Pathology, Chemoprevention, and Preclinical Models for Target Validation in Barrett Esophagus.

abstract：:Pancreatic cancer is highly resistant to current chemotherapy agents. We therefore examined the effects of triptolide (a diterpenoid triepoxide) on pancreatic cancer growth and local-regional tumor spread using an orthotopic model of pancreatic cancer. We have recently shown that an increased level of HSP70 in pancrea...

journal_title：Cancer research

authors： Phillips PA,Dudeja V,McCarroll JA,Borja-Cacho D,Dawra RK,Grizzle WE,Vickers SM,Saluja AK

更新日期：2007-10-01 00:00:00

abstract：:Whereas transplantable tumors can be readily cured with immunotherapeutic approaches, similar therapies in cancer patients have been less effective. This difference may be explained by an immunosuppression resulting from the presence of a slowly growing primary tumor in the patient, whereas the immune system in a mous...

journal_title：Cancer research

authors： Horiguchi S,Petersson M,Nakazawa T,Kanda M,Zea AH,Ochoa AC,Kiessling R

更新日期：1999-06-15 00:00:00

abstract：:In vitro responsiveness of endometrial adenocarcinoma to progestins was evaluated histologically by incubation of tissue fragments in medium containing 10(-6) M medroxyprogesterone acetate. In a series of 19 experiments, formation of sub- and supranuclear vacuoles, which reflects accumulation of glycogen in response t...

journal_title：Cancer research

authors： Holinka CF,Deligdisch L,Gurpide E

更新日期：1984-01-01 00:00:00

abstract：:While the therapeutic activity of the deoxycytidine analogue decitabine is thought to reflect its ability to reactivate methylation-silenced genes, this agent is also known to trigger p53-dependent DNA damage responses. Here, we report that p53-inducible ribonucleotide reductase (p53R2/RRM2B) is a robust transcription...

journal_title：Cancer research

authors： Link PA,Baer MR,James SR,Jones DA,Karpf AR

更新日期：2008-11-15 00:00:00

abstract：:The biosynthesis, structure, and topology of a melanoma-associated antigen, previously defined with the monoclonal antibody NKI/C-3 was studied. A polyclonal rabbit antiserum was raised against the antigen with a broader reactivity than the previously used monoclonal antibody NKI/C-3. The antigen was shown to consist ...

journal_title：Cancer research

authors： Gruters RA,Calafat J,Vennegoor CJ,Jansen H,Ploegh HL

更新日期：1989-01-15 00:00:00

abstract：:Phosphatidylinositol-3-kinase is an important enzyme for intracellular signaling. The microbial product wortmannin and some of its analogues have been shown to be potent inhibitors of phosphatidylinositol-3-kinase. The 50% inhibitory concentration for inhibition by wortmannin is 2 to 4 nM. Kinetic analysis demonstrate...

journal_title：Cancer research

authors： Powis G,Bonjouklian R,Berggren MM,Gallegos A,Abraham R,Ashendel C,Zalkow L,Matter WF,Dodge J,Grindey G

更新日期：1994-05-01 00:00:00

abstract：:The immune system is a robust and often untapped accomplice of many standard cancer therapies. A majority of tumors exist in a state of immune tolerance where the patient's immune system has become insensitive to the cancer cells. Because of its lymphodepleting effects, chemotherapy has the potential to break this tol...

journal_title：Cancer research

authors： Park DS,Robertson-Tessi M,Luddy KA,Maini PK,Bonsall MB,Gatenby RA,Anderson ARA

更新日期：2019-10-15 00:00:00

abstract：:Selectins bind to carbohydrate ligands in a calcium-dependent manner and play critical roles in host defense and possibly in tumor metastasis. To isolate peptides that mimic E-selectin ligands, we screened a phage peptide library using E-selectin as a target molecule. This attempt unexpectedly failed, probably because...

journal_title：Cancer research

authors： Fukuda MN,Ohyama C,Lowitz K,Matsuo O,Pasqualini R,Ruoslahti E,Fukuda M

更新日期：2000-01-15 00:00:00

abstract：:Expression of the c-Myc oncoprotein is affected by conserved threonine 58 (T58) and serine 62 (S62) phosphorylation sites that help to regulate c-Myc protein stability, and altered ratios of T58 and S62 phosphorylation have been observed in human cancer. Here, we report the development of 3 unique c-myc knock-in mice ...

journal_title：Cancer research

authors： Wang X,Cunningham M,Zhang X,Tokarz S,Laraway B,Troxell M,Sears RC

更新日期：2011-02-01 00:00:00

abstract：:Fluorescent-labeled hormones can be used to study hormone-receptor interactions by means of fluorescence polarization, visualization by fluorescence microscopy, or separation methods, e.g., dextran-coated charcoal. Subcellular fragments, single cells, and tissue preparations are amenable to study; in this work rat ute...

journal_title：Cancer research

authors： Dandliker WB,Brawn RJ,Hsu ML,Brawn PN,Levin J,Meyers CY,Kolb VM

更新日期：1978-11-01 00:00:00

abstract：:We have defined the chromosomal location of the human MAGE (melanoma antigen) gene family by polymerase chain reaction amplification of several segments of the MAGE genes from somatic cell hybrids containing well-defined groups of human chromosomes and hybrids containing human derivative chromosomes. The data show tha...

journal_title：Cancer research

authors： Oaks MK,Hanson JP Jr,O'Malley DP

更新日期：1994-04-01 00:00:00

abstract：:Taxol is a novel antitumor agent with demonstrated efficacy against ovarian, breast, and non-small cell lung cancers in Phase II clinical trials, but which has been shown not to cross the blood-brain barrier. To adapt taxol as a therapy for brain tumors, we have incorporated it into a biodegradable polyanhydride matri...

journal_title：Cancer research

authors： Walter KA,Cahan MA,Gur A,Tyler B,Hilton J,Colvin OM,Burger PC,Domb A,Brem H

更新日期：1994-04-15 00:00:00

abstract：:The rate of repopulation of surviving cells increases during fractionated radiotherapy and limits the ability to control tumors. Repopulation is likely to be more important during the longer intervals between courses of chemotherapy and is a potential cause of clinical resistance to chemotherapy. To evaluate the rate ...

journal_title：Cancer research

authors： Wu L,Tannock IF

更新日期：2003-05-01 00:00:00

abstract：:Histone deacetylase (HDAC) inhibitors are undergoing clinical evaluation for cancer therapy. Because HDAC modulates chromatin structure and gene expression, parameters considered to influence radioresponse, we have investigated the effects of the HDAC inhibitor MS-275 on the radiosensitivity of two human tumor cell li...

journal_title：Cancer research

authors： Camphausen K,Burgan W,Cerra M,Oswald KA,Trepel JB,Lee MJ,Tofilon PJ

更新日期：2004-01-01 00:00:00

abstract：:The presence of metastases in the regional lymph nodes is the major prognostic factor in breast cancer in the absence of overt distant metastases and is also an important indicator of the need for adjuvant therapy in "early" breast cancer. Currently, the accurate assessment of axillary lymph node status requires axill...

journal_title：Cancer research

authors： Tjandra JJ,Russell IS,Collins JP,Andrews JT,Lichtenstein M,Binns D,McKenzie IF

更新日期：1989-03-15 00:00:00

abstract：:Arsenite-induced mitotic abnormalities result in mitotic death in several cancer cell lines. However, how arsenite induces these effects is not known. We have previously shown that arsenite induces mitotic arrest, mitotic abnormalities, and mitotic death in CGL-2 cells. To further delineate the mechanism of action of ...

journal_title：Cancer research

authors： Yih LH,Tseng YY,Wu YC,Lee TC

更新日期：2006-02-15 00:00:00

abstract：:The early cellular and molecular changes in the Solt-Farber model of hepatocarcinogenesis with and without initiation was studied by using histochemical, immunohistochemical, and in situ hybridization techniques. Increased cellularity was observed in the periductal space in both models 32 to 56 h after partial hepatec...

journal_title：Cancer research

authors： Evarts RP,Nakatsukasa H,Marsden ER,Hsia CC,Dunsford HA,Thorgeirsson SS

更新日期：1990-06-01 00:00:00

abstract：:Recent studies have proposed that tumor necrosis factor alpha (TNF-alpha) and ionizing radiation induce apoptosis by activating hydrolysis of sphingomyelin to ceramide. Bcl-2 and a related gene, Bcl-X, inhibit several forms of apoptosis. Herein, we report that internucleosomal DNA fragmentation, characteristic of apop...

journal_title：Cancer research

authors： Chen M,Quintans J,Fuks Z,Thompson C,Kufe DW,Weichselbaum RR

更新日期：1995-03-01 00:00:00

abstract：:Estrogen-related receptor alpha (ERRalpha) was identified as a gene related to estrogen receptor alpha (ERalpha) and belongs to a class of nuclear orphan receptors. ERRalpha binds to estrogen responsive element(s) (ERE) and is considered to be involved in modulation of estrogenic actions. However, biological significa...

journal_title：Cancer research

authors： Suzuki T,Miki Y,Moriya T,Shimada N,Ishida T,Hirakawa H,Ohuchi N,Sasano H

更新日期：2004-07-01 00:00:00

abstract：:UV radiation has been shown to play a role in the initiation of human cutaneous melanoma, but its role in the development of malignant melanoma to the metastatic state is not very well defined. Although previous studies have concentrated on the effect of UV-B on the host immune response, the effect of UV-B on the tumo...

journal_title：Cancer research

authors： Singh RK,Gutman M,Reich R,Bar-Eli M

更新日期：1995-08-15 00:00:00

abstract：:Intracellular nickel ions (Ni2+) have been shown to cause single-strand breaks in DNA, that were rapidly repaired, and DNA-protein cross-links, that persisted for at least 24 h following removal of extracellular ionic nickel. In this study, we have used the techniques of alkaline elution, chromatin fractionation, and ...

journal_title：Cancer research

authors： Patierno SR,Sugiyama M,Basilion JP,Costa M

更新日期：1985-11-01 00:00:00

abstract：:Recently the putative tumor suppressor gene p16INK4 was mapped to human chromosome 9p21, which is homologous to rat chromosome 5. Monosomy of rat chromosome 5 occurs with high frequency in rat kidney tumor-derived cell lines (ERC lines). Thus, we studied these lines in order to investigate the involvement of p15INK4B ...

journal_title：Cancer research

authors： Knapek DF,Serrano M,Beach D,Trono D,Walker CL

更新日期：1995-04-15 00:00:00

abstract：:Aniline of unknown purity has been reported to induce spleen hemangiosarcoma in rats. Aniline has been found to be negative in terms of mutagenicity in both bacteria and yeasts. We have found that both commercial (already rather pure) and repurified aniline are clearly positive to a similar extent in inducing DNA dama...

journal_title：Cancer research

authors： Parodi S,Pala M,Russo P,Zunino A,Balbi C,Albini A,Valerio F,Cimberle MR,Santi L

更新日期：1982-06-01 00:00:00

abstract：:Low oxygen levels have been shown to promote self-renewal in many stem cells. In tumors, hypoxia is associated with aggressive disease course and poor clinical outcomes. Furthermore, many aggressive tumors have been shown to display gene expression signatures characteristic of human embryonic stem cells (hESC). We now...

journal_title：Cancer research

authors： Mathieu J,Zhang Z,Zhou W,Wang AJ,Heddleston JM,Pinna CM,Hubaud A,Stadler B,Choi M,Bar M,Tewari M,Liu A,Vessella R,Rostomily R,Born D,Horwitz M,Ware C,Blau CA,Cleary MA,Rich JN,Ruohola-Baker H

更新日期：2011-07-01 00:00:00

abstract：:Targeted therapies for cancer are inherently limited by the inevitable recurrence of resistant disease after initial responses. To define early molecular changes within residual tumor cells that persist after treatment, we analyzed drug-sensitive lung adenocarcinoma cell lines exposed to reversible or irreversible epi...

journal_title：Cancer research

authors： Fan W,Tang Z,Yin L,Morrison B,Hafez-Khayyata S,Fu P,Huang H,Bagai R,Jiang S,Kresak A,Howell S,Vasanji A,Flask CA,Halmos B,Koon H,Ma PC

更新日期：2011-07-01 00:00:00

abstract：:The issue of resistance to targeted drug therapy is of pressing concern, as it constitutes a major barrier to progress in managing cancer. One important aspect is the role of stochasticity in determining the nature of the patient response. We examine two particular experiments. The first measured the maximal response ...

journal_title：Cancer research

authors： Kessler DA,Austin RH,Levine H

更新日期：2014-09-01 00:00:00

abstract：:The liver represents a major and frequently sole site of metastases for many types of cancer, particularly gastrointestinal cancers. We showed previously that coadministration of an engineered hepatic-targeting Listeria monocytogenes (LM) with a cancer vaccine enhanced the antitumor effect of vaccine-induced T cells s...

journal_title：Cancer research

authors： Yoshimura K,Laird LS,Chia CY,Meckel KF,Slansky JE,Thompson JM,Jain A,Pardoll DM,Schulick RD

更新日期：2007-10-15 00:00:00

abstract：:The pancreatic carcinogen N-nitrosobis(2-oxopropyl)-amine was administered to Syrian golden hamsters after cholecystoduodenostomy and choledochostomy to investigate a possible bile reflux mechanism as a factor in pancreatic carcinogenesis. The induced lesions were similar in morphology, multiplicity, and distribution ...

journal_title：Cancer research

authors： Pour P,Donnelly T

更新日期：1978-07-01 00:00:00

abstract：:Human mammary and other carcinoma cells secrete and express on their cell surfaces complex, mucin-like glycoproteins (Mr greater than 10(6] that are recognized as tumor-associated antigens by a variety of monoclonal antibodies (MAbs). One such MAb, B72.3, has been extensively studied as to range of reactivity for a va...

journal_title：Cancer research

authors： Sheer DG,Schlom J,Cooper HL

更新日期：1988-12-01 00:00:00

abstract：:The alternative reading frame (ARF) tumor suppressor mediates growth arrest or apoptosis through activation of the p53 tumor suppressor. A prevailing concept is that ARF uses p21Cip1/Waf1, a p53-responsive gene and cyclin-dependent kinase (Cdk) inhibitor, to block cell cycle progression. Using p21 nullizygous cells, w...

journal_title：Cancer research

authors： Modestou M,Puig-Antich V,Korgaonkar C,Eapen A,Quelle DE

更新日期：2001-04-01 00:00:00