Chemopreventive isothiocyanates induce apoptosis and caspase-3-like protease activity.

abstract：:This study was undertaken to examine relationships of the phenotype of malignant cells to target cell properties and to events early in the transformation process. Eighteen transformed lines were obtained by Kirsten murine sarcoma virus infection of cells from adrenal glands of rats ages 4 to 30 weeks, at first or sec...

journal_title：Cancer research

authors： Auersperg N,Wan MW,Sanderson RA,Wong KS,Mauldin D

更新日期：1981-05-01 00:00:00

abstract：:The activity of gemcitabine (dFdC), an effective agent against solid tumors, depends on the incorporation of its triphosphate into DNA. In vitro investigations demonstrated that, depending on the sequence of template DNA, polymerases may pause after incorporation of gemcitabine nucleotide at either the 3'-terminal or ...

journal_title：Cancer research

authors： Gandhi V,Legha J,Chen F,Hertel LW,Plunkett W

更新日期：1996-10-01 00:00:00

abstract：:We studied the clinical and karyotypic features of 50 patients with acute lymphoblastic leukemia, including 33 American and 17 Japanese patients, at two institutions. Clonal chromosome abnormalities were found in 39 of the 50 patients (78%) at diagnosis. Eleven patients had diploidy (N patients). Among the 39 aneuploi...

journal_title：Cancer research

authors： Kaneko Y,Rowley JD,Variakojis D,Chilcote RR,Check I,Sakurai M

更新日期：1982-07-01 00:00:00

abstract：:Although chemoresistance remains a primary challenge in the treatment of pancreatic ductal adenocarcinoma (PDAC), exploiting oxidative stress might offer novel therapeutic clues. Here we explored the potential of targeting cystine/glutamate exchanger (SLC7A11/xCT), which contributes to the maintenance of intracellular...

journal_title：Cancer research

authors： Daher B,Parks SK,Durivault J,Cormerais Y,Baidarjad H,Tambutte E,Pouysségur J,Vučetić M

更新日期：2019-08-01 00:00:00

abstract：:Colorectal cancer (CRC) has traditionally been classified into two groups: microsatellite stable/low-level instability (MSS/MSI-L) and high-level MSI (MSI-H) groups on the basis of multiple molecular and clinicopathologic criteria. Using methylated in tumor (MINT) markers 1, 2, 12, and 31, we stratified 77 primary CRC...

journal_title：Cancer research

authors： Whitehall VL,Wynter CV,Walsh MD,Simms LA,Purdie D,Pandeya N,Young J,Meltzer SJ,Leggett BA,Jass JR

更新日期：2002-11-01 00:00:00

abstract：:L-Type amino acid transporters such as LAT1 and LAT3 mediate the uptake of essential amino acids. Here, we report that prostate cancer cells coordinate the expression of LAT1 and LAT3 to maintain sufficient levels of leucine needed for mTORC1 signaling and cell growth. Inhibiting LAT function was sufficient to decreas...

journal_title：Cancer research

authors： Wang Q,Bailey CG,Ng C,Tiffen J,Thoeng A,Minhas V,Lehman ML,Hendy SC,Buchanan G,Nelson CC,Rasko JE,Holst J

更新日期：2011-12-15 00:00:00

abstract：:The effect of commercial saccharin preparations on urethan-induced mouse lung tumorigenesis was assessed by gavaging groups of male strain A mice with 1-g/kg doses of each saccharin preparation on a daily basis 5 days/week. Gavage was initiated 1 week before i.p. injection of either a low (0.1 mg/g) or a high (1 mg/g)...

journal_title：Cancer research

authors： Theiss JC,Arnold LJ,Shimkin MB

更新日期：1980-11-01 00:00:00

abstract：:Metastasis is the primary cause of death from breast cancer. A xenograft model was used to identify genes potentially involved with metastasis, comparing expression in the poorly metastatic GI101A human breast cancer cell line and a highly metastatic variant, GILM2. cDNA microarray analyses of these isogenic variants ...

journal_title：Cancer research

authors： Kluger HM,Chelouche Lev D,Kluger Y,McCarthy MM,Kiriakova G,Camp RL,Rimm DL,Price JE

更新日期：2005-07-01 00:00:00

abstract：:Hypoxia drives malignant progression in part by promoting accumulation of the oncogenic transcription factor hypoxia inducible factor-1α (HIF-1α) in tumor cells. Tumor aggressiveness also relates to elevation of the cancer stem cell-associated membrane protein CD24, which has been causally implicated in tumor formatio...

journal_title：Cancer research

authors： Thomas S,Harding MA,Smith SC,Overdevest JB,Nitz MD,Frierson HF,Tomlins SA,Kristiansen G,Theodorescu D

更新日期：2012-11-01 00:00:00

abstract：:Although African-American (AA) patients with prostate cancer tend to develop greater therapeutic resistance and faster prostate cancer recurrence compared with Caucasian-American (CA) men, the molecular mechanisms of this racial prostate cancer disparity remain undefined. In this study, we provide the first comprehens...

journal_title：Cancer research

authors： Kumar R,Bhat TA,Walsh EM,Chaudhary AK,O'Malley J,Rhim JS,Wang J,Morrison CD,Attwood K,Bshara W,Mohler JL,Yadav N,Chandra D

更新日期：2019-04-01 00:00:00

abstract：:We evaluated primary lung cancers, tumor cell lines, and preneoplastic bronchial lesions for molecular genetic abnormalities in the candidate tumor suppressor gene FHIT, which spans the FRA3B fragile site at 3p14.2. 3p14.2 allele loss was very frequent in 32 lung cancer cell lines [100% of small cell lung cancer and 8...

journal_title：Cancer research

authors： Fong KM,Biesterveld EJ,Virmani A,Wistuba I,Sekido Y,Bader SA,Ahmadian M,Ong ST,Rassool FV,Zimmerman PV,Giaccone G,Gazdar AF,Minna JD

更新日期：1997-06-01 00:00:00

abstract：:The gastrin gene is expressed widely in pancreatic adenocarcinomas and the study aimed to assess its role in both the resistance of cancer cells to apoptosis and the sensitivity of cells to chemotherapeutic agents. Two human pancreatic cell lines, PAN1 and BXPC3, expressed gastrin at both the RNA and protein levels an...

journal_title：Cancer research

authors： Harris JC,Gilliam AD,McKenzie AJ,Evans SA,Grabowska AM,Clarke PA,McWilliams DF,Watson SA

更新日期：2004-08-15 00:00:00

abstract：:8-Chloroadenosine 3',5'-monophosphate has been reported to inhibit growth of various mammalian cell lines at micromolar concentrations. We have used Chinese hamster ovary cell lines with mutated cyclic AMP-dependent protein kinase or altered cyclic nucleotide metabolism to show that a metabolite, 8-chloroadenosine, is...

journal_title：Cancer research

authors： Van Lookeren Campagne MM,Villalba Díaz F,Jastorff B,Kessin RH

更新日期：1991-03-15 00:00:00

abstract：:Von Hippel-Lindau (VHL) tumor suppressor protein is expressed in neurons of the central nervous system and plays an important role during the neuronal differentiation of central nervous system progenitor cells. To elucidate the neuronal differentiating potential of VHL protein in neuroblastoma cells, we overexpressed ...

journal_title：Cancer research

authors： Murata H,Tajima N,Nagashima Y,Yao M,Baba M,Goto M,Kawamoto S,Yamamoto I,Okuda K,Kanno H

更新日期：2002-12-01 00:00:00

abstract：:Comparison of the cell surface characteristics of the parental strain-specific TA3-St ascites cell (I) of the strain A mouse and the more allotransplantable TA3-St/ticol ascites cell (II), immunoselected for reduced absorption of anti-H-2a antibody from Cell I, revealed the following. Cell II, like Cell I, possessed n...

journal_title：Cancer research

authors： Codington JF,Das HR,Dalianis T,Klein G,Miller SC,Silber C,Lampert LA,Darby DM,Jeanloz RW

更新日期：1983-09-01 00:00:00

abstract：:Analyses are reported from a case-control interview study of incident laryngeal cancer on the Gulf Coast of Texas. Study subjects were 183 white men with squamous cell carcinoma of the larynx and 250 frequency matched controls. Occupational exposures were examined controlling for potential confounding by cigarette smo...

journal_title：Cancer research

authors： Brown LM,Mason TJ,Pickle LW,Stewart PA,Buffler PA,Burau K,Ziegler RG,Fraumeni JF Jr

更新日期：1988-04-01 00:00:00

abstract：:The rate of repopulation of surviving cells increases during fractionated radiotherapy and limits the ability to control tumors. Repopulation is likely to be more important during the longer intervals between courses of chemotherapy and is a potential cause of clinical resistance to chemotherapy. To evaluate the rate ...

journal_title：Cancer research

authors： Wu L,Tannock IF

更新日期：2003-05-01 00:00:00

abstract：:Antitumor effects of a soluble form dominant negative of the type I insulin-like growth factor receptor (IGF-IR) designated as 486/STOP were evaluated in CaOV-3 human ovarian cancer cells by establishing stable transformants overexpressing 486/STOP and by administration of 486/STOP recombinant protein. Expression of 4...

journal_title：Cancer research

authors： Hongo A,Kuramoto H,Nakamura Y,Hasegawa K,Nakamura K,Kodama J,Hiramatsu Y

更新日期：2003-11-15 00:00:00

abstract：:In a preceding paper (D. B. Alexander et al., Cancer Res., 53: 1808-1815, 1993), we demonstrated that the in vitro glucocorticoid inhibition of Con8 mammary tumor cell growth is accompanied by the disruption of a transforming growth factor alpha (TGF-alpha) autocrine loop. This growth suppression response functions in...

journal_title：Cancer research

authors： Goya L,Alexander DB,Webster MK,Kern FG,Guzman RC,Nandi S,Firestone GL

更新日期：1993-04-15 00:00:00

abstract：:Xeroderma pigmentosum variant (XPV) patients with mutations in the DNA polymerase eta (pol eta) gene are hypersensitive to sunlight and have greatly increased susceptibility to sunlight-induced skin cancer. Consistent with the ability of Pol eta to efficiently bypass UV light-induced cyclobutane pyrimidine dimers, XPV...

journal_title：Cancer research

authors： Lin Q,Clark AB,McCulloch SD,Yuan T,Bronson RT,Kunkel TA,Kucherlapati R

更新日期：2006-01-01 00:00:00

abstract：:The signaling pathways that mediate the development of pancreatic ductal adenocarcinoma (PDAC) downstream of mutant Kras remain incompletely understood. Here, we focus on ribosomal protein S6 (rpS6), an mTOR effector not implicated previously in cancer. Phosphorylation of rpS6 was increased in pancreatic acinar cells ...

journal_title：Cancer research

authors： Khalaileh A,Dreazen A,Khatib A,Apel R,Swisa A,Kidess-Bassir N,Maitra A,Meyuhas O,Dor Y,Zamir G

更新日期：2013-03-15 00:00:00

abstract：:The p75 and p110 isoforms of the CUX1 homeodomain protein are overexpressed in breast tumors and cancer cell lines. To assess and compare the ability of these short CUX1 isoforms in driving mammary tumor development, we used site-specific transgenesis into the Hprt locus to generate transgenic mice expressing p75 or p...

journal_title：Cancer research

authors： Cadieux C,Kedinger V,Yao L,Vadnais C,Drossos M,Paquet M,Nepveu A

更新日期：2009-09-15 00:00:00

abstract：:Lymphoid cell subpopulations infiltrating into autografts of methylcholanthrene-induced sarcomas in rats immunized with autologous tumor cells were identified in terms of immunohistochemical and cytofluorographic techniques using various monoclonal antibodies raised against different classes of rat lymphohemopoietic c...

journal_title：Cancer research

authors： Ishii Y,Matsuura A,Takami T,Uede T,Ibayashi Y,Uede T,Imamura M,Kikuchi K,Kikuchi Y

更新日期：1984-09-01 00:00:00

abstract：:Decyl and phenyl disulfide derivatives of 6-mercaptopurine and 6-thioguanine (6-TG) were examined for antineoplastic activity under aerobic and hypoxic conditions toward EMT6 cells in culture. Although these derivatives did not display selective toxicity toward the hypoxic cells, they were significantly more toxic tha...

journal_title：Cancer research

authors： Kirkpatrick DL

更新日期：1987-08-15 00:00:00

abstract：:The ErbB2 (Neu) receptor tyrosine kinase is frequently overexpressed in human breast cancers, and this phenotype correlates with a poor clinical prognosis. We examined the effects of the mammalian target of rapamycin inhibitor, rapamycin, on mammary tumorigenesis in transgenic mice bearing an activated ErbB2 (NeuYD) t...

journal_title：Cancer research

authors： Liu M,Howes A,Lesperance J,Stallcup WB,Hauser CA,Kadoya K,Oshima RG,Abraham RT

更新日期：2005-06-15 00:00:00

abstract：:The nucleoside analogue 1-beta-D-arabinofuranosylcytosine (ara-C) is incorporated into herpes simplex virus type 1 (HSV-1) DNA, and this correlates with inhibition of virus replication. The technique of Weigle-type reactivation (WR) was used to compare the ability of induced cellular DNA repair pathways to recognize o...

journal_title：Cancer research

authors： Bubley GJ,Crumpacker CS,Schnipper LE

更新日期：1984-05-01 00:00:00

abstract：:An assay using a bimane derivative has been developed to detect free glutathione (GSH) in individual viable cells by flow cytometry. Monochlorobimane [syn-(ClCH2CH3)-1,5-diazabicycla[3.30]acta-3,6-diene-2,8-dio ne], itself nonfluorescent, reacts with GSH to form a highly fluorescent derivative. High pressure liquid ch...

journal_title：Cancer research

authors： Rice GC,Bump EA,Shrieve DC,Lee W,Kovacs M

更新日期：1986-12-01 00:00:00

abstract：:CAMA-1 cells, isolated from malignant pleural effusion, are grown in long-term cultures as monolayers. The rate of growth is dependent upon fetal bovine serum and estradiol. These cells also exhibit a dose response to added 17 beta-estradiol with respect to the incorporation of radiolabeled thymidine into cells. The u...

journal_title：Cancer research

authors： Leung BS,Qureshi S,Leung JS

更新日期：1982-12-01 00:00:00

abstract：:Hematogenous carcinoma metastasis is supported by aggregated platelets and leukocytes, forming tumor cell emboli. Early tumor cell-platelet interactions can be mediated by P-selectin binding to tumor cell surface ligands and this process is blocked by heparin. We previously showed that L-selectin deficiency also atten...

journal_title：Cancer research

authors： Läubli H,Stevenson JL,Varki A,Varki NM,Borsig L

更新日期：2006-02-01 00:00:00

abstract：:Chinese hamster ovary cells exposed to the sulfhydryl compound cysteamine combined with heat treatment at 44 degrees C developed thermotolerance within 8 h. After initial treatment either with 15 min cysteamine (0.4 mM) at 37 degrees C immediately followed by 15 min heat at 44 degrees C or with 15 min cysteamine (0.4 ...

journal_title：Cancer research

authors： Issels RD,Bourier S,Böning B,Li GC,Mak JJ,Wilmanns W

更新日期：1987-05-01 00:00:00