The inhibition of ribosomal RNA synthesis and maturation in Novikoff hepatoma cells by 5-fluorouridine.

abstract：:Thirty-one patients with metastatic hormone-refractory prostatic adenocarcinoma were investigated scintigraphically with the 111In-labeled somatostatin analogue [DTPA-D-Phe1]-octreotide (OctreoScan) and with 99mTc-labeled HDP. In vitro somatostatin receptor autoradiography was performed on biopsies obtained from eight...

journal_title：Cancer research

authors： Nilsson S,Reubi JC,Kalkner KM,Laissue JA,Horisberger U,Olerud C,Westlin JE

更新日期：1995-12-01 00:00:00

abstract：:The adhesive characteristics of cultured acute lymphocytic leukemia cells (CCRF-CEM), lymphoma cells (Raji), and freshly isolated acute lymphocytic leukemia cells to human cultured endothelial cells were studied. An assay system was used whereby these neoplastic cells were allowed to interact with endothelial cells wh...

journal_title：Cancer research

authors： Maca RD,Fry GL,Hakes AD

更新日期：1978-08-01 00:00:00

abstract：:Targeted therapies for cancer are inherently limited by the inevitable recurrence of resistant disease after initial responses. To define early molecular changes within residual tumor cells that persist after treatment, we analyzed drug-sensitive lung adenocarcinoma cell lines exposed to reversible or irreversible epi...

journal_title：Cancer research

authors： Fan W,Tang Z,Yin L,Morrison B,Hafez-Khayyata S,Fu P,Huang H,Bagai R,Jiang S,Kresak A,Howell S,Vasanji A,Flask CA,Halmos B,Koon H,Ma PC

更新日期：2011-07-01 00:00:00

abstract：:Synovial sarcoma is a soft tissue malignancy characterized by the fusion of SS18 to either SSX1, SSX2, or SSX4 genes. SS18 and SSX are transcriptional cofactors involved in activation and repression of gene transcription, respectively. SS18 interacts with SWI/SNF, whereas SSX associates with the polycomb chromatin rem...

journal_title：Cancer research

authors： Lubieniecka JM,de Bruijn DR,Su L,van Dijk AH,Subramanian S,van de Rijn M,Poulin N,van Kessel AG,Nielsen TO

更新日期：2008-06-01 00:00:00

abstract：:The effect of dietary orotic acid (OA) in liver-pancreas carcinogenesis induced in female Syrian hamsters by N-Nitroso(2-hydroxypropyl) (2-oxopropyl)amine (HPOP) was evaluated. All animals infused with the carcinogen received the same doses. Results of the control group which received no OA or carcinogen were compared...

journal_title：Cancer research

authors： Kokkinakis DM,Albores-Saavedra J

更新日期：1994-10-15 00:00:00

abstract：:We have pursued our analysis of antigens recognized by autologous cytolytic T lymphocytes (CTLs) on the melanoma cells of patient LB33. This patient enjoys an unusually favorable evolution, which is associated with a strong and sustained antitumor CTL response. We reported previously the analysis of two melanoma cell ...

journal_title：Cancer research

authors： Chiari R,Foury F,De Plaen E,Baurain JF,Thonnard J,Coulie PG

更新日期：1999-11-15 00:00:00

abstract：:Hepatocellular carcinoma (HCC) was thought historically to arise from hepatocytes, but gene expression studies have suggested that it can also arise from fetal progenitor cells or their adult progenitor progeny. Here, we report the identification of a unique population of fetal liver progenitor cells in mice that can ...

journal_title：Cancer research

authors： Mokkapati S,Niopek K,Huang L,Cunniff KJ,Ruteshouser EC,deCaestecker M,Finegold MJ,Huff V

更新日期：2014-08-15 00:00:00

abstract：:Inactivation of p53 by human papillomavirus 16/18 E6 plays a crucial role in cervical tumorigenesis. To investigate the involvement of HPV16/18 in lung tumorigenesis, the association between HPV16 or HPV18 E6 and p53 protein expression in 122 lung tumors was evaluated by immunohistochemistry, and data showed that HPV1...

journal_title：Cancer research

authors： Cheng YW,Wu MF,Wang J,Yeh KT,Goan YG,Chiou HL,Chen CY,Lee H

更新日期：2007-11-15 00:00:00

abstract：:The RNA-binding protein PNO1 is critical for ribosome biogenesis, but its potential role in cancer remains unknown. In this study, online data mining, cDNA, and tissue microarrays indicated that PNO1 expression was higher in colorectal cancer tissue than in noncancerous tissue, and its overexpression was associated wi...

journal_title：Cancer research

authors： Shen A,Chen Y,Liu L,Huang Y,Chen H,Qi F,Lin J,Shen Z,Wu X,Wu M,Li Q,Qiu L,Yu N,Sferra TJ,Peng J

更新日期：2019-05-01 00:00:00

abstract：:Potentiation of the EBV-specific CTL response by immunization with CTL epitopes has been proposed as a logical approach for immune-targeting nasopharyngeal carcinoma (NPC) cells in vivo. This approach will undoubtedly be influenced by the ability of these malignant cells to endogenously process and present target epit...

journal_title：Cancer research

authors： Khanna R,Busson P,Burrows SR,Raffoux C,Moss DJ,Nicholls JM,Cooper L

更新日期：1998-01-15 00:00:00

abstract：:Reduced expression of neural cell adhesion molecule (NCAM) has been implicated in the progression to tumor malignancy in cancer patients. Previously, we have shown that the loss of NCAM function causes the formation of lymph node metastasis in a transgenic mouse model of pancreatic beta cell carcinogenesis (Rip1Tag2)....

journal_title：Cancer research

authors： Crnic I,Strittmatter K,Cavallaro U,Kopfstein L,Jussila L,Alitalo K,Christofori G

更新日期：2004-12-01 00:00:00

abstract：:Multi-targeting strategies improve the efficacy of antibody and immunotoxin therapies but have not yet been thoroughly explored for HER2-based cancer treatments. We investigated multi-epitope HER2 targeting to boost photosensitizer immunoconjugate uptake as a way of enhancing photoimmunotherapy. Photoimmunotherapy may...

journal_title：Cancer research

authors： Savellano MD,Pogue BW,Hoopes PJ,Vitetta ES,Paulsen KD

更新日期：2005-07-15 00:00:00

abstract：:Chemotherapy with 4'-O-tetrahydropyranyladriamycin (THP-ADM), a new derivative of Adriamycin, was equally or more effective against several experimental mouse tumors than it was with Adriamycin (ADM). When mice with P388 leukemia were given i.p. injections of THP-ADM or ADM daily for 9 consecutive days, the maximum in...

journal_title：Cancer research

authors： Tsuruo T,Iida H,Tsukagoshi S,Sakurai Y

更新日期：1982-04-01 00:00:00

abstract：:Amyloid fibrils from two cases of cancer-associated, systemic amyloidosis with renal cell carcinoma and mesothelioma as the respective underlying disorders were studied. The immunochemical studies suggested strongly that amyloid A comprised a principal fibril component in both cases of cancer-associated amyloidosis. T...

journal_title：Cancer research

authors： Husby G,Marhaug G,Sletten K

更新日期：1982-04-01 00:00:00

abstract：:We have examined three methods that may be useful for improving the therapeutic efficacy of antibody-targeted radionuclides. The principal limitation of radioimmunotherapy is myelotoxicity and thrombocytopenia. These are due mainly to the length of time the radioantibody remains in the blood. The clearance time of a r...

journal_title：Cancer research

authors： Sharkey RM,Blumenthal RD,Hansen HJ,Goldenberg DM

更新日期：1990-02-01 00:00:00

abstract：:Radioimmunoassay has been used to measure acetylated and deacetylated deoxyguanosine C-8 DNA adducts of 2-acetylaminofluorene in liver and kidney DNA of male Wistar-Furth rats fed a dietary regimen of 0.02 or 0.04% 2-acetylaminofluorene. When adduct formation was monitored during continuous feeding up to 60 days, subs...

journal_title：Cancer research

authors： Poirier MC,True B,Laishes BA

更新日期：1982-04-01 00:00:00

abstract：:There is considerable evidence that sphingosine kinases play a key role in cancer progression, which might involve positive selection of cancer cells that have been provided with a survival and growth advantage as a consequence of overexpression of the enzyme. Therefore, inhibitors of sphingosine kinase represent a no...

journal_title：Cancer research

authors： Pyne S,Bittman R,Pyne NJ

更新日期：2011-11-01 00:00:00

abstract：:Aberrant FLT3 expression and/or mutation plays a significant role in leukemogenesis. This has prompted the development of selective small molecule tyrosine kinase inhibitors against FLT3. However, like most tyrosine kinase inhibitors, those against FLT3 are not completely specific and at the doses required to complete...

journal_title：Cancer research

authors： Piloto O,Levis M,Huso D,Li Y,Li H,Wang MN,Bassi R,Balderes P,Ludwig DL,Witte L,Zhu Z,Hicklin DJ,Small D

更新日期：2005-02-15 00:00:00

abstract：:The MCT-1 oncogene was originally identified from lymphoma cell lines. Herein we establish that MCT-1 is highly expressed in 85% of human diffuse large B-cell lymphomas (DLBCL) and that knocking down MCT-1 by a specific short hairpin RNA in DLBCL cells induces apoptosis, supporting a critical role for MCT-1 in DLBCL c...

journal_title：Cancer research

authors： Dai B,Zhao XF,Hagner P,Shapiro P,Mazan-Mamczarz K,Zhao S,Natkunam Y,Gartenhaus RB

更新日期：2009-10-01 00:00:00

abstract：:L1210 murine leukemia cells were treated in vitro with the novel antineoplastic agent 8-carbamoyl-3-(2-chloroethyl)imidazo[5,1-d] -1,2,3,5-tetrazin-4(3H)-one (M&B 39565), and its interaction with cellular DNA was assessed by alkaline elution. DNA interstrand cross-link and DNA-protein cross-link formation was quantifi...

journal_title：Cancer research

authors： Gibson NW,Erickson LC,Hickman JA

更新日期：1984-05-01 00:00:00

abstract：:Recent genomic studies have identified subtypes of uterine leiomyoma (LM) with distinctive genetic alterations. Here, we report the elucidation of the biological characteristics of the two most prevalent uterine leiomyoma subtypes, MED12-mutant (MED12-LM) and HMGA2-overexpressing (HMGA2-LM) uterine leiomyomas. Because...

journal_title：Cancer research

authors： Wu X,Serna VA,Thomas J,Qiang W,Blumenfeld ML,Kurita T

更新日期：2017-12-15 00:00:00

abstract：:Human prostate cancer has a high predisposition to metastasize to bone, resulting in the formation of osteoblastic metastases. The mechanism through which prostate cancer cells promote osteoblastic lesions is undefined. Vascular endothelial growth factor (VEGF) has been implicated as a mediator of osteoblast activity....

journal_title：Cancer research

authors： Dai J,Kitagawa Y,Zhang J,Yao Z,Mizokami A,Cheng S,Nör J,McCauley LK,Taichman RS,Keller ET

更新日期：2004-02-01 00:00:00

abstract：:Breast carcinomas < or = 1 cm in size (T1a,b) are being detected more frequently as a result of screening. Because traditional prognostic parameters are either lacking (tumor size) or rare (nodal metastases), a marker(s) is needed to identify the subset of patients who could benefit from adjuvant therapy. A retrospect...

journal_title：Cancer research

authors： Tan P,Cady B,Wanner M,Worland P,Cukor B,Magi-Galluzzi C,Lavin P,Draetta G,Pagano M,Loda M

更新日期：1997-04-01 00:00:00

abstract：:Glucocorticoids are used for the treatment of lymphoid neoplasms, taking advantage of the well-known ability of these compounds to cause apoptosis in lymphoid tissues. Previously, we have shown that dexamethasone, a synthetic glucocorticoid, causes a down-regulation of several antioxidant defense enzymes and proteins,...

journal_title：Cancer research

authors： Tome ME,Baker AF,Powis G,Payne CM,Briehl MM

更新日期：2001-03-15 00:00:00

abstract：:Sulindac is the most extensively investigated clinically relevant chemopreventive nonsteroidal anti-inflammatory drug. Sulindac sulfide is one of the major metabolites of sulindac that is believed to mediate its antitumorigenic effects by inducing apoptosis. Recent evidence suggests that sulindac sulfide engages the m...

journal_title：Cancer research

authors： Huang Y,He Q,Hillman MJ,Rong R,Sheikh MS

更新日期：2001-09-15 00:00:00

abstract：:The binding of tritium-labeled 5-methylchrysene to DNA of CD-1 mouse skin 24 hr after treatment has been studied. DNA was isolated from the treated skin areas of mice and hydrolyzed enzymatically to deoxyribonucleosides, and the hydrolysate was chromatographed on a Sephadex LH-20 column using a methanol:water gradient...

journal_title：Cancer research

authors： Melikian AA,LaVoie EJ,Hecht SS,Hoffmann D

更新日期：1982-04-01 00:00:00

abstract：:Elongation factor-2 kinase (eEF-2 kinase), also known as Ca(2+)/calmodulin-dependent kinase III, regulates protein synthesis by controlling the rate of peptide chain elongation. The activity of eEF-2 kinase is increased in glioblastoma and other malignancies, yet its role in neoplasia is uncertain. Recent evidence sug...

journal_title：Cancer research

authors： Wu H,Yang JM,Jin S,Zhang H,Hait WN

更新日期：2006-03-15 00:00:00

abstract：:The cultivated mushroom of commerce in the Western hemisphere, Agaricus bisporus, was given p.o. to randomly bred Swiss mice for 3 days and was followed by semisynthetic diet for 4 days each week for life. The mice were 6 weeks old at the beginning of the experiment. As a result of treatment, tumors were induced in th...

journal_title：Cancer research

authors： Toth B,Erickson J

更新日期：1986-08-01 00:00:00

abstract：:Estrogens are known to induce tumors in high frequency in orchiectomized Syrian golden hamsters, but the histogenesis of the tumors is controversial. In order to identify the earliest precursors of the tumors, animals were implanted with pellets of four different estrogens, sacrificed at times ranging up to 6.4 months...

journal_title：Cancer research

authors： Goldfarb S,Pugh TD

更新日期：1990-01-01 00:00:00

abstract：:Fes is a protein tyrosine kinase with cell autonomous oncogenic activities that are well established in cell culture and animal models, but its involvement in human cancer has been unclear. Abundant expression of Fes in vascular endothelial cells and myeloid cell lineages prompted us to explore roles for Fes in the tu...

journal_title：Cancer research

authors： Zhang S,Chitu V,Stanley ER,Elliott BE,Greer PA

更新日期：2011-02-15 00:00:00