A multi-institutional study confirms the presence and expression of simian virus 40 in human malignant mesotheliomas.

abstract：:Hepatocyte nuclear factor-4α (Hnf4α) is a transcription factor that controls epithelial cell polarity and morphogenesis. Hnf4α conditional deletion during postnatal development has minor effects on intestinal epithelium integrity but promotes activation of the Wnt/β-catenin pathway without causing tumorigenesis. Here,...

journal_title：Cancer research

authors： Darsigny M,Babeu JP,Seidman EG,Gendron FP,Levy E,Carrier J,Perreault N,Boudreau F

更新日期：2010-11-15 00:00:00

abstract：:A series of rat 13762NF mammary adenocarcinoma cell clones and subclones of various lung metastatic potentials were examined for their abilities to degrade rat lung subendothelial matrix and purified basement membrane type IV collagen. Metastatic potentials were simultaneously determined based on the ability to form "...

journal_title：Cancer research

authors： Nakajima M,Welch DR,Belloni PN,Nicolson GL

更新日期：1987-09-15 00:00:00

abstract：:A case-control study was undertaken to clarify reasons for a four-fold increased incidence of mesothelioma discovered among white males in coastal Tidewater, Va., from 1972 to 1978. Sixty-one cases were identified. Interviews with next of kin revealed that the excess was linked to employment in area shipyards. Three-f...

journal_title：Cancer research

authors： Tagnon I,Blot WJ,Stroube RB,Day NE,Morris LE,Peace BB,Fraumeni JF Jr

更新日期：1980-11-01 00:00:00

abstract：:A number of metabolic inhibitors and chemotherapeutic agents have been found to increase the sensitivity of a chemically induced guinea pig hepatoma (line 1) to killing by antibody and complement. We have investigated whether the mechanism whereby these drugs increase sensitivity to killing is attributable to their pr...

journal_title：Cancer research

authors： Schlager SI,Boyle MD,Ohanian SH,Borsos T

更新日期：1977-05-01 00:00:00

abstract：:The incidence, distribution, size, and histopathology of grossly visible colonic tumors induced by parenteral administration of 1,2-dimethylhydrazine were examined in rats fed either a chemically defined fiber-free diet or a nutritionally and calorically equivalent diet containing a purified fiber component, microcrys...

journal_title：Cancer research

authors： Freeman HJ,Spiller GA,Kim YS

更新日期：1978-09-01 00:00:00

abstract：:Altered DNA methylation is a key feature of cancer, and aberrant methylation is important in nasopharyngeal carcinoma (NPC) development. However, the methylation mechanisms underlying metastasis of NPC remain unclear. Analyzing data from public databases and conducting our own experiments, we report here that promoter...

journal_title：Cancer research

authors： Zhang J,Li YQ,Guo R,Wang YQ,Zhang PP,Tang XR,Wen X,Hong XH,Lei Y,He QM,Yang XJ,Sun Y,Ma J,Liu N

更新日期：2019-02-15 00:00:00

abstract：:Recent expression profile analyses revealed that lung adenocarcinomas can be divided into several subgroups with diverse pathological features. Because cellular heterogeneity of tumors can confound these analyses, we used laser capture microdissection and microarray expression analysis to characterize the molecular pr...

journal_title：Cancer research

authors： Miura K,Bowman ED,Simon R,Peng AC,Robles AI,Jones RT,Katagiri T,He P,Mizukami H,Charboneau L,Kikuchi T,Liotta LA,Nakamura Y,Harris CC

更新日期：2002-06-01 00:00:00

abstract：:A new type of monoclonal antibody (mAb)-based, highly specific phototherapy (photoimmunotherapy; PIT) that uses a near infrared (NIR) phthalocyanine dye, IRDye700DX (IR700) conjugated with a mAb, has recently been described. NIR light exposure leads to immediate, target-selective necrotic cell death in vitro. Detectin...

journal_title：Cancer research

authors： Nakajima T,Sano K,Mitsunaga M,Choyke PL,Kobayashi H

更新日期：2012-09-15 00:00:00

abstract：:In summary, analysis of the P01 program indicates that differences exist in scores and funding requirements between purely basic and translational P01s; P01 funding has been stable and the P01 policies consistent; growth in average costs for P01s has lagged compared to R01s; P01 grantees have a higher success rate tha...

journal_title：Cancer research

authors： Broder S,Cushing M

更新日期：1993-02-01 00:00:00

abstract：:This paper describes the reactions of purine nucleosides and nucleic acids with 2,3-epoxy-4-hydroxynonanal. 2,3-Epoxy-4-hydroxynonanal was produced with tert-butyl hydroperoxide by epoxidation of trans-4-hydroxy-2-nonenal, a lipid peroxidation product. The epoxy aldehyde exists as a pair of diastereomers, I and II. Be...

journal_title：Cancer research

authors： Sodum RS,Chung FL

更新日期：1991-01-01 00:00:00

abstract：:The present studies were performed to delineate the effect of high-dose methotrexate with citrovorum factor rescue on the measurable compartments of human granulopoiesis, including peripheral blood cells and bone marrow stem cells committed to granulopoiesis-monocytopoiesis. Parameters of granulopoiesis were determine...

journal_title：Cancer research

authors： Schremi W,Lohrmann HP

更新日期：1979-10-01 00:00:00

abstract：:Cancer cells commonly display aberrant surface glycans and related glycoconjugate scaffolds. Compared with their normal counterparts, cancer cell glycans are variably produced and often structurally distinct, serving as biomarkers of cancer progression or as functional entities to malignancy. The glycan signature of a...

journal_title：Cancer research

authors： Dimitroff CJ

更新日期：2015-08-15 00:00:00

abstract：:Cellular pools of free arachidonic acid are tightly controlled through enzymatic release of the fatty acid and subsequent utilization by downstream enzymes including the cyclooxygenases. Arachidonic acid cleavage from membrane phospholipids is accomplished by the actions of phospholipase A(2) (PLA(2)). Upon release, f...

journal_title：Cancer research

authors： Ilsley JN,Nakanishi M,Flynn C,Belinsky GS,De Guise S,Adib JN,Dobrowsky RT,Bonventre JV,Rosenberg DW

更新日期：2005-04-01 00:00:00

abstract：:3q27 translocations affecting the BCL6 gene can involve not only immunoglobulin genes (IG) but also other as yet uncharacterized chromosomal loci as partners. Here, we describe cloning of the junctional area of a recurring translocation, t(3;6)(q27;p21), in non-Hodgkin's lymphoma of B-cell type and isolation of clones...

journal_title：Cancer research

authors： Akasaka T,Miura I,Takahashi N,Akasaka H,Yonetani N,Ohno H,Fukuhara S,Okuma M

更新日期：1997-01-01 00:00:00

abstract：:N-Demethylated metabolites of the antineoplastic agent hexamethylmelamine were synthesized, and their toxicities and antitumor activities were determined in vivo. Determinations of the lethal dose for 10% of the male C57BL X DBA/2 F1 (hereafter called BD2F1) mice showed hexamethylmelamine toxicity to be decreased by N...

journal_title：Cancer research

authors： Lake LM,Grunden EE,Johnson BM

更新日期：1975-10-01 00:00:00

abstract：:Multiple tobacco smoke-related premalignant and malignant lesions develop synchronously or metachronously in various organ sites, including the oral cavity. Both field cancerization and clonal migration seem to contribute to the occurrence of multiple tumors. Although the importance of endogenous factors (e.g., oncoge...

journal_title：Cancer research

authors： Du B,Leung H,Khan KM,Miller CG,Subbaramaiah K,Falcone DJ,Dannenberg AJ

更新日期：2007-09-15 00:00:00

abstract：:Telomerase is a ribonucleoprotein that synthesizes telomeric DNA on chromosomal ends. Telomerase activation has been seen in many immortal cell lines and cancers. Telomerase activity was analyzed in prostate carcinoma; in coexistent prostatic intraepithelial neoplasia (PIN), benign prostatic hyperplasia (BPH), atrophy...

journal_title：Cancer research

authors： Zhang W,Kapusta LR,Slingerland JM,Klotz LH

更新日期：1998-02-15 00:00:00

abstract：:: Cancer cells in quiescence (G0 phase) are resistant to death, and re-entry of quiescent cancer cells into the cell-cycle plays an important role in cancer recurrence. Here we show that two p53-responsive miRNAs utilize distinct but complementary mechanisms to promote cancer cell quiescence by facilitating stabilizat...

journal_title：Cancer research

authors： La T,Liu GZ,Farrelly M,Cole N,Feng YC,Zhang YY,Sherwin SK,Yari H,Tabatabaee H,Yan XG,Guo ST,Liu T,Thorne RF,Jin L,Zhang XD

更新日期：2018-12-01 00:00:00

abstract：:The ability of the vitamin E (RRR-alpha-tocopherol) derivatives alpha-tocopheryl succinate (alpha-TOS) and alpha-tocopheryloxyacetic acid (alpha-TEA) to suppress tumor growth in preclinical animal models has recently led to increased interest in their potential use for treating human cancer. To make the use of these v...

journal_title：Cancer research

authors： Hahn T,Szabo L,Gold M,Ramanathapuram L,Hurley LH,Akporiaye ET

更新日期：2006-10-01 00:00:00

abstract：:Idoxifene, a novel antiestrogen with reduced estrogenic activity when compared to tamoxifen, has been given to 20 women with metastatic breast cancer, 19 of whom had received tamoxifen previously, in doses between 10-60 mg. Idoxifene had an initial half-life of 15 h and a terminal half-life of 23.3 days. At a maintena...

journal_title：Cancer research

authors： Coombes RC,Haynes BP,Dowsett M,Quigley M,English J,Judson IR,Griggs LJ,Potter GA,McCague R,Jarman M

更新日期：1995-03-01 00:00:00

abstract：:Proliferating cell nucleolar antigen P40 is a late G1-specific protein, which was found in a variety of human tumors (A. Chatterjee, J. W. Freeman, and H. Busch. Cancer Res., 47: 1123-1129, 1987). Two overlapping complementary DNA clones for antigen P40 were isolated by immunoscreening a lambda gt11 human expression l...

journal_title：Cancer research

authors： Reddy AB,Chatterjee A,Rothblum LI,Black A,Busch H

更新日期：1989-04-01 00:00:00

abstract：:When nitric oxide (NO) is produced at micromolar concentrations, as during inflammation, exposure to surrounding cells is potentially cytotoxic. The NO-dependent signaling pathways that initiate cell death are thought to involve the tumor suppressor protein p53, but the degree to which this factor contributes to NO-in...

journal_title：Cancer research

authors： McLaughlin LM,Demple B

更新日期：2005-07-15 00:00:00

abstract：:Dysregulation of Wnt/β-catenin signaling is frequently observed in human gastric cancer. Elucidation of the tumor immune microenvironment is essential for understanding tumorigenesis and for the development of immunotherapeutic strategies. However, it remains unclear how β-catenin signaling regulates the tumor immune ...

journal_title：Cancer research

authors： Ji L,Qian W,Gui L,Ji Z,Yin P,Lin GN,Wang Y,Ma B,Gao WQ

更新日期：2020-05-15 00:00:00

abstract：:Oxidative stress exerted by superoxide-generating (redox-cycling) agents such as paraquat triggers the soxRS regulon of Escherichia coli. In this system, SoxR protein is the redox-sensitive activator of the soxS gene, the product of which then activates the approximately 10 promoters of this regulon. We found that 4-n...

journal_title：Cancer research

authors： Nunoshiba T,Demple B

更新日期：1993-07-15 00:00:00

abstract：:Ras associated with diabetes (Rad) is a Ras-related GTPase that promotes cell growth by accelerating cell cycle transitions. Rad knockdown induced cell cycle arrest and premature senescence without additional cellular stress in multiple cancer cell lines, indicating that Rad expression might be critical for the cell c...

journal_title：Cancer research

authors： Lee I,Yeom SY,Lee SJ,Kang WK,Park C

更新日期：2010-06-01 00:00:00

abstract：:Germ line p53 mutations represent a genetic predisposition for cancer development. At the present time, their detection requires extensive work and their functional significance must be documented. Therefore, we have designed a simple biological assay which detects functionally significant germ line p53 mutations. Thi...

journal_title：Cancer research

authors： Frebourg T,Barbier N,Kassel J,Ng YS,Romero P,Friend SH

更新日期：1992-12-15 00:00:00

abstract：:To determine the role of the transcription factor signal transducer and activator of transcription (STAT) 1 on endothelial cell function, human umbilical vein endothelial cells (HUVEC) were treated with IFN-gamma, a potent activator of STAT1. IFN-gamma inhibited cell growth and tube formation of HUVECs. Although the p...

journal_title：Cancer research

authors： Battle TE,Lynch RA,Frank DA

更新日期：2006-04-01 00:00:00

abstract：:A structure-activity relationship study was carried out to identify structural features in arylalkyl and alkyl isothiocyanates that are associated with the inhibitory potency of these compounds against lung tumorigenesis induced in A/J mice by the tobacco-specific nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-buta...

journal_title：Cancer research

authors： Jiao D,Eklind KI,Choi CI,Desai DH,Amin SG,Chung FL

更新日期：1994-08-15 00:00:00

abstract：:A cell line (NCE-G28) was established from the biopsy material of a human gliosarcoma of low histological differentiation. The initial cultures showed a mixed population of cells which in later stages became more uniform due to loss of slower growing constituents. The cells have been growing steadily for 20 months. A ...

journal_title：Cancer research

authors： Westphal M,Haensel M,Mueller D,Laas R,Kunzmann R,Rohde E,Koenig A,Hoelzel F,Herrmann HD

更新日期：1988-02-01 00:00:00

abstract：:Proteasome inhibitors sensitize tumor cells to DNA-damaging agents, including ionizing radiation (IR), and DNA cross-linking agents (melphalan and cisplatin) through unknown mechanisms. The Fanconi anemia pathway is a DNA damage-activated signaling pathway, which regulates cellular resistance to DNA cross-linking agen...

journal_title：Cancer research

authors： Jacquemont C,Taniguchi T

更新日期：2007-08-01 00:00:00