Del Rincon SV,Emond A,Huor B,Ngan E,Ng J,Dobocan MC,Siegel PM,Miller WH Jr

更新日期：2015-03-15 00:00:00

abstract：:Subcellular localization of von Hippel-Lindau (VHL) tumor suppressor may clarify its role in tumorigenesis. In rat kidney, we observed a granular cytoplasmic immunostaining of VHL, as seen in human tissues. The green fluorescent protein (GFP)-tagged VHL also appeared as cytoplasmic granules in vitro and was colocalize...

journal_title：Cancer research

authors： Shiao YH,Resau JH,Nagashima K,Anderson LM,Ramakrishna G

更新日期：2000-06-01 00:00:00

abstract：:After 16 months, an established line of human small cell lung cancer (OH-1) underwent a subtle morphological change which was associated with a virtually complete loss of neuroendocrine differentiation as judged by electron microscopy studies and a 12-fold loss in L-dopa decarboxylase activity. In nude (athymic) mouse...

journal_title：Cancer research

authors： Goodwin G,Baylin SB

更新日期：1982-04-01 00:00:00

abstract：:We recently reported trophic response of transplantable mouse colon cancer cells (MC-26) to pentagastrin, in vivo, and demonstrated gastrin receptors on MC-26 cells, in vitro. In the present study, growth of MC-26 cells in mice, in response to pentagastrin, was studied in relation to binding kinetics and capacity of g...

journal_title：Cancer research

authors： Singh P,Walker JP,Townsend CM Jr,Thompson JC

更新日期：1986-04-01 00:00:00

abstract：:BRCA1 inactivation is a frequent event in basal-like breast carcinomas (BLC). However, BRCA1 can be inactivated by multiple mechanisms and determining its status is not a trivial issue. As an alternate approach, we profiled 65 BLC cases using single-nucleotide polymorphism arrays to define a signature of BRCA1-associa...

journal_title：Cancer research

authors： Popova T,Manié E,Rieunier G,Caux-Moncoutier V,Tirapo C,Dubois T,Delattre O,Sigal-Zafrani B,Bollet M,Longy M,Houdayer C,Sastre-Garau X,Vincent-Salomon A,Stoppa-Lyonnet D,Stern MH

更新日期：2012-11-01 00:00:00

abstract：:We developed a new simple enzymatic assay method for measuring urinary polyamines (total amount of putrescine, spermidine, and cadaverine), using an acylpolyamine amidohydrolase and a putrescine oxidase. First conjugated polyamines (putrescine, spermidine, and cadaverine) in urine were hydrolyzed by incubation with an...

journal_title：Cancer research

authors： Kubota S,Okada M,Imahori K,Ohsawa N

更新日期：1983-05-01 00:00:00

abstract：:Breast cancer resistance protein (BCRP), also called ABCG2, confers resistance to anticancer agents such as 7-ethyl-10-hydroxycamptothecin (SN-38), mitoxantrone, and topotecan. We found previously that sulfated estrogens are physiologic substrates of BCRP. Flavonoids with weak estrogenic activities are called phytoest...

journal_title：Cancer research

authors： Imai Y,Tsukahara S,Asada S,Sugimoto Y

更新日期：2004-06-15 00:00:00

abstract：:The Ras proto-oncogene has been implicated in the in vivo development of tumors and in the in vitro transformation of cultured cell lines. In both of these conditions, Ras-mediated disruption of cell cycle-regulatory mechanisms leads to unregulated cellular proliferation, although the exact mechanisms by which Ras acc...

journal_title：Cancer research

authors： LaRue KE,Bradbury EM,Freyer JP

更新日期：1998-03-15 00:00:00