Application of a tumor suppressor (C-CAM1)-expressing recombinant adenovirus in androgen-independent human prostate cancer therapy: a preclinical study.

abstract：:Although there is considerable knowledge of how DNA damage triggers cell cycle arrest, DNA repair, and apoptosis, little was known about its potential role in immune responses. Recently, we showed that genotoxic stress and stalled DNA replication forks induce the expression of ligands for the NKG2D receptor found in n...

journal_title：Cancer research

authors： Gasser S,Raulet DH

更新日期：2006-04-15 00:00:00

abstract：:Adult rat parenchymal hepatocytes in primary culture can be induced to enter into DNA synthesis and mitosis. The optimal conditions for hepatocyte replication are low plating density (less than 10,000 cells/sq cm) and 50% serum from two-thirds partially hepatectomized rats (48 hr after hepatectomy). Approximately 80% ...

journal_title：Cancer research

authors： Michalopoulos G,Cianciulli HD,Novotny AR,Kligerman AD,Strom SC,Jirtle RL

更新日期：1982-11-01 00:00:00

abstract：:Using a sensitive radioimmunoassay, concentrations of vincristine and its products were determined in cerebrospinal fluid (CSF) and corresponding blood samples from four patients with lymphoma and two patients with leukemia who had received i.v. bolus injection of 2 mg vincristine. Serial samples of CSF were withdrawn...

journal_title：Cancer research

authors： Jackson DV Jr,Sethi VS,Spurr CL,McWhorter JM

更新日期：1981-04-01 00:00:00

abstract：:To study the influence of reflux esophagitis on the carcinogenic response of 2,6-dimethylnitrosomorpholine (2,6-DMNM), an experiment was designed, composed of 6 groups of 8-week-old Sprague-Dawley rats, each consisting of 20 males and 20 females. Group 1 served as untreated controls. All animals of groups 2, 4, and 6 ...

journal_title：Cancer research

authors： Pera M,Cardesa A,Bombi JA,Ernst H,Pera C,Mohr U

更新日期：1989-12-01 00:00:00

abstract：:Morris 7777 hepatoma cells, maintained in culture for 5 days in Lewis medium supplemented with 0.1 to 0.35 mM cis-unsaturated fatty acid of the oleic (number of carbon atoms: number of double bonds, 18:1), linoleic (18:2), or arachidonic (20:4) type, were compared to similarly maintained, unsupplemented cells as to ul...

journal_title：Cancer research

authors： Abbas MK,Yoo TJ,Viles J

更新日期：1982-11-01 00:00:00

abstract：:The role of natural killer group 2, member D receptor (NKG2D)-expressing natural killer (NK) cells in tumor immunosurveillance is now well established. Nevertheless, tumor progression occurs despite tumor immunosurveillance, leading to cancer persistence in immunocompetent hosts. STAT3 plays a pivotal role both in onc...

journal_title：Cancer research

authors： Bedel R,Thiery-Vuillemin A,Grandclement C,Balland J,Remy-Martin JP,Kantelip B,Pallandre JR,Pivot X,Ferrand C,Tiberghien P,Borg C

更新日期：2011-03-01 00:00:00

abstract：:Epidermal growth factor receptor (EGFR) plays critical roles in many biological processes and in tumorigenesis. Here, we show that two mutated EGFRs found in lung and other malignancies, EGFR-G719S and EGFR-L858R, could transform Ba/F3 cells to interleukin-3 (IL-3)-independent growth, in a ligand-independent manner, a...

journal_title：Cancer research

authors： Jiang J,Greulich H,Jänne PA,Sellers WR,Meyerson M,Griffin JD

更新日期：2005-10-01 00:00:00

abstract：:Epstein-Barr virus (EBV) infection is associated with immunoblastic B-cell lymphomas in immunosuppressed or human immunodeficiency virus-infected individuals and in SCID mice reconstituted with human peripheral blood leukocytes (hu-PBL-SCID) from EBV-seropositive donors. The risk of tumors appearing in the hu-PBL-SCID...

journal_title：Cancer research

authors： Mosier DE,Picchio GR,Baird SM,Kobayashi R,Kipps TJ

更新日期：1992-10-01 00:00:00

abstract：:Clinical studies have suggested a close correlation between cis-diamminedichloroplatinum(II) (cisplatin) and radiation resistance. To determine whether this cross-resistance is due to an inherent cellular resistance to both agents, ten early passage human tumor cell lines were examined for their radiation and cisplati...

journal_title：Cancer research

authors： Schwartz JL,Rotmensch J,Beckett MA,Jaffe DR,Toohill M,Giovanazzi SM,McIntosh J,Weichselbaum RR

更新日期：1988-09-15 00:00:00

abstract：:Epithelial ovarian cancer (EOC) is the sixth most common cancer in women worldwide and, despite advances in detection and therapies, it still represents the most lethal gynecologic malignancy in the industrialized countries. Unfortunately, still relatively little is known about the molecular events that lead to the de...

journal_title：Cancer research

authors： Iorio MV,Visone R,Di Leva G,Donati V,Petrocca F,Casalini P,Taccioli C,Volinia S,Liu CG,Alder H,Calin GA,Ménard S,Croce CM

更新日期：2007-09-15 00:00:00

abstract：:In this study, we performed high-resolution array comparative genomic hybridization with an array of 4153 bacterial artificial chromosome clones to assess copy number changes in 44 archival breast cancers. The tumors were flow sorted to exclude non-tumor DNA and increase our ability to detect gene copy number changes....

journal_title：Cancer research

authors： Loo LW,Grove DI,Williams EM,Neal CL,Cousens LA,Schubert EL,Holcomb IN,Massa HF,Glogovac J,Li CI,Malone KE,Daling JR,Delrow JJ,Trask BJ,Hsu L,Porter PL

更新日期：2004-12-01 00:00:00

abstract：:Our understanding of the cellular mechanisms governing carcinoma invasiveness and metastasis has evolved dramatically over the last several years. The previous emphasis on the epithelial-mesenchymal transition as a driver of the migratory properties of single cells has expanded with the observation that carcinoma cell...

journal_title：Cancer research

authors： VanderVorst K,Dreyer CA,Konopelski SE,Lee H,Ho HH,Carraway KL 3rd

更新日期：2019-04-15 00:00:00

abstract：:A two-stage genome-wide association study (GWAS) of the Cancer Genetic Markers of Susceptibility (CGEMS) initiative identified single nucleotide polymorphisms (SNP) in 150 regions across the genome that may be associated with prostate cancer (PCa) risk. We filtered these results to identify 43 independent SNPs where t...

journal_title：Cancer research

authors： Hsu FC,Sun J,Wiklund F,Isaacs SD,Wiley KE,Purcell LD,Gao Z,Stattin P,Zhu Y,Kim ST,Zhang Z,Liu W,Chang BL,Walsh PC,Duggan D,Carpten JD,Isaacs WB,Grönberg H,Xu J,Zheng SL

更新日期：2009-04-01 00:00:00

abstract：:In a hospital-based case-control study of 124 (105 male and 19 female) histologically confirmed malignant mesothelioma cases and age- and sex-matched controls, the role of cigarette smoking and the risk of asbestos exposure was investigated. Exposure to asbestos for at least 1 year was likely for 78% of male cases and...

journal_title：Cancer research

authors： Muscat JE,Wynder EL

更新日期：1991-05-01 00:00:00

abstract：:The mouse breast cancer cell lines 4T1, 4T07, and 67NR are highly tumorigenic but vary in metastatic potential: 4T1 widely disseminates, resulting in secondary tumors in the lung, liver, bone, and brain; 4T07 spreads to the lung and liver but is unable to establish metastatic nodules; 67NR is unable to metastasize. Th...

journal_title：Cancer research

authors： Manka D,Spicer Z,Millhorn DE

更新日期：2005-12-15 00:00:00

abstract：:Previous studies with Adriamycin-sensitive and -resistant (ADRR) MCF-7 human breast tumor cell lines indicated that Adriamycin formed significantly less hydroxyl radical (.OH) as the result of enhanced detoxification of reactive oxygen intermediates in the ADRR cell line. In order to further define the sites of drug a...

journal_title：Cancer research

authors： Sinha BK,Mimnaugh EG,Rajagopalan S,Myers CE

更新日期：1989-07-15 00:00:00

abstract：:Phenobarbital (PB), a classical rodent hepatopromoter, remarkably enhances hepatocarcinogenesis initiated by diethylnitrosamine (DEN) in adult B6C3F1 mice. However, it is also known to strongly inhibit liver tumor development in the B6C3F1 mice initiated with DEN in their infancy. The present study aimed to elucidate ...

journal_title：Cancer research

authors： Lee GH,Ooasa T,Osanai M

更新日期：1998-04-15 00:00:00

abstract：:Busulfan, a bifunctional alkylating agent, is a mainstay of myeloablative preparative regimens before hematopoietic stem cell transplantation. The apparent oral clearance of busulfan expressed relative to body surface area is 2-3-fold higher in children 1-4 years old than it is in adults. The first step in busulfan el...

journal_title：Cancer research

authors： Gibbs JP,Murray G,Risler L,Chien JY,Dev R,Slattery JT

更新日期：1997-12-15 00:00:00

abstract：:Lymphangioleiomyomatosis (LAM) is a progressive destructive neoplasm of the lung associated with inactivating mutations in the TSC1 or TSC2 tumor suppressor genes. Cell or animal models that accurately reflect the pathology of LAM have been challenging to develop. Here, we generated a robust human cell model of LAM by...

journal_title：Cancer research

authors： Julian LM,Delaney SP,Wang Y,Goldberg AA,Doré C,Yockell-Lelièvre J,Tam RY,Giannikou K,McMurray F,Shoichet MS,Harper ME,Henske EP,Kwiatkowski DJ,Darling TN,Moss J,Kristof AS,Stanford WL

更新日期：2017-10-15 00:00:00

abstract：:Understanding the intratumoral heterogeneity of hepatocellular carcinoma is instructive for developing personalized therapy and identifying molecular biomarkers. Here we applied whole-exome sequencing to 69 samples from 11 patients to resolve the genetic architecture of subclonal diversification. Spatial genomic diver...

journal_title：Cancer research

authors： Lin DC,Mayakonda A,Dinh HQ,Huang P,Lin L,Liu X,Ding LW,Wang J,Berman BP,Song EW,Yin D,Koeffler HP

更新日期：2017-05-01 00:00:00

abstract：:Microtubule inhibitors as chemotherapeutic drugs are widely used for cancer treatment. However, the development of multidrug resistance (MDR) in cancer is a major challenge for microtubule inhibitors in their clinical implementation. From a high-throughput drug screen using cells transformed by oncogenic RAS, we ident...

journal_title：Cancer research

authors： Ning N,Yu Y,Wu M,Zhang R,Zhang T,Zhu C,Huang L,Yun CH,Benes CH,Zhang J,Deng X,Chen Q,Ren R

更新日期：2018-10-15 00:00:00

abstract：:The human melanoma cell line NEL-M1 proliferates in Ham's F-12 medium in the absence of serum, hormones, and growth factors. Culturing NEL-M1 cells in defined medium supplemented with insulin (5 micrograms/ml) and transferrin (5 micrograms/ml) results in a 94% increase in [3H]thymidine incorporation after 24 h and a 6...

journal_title：Cancer research

authors： DiSorbo DM

更新日期：1986-08-01 00:00:00

abstract：:Multiple endocrine neoplasia 2B (MEN 2B) is an inherited syndrome of early onset endocrine tumors and developmental anomalies. The disease is caused primarily by a methionine to threonine substitution of residue 918 in the kinase domain of the RET receptor (2B-RET); however, the molecular mechanisms that lead to the d...

journal_title：Cancer research

authors： Gujral TS,Singh VK,Jia Z,Mulligan LM

更新日期：2006-11-15 00:00:00

abstract：:We have examined a t(9;11)(p22;q23) chromosome translocation in an acute myeloid leukemia of an infant. The breakpoints on the two chromosomes occurred within introns of the involved genes: AF-9 on chromosome 9, and ALL-1 on chromosome 11. Sequence analysis identified heptamers flanking the breakpoints on both chromos...

journal_title：Cancer research

authors： Negrini M,Felix CA,Martin C,Lange BJ,Nakamura T,Canaani E,Croce CM

更新日期：1993-10-01 00:00:00

abstract：:Advocates bring unique and important viewpoints to the cancer research process, ensuring that scientific and medical advances are patient-centered and relevant. In this article, we discuss the benefits of engaging advocates in cancer research and underscore ways in which both the scientific and patient communities can...

journal_title：Cancer research

authors： Salamone JM,Lucas W,Brundage SB,Holloway JN,Stahl SM,Carbine NE,London M,Greenwood N,Goyes R,Chisholm DC,Price E,Carlin R,Winarsky S,Baker KB,Maues J,Shajahan-Haq AN

更新日期：2018-10-15 00:00:00

abstract：:Recombinant human gamma-interferon (IFN-gamma) has recently been shown to enhance localization of radiolabeled monoclonal antibodies (MAb) to human colon carcinoma xenografts in athymic mice. The present study investigates the ability of gamma-interferon to enhance radioimmunotherapy of a low carcinoembryonic antigen-...

journal_title：Cancer research

authors： Kuhn JA,Beatty BG,Wong JY,Esteban JM,Wanek PM,Wall F,Buras RR,Williams LE,Beatty JD

更新日期：1991-05-01 00:00:00

abstract：:Hedgehog (Hh) and transforming growth factor-beta (TGF-beta) family members are involved in numerous overlapping processes during embryonic development, hair cycle, and cancer. Herein, we show that TGF-beta induces the expression of the Hh signaling molecules Gli1 and Gli2 in various human cell types, including normal...

journal_title：Cancer research

authors： Dennler S,André J,Alexaki I,Li A,Magnaldo T,ten Dijke P,Wang XJ,Verrecchia F,Mauviel A

更新日期：2007-07-15 00:00:00

abstract：:Mouse bladder tumor (MBT-2), derived from a carcinogen-induced transitional cell carcinoma of the bladder, has proven a useful model for study of pathogenesis and prediction of cytotoxic drug sensitivity of human bladder carcinoma. To define optimal conditions for activity of the potent interferon inducer polyriboinos...

journal_title：Cancer research

authors： Borden EC,Sidky YA,Groveman DS,Bryan GT

更新日期：1985-01-01 00:00:00

abstract：:The deregulation of several cell cycle-related genes participates in neoplastic transformation. Cell cycle progression is driven by cyclin-dependent kinases, which are positively regulated by association with cyclins and negatively regulated by binding to inhibitory subunits. The activity of cyclin-dependent kinases i...

journal_title：Cancer research

authors： Gasparotto D,Maestro R,Piccinin S,Vukosavljevic T,Barzan L,Sulfaro S,Boiocchi M

更新日期：1997-06-15 00:00:00

abstract：:A number of studies in bacteria have indicated that deoxythymidine 5'-triphosphate may be a repressor or corepressor of ribonucleotide reductase. For determination of whether a similar regulating mechanism exists in mammalian cells, HeLa cells and partially hepatectomized rats were treated with either methotrexate, 5-...

journal_title：Cancer research

authors： Elford HL,Bonner EL,Kerr BH,Hanna SD,Smulson M

更新日期：1977-12-01 00:00:00