Gene expression in colorectal cancer.

abstract：:Previous experiments have suggested that some mutant forms of p53 are able to inactivate the endogenous wild-type p53 protein in a dominant-negative fashion. However, it remains unknown whether tumors with such dominant-negative (transdominant) p53 mutants have a biological significance that is different from that of ...

journal_title：Cancer research

authors： Marutani M,Tonoki H,Tada M,Takahashi M,Kashiwazaki H,Hida Y,Hamada J,Asaka M,Moriuchi T

更新日期：1999-10-01 00:00:00

abstract：:p53 alterations in human tumors often involve missense mutations that may confer dominant-negative or gain-of-function properties. Dominant-negative effects result in inactivation of wild-type p53 protein in heterozygous mutant cells and as such in a p53 null phenotype. Gain-of-function effects can directly promote tu...

journal_title：Cancer research

authors： Wijnhoven SW,Speksnijder EN,Liu X,Zwart E,vanOostrom CT,Beems RB,Hoogervorst EM,Schaap MM,Attardi LD,Jacks T,van Steeg H,Jonkers J,de Vries A

更新日期：2007-05-15 00:00:00

abstract：:Cultures of human mammary epithelial cells (HMECs) contain a subpopulation of variant cells with the capacity to propagate beyond an in vitro proliferation barrier. These variant HMECs, which contain hypermethylated and silenced p16(INK4a) (p16) promoters, eventually accumulate multiple chromosomal changes, many of wh...

journal_title：Cancer research

authors： Holst CR,Nuovo GJ,Esteller M,Chew K,Baylin SB,Herman JG,Tlsty TD

更新日期：2003-04-01 00:00:00

abstract：:The study of DNA tumor viruses has been invaluable in uncovering the cellular nodes and pathways that contribute to oncogenesis. Perhaps one of the best-studied oncoproteins encoded by a DNA tumor virus is adenovirus E1A, which modifies the function of key regulatory proteins such as retinoblastoma (Rb) and the chroma...

journal_title：Cancer research

authors： Chakraborty AA,Tansey WP

更新日期：2009-01-01 00:00:00

abstract：:Tumor cells can evolve to evade immune responses by down-modulating surface MHC class I expression and become refractory to T cell-directed immunotherapy. We employed a strategy to bypass this escape mechanism using a recombinant adenovirus vector expressing interleukin-12 (Ad5IL-12) to target natural killer (NK) cell...

journal_title：Cancer research

authors： Raja Gabaglia C,Diaz de Durana Y,Graham FL,Gauldie J,Sercarz EE,Braciak TA

更新日期：2007-03-01 00:00:00

abstract：:MYC exerts both positive and negative functions in cancer cells, such that its procancerous effects are unmasked only after its anticancer effects are blocked. Here we used multiple mouse models of lung adenocarcinoma to identify genetic events that can cooperate with MYC activation to promote the genesis of non-small...

journal_title：Cancer research

authors： Allen TD,Zhu CQ,Jones KD,Yanagawa N,Tsao MS,Bishop JM

更新日期：2011-03-15 00:00:00

abstract：:Several members of the kinesin family of microtubule motor proteins play essential roles in mitotic spindle function and are potential targets for the discovery of novel antimitotic cancer therapies. KSP, also known as HsEg5, is a kinesin that plays an essential role in formation of a bipolar mitotic spindle and is re...

journal_title：Cancer research

authors： Sakowicz R,Finer JT,Beraud C,Crompton A,Lewis E,Fritsch A,Lee Y,Mak J,Moody R,Turincio R,Chabala JC,Gonzales P,Roth S,Weitman S,Wood KW

更新日期：2004-05-01 00:00:00

abstract：:Most patients' prostate cancers respond to androgen deprivation but relapse after periods of several months to years. Only two prostate cancer xenografts, LNCaP and PC-346, have been reported to be responsive to androgen deprivation and to relapse subsequently. Both of these tumors shrink slightly, if at all, and rela...

journal_title：Cancer research

authors： Nagabhushan M,Miller CM,Pretlow TP,Giaconia JM,Edgehouse NL,Schwartz S,Kung HJ,de Vere White RW,Gumerlock PH,Resnick MI,Amini SB,Pretlow TG

更新日期：1996-07-01 00:00:00

abstract：:Several genome-wide searches for common cancers have lead to the identification of a small number of loci that harbor low-risk cancer susceptibility markers. One marker, rs6983267 on chromosome 8q24, has been linked to both colon and prostate cancer, and is therefore a good candidate for a multicancer susceptibility m...

journal_title：Cancer research

authors： Wokolorczyk D,Gliniewicz B,Sikorski A,Zlowocka E,Masojc B,Debniak T,Matyjasik J,Mierzejewski M,Medrek K,Oszutowska D,Suchy J,Gronwald J,Teodorczyk U,Huzarski T,Byrski T,Jakubowska A,Górski B,van de Wetering T,Walczak

更新日期：2008-12-01 00:00:00

abstract：:In breast cancer bone metastasis, tumor cells stimulate osteoclast-mediated bone resorption, and bone-derived growth factors released from resorbed bone stimulate tumor growth. The alphavbeta3 integrin is an adhesion receptor expressed by breast cancer cells and osteoclasts. It is implicated in tumor cell invasion and...

journal_title：Cancer research

authors： Zhao Y,Bachelier R,Treilleux I,Pujuguet P,Peyruchaud O,Baron R,Clément-Lacroix P,Clézardin P

更新日期：2007-06-15 00:00:00

abstract：:The small leucine-rich proteoglycan lumican was identified from a human placenta cDNA library by the expression cloning method as a gene product that interacts with membrane-type matrix metalloproteinase-1 (MT1-MMP). Coexpression of MT1-MMP with lumican in HEK293T cells reduced the concentration of lumican secreted in...

journal_title：Cancer research

authors： Li Y,Aoki T,Mori Y,Ahmad M,Miyamori H,Takino T,Sato H

更新日期：2004-10-01 00:00:00

abstract：:The relationship between adenosine deaminase (ADA) and a human membrane thymus leukemia (HTL) antigen-detected by an antithymocyte serum was explored. A freeze-thaw extract of the T-cell-derived cell line, MOLT 4, was applied to an immunoabsorbant column of a rabbit antiserum to calf ADA. The bound MOLT 4 ADA was elut...

journal_title：Cancer research

authors： Dowell BL,Segars JH,Metzgar RS

更新日期：1981-01-01 00:00:00

abstract：:Nude mice bearing s.c. xenografts of the human colon adenocarcinoma HT29 were given intratumor injections of a mixture of 125I-labeled specific antibody (AUA1) and 131I-labeled control antibody (HMFG1), or with the labels reversed. After dissection at 1 and 4 h postadministration, both specific and control antibodies ...

journal_title：Cancer research

authors： Rowlinson-Busza G,Bamias A,Krausz T,Epenetos AA

更新日期：1991-06-15 00:00:00

abstract：:The carcinogenicities for rats and mice of N-methyl-4-aminoazobenzene (MAB) and its hepatic microsomal metabolite N-hydroxy-N-methyl-4-aminoazobenzene (N-hydroxy-MAB) were compared under several conditions. N-Ethyl-4-aminoazobenzene, 4-aminoazobenzene, and their N-hydroxy derivatives were also included in some of the ...

journal_title：Cancer research

authors： Miller EC,Kadlubar FF,Miller JA,Pitot HC,Drinkwater NR

更新日期：1979-09-01 00:00:00

abstract：:SOX9 is a transcription factor that plays a critical role in the development of multiple tissues. We previously reported that SOX9 in normal human adult prostate was restricted to basal epithelium. SOX9 was also expressed in a subset of prostate cancer (PCa) cells and was increased in relapsed hormone-refractory PCa. ...

journal_title：Cancer research

authors： Wang H,Leav I,Ibaragi S,Wegner M,Hu GF,Lu ML,Balk SP,Yuan X

更新日期：2008-03-15 00:00:00

abstract：:We observed that photodynamic therapy (PDT) induces the expression and phosphorylation of the inhibitor of apoptosis (IAP) protein survivin in murine and human cancer cells and tumors. Survivin inhibits caspase-9, blocks apoptosis, and is associated with resistance to chemotherapy and radiation. Survivin is a client p...

journal_title：Cancer research

authors： Ferrario A,Rucker N,Wong S,Luna M,Gomer CJ

更新日期：2007-05-15 00:00:00

abstract：:Recently, we demonstrated that an androgen-regulated cell adhesion molecule, C-CAM, acts as a tumor suppressor in prostate cancer development. In this study, we further explored the possibility of applying C-CAM as a potential agent for developing prostate cancer gene therapy using an adenoviral delivery system. We fo...

journal_title：Cancer research

authors： Kleinerman DI,Zhang WW,Lin SH,Nguyen TV,von Eschenbach AC,Hsieh JT

更新日期：1995-07-01 00:00:00

abstract：:Aberrant activation of Wnt signaling plays an important role in hepatocarcinogenesis. In addition to direct effects on tumor cells, Wnt signaling might be involved in the organization of tumor microenvironment. In this study, we have explored whether Wnt signaling blockade by exogenous expression of Wnt antagonists co...

journal_title：Cancer research

authors： Hu J,Dong A,Fernandez-Ruiz V,Shan J,Kawa M,Martínez-Ansó E,Prieto J,Qian C

更新日期：2009-09-01 00:00:00

abstract：:The anticancer oxazaphosphorine prodrugs cyclophosphamide and ifosfamide are activated in human liver by a 4-hydroxylation reaction catalyzed by multiple cytochrome P450 (CYP) enzymes. In the present study, we used a cultured human hepatocyte model to identify possible inducers of the CYP-catalyzed activation of these...

journal_title：Cancer research

authors： Chang TK,Yu L,Maurel P,Waxman DJ

更新日期：1997-05-15 00:00:00

abstract：:Immune system status was characterized in patients with hairy cell leukemia (HCL) with respect to explaining their chronic or recurrent infections with Epstein-Barr virus. Measures of cellular immune responsiveness for a group of 11 HCL patients were, in general, decreased when expressed as the proportion of tested pa...

journal_title：Cancer research

authors： Sairenji T,Sullivan JL,Sakamoto K,Spiro RC,Katayama I,Humphreys RE

更新日期：1985-01-01 00:00:00

abstract：:We applied 1H-decoupling and nuclear Overhauser enhancement to obtain well-resolved 31P magnetic resonance spectra accurately localized to 20 soft tissue sarcomas in vivo, using three-dimensional chemical shift imaging. Fifteen spectra had large phosphomonoester signals (21% of total phosphorus) that contained high am...

journal_title：Cancer research

authors： Li CW,Kuesel AC,Padavic-Shaller KA,Murphy-Boesch J,Eisenberg BL,Schmidt RG,von Roemeling RW,Patchefsky AS,Brown TR,Negendank WG

更新日期：1996-07-01 00:00:00

abstract：:The presence of a valine (V) versus a phenylanaline (F) at position 158 of Fc gamma RIIIa/CD16a improves the affinity for IgG and is associated with higher therapeutic response to rituximab. Increased CD16 expression on natural killer (NK) cells from donors with the VV or VF versus FF genotype has recently been report...

journal_title：Cancer research

authors： Congy-Jolivet N,Bolzec A,Ternant D,Ohresser M,Watier H,Thibault G

更新日期：2008-02-15 00:00:00

abstract：:The timing of bleomycin (BLM) administration after KMT-17 tumor inoculation was found to be important for optimizing its therapeutic effect on tumor-bearing rats. A remarkable therapeutic effect was observed when BLM (5 mg/kg/day) was administered i.p. for 5 days from the eighth day after tumor inoculation (Day 8 to D...

journal_title：Cancer research

authors： Morikawa K,Hosokawa M,Hamada J,Sugawara M,Kobayashi H

更新日期：1985-04-01 00:00:00

abstract：:The proto-oncogene, c-src, has been implicated in the tumorigenesis in breast cancer. However, the relationship of c-src with distant metastasis is unclear. Moreover, the role of c-src in organ-preferential metastasis of breast cancer is unknown. Because breast cancer has a strong predilection for metastasizing to bon...

journal_title：Cancer research

authors： Myoui A,Nishimura R,Williams PJ,Hiraga T,Tamura D,Michigami T,Mundy GR,Yoneda T

更新日期：2003-08-15 00:00:00

abstract：:In vivo experiments performed with NIH (nu/nu, bg/bg, xid/xid) triple immunodeficient (TD) mice revealed the striking ability of i.v. injected B16-F1 and B16-F10 murine melanoma cells to colonize not only the lungs but also the liver of TD mice. Subsequently, B16 melanoma cell cultures, which express very low levels o...

journal_title：Cancer research

authors： Calorini L,Marozzi A,Byers HR,Waneck GL,Lee KW,Isselbacher KJ,Gattoni-Celli S

更新日期：1992-07-15 00:00:00

abstract：:The cytotoxic, antimitotic, and growth inhibition properties of a photoactive analogue of vinblastine, N-(p-azidobenzoyl)-N'-beta-aminoethylvindesine (NABV), and vinblastine on P388 murine leukemia cells were compared. After 72-h exposure, the 50% drug-inhibitory concentrations for exponentially growing P388 leukemic ...

journal_title：Cancer research

authors： Safa AR,Glover CJ,Felsted RL

更新日期：1987-10-01 00:00:00

abstract：:The tumorigenicity of dexamethasone-treated tissue-cultured mammary tumor cells was compared to that of untreated mammary tumor cells. The dexamethasone-induced cells progressed faster in normal syngeneic animals than did untreated mammary tumor cells. The fact that the growth rate differential was also observed in at...

journal_title：Cancer research

authors： Gillette RW,Wunderlich DA

更新日期：1978-10-01 00:00:00

abstract：:miR-31 inhibits breast cancer metastasis via the pleiotropic suppression of a cohort of prometastatic target genes that include integrin alpha(5) (ITGA5), radixin (RDX), and RhoA. We previously showed that the concomitant overexpression of ITGA5, RDX, and RhoA was capable of overriding the antimetastatic effects of ec...

journal_title：Cancer research

authors： Valastyan S,Chang A,Benaich N,Reinhardt F,Weinberg RA

更新日期：2010-06-15 00:00:00

abstract：:Inhibition of the survival kinase Akt can trigger apoptosis, and also has been found to activate autophagy, which may confound tumor attack. In this study, we investigated regulatory mechanisms through which apoptosis and autophagy were modulated in tumor cells subjected to Akt inhibition by MK-2206, the first alloste...

journal_title：Cancer research

authors： Cheng Y,Ren X,Zhang Y,Patel R,Sharma A,Wu H,Robertson GP,Yan L,Rubin E,Yang JM

更新日期：2011-04-01 00:00:00

abstract：:The reactivity of normal and tumor host lymphocytes incubated with normal serum or with serum or malignant ascites fluid from tumor hosts was measured by the ability of the lymphocytes to synthesize ornithine decarboxylase after phytohemagglutinin stimulation. Each of three tumors tested (a solid fibrosarcoma, an asci...

journal_title：Cancer research

authors： Vaage J,Agarwal S,Reinertsen JL

更新日期：1978-08-01 00:00:00