Eleutherobin, a novel cytotoxic agent that induces tubulin polymerization, is similar to paclitaxel (Taxol).

abstract：:Targeting of steroidogenic enzymes (e.g., abiraterone acetate targeting CYP17A1) has been developed as a novel therapeutic strategy against metastatic castration-resistant prostate cancer (CRPC). However, resistance to steroidal inhibitors inevitably develops in patients, the mechanisms of which remain largely unknown...

journal_title：Cancer research

authors： Xiao L,Wang Y,Xu K,Hu H,Xu Z,Wu D,Wang Z,You W,Ng CF,Yu S,Chan FL

更新日期：2018-05-01 00:00:00

abstract：:We analyzed the mRNA expression of the FHIT gene by reverse transcription-PCR (RT-PCR) in 54 cases of acute lymphoblastic leukemia (ALL; 11 cases of T-cell ALL [T-ALL] and 43 cases of non-T-ALL) and 40 cases of acute myeloid leukemia (AML). In 46% of the ALL cases and 55% of the AML cases, FHIT expression was absent o...

journal_title：Cancer research

authors： Iwai T,Yokota S,Nakao M,Nakazawa N,Taniwaki M,Kimura T,Sonoda Y,Kaneko H,Okuda T,Azuma H,Oka T,Takeda T,Watanabe A,Kikuta A,Asami K,Sekine I,Matsushita T,Tsuchiya T,Mimaya J,Koizumi S,Ohta S,Miyake M,Takaue Y

更新日期：1998-11-15 00:00:00

abstract：:Following DNA damage, human cells arrest primarily in the G(1) and G(2) phases of the cell cycle. Here, we show that after irradiation, human cancer cells with targeted deletion of PTEN or naturally occurring PTEN mutations can exert G(1) and G(2) arrests but are unable to arrest in size. Pharmacological inhibition of...

journal_title：Cancer research

authors： Lee C,Kim JS,Waldman T

更新日期：2004-10-01 00:00:00

abstract：:The oncoprotein HER-2/neu is a prosurvival factor, and its overexpression has been correlated with poor prognosis in patients with breast cancer. We report that HER-2 is a new substrate for caspase-8 and that tumor necrosis factor alpha (TNF-alpha) stimulation leads to an early caspase-8-dependent HER-2 cleavage in MC...

journal_title：Cancer research

authors： Benoit V,Chariot A,Delacroix L,Deregowski V,Jacobs N,Merville MP,Bours V

更新日期：2004-04-15 00:00:00

abstract：:Human prostate cancer has a high predisposition to metastasize to bone, resulting in the formation of osteoblastic metastases. The mechanism through which prostate cancer cells promote osteoblastic lesions is undefined. Vascular endothelial growth factor (VEGF) has been implicated as a mediator of osteoblast activity....

journal_title：Cancer research

authors： Dai J,Kitagawa Y,Zhang J,Yao Z,Mizokami A,Cheng S,Nör J,McCauley LK,Taichman RS,Keller ET

更新日期：2004-02-01 00:00:00

abstract：:Alterations in expression of or responsiveness to transforming growth factor beta (TGF-beta) are frequently found in human and animal epithelial cancers and are though to be important for loss of growth control in the neoplastic cell. We show here that keratinocyte cell lines from mice with a targeted deletion of the ...

journal_title：Cancer research

authors： Glick AB,Weinberg WC,Wu IH,Quan W,Yuspa SH

更新日期：1996-08-15 00:00:00

abstract：:The treatment of K562 human myeloblastic leukemia cells and YAC-1 murine lymphoma cells with cadeguomycin at concentrations over 0.6 microM significantly enhanced the cytotoxicity of 1-beta-D-arabinofuranosylcytosine (ara-C). The degree of potentiation depended upon the antibiotic concentration. The treatment with 75 ...

journal_title：Cancer research

authors： Suzuki H,Kim SH,Tanara M,Okazaki K,Okabe T,Wu RT,Tanaka N

更新日期：1987-02-01 00:00:00

abstract：:Oligodendrogliomas are a specific subtype of brain tumor of which the majority responds favorably to chemotherapy. In this study, we made use of expression profiling to identify chemosensitive oligodendroglial tumors. Correlation of expression profiles to loss of heterozygosity on 1p and 19q, common chromosomal aberra...

journal_title：Cancer research

authors： French PJ,Swagemakers SM,Nagel JH,Kouwenhoven MC,Brouwer E,van der Spek P,Luider TM,Kros JM,van den Bent MJ,Sillevis Smitt PA

更新日期：2005-12-15 00:00:00

abstract：:The chemokine receptor, CXCR4, is expressed by human melanomas, and its ligand, CXCL12, is frequently produced at sites of melanoma metastasis. Herein, we examine CXCR4-enhanced binding of B16 murine melanoma cells to endothelial cells (ECs) and recombinant adhesion molecules in vitro to determine the role of tumor- a...

journal_title：Cancer research

authors： Cardones AR,Murakami T,Hwang ST

更新日期：2003-10-15 00:00:00

abstract：:Local irradiation of tumors of rats bearing 3924A hepatomas resulted in more than a doubling of the putrescine levvel and nearly a doubling of spermidine concentration in the serum within 12 hr. Within 24 hr, the putrescine concentration had increased four-fold in the serum, along with a continued increase in the sper...

journal_title：Cancer research

authors： Russell DH,Looney WB,Kovacs CJ,Hopkins HA,Dattilo JW,Morris HP

更新日期：1976-02-01 00:00:00

abstract：:The efficacy of novel cancer therapeutics has been hampered by the ability to deliver these agents to the tumor at effective concentrations. Liposomes have been used as a method to overcome some delivery issues and, in combination with hyperthermia, have been shown to increase drug delivery to tumors. Particle size ha...

journal_title：Cancer research

authors： Kong G,Braun RD,Dewhirst MW

更新日期：2000-08-15 00:00:00

abstract：:In the vascular system, circulating tumor cells interact with endothelial cells. Tumor-endothelial cross-talk transforms the intravascular milieu to a prothrombotic, proinflammatory, and cell-adhesive state called endothelial cell activation (ECA). In the present study, we analyze the potential of metastatic tumor-der...

journal_title：Cancer research

authors： Goerge T,Barg A,Schnaeker EM,Poppelmann B,Shpacovitch V,Rattenholl A,Maaser C,Luger TA,Steinhoff M,Schneider SW

更新日期：2006-08-01 00:00:00

abstract：:The nucleus has been shown to be a site for the inositol lipid cycle that can be affected by treatment of quiescent cells with growth factors such as insulin-like growth factor I (IGF-I). Indeed, the exposure of Swiss 3T3 cells to IGF-I results in a rapid and transient increase in nuclear phospholipase C (PLC) beta1 a...

journal_title：Cancer research

authors： Manzoli L,Billi AM,Rubbini S,Bavelloni A,Faenza I,Gilmour RS,Rhee SG,Cocco L

更新日期：1997-06-01 00:00:00

abstract：:The immunology of herpes simplex infections has been reviewed, particularly in relation to potential herpes simplex virus (HSV) vaccines, and to the association between HSV and cervical cancer. Relevant data from humans, experimental animals, and in vitro systems implicate both specific immune mechanisms and nonspecif...

journal_title：Cancer research

authors： Nahmias AJ,Shore SL,Kohl S,Starr SE,Ashman RB

更新日期：1976-02-01 00:00:00

abstract：:Progression of the eukaryotic cell division cycle is regulated by a series of structurally related serine/threonine protein kinases known as cyclin-dependent kinases (CDKs). The D-type cyclin-dependent kinases, CDK4 and CDK6, have been strongly implicated in the control of G1 progression and the phosphorylation of the...

journal_title：Cancer research

authors： Li Y,Nichols MA,Shay JW,Xiong Y

更新日期：1994-12-01 00:00:00

abstract：:The adhesive characteristics of cultured acute lymphocytic leukemia cells (CCRF-CEM), lymphoma cells (Raji), and freshly isolated acute lymphocytic leukemia cells to human cultured endothelial cells were studied. An assay system was used whereby these neoplastic cells were allowed to interact with endothelial cells wh...

journal_title：Cancer research

authors： Maca RD,Fry GL,Hakes AD

更新日期：1978-08-01 00:00:00

abstract：:An extremely rapid blood clearance rate of murine IgG2a antibodies was found in all strains tested of outbred Swiss nu/nu mice, including mice from the major commercial suppliers. The clearance half-life was less than 5 h, in comparison to a 4-5-day half-life in BALB/c mice. Therefore, most of the IgG2a antibody injec...

journal_title：Cancer research

authors： Sharkey RM,Natale A,Goldenberg DM,Mattes MJ

更新日期：1991-06-15 00:00:00

abstract：:Although many clinicians and researchers work to understand cancer, there has been limited success to effectively combine forces and collaborate over time, distance, data, and budget constraints. Here we present a workflow template for multidisciplinary cancer therapy that was developed during the 2nd Annual Workshop ...

journal_title：Cancer research

authors： McGuire MF,Enderling H,Wallace DI,Batra J,Jordan M,Kumar S,Panetta JC,Pasquier E

更新日期：2013-10-15 00:00:00

abstract：:We have previously shown that interleukin 2 (IL-2) synergizes with interferon alpha (IFN-alpha) in mediating the regression of established pulmonary and hepatic metastases and the reduction of intradermal tumor in various murine tumor models. To understand the mechanism of synergy, we have examined lymphoid cell proli...

journal_title：Cancer research

authors： Puri RK,Travis WD,Rosenberg SA

更新日期：1990-09-01 00:00:00

abstract：:In this report, we describe the immunomodulatory characteristics of poly(I,C)-LC, a synthetic, double-stranded nucleic acid polymer, polyinosinic-polycytidylic acid, that is complexed with poly-L-lysine and solubilized by the addition of carboxymethylcellulose. We consistently observed, both in vitro and in vivo, stim...

journal_title：Cancer research

authors： Talmadge JE,Adams J,Phillips H,Collins M,Lenz B,Schneider M,Schlick E,Ruffmann R,Wiltrout RH,Chirigos MA

更新日期：1985-03-01 00:00:00

abstract：:Immune checkpoint therapies exhibit impressive efficacy in some patients with melanoma or lung cancer, but the lack of response in most cases presses the question of how general efficacy can be improved. In addressing this question, we generated a preclinical tumor model to study anti-PD-1 resistance by in vivo passag...

journal_title：Cancer research

authors： Wang X,Schoenhals JE,Li A,Valdecanas DR,Ye H,Zang F,Tang C,Tang M,Liu CG,Liu X,Krishnan S,Allison JP,Sharma P,Hwu P,Komaki R,Overwijk WW,Gomez DR,Chang JY,Hahn SM,Cortez MA,Welsh JW

更新日期：2017-02-15 00:00:00

abstract：:Recent reports suggest that expression of an activated c-Ha-ras oncogene is associated with cisplatin resistance in NIH-3T3 fibroblasts. To investigate the generality of these observations, cisplatin cytotoxicity was determined in a series of clonal Rat-1 fibroblast and rat ovarian surface epithelial (ROSE) cell lines...

journal_title：Cancer research

authors： Perez RP,Hamaguchi K,Tracey PA,Handel LM,Hamilton TC,Godwin AK

更新日期：1993-08-15 00:00:00

abstract：:Amplification and rearrangement of the epidermal growth factor receptor (EGFR) gene are characteristics of many types of tumors. One class of EGFR mutations, EGFRvIII, is characterized by an in-frame deletion resulting in a truncated external domain of the receptor. EGFRvIII was first identified in a subset of gliomas...

journal_title：Cancer research

authors： Reist CJ,Archer GE,Kurpad SN,Wikstrand CJ,Vaidyanathan G,Willingham MC,Moscatello DK,Wong AJ,Bigner DD,Zalutsky MR

更新日期：1995-10-01 00:00:00

abstract：:Two continuous retinoblastoma cell lines were observed by scanning electron microscopy. Both cell lines spontaneously grow as a suspension of round cells in clusters, chains, and unique ring (rosette) formations. Scanning electron microscopy of suspension cells reveals some variation in the number and frequency of sur...

journal_title：Cancer research

authors： McFall RC,Nagy RM,Nagle BT,McGreevy LM

更新日期：1978-09-01 00:00:00

abstract：:In eight estrogen receptor (ER)-positive breast cancer cell lines (including three sublines of MCF-7) and five ER-negative breast lines, the action of the nonsteroidal antiestrogen, tamoxifen, was studied, and the concentrations of ER and antiestrogen binding site were measured. The concentration of antiestrogen bindi...

journal_title：Cancer research

authors： Reddel RR,Murphy LC,Hall RE,Sutherland RL

更新日期：1985-04-01 00:00:00

abstract：:Activation of the matrix metalloproteinase 2 (MMP-2) has been shown to play a major role in the proteolysis of extracellular matrix (ECM) associated with tumor invasion. Although the precise mechanism of this activation remains elusive, levels of the membrane type 1-MMP (MT1-MMP) at the cell surface and of the tissue ...

journal_title：Cancer research

authors： Gilles C,Bassuk JA,Pulyaeva H,Sage EH,Foidart JM,Thompson EW

更新日期：1998-12-01 00:00:00

abstract：:Genome-wide association studies (GWAS) of bladder cancer have identified a number of susceptibility loci in European populations but have yet to uncover the genetic determinants underlying bladder cancer incidence among other ethnicities. Therefore, we performed the first GWAS in a Chinese cohort comprising 3,406 case...

journal_title：Cancer research

authors： Wang M,Li Z,Chu H,Lv Q,Ye D,Ding Q,Xu C,Guo J,Du M,Chen J,Song Z,Yin C,Qin C,Gu C,Zhu Y,Xia G,Liu F,Zhang Z,Yuan L,Fu G,Hu Z,Tong N,Shen J,Liu K,Sun J,Sun Y,Li J,Li X,Shen H,Xu J,Shi Y,Zhang

更新日期：2016-06-01 00:00:00

abstract：:Sixty % of clones isolated from HeLa cells treated with toxic concentrations of a methylating carcinogen showed increased resistance to the cytotoxicity of N-methyl-N-nitrosourea. D37 values were 6- to 100-fold higher than in the parental cell population. The absence of detectable levels of the repair enzyme O6-methyl...

journal_title：Cancer research

authors： Aquilina G,Hess P,Fiumicino S,Ceccotti S,Bignami M

更新日期：1995-06-15 00:00:00

abstract：:The inhibition of dihydrofolate reductase from L1210 leukemia cells as well as the inhibition of intact L1210 cells, both sensitive and resistant, to methotrexate by over 100, 4,6-diamino-2,2-dihydro-2,2-dimethyl-1-(X-phenyl)-s-triazines was studied. Quantitative structure-activity relationships were derived for the t...

journal_title：Cancer research

authors： Selassie CD,Strong CD,Hansch C,Delcamp TJ,Freisheim JH,Khwaja TA

更新日期：1986-02-01 00:00:00

abstract：:Inflammatory pathways may mediate preparation of the "metastatic soil" in the lungs. Some of these pathways--activation and/or the recruitment of certain inflammatory cells--might depend on vascular endothelial growth factor receptor 1 (VEGFR1) activity. Thus, blocking the activity of VEGFR1 (or the interaction with i...

journal_title：Cancer research

authors： Duda DG,Jain RK

更新日期：2010-07-15 00:00:00