Serum acute-phase proteins and immunoglobulins in patients with gliomas.

abstract：:HER2-directed therapies, such as trastuzumab and lapatinib, are important treatments for breast cancer. However, some tumors do not respond or develop resistance to these agents. We isolated and characterized multiple lapatinib-resistant, HER2-positive, estrogen receptor (ER)-positive breast cancer clones derived from...

journal_title：Cancer research

authors： Liu L,Greger J,Shi H,Liu Y,Greshock J,Annan R,Halsey W,Sathe GM,Martin AM,Gilmer TM

更新日期：2009-09-01 00:00:00

abstract：:Using alternative reading frames, the human ARF-INK4a locus encodes two unrelated proteins that both function in tumor suppression. p16(INK4a) maintains the retinoblastoma protein in its growth-suppressive state through inhibition of cyclin D-dependent kinase activity, whereas ARF binds with MDM2 and stabilizes p53. T...

journal_title：Cancer research

authors： Yarbrough WG,Bessho M,Zanation A,Bisi JE,Xiong Y

更新日期：2002-02-15 00:00:00

abstract：:Current standard of care for patients with pediatric acute lymphoblastic leukemia (ALL) is mainly effective, with high remission rates after treatment. However, the genetic perturbations that give rise to this disease remain largely undefined, limiting the ability to address resistant tumors or develop less toxic targ...

journal_title：Cancer research

authors： Ding LW,Sun QY,Tan KT,Chien W,Mayakonda A,Yeoh AEJ,Kawamata N,Nagata Y,Xiao JF,Loh XY,Lin DC,Garg M,Jiang YY,Xu L,Lim SL,Liu LZ,Madan V,Sanada M,Fernández LT,Hema Preethi SS,Lill M,Kantarjian HM,Kornblau SM,

更新日期：2017-01-15 00:00:00

abstract：:After the Chernobyl accident, the incidence of urinary bladder cancers in the Ukraine population increased gradually from 26.2 to 36.1 per 100,000 between 1986 and 1996. Urinary bladder epithelium biopsied from 45 male patients with benign prostatic hyperplasia living in radiocontaminated areas of Ukraine demonstrated...

journal_title：Cancer research

authors： Yamamoto S,Romanenko A,Wei M,Masuda C,Zaparin W,Vinnichenko W,Vozianov A,Lee CC,Morimura K,Wanibuchi H,Tada M,Fukushima S

更新日期：1999-08-01 00:00:00

abstract：:The treatment of HeLa and HL-60 cells with various concentrations of pentakis(arizidino)thiatriazadiphosphorine oxide results in inhibition of growth and modification of cell cycle distribution. These phenomena were observed at 10(-4) M and 5 X 10(-5) M for HeLa cells and 10(-5) M and 5 X 10(-6) M for HL-60 cells. The...

journal_title：Cancer research

authors： Hecquet C,Nafziger J,Ronot X,Marie JP,Adolphe M

更新日期：1985-02-01 00:00:00

abstract：:Decreased BRCA1 expression in the absence of genetic mutation is observed frequently in sporadic cancers of the breast and other sites, although little is known regarding the mechanisms by which the expression of this gene can be repressed. Here, we show that activating and repressive E2Fs simultaneously bind the BRCA...

journal_title：Cancer research

authors： Bindra RS,Gibson SL,Meng A,Westermark U,Jasin M,Pierce AJ,Bristow RG,Classon MK,Glazer PM

更新日期：2005-12-15 00:00:00

abstract：:Female Sprague-Dawley rats were treated at 53 days of age with a single intubation of 7,12-dimethylbenzanthracene (DMBA). Three days after carcinogen treatment, the animals were treated with retinyl acetate (RA) (at 3 dietary levels), hormone inhibition (HI) [tamoxifen (1-rho-beta-dimethylaminoethoxyphenyl-trans-1,2-d...

journal_title：Cancer research

authors： Welsch CW,DeHoog JV

更新日期：1983-02-01 00:00:00

abstract：:Our previous studies demonstrated that reexpression of the alpha2beta1 integrin by a poorly differentiated breast carcinoma cell line, Mm5MT, resulted in dramatic reversion of a malignant phenotype to a differentiated epithelial phenotype. We hypothesized that reexpression of the alpha2beta1 integrin may regulate expr...

journal_title：Cancer research

authors： Sun H,Santoro SA,Zutter MM

更新日期：1998-05-15 00:00:00

abstract：:Human cancer cell lines are commonly used in basic cancer research to understand the behavior of primary tumors. Aberrations in the DNA methylation patterns are nowadays recognized as a hallmark of the cancer cell. However, no comprehensive study defines the DNA methylation environment present in the established cance...

journal_title：Cancer research

authors： Paz MF,Fraga MF,Avila S,Guo M,Pollan M,Herman JG,Esteller M

更新日期：2003-03-01 00:00:00

abstract：:Despite some advances, pancreatic ductal adenocarcinoma (PDAC) remains generally refractory to current treatments. Desmoplastic stroma, a consistent hallmark of PDAC, has emerged as a major source of therapeutic resistance and thus potentially promising targets for improved treatment. The glycan-binding protein galect...

journal_title：Cancer research

authors： Martínez-Bosch N,Fernández-Barrena MG,Moreno M,Ortiz-Zapater E,Munné-Collado J,Iglesias M,André S,Gabius HJ,Hwang RF,Poirier F,Navas C,Guerra C,Fernández-Zapico ME,Navarro P

更新日期：2014-07-01 00:00:00

abstract：:Microbial carboxyl and catechol siderophores have been shown to have natural iron-chelating abilities, suggesting that hyaluronic acid (HA) and the catechol compound, gallic acid (GA), may have iron-coordinating activities. Here, a photoresponsive self-gelling hydrogel that was both injectable and could be applied to ...

journal_title：Cancer research

authors： Ko S,Park JY,Oh YK

更新日期：2019-12-15 00:00:00

abstract：:Metastasis via the lymphatic vasculature is an important step in cancer progression. The formation of new lymphatic vessels (lymphangiogenesis), or remodeling of existing lymphatics, is thought to facilitate the entry and transport of tumor cells into lymphatic vessels and on to distant organs. The migration of lympha...

journal_title：Cancer research

authors： Karnezis T,Farnsworth RH,Harris NC,Williams SP,Caesar C,Byrne DJ,Herle P,Macheda ML,Shayan R,Zhang YF,Yazar S,Takouridis SJ,Gerard C,Fox SB,Achen MG,Stacker SA

更新日期：2019-04-01 00:00:00

abstract：:General anesthesia was used to facilitate 259 whole-body hyperthermia treatments in 90 patients. These patients fell into American Society of Anesthesiologists Classifications 3 (moderate to severe systemic disease) and 4 (severe systemic disease with life-threatening potential). Whole-body hyperthermia imposes severe...

journal_title：Cancer research

authors： Cronau LH Jr,Bourke DL,Bull JM

更新日期：1984-10-01 00:00:00

abstract：:The ets oncogene superfamily codes for a family of transcriptional factors that are involved in gene regulation not only by autonomous DNA binding but also by indirect DNA binding through interaction with cellular factors. We have previously shown that a member of this superfamily, elk-1, is a sequence specific transc...

journal_title：Cancer research

authors： Rao VN,Reddy ES

更新日期：1993-01-15 00:00:00

abstract：:The androgen receptor (AR) regulates gene transcription by binding to androgen response elements in target gene promoters. The prostate-specific antigen (PSA) gene has a polymorphic androgen response element sequence with two alleles, A and G. We hypothesize that allelic differences in AR-driven PSA expression may inf...

journal_title：Cancer research

authors： Xue W,Irvine RA,Yu MC,Ross RK,Coetzee GA,Ingles SA

更新日期：2000-02-15 00:00:00

abstract：:We previously showed that introduction of a normal, neomycin-tagged human chromosome 11 reduces the metastatic capacity of MDA-MB-435 (435) human breast carcinoma cells by 70-90% without affecting tumorigenicity, suggesting the presence of one or more metastasis suppressor genes encoded on human chromosome 11. To iden...

journal_title：Cancer research

authors： Seraj MJ,Samant RS,Verderame MF,Welch DR

更新日期：2000-06-01 00:00:00

abstract：:The abundance of circulating tumor cells (CTC) indicates patient prognosis. Molecular characterization of CTCs may add additional information about a patient's disease. However, currently available methods are limited by contamination with blood cells. We describe a study using a modified CTC-chip to capture CTCs from...

journal_title：Cancer research

authors： Helzer KT,Barnes HE,Day L,Harvey J,Billings PR,Forsyth A

更新日期：2009-10-01 00:00:00

abstract：:Active-specific immunotherapy with dendritic cells loaded with peptide derived from the melanoma antigen, gp100, failed to mediate regression of established B16F10 melanoma in normal mice. Dendritic cell vaccination induced activation and subsequent deletion of adoptively transferred naive CD8+ T-cell receptor transge...

journal_title：Cancer research

authors： Wang LX,Li R,Yang G,Lim M,O'Hara A,Chu Y,Fox BA,Restifo NP,Urba WJ,Hu HM

更新日期：2005-11-15 00:00:00

abstract：:Hedgehog (Hh) and transforming growth factor-beta (TGF-beta) family members are involved in numerous overlapping processes during embryonic development, hair cycle, and cancer. Herein, we show that TGF-beta induces the expression of the Hh signaling molecules Gli1 and Gli2 in various human cell types, including normal...

journal_title：Cancer research

authors： Dennler S,André J,Alexaki I,Li A,Magnaldo T,ten Dijke P,Wang XJ,Verrecchia F,Mauviel A

更新日期：2007-07-15 00:00:00

abstract：:Recent studies have indicated that angiogenesis may be regulated, in part, by p53 tumor suppressor gene function. We hypothesized that wild-type p53 replacement would down-regulate vascular endothelial growth factor (VEGF) expression and inhibit angiogenesis. KM12L4 and SW620, human colon cancer cell lines with p53 mu...

journal_title：Cancer research

authors： Bouvet M,Ellis LM,Nishizaki M,Fujiwara T,Liu W,Bucana CD,Fang B,Lee JJ,Roth JA

更新日期：1998-06-01 00:00:00

abstract：:To determine alpha-fetoprotein (AFP) immunogenicity in vivo, the presence of antibodies in sera of 60 hepatocellular carcinoma, 15 liver cirrhosis, and 15 chronic hepatitis patients was evaluated by Western blotting and immunoprecipitation analyses using purified human AFP. High titers of anti-AFP immunoglobulins were...

journal_title：Cancer research

authors： Bei R,Budillon A,Reale MG,Capuano G,Pomponi D,Budillon G,Frati L,Muraro R

更新日期：1999-11-01 00:00:00

abstract：:Radiolysis of N2O-saturated solutions of transfer RNA (tRNA) and the arylacethydroxamic acids, N-hydroxy-N-2-acetylaminofluorene and N-hydroxy-N-4-acetylaminobiphenyl; their corresponding acetamides, 2-acetylaminofluorene and 4-acetylaminofluorene; or the O-glucuronide of N-hydroxy-N-2-acetylaminofluorene resulted in ...

journal_title：Cancer research

authors： Cardona RA,King CM,Redpath JL

更新日期：1975-08-01 00:00:00

abstract：:Overexpression of the prosurvival Bcl-2 family members (Bcl-2, Bcl-xL, and Mcl-1) is commonly associated with tumor maintenance, progression, and chemoresistance. We previously reported the discovery of ABT-737, a potent, small-molecule Bcl-2 family protein inhibitor. A major limitation of ABT-737 is that it is not or...

journal_title：Cancer research

authors： Tse C,Shoemaker AR,Adickes J,Anderson MG,Chen J,Jin S,Johnson EF,Marsh KC,Mitten MJ,Nimmer P,Roberts L,Tahir SK,Xiao Y,Yang X,Zhang H,Fesik S,Rosenberg SH,Elmore SW

更新日期：2008-05-01 00:00:00

abstract：:We have shown previously that the transduction of a number of human tumor cell lines with an adenovirus (AV1Y28) expressing a single-chain antibody fragment (scFv) directed against Ras proteins results in radiosensitization. Because Ras is involved in the regulation of a number of transcription factors, we have determ...

journal_title：Cancer research

authors： Russell JS,Raju U,Gumin GJ,Lang FF,Wilson DR,Huet T,Tofilon PJ

更新日期：2002-04-15 00:00:00

abstract：:Rhabdomyosarcoma (RMS) is a common soft-tissue sarcoma of childhood in need of more effective therapeutic options. The expression of p53 in RMS is heterogeneous such that some tumors are wild-type whereas others are p53 mutant. The small molecule CP-31398 modulates both the wild-type and the mutant p53 proteins. Here,...

journal_title：Cancer research

authors： Xu J,Timares L,Heilpern C,Weng Z,Li C,Xu H,Pressey JG,Elmets CA,Kopelovich L,Athar M

更新日期：2010-08-15 00:00:00

abstract：:The uptake of Photofrin by murine peritoneal macrophages in vivo and in vitro was examined. Cellular Photofrin content was measured either by performing a fluorometric assay or by using 14C-labeled drug. For comparison, the uptake of Photofrin by murine SCCVII tumor cells (squamous cell carcinoma) was also examined un...

journal_title：Cancer research

authors： Korbelik M,Krosl G,Chaplin DJ

更新日期：1991-05-01 00:00:00

abstract：:3q27 translocations affecting the BCL6 gene can involve not only immunoglobulin genes (IG) but also other as yet uncharacterized chromosomal loci as partners. Here, we describe cloning of the junctional area of a recurring translocation, t(3;6)(q27;p21), in non-Hodgkin's lymphoma of B-cell type and isolation of clones...

journal_title：Cancer research

authors： Akasaka T,Miura I,Takahashi N,Akasaka H,Yonetani N,Ohno H,Fukuhara S,Okuma M

更新日期：1997-01-01 00:00:00

abstract：:MicroRNAs (miRNAs) are small noncoding RNAs, thought to be involved in physiologic and developmental processes by negatively regulating expression of target genes. We have previously reported frequent down-regulation of the let-7 miRNA family in lung cancers and, in the present study, assessed alteration in a panel of...

journal_title：Cancer research

authors： Hayashita Y,Osada H,Tatematsu Y,Yamada H,Yanagisawa K,Tomida S,Yatabe Y,Kawahara K,Sekido Y,Takahashi T

更新日期：2005-11-01 00:00:00

abstract：:Preclinical and clinical development of agents that inhibit cell-cycle progression have brought an understanding of the feasibility of targeting various cell-cycle regulators in patients with cancer. Small molecule inhibitors targeting key proteins that participate in cell-cycle progression including the cyclin-depend...

journal_title：Cancer research

authors： Mills CC,Kolb EA,Sampson VB

更新日期：2018-01-15 00:00:00

abstract：:Identification of signaling pathways downstream of Abl tyrosine kinase may increase our understanding of the pathogenesis of chronic myelogenous leukemia (CML) and suggest strategies to improve clinical treatment of the disease. By combining the use of a phosphospecific antibody recognizing a substrate motif of serine...

journal_title：Cancer research

authors： Ly C,Arechiga AF,Melo JV,Walsh CM,Ong ST

更新日期：2003-09-15 00:00:00