Molecular cytogenetic mapping of the human melanoma antigen (MAGE) gene family to chromosome region Xq27-qter: implications for MAGE immunotherapy.

abstract：:Environmental and occupational exposure to arsenite is associated with an increased risk of human cancers, including skin, urinary bladder, and respiratory tract cancers. Although much evidence suggests that alterations in cell cycle machinery are implicated in the carcinogenic effect of arsenite, the molecular mechan...

journal_title：Cancer research

authors： Ouyang W,Ma Q,Li J,Zhang D,Liu ZG,Rustgi AK,Huang C

更新日期：2005-10-15 00:00:00

abstract：:Two principal virus-directed antigens have been identified on the surface of oncornavirus-infected chick embryo cells. One is identical with the major virus type-specific envelope antigen, which is a glycoprotein with a molecular weight of 85,000. The 2nd antigen (tumor-specific cell surface antigen) is specific for t...

journal_title：Cancer research

authors： Bauer H,Kurth R,Rohrschneider L,Gelderblom H

更新日期：1976-02-01 00:00:00

abstract：:Fischer X Copenhagen rats bearing Dunning R3327-AT tumors were treated with hematoporphyrin derivative and red light (630 nm from an argon-driven dye laser) alone or in combination with the hypoxic cell radiosensitizer, misonidazole (MISO). In vitro studies had suggested that hypoxia might significantly decrease the c...

journal_title：Cancer research

authors： Gonzalez S,Arnfield MR,Meeker BE,Tulip J,Lakey WH,Chapman JD,McPhee MS

更新日期：1986-06-01 00:00:00

abstract：:Effect of pretransplantation hyperthermia of tumor bed on tumor growth was studied. Experimental tumors were isotransplants of a fibrosarcoma which arose spontaneously in C3Hf/Sed mice. The pretransplantation hyperthermia was given at 43.5 degrees fro 120 min by immersing the mouse foot into a constant temperature wat...

journal_title：Cancer research

authors： Urano M,Cunningham M

更新日期：1980-01-01 00:00:00

abstract：:Renal cell carcinoma is frequently infiltrated by cells of the immune system. This makes it important to understand interactions between cancer cells and immune cells so they can be manipulated to bring clinical benefit. Here, we analyze subsets and functions of T lymphocytes infiltrating renal cell tumors directly ex...

journal_title：Cancer research

authors： Attig S,Hennenlotter J,Pawelec G,Klein G,Koch SD,Pircher H,Feyerabend S,Wernet D,Stenzl A,Rammensee HG,Gouttefangeas C

更新日期：2009-11-01 00:00:00

abstract：:Interplay between tumor cells and host cells in the tumor microenvironment dictates the development of all cancers. In breast cancer, malignant cells educate host macrophages to adopt a protumorigenic phenotype. In this study, we show how the integrin-regulatory protein kindlin-2 (FERMT2) promotes metastatic progressi...

journal_title：Cancer research

authors： Sossey-Alaoui K,Pluskota E,Bialkowska K,Szpak D,Parker Y,Morrison CD,Lindner DJ,Schiemann WP,Plow EF

更新日期：2017-09-15 00:00:00

abstract：:The relationship between tumorigenicity and enhanced chromosomal radiosensitivity during the G2 cell cycle phase was examined through the use of nontumorigenic human cell hybrids and their nontumorigenic and tumorigenic segregants. The hybrid cells were produced by fusion of a normal and tumor cell. The parental lines...

journal_title：Cancer research

authors： Sanford KK,Parshad R,Stanbridge EJ,Frost JK,Jones GM,Wilkinson JE,Tarone RE

更新日期：1986-04-01 00:00:00

abstract：:Sequential morphological changes occurring after brief carcinogen exposures of heterotopic tracheal transplants in rats were semiquantitatively studied. Tracheas were exposed to 7,12-dimethylbenz(a)anthracene for 1, 2, or 4 weeks, during which time means of 138, 152, and 160 microgram 7,12-dimethylbenz(a)anthracene, r...

journal_title：Cancer research

authors： Topping DC,Griesemer RA,Nettesheim P

更新日期：1979-12-01 00:00:00

abstract：:Recent studies have revealed that procaspase-8 has an important function in cell adhesion and motility. Src phosphorylation controls this function by preventing the conversion of procaspase-8, which is an adhesion/migration factor, to mature caspase-8, which is an apoptosis-inducing factor. This provides a mechanism t...

journal_title：Cancer research

authors： Frisch SM

更新日期：2008-06-15 00:00:00

abstract：:In this paper, we describe the role of chemokine receptor CXCR4 activation by its natural ligand, the chemokine stromal cell-derived factor (SDF-1) (CXCL12), in glioblastoma cell growth in vitro. We show that both CXC chemokine receptor 4 (CXCR4) and SDF-1 mRNA are expressed in several human glioblastoma multiforme tu...

journal_title：Cancer research

authors： Barbero S,Bonavia R,Bajetto A,Porcile C,Pirani P,Ravetti JL,Zona GL,Spaziante R,Florio T,Schettini G

更新日期：2003-04-15 00:00:00

abstract：:To reach a clinically detectable size, neoplasms must be able to suppress or evade a host immune response. Activated T cells may enter apoptosis in the presence of Fas ligand (FasL) (1), and tissue expression of FasL has been shown to contribute to immune privilege in the eye and testis (2, 3). We have demonstrated th...

journal_title：Cancer research

authors： Niehans GA,Brunner T,Frizelle SP,Liston JC,Salerno CT,Knapp DJ,Green DR,Kratzke RA

更新日期：1997-03-15 00:00:00

abstract：:Anti-VEGF pathway therapies primarily target immature blood vessels in tumors. However, emerging approaches to combine with targeted therapies impacting the later stages of remodeling and vessel maturation are expected to improve clinical efficacy by expanding the target vessel population. The angiopoietin/Tie ligand/...

journal_title：Cancer research

authors： Gerald D,Chintharlapalli S,Augustin HG,Benjamin LE

更新日期：2013-03-15 00:00:00

abstract：:8-Chloro-cAMP (8-Cl-cAMP) is a novel agent that is able to inhibit the growth of a wide variety of cancer cell types in vitro and in vivo and, at doses devoid of toxicity, to achieve plasma concentrations in cancer patients in a range effective for cancer cell growth inhibition. In this study, we have demonstrated tha...

journal_title：Cancer research

authors： Tortora G,di Isernia G,Sandomenico C,Bianco R,Pomatico G,Pepe S,Bianco AR,Ciardiello F

更新日期：1997-11-15 00:00:00

abstract：:Centrosome amplification is a hallmark of virtually all types of cancers, including solid tumors and hematologic malignancies. Cancer cells with extra centrosomes use centrosome clustering (CC) to allow for successful division. Because normal cells do not rely on this mechanism, CC is regarded as a promising target to...

journal_title：Cancer research

authors： Konotop G,Bausch E,Nagai T,Turchinovich A,Becker N,Benner A,Boutros M,Mizuno K,Krämer A,Raab MS

更新日期：2016-11-15 00:00:00

abstract：:Elucidation of the underlying molecular mechanisms of immune evasion in cancer is critical for the development of immunotherapies aimed to restore and stimulate effective antitumor immunity. Here, we evaluate the role of the actin cytoskeleton in breast cancer cell resistance to cytotoxic natural killer (NK) cells. A ...

journal_title：Cancer research

authors： Al Absi A,Wurzer H,Guerin C,Hoffmann C,Moreau F,Mao X,Brown-Clay J,Petrolli R,Casellas CP,Dieterle M,Thiery JP,Chouaib S,Berchem G,Janji B,Thomas C

更新日期：2018-10-01 00:00:00

abstract：:The ability of four steroids and three bile acids to promote the appearance of hyperplastic foci and hyperplastic nodules initiated by diethylnitrosamine (DEN) in the liver of male Fischer rats was tested and compared with that of the known promoter phenobarbital (PB, 0.05%) as a standard value. Two weeks after a sing...

journal_title：Cancer research

authors： Cameron RG,Imaida K,Tsuda H,Ito N

更新日期：1982-06-01 00:00:00

abstract：:Mucin-depleted foci (MDF) are microscopic dysplastic lesions induced in the colon of rodents by specific colon carcinogens. Most MDF show Wnt pathway activation, whereas only a subset shows mutations in the Ctnnb1 gene, coding for beta-catenin. Because Apc is a member of the Wnt pathway and the most frequent mutated g...

journal_title：Cancer research

authors： Femia AP,Dolara P,Giannini A,Salvadori M,Biggeri A,Caderni G

更新日期：2007-01-15 00:00:00

abstract：:The effect of i.v. administration of the nitric oxide synthase (NOS) inhibitor N(omega)-nitro-L-arginine (L-NNA) on tumor blood flow compared with normal tissue blood flow was studied in anesthetized BD9 rats bearing subcutaneous P22 carcinosarcomas. Blood flow was measured by the tissue uptake of radiolabeled iodoant...

journal_title：Cancer research

authors： Tozer GM,Prise VE,Chaplin DJ

更新日期：1997-03-01 00:00:00

abstract：:The oncoprotein HER-2/neu is a prosurvival factor, and its overexpression has been correlated with poor prognosis in patients with breast cancer. We report that HER-2 is a new substrate for caspase-8 and that tumor necrosis factor alpha (TNF-alpha) stimulation leads to an early caspase-8-dependent HER-2 cleavage in MC...

journal_title：Cancer research

authors： Benoit V,Chariot A,Delacroix L,Deregowski V,Jacobs N,Merville MP,Bours V

更新日期：2004-04-15 00:00:00

abstract：:The existence of CD8+ CTLs that are capable of recognizing MHC class I-bound, human tumor-associated peptide antigens is now unequivocally documented in cancer patients. Thus far, the role of CD8+ T cells in tumor immunity has been predominantly viewed in terms of cytolytic ability as the prime mode of their function....

journal_title：Cancer research

authors： Chakraborty NG,Mukherji B

更新日期：1998-04-01 00:00:00

abstract：:Activity increase of the cytosolic isozyme of thymidine kinase (TK) in resected specimens of lung tumor patients would be a useful marker for tumor malignancy and prognosis. In 24 resected cases of malignant lung tumors, the whole enzyme extracts of the tumorous part of the specimens showed that the activities of TK, ...

journal_title：Cancer research

authors： Yusa T,Yamaguchi Y,Ohwada H,Hayashi Y,Kuroiwa N,Morita T,Asanagi M,Moriyama Y,Fujimura S

更新日期：1988-09-01 00:00:00

abstract：:The majority of patients with colon cancer will develop advanced disease, with the liver being the most common site of metastatic disease. Patients with increased numbers of tumor-infiltrating lymphocytes in primary colon tumors and liver metastases have improved outcomes. However, the molecular factors that could emp...

journal_title：Cancer research

authors： Qiao G,Qin J,Kunda N,Calata JF,Mahmud DL,Gann P,Fu YX,Rosenberg SA,Prabhakar BS,Maker AV

更新日期：2017-04-15 00:00:00

abstract：:An extract of a human cervical squamous carcinoma was used to produce rabbit antiserum with immunoreactivity against an antigen in several types of normal and neoplastic tissues. This antigen was abundant in cervical cancer as well as in normal adult and fetal kidney and liver. The antigen had a beta mobility in immun...

journal_title：Cancer research

authors： Goldenberg DM,Garner TF,Pant KD,van Nagell JR Jr

更新日期：1978-05-01 00:00:00

abstract：:Technical modifications of the quantitative determination of unscheduled DNA synthesis in cultured hepatocytes are described which allow for the rapid identification of potentially carcinogenic chemicals on a large-scale screening basis. The test is based on the biochemical quantification of [methyl-3H]thymidine incor...

journal_title：Cancer research

authors： Althaus FR,Lawrence SD,Sattler GL,Longfellow DG,Pitot HC

更新日期：1982-08-01 00:00:00

abstract：:Between June 1977 and December 1979, 72 evaluable patients with childhood non-T-cell acute lymphoblastic leukemia were induced into complete remission using vincristine, prednisone, and doxorubicin. All received asparaginase consolidation and central nervous system prophylaxis with cranial irradiation and intrathecal ...

journal_title：Cancer research

authors： Sallan SE,Hitchcock-Bryan S,Gelber R,Cassady JR,Frei E 3rd,Nathan DG

更新日期：1983-11-01 00:00:00

abstract：:Continued monitoring of a family for new malignant tumors has revealed diverse immunological and neoplastic disorders during a 15-year period. In 1966, the proband developed lymphoma. In 1975, his antibody titers to Epstein-Barr virus (EBV) became elevated, and again, he developed a malignant lymphoma. He also had bor...

journal_title：Cancer research

authors： Purtilo DT,Liao SA,Sakamoto K,Snyder LM,DeFlorio D Jr,Bhawan J,Paquin L,Yang JP,Hutt-Fletcher LM,Muralidharan K,Raffa P,Saemundsen AK,Klein G

更新日期：1981-11-01 00:00:00

abstract：:We have demonstrated previously that there is a marked decrease in the level of labeled fucose incorporated into an amino acid fucoside, i.e., fucosyl-N-acetylglucosaminylasparagine (FL4c) in SV40-transformed human embryonic lung cells (SV40-WI-38) as compared to WI-38 cells (Morton, P.A., Klinger, M. M., and Steiner,...

journal_title：Cancer research

authors： Steiner SM,Morton PA

更新日期：1984-10-01 00:00:00

abstract：:Flow cytometry was used to determine the daunomycin content of rat bone marrow cells after incubation in vitro. The spontaneous fluorescence of daunomycin was measured upon excitation with laser light at 488 nm. Forward and perpendicular light scatters of the cells were simultaneously measured to allow identification ...

journal_title：Cancer research

authors： Nooter K,van den Engh G,Sonneveld P

更新日期：1983-11-01 00:00:00

abstract：:XRCC1 is a key component of DNA base excision repair, single strand break repair, and backup nonhomologous end-joining pathway. XRCC1 (X-ray repair cross-complementing gene 1) deficiency promotes genomic instability, increases cancer risk, and may have clinical application in breast cancer. We investigated XRCC1 expre...

journal_title：Cancer research

authors： Sultana R,Abdel-Fatah T,Abbotts R,Hawkes C,Albarakati N,Seedhouse C,Ball G,Chan S,Rakha EA,Ellis IO,Madhusudan S

更新日期：2013-03-01 00:00:00

abstract：:In order to further understand the role of the host organ in tumor progression, we have transplanted into nude mice histologically intact human colon cancer tissue on the serosal layers of the stomach (heterotopic site) and the serosal layers of the colon (orthotopic site). Xenograft lines Co-3, which is well differen...

journal_title：Cancer research

authors： Togo S,Shimada H,Kubota T,Moossa AR,Hoffman RM

更新日期：1995-02-01 00:00:00