Abstract：
:Alteration of the phenotype of breast cancers from estrogen-dependent to estrogen-independent growth often leads to the failure of antiestrogenic tumor therapies. We report that overexpression of vascular endothelial growth factor (VEGF) by estrogen-dependent MCF-7 breast cancer cells could abolish estrogen-dependent tumor growth in ovariectomized mice. In the absence of estrogen, MCF-7 VEGF-expressing tumors with increased vessel density showed growth kinetics similar to, or even greater than, that of parental MCF-7 tumors with estrogen supplementation. Overexpression of VEGF by MCF-7 cells or treatment on parental MCF-7 cells with recombinant VEGF also stimulated cell proliferation in culture. Our data suggest that VEGF stimulation of MCF-7 tumor angiogenesis and growth is mediated by both autocrine and paracrine mechanisms.
journal_name
Cancer Resjournal_title
Cancer researchauthors
Guo P,Fang Q,Tao HQ,Schafer CA,Fenton BM,Ding I,Hu B,Cheng SYsubject
Has Abstractpub_date
2003-08-01 00:00:00pages
4684-91issue
15eissn
0008-5472issn
1538-7445journal_volume
63pub_type
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