Caspase-8: fly or die.

abstract：:A number of metabolic inhibitors and chemotherapeutic agents have been found to increase the sensitivity of a chemically induced guinea pig hepatoma (line 1) to killing by antibody and complement. We have investigated whether the mechanism whereby these drugs increase sensitivity to killing is attributable to their pr...

journal_title：Cancer research

authors： Schlager SI,Boyle MD,Ohanian SH,Borsos T

更新日期：1977-05-01 00:00:00

abstract：:The p53-regulated gene product p21WAF1/CIP1 is the prototype of a family of small proteins that negatively regulate the cell cycle. To learn more about p21WAF1/CIP1 regulation in vivo, monoclonal antibodies were developed for immunohistochemistry. These revealed that p21WAF1/CIP1 expression followed radiation-induced ...

journal_title：Cancer research

authors： el-Deiry WS,Tokino T,Waldman T,Oliner JD,Velculescu VE,Burrell M,Hill DE,Healy E,Rees JL,Hamilton SR

更新日期：1995-07-01 00:00:00

abstract：:The monoclonal antibodies (MAbs) 323/A3 and 17-1A both recognize a 40-kDa carcinoma-associated epithelial glycoprotein (EGP40). MAb 17-1A has been used in many therapeutic trials as an immunotherapeutic agent to combat advanced colorectal cancer, and about 5-10% overall responses have been observed. It has been shown ...

journal_title：Cancer research

authors： Velders MP,Litvinov SV,Warnaar SO,Gorter A,Fleuren GJ,Zurawski VR Jr,Coney LR

更新日期：1994-04-01 00:00:00

abstract：:It has been suggested that P-glycoprotein (P-gp), an ATP-dependent transporter responsible for classical multidrug resistance, is also a volume-regulated chloride channel. We reexamined this hypothesis by use of whole-cell patch clamp recordings of three matched pairs of cell lines, which were either drug-sensitive or...

journal_title：Cancer research

authors： Dong Y,Chen KG,Durán GE,Kouyama K,Chao AC,Sikic BI,Gollapudi SV,Gupta S,Gardner P

更新日期：1994-10-01 00:00:00

abstract：:Increasing evidence argues that the success of an anticancer treatment may rely on immunoadjuvant side effects including the induction of immunogenic tumor cell death. Based on the assumption that this death mechanism is a similar prerequisite for the efficacy of an active immunotherapy using killed tumor cells, we ex...

journal_title：Cancer research

authors： Zappasodi R,Pupa SM,Ghedini GC,Bongarzone I,Magni M,Cabras AD,Colombo MP,Carlo-Stella C,Gianni AM,Di Nicola M

更新日期：2010-11-15 00:00:00

abstract：:The alternative reading frame (ARF) tumor suppressor mediates growth arrest or apoptosis through activation of the p53 tumor suppressor. A prevailing concept is that ARF uses p21Cip1/Waf1, a p53-responsive gene and cyclin-dependent kinase (Cdk) inhibitor, to block cell cycle progression. Using p21 nullizygous cells, w...

journal_title：Cancer research

authors： Modestou M,Puig-Antich V,Korgaonkar C,Eapen A,Quelle DE

更新日期：2001-04-01 00:00:00

abstract：:Pemetrexed is a novel antifolate effective in the treatment of mesothelioma. Studies were undertaken to characterize the transport of this antifolate in this tumor. We report the presence of a novel, concentrative high-affinity transport activity in three human mesothelioma cell lines, characterized in detail in the N...

journal_title：Cancer research

authors： Wang Y,Zhao R,Chattopadhyay S,Goldman ID

更新日期：2002-11-15 00:00:00

abstract：:GPRC5A is a G-protein-coupled receptor expressed in lung tissue but repressed in most human lung cancers. Studies in Gprc5a(-/-) mice have established its role as a tumor-suppressor function in this setting, but the basis for its role has been obscure. Here, we report that GPRC5A functions as a negative modulator of E...

journal_title：Cancer research

authors： Zhong S,Yin H,Liao Y,Yao F,Li Q,Zhang J,Jiao H,Zhao Y,Xu D,Liu S,Song H,Gao Y,Liu J,Ma L,Pang Z,Yang R,Ding C,Sun B,Lin X,Ye X,Guo W,Han B,Zhou BP,Chin YE,Deng J

更新日期：2015-05-01 00:00:00

abstract：:Variant cell lines that are sensitive to density-dependent inhibition of growth have been isolated from three of four SV40-transformed human fibroblast cell lines. Variants were isolated by plating the transformed cells at low density, by treating them with 5-fluorodeoxyuridine, or by growing them on glutaraldehyde-fi...

journal_title：Cancer research

authors： Rosenberg N,Schaeffer WI,Diamond L

更新日期：1975-08-01 00:00:00

abstract：:The presence of estrogen-independent progesterone receptors (PgR) was demonstrated in a subline of a human endometrial cancer cell line, Ishikawa cells, although the original Ishikawa cells contained estrogen-inducible PgR. Scatchard plot analysis of cytoplasmic binding data in our subline (IK-90) revealed a high affi...

journal_title：Cancer research

authors： Terakawa N,Hayashida M,Shimizu I,Ikegami H,Wakimoto H,Aono T,Tanizawa O,Matsumoto K,Nishida M

更新日期：1987-04-01 00:00:00

abstract：:The binding of tritium-labeled 5-methylchrysene to DNA of CD-1 mouse skin 24 hr after treatment has been studied. DNA was isolated from the treated skin areas of mice and hydrolyzed enzymatically to deoxyribonucleosides, and the hydrolysate was chromatographed on a Sephadex LH-20 column using a methanol:water gradient...

journal_title：Cancer research

authors： Melikian AA,LaVoie EJ,Hecht SS,Hoffmann D

更新日期：1982-04-01 00:00:00

abstract：:A model for medulloblastoma-like primitive neuroectodermal tumors was established in rat using retrovirally transduced SV40 large T antigen (LT) as an inducing agent (O. D. Wiestler et al., Brain Pathol., 2: 47-59, 1992). A cell line isolated from such a tumor and clonal derivatives thereof were biologically and molec...

journal_title：Cancer research

authors： Salewski H,Bayer TA,Eidhoff U,Preuss U,Weggen S,Scheidtmann KH

更新日期：1999-04-15 00:00:00

abstract：:In order to elucidate the response of mitochondria to the increase in cellular energy demand after hepatectomy, we have examined the effects of partial hepatectomy and hepatic artery ligation on the energy-transducing system of rat liver mitochondria. Specific content of DNA in the mitochondria increased on the first ...

journal_title：Cancer research

authors： Nagino M,Tanaka M,Nishikimi M,Nimura Y,Kubota H,Kanai M,Kato T,Ozawa T

更新日期：1989-09-01 00:00:00

abstract：:An epitope region, located at amino acid residues 173-180 (EAAA-GIQW), of a human cell proliferation-associated nucleolar antigen, P120, has been defined by mutational analysis and competition assays. A synthetic peptide corresponding to this epitope region completely blocks the binding of the anti-P120 antibody to Es...

journal_title：Cancer research

authors： Valdez BC,Busch RK,Larson RG,Busch H

更新日期：1990-05-01 00:00:00

abstract：:EphA2 receptor tyrosine kinase is frequently overexpressed in different human cancers, suggesting that it may promote tumor development and progression. However, evidence also exists that EphA2 may possess antitumorigenic properties, raising a critical question on the role of EphA2 kinase in tumorigenesis in vivo. We ...

journal_title：Cancer research

authors： Guo H,Miao H,Gerber L,Singh J,Denning MF,Gilliam AC,Wang B

更新日期：2006-07-15 00:00:00

abstract：:MicroRNAs (miRNA) are negative regulators of gene expression at the posttranscriptional level, which are involved in tumorigenesis. Two miRNAs, miR-15a and miR-16, which are located at chromosome 13q14, have been implicated in cell cycle control and apoptosis, but little information is available about their role in so...

journal_title：Cancer research

authors： Bandi N,Zbinden S,Gugger M,Arnold M,Kocher V,Hasan L,Kappeler A,Brunner T,Vassella E

更新日期：2009-07-01 00:00:00

abstract：:Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) and its agonistic antibodies, which are currently in early clinical trials for treating various malignancies, induce apoptosis through triggering of either TRAIL-R1 or TRAIL-R2. Based on studies using agonistic monoclonal antibodies, we recently proposed ...

journal_title：Cancer research

authors： MacFarlane M,Kohlhaas SL,Sutcliffe MJ,Dyer MJ,Cohen GM

更新日期：2005-12-15 00:00:00

abstract：:The sodium iodide symporter (NIS) is a classical iodide pump typically localized within the cell plasma membrane in thyroid cells, where NIS expression is believed to ensure success of mainstay radioiodide therapy in thyroid cancers. Although radioiodide uptake is generally reduced in thyroid cancer tissue, intracellu...

journal_title：Cancer research

authors： Feng F,Yehia L,Ni Y,Chang YS,Jhiang SM,Eng C

更新日期：2018-11-01 00:00:00

abstract：:Autologous hematopoietic stem cell transplantation after myelosuppressive chemotherapy is used for the treatment of high-risk breast cancer and other solid tumors. However, contamination of the autologous graft with tumor cells may adversely affect outcomes. Human hematopoietic bone marrow cells are resistant to herpe...

journal_title：Cancer research

authors： Wu A,Mazumder A,Martuza RL,Liu X,Thein M,Meehan KR,Rabkin SD

更新日期：2001-04-01 00:00:00

abstract：:Neurofibromas are benign tumors of the peripheral nerve sheath, which occur sporadically and in association with the common familial cancer syndrome, neurofibromatosis type 1. There are intriguing links between the growth of neurofibromas and levels of circulating hormones: neurofibromas often first appear around the ...

journal_title：Cancer research

authors： McLaughlin ME,Jacks T

更新日期：2003-02-15 00:00:00

abstract：:The introduction of normal chromosomes into tumor cells by microcell fusion-mediated transfer is a powerful technique to identify putative tumor suppressor genes. We have used this approach to independently transfer human chromosomes 3 and 12 into a human prostate cancer cell line, DU 145. We showed that while the ext...

journal_title：Cancer research

authors： Bérubé NG,Speevak MD,Chevrette M

更新日期：1994-06-15 00:00:00

abstract：:Monoclonal antibody HT462 recognizes a human T-cell leukemia virus type I (HTLV-I)-associated Mr 52,000 glycoprotein (HA-gp52), which is found on the surface of HTLV-infected cells. Whether HA-gp52 is encoded by the virus or by the infected cells has not yet been established. Using monoclonal HT462 in a competitive bi...

journal_title：Cancer research

authors： Robert-Guroff M,Clark JW

更新日期：1985-07-01 00:00:00

abstract：:7-Hydroxystaurosporine (UCN-01) is a protein kinase inhibitor that is under development as an anticancer agent in the United States and Japan. Long-term exposure of human A549 non-small cell lung cancer cells to UCN-01 furnished cells (A549/UCN) with acquired resistance against UCN-01. In this study, the sensitivity o...

journal_title：Cancer research

authors： Sugiyama K,Akiyama T,Shimizu M,Tamaoki T,Courage C,Gescher A,Akinaga S

更新日期：1999-09-01 00:00:00

abstract：:Although radiotherapy (RT) decreases the incidence of locoregional recurrence in breast cancer, patients with triple-negative breast cancer (TNBC) have increased risk of local recurrence following breast-conserving therapy. The relationship between RT and local recurrence is unknown. Here, we tested the hypothesis tha...

journal_title：Cancer research

authors： Rafat M,Aguilera TA,Vilalta M,Bronsart LL,Soto LA,von Eyben R,Golla MA,Ahrari Y,Melemenidis S,Afghahi A,Jenkins MJ,Kurian AW,Horst KC,Giaccia AJ,Graves EE

更新日期：2018-08-01 00:00:00

abstract：:In L1210 cells in culture, 3-deazaguanine (DG), a relatively new purine analog, was found to inhibit DNA and protein synthesis but not total RNA synthesis. The effect of the drug on protein synthesis was therefore further examined. Polyadenylic acid-containing RNA synthesis was not decreased by DG treatment, suggestin...

journal_title：Cancer research

authors： Rivest RS,Irwin D,Mandel HG

更新日期：1982-10-01 00:00:00

abstract：:We have measured the 31P nuclear magnetic resonance spectra of EMT6/Ro multicellular tumor spheroids over a wide range of sizes under constant nutrient conditions which matched those used for culturing the spheroids. The amount of nucleotide triphosphate per cell decreased with spheroid growth, roughly in proportion t...

journal_title：Cancer research

authors： Freyer JP,Schor PL,Jarrett KA,Neeman M,Sillerud LO

更新日期：1991-08-01 00:00:00

abstract：:Understanding molecular alterations in colorectal cancer (CRC) is needed to define new biomarkers and treatment targets. We used oligonucleotide microarrays to monitor gene expression of about 6,800 known genes and 35,000 expressed sequence tags (ESTs) on five pools (four to six samples in each pool) of total RNA from...

journal_title：Cancer research

authors： Birkenkamp-Demtroder K,Christensen LL,Olesen SH,Frederiksen CM,Laiho P,Aaltonen LA,Laurberg S,Sørensen FB,Hagemann R,ØRntoft TF

更新日期：2002-08-01 00:00:00

abstract：:Traditionally, non-small cell lung cancer (NSCLC) has been evaluated as a unique entity in genotyping studies. However, recent biological data suggest that different NSCLC subtypes, specifically adenocarcinomas (AC) and squamous cell carcinomas (SCC), differentially alter cancer behavior. Several studies have associat...

journal_title：Cancer research

authors： Liu G,Miller DP,Zhou W,Thurston SW,Fan R,Xu LL,Lynch TJ,Wain JC,Su L,Christiani DC

更新日期：2001-12-15 00:00:00

abstract：:Photodynamic therapy (PDT), an experimental cancer treatment employing a photosensitizer and visible light, is a highly efficient inducer of apoptosis (or programmed cell death) in mouse L5178Y lymphoma cells, resulting in extensive DNA fragmentation within 1-2 h. The major targets for PDT are in cellular membranes, a...

journal_title：Cancer research

authors： Agarwal ML,Larkin HE,Zaidi SI,Mukhtar H,Oleinick NL

更新日期：1993-12-15 00:00:00

abstract：:Pancreatic ductal adenocarcinoma (PDAC) is a devastating disease with poor outcomes with current therapies. Gemcitabine is the primary adjuvant drug used clinically, but its effectiveness is limited. In this study, our objective was to use a rationale-driven approach to identify novel biomarkers for outcome in patient...

journal_title：Cancer research

authors： Colbert LE,Petrova AV,Fisher SB,Pantazides BG,Madden MZ,Hardy CW,Warren MD,Pan Y,Nagaraju GP,Liu EA,Saka B,Hall WA,Shelton JW,Gandhi K,Pauly R,Kowalski J,Kooby DA,El-Rayes BF,Staley CA 3rd,Adsay NV,Curran WJ Jr,

更新日期：2014-05-15 00:00:00