Potential topoisomerase II DNA-binding sites at the breakpoints of a t(9;11) chromosome translocation in acute myeloid leukemia.

abstract：:In the first Phase I clinical trials of endostatin as an antiangiogenic therapy for cancer, the protein was administered as an i.v. bolus for approximately 20-30 min each day. This protocol was based on experimental studies in which animals were treated by s.c. bolus once a day. However, it was not clear in the previo...

journal_title：Cancer research

authors： Kisker O,Becker CM,Prox D,Fannon M,D'Amato R,Flynn E,Fogler WE,Sim BK,Allred EN,Pirie-Shepherd SR,Folkman J

更新日期：2001-10-15 00:00:00

abstract：:mtCLIC/CLIC4 is a p53 and tumor necrosis factor alpha (TNFalpha) regulated intracellular chloride channel protein that localizes to cytoplasm and organelles and induces apoptosis when overexpressed in several cell types of mouse and human origin. CLIC4 is elevated during TNFalpha-induced apoptosis in human osteosarcom...

journal_title：Cancer research

authors： Suh KS,Mutoh M,Gerdes M,Crutchley JM,Mutoh T,Edwards LE,Dumont RA,Sodha P,Cheng C,Glick A,Yuspa SH

更新日期：2005-01-15 00:00:00

abstract：:Elongation factor-2 kinase (eEF-2 kinase), also known as Ca(2+)/calmodulin-dependent kinase III, regulates protein synthesis by controlling the rate of peptide chain elongation. The activity of eEF-2 kinase is increased in glioblastoma and other malignancies, yet its role in neoplasia is uncertain. Recent evidence sug...

journal_title：Cancer research

authors： Wu H,Yang JM,Jin S,Zhang H,Hait WN

更新日期：2006-03-15 00:00:00

abstract：:Thirty-seven endometrial cancers were subjected to an allelotype analysis in an attempt to identify chromosomal regions that are lost in a significant portion of tumors and to identify tumors characterized by replication errors. Thirty-nine highly polymorphic microsatellite markers representing all chromosomal arms, e...

journal_title：Cancer research

authors： Peiffer SL,Herzog TJ,Tribune DJ,Mutch DG,Gersell DJ,Goodfellow PJ

更新日期：1995-05-01 00:00:00

abstract：:A recent pilot study that we performed on 12 individuals who are involved in the cultivation and processing of grains and legumes suggests to us that we may have in hand a relatively quick, inexpensive, and highly sensitive assay that identifies individuals at increased risk for the development of lymphoid malignancy....

journal_title：Cancer research

authors： Kirsch IR,Lipkowitz S

更新日期：1992-10-01 00:00:00

abstract：:The oxidation of the bladder carcinogen 2-naphthylamine (2-NA) by prostaglandin H synthase (PHS) in vitro was examined. Oxygen uptake studies of 2-NA oxidation in the presence of glutathione, as well as extensive product analysis data, are consistent with a one-electron mechanism of 2-NA oxidation by PHS. The formatio...

journal_title：Cancer research

authors： Boyd JA,Eling TE

更新日期：1987-08-01 00:00:00

abstract：:We examined the effect of human interferon (HuIFN) -alpha and -beta on the proliferation and differentiation induced by dimethyl sulfoxide (DMSO) of HL-60 human promyelocytic leukemia cells into mature granulocytes. Neither HuIFN-alpha nor -beta, alone, from 1 to 1000 IU/ml, nor the homologous mock HuIFN preparations ...

journal_title：Cancer research

authors： Hamburger AW,White CP,Siebenlist RE,Sedmak JJ,Grossberg SE

更新日期：1985-11-01 00:00:00

abstract：:Micropthalmia transcription factor (Mitf) is involved in melanocyte development and differentiation. The current study was undertaken to determine whether there is a relationship between Mitf expression and survival in patients with intermediate-thickness (1.0-4.0 mm) melanoma. Original paraffin blocks or slides of th...

journal_title：Cancer research

authors： Salti GI,Manougian T,Farolan M,Shilkaitis A,Majumdar D,Das Gupta TK

更新日期：2000-09-15 00:00:00

abstract：:Pancreatic cancer is an aggressive neoplasm with no current viable, effective treatment options. In the majority of cases, at first diagnosis, pancreatic cancer has already become metastatic so that conventional treatment regimens provide minimal, if any, clinical benefit in prolonging life or ameliorating the negativ...

journal_title：Cancer research

authors： Sarkar D,Su ZZ,Vozhilla N,Park ES,Randolph A,Valerie K,Fisher PB

更新日期：2005-10-01 00:00:00

abstract：:Epigenetic changes in pediatric neuroblastoma may contribute to the aggressive pathophysiology of this disease, but little is known about the basis for such changes. In this study, we examined a role for the DNA methyltransferase DNMT3B, in particular, the truncated isoform DNMT3B7, which is generated frequently in ca...

journal_title：Cancer research

authors： Ostler KR,Yang Q,Looney TJ,Zhang L,Vasanthakumar A,Tian Y,Kocherginsky M,Raimondi SL,DeMaio JG,Salwen HR,Gu S,Chlenski A,Naranjo A,Gill A,Peddinti R,Lahn BT,Cohn SL,Godley LA

更新日期：2012-09-15 00:00:00

abstract：:LEC/chTNT-3, a chemokine fusion protein generated previously in our laboratory, produces a 40-60% reduction in well-established solid tumors of the BALB/c mouse. In this study, CD25(+) T-cell depletion was used in combination with LEC/chTNT-3 treatment to enhance the therapeutic value of this approach. In two tumor mo...

journal_title：Cancer research

authors： Li J,Hu P,Khawli LA,Epstein AL

更新日期：2003-12-01 00:00:00

abstract：:The present work is a continuation of our studies to improve the graft versus leukemia (GVL) effect in autologous bone marrow transplantation. We have recently shown that the GVL effect of bone marrow transplantation (BMT) with interleukin 2 (IL-2)-activated bone marrow (ABM) followed by IL-2 therapy immediately after...

journal_title：Cancer research

authors： Charak BS,Brynes RK,Katsuda S,Groshen S,Chen SC,Mazumder A

更新日期：1991-04-15 00:00:00

abstract：:The pharmacokinetics of melphalan following high-dose p.o. administration were determined in 17 patients with various malignancies for the purpose of assessing interpatient and intrapatient pharmacokinetic variability. All patients underwent bone marrow harvest on day -8 (relative to bone marrow reinfusion). On days -...

journal_title：Cancer research

authors： Choi KE,Ratain MJ,Williams SF,Golick JA,Beschorner JC,Fullem LJ,Bitran JD

更新日期：1989-03-01 00:00:00

abstract：:In a search for the molecular basis of ABH status of tumors as correlated with malignancy, we studied various malignancy-related phenotypes of high H/Le(y)-expressing tumor cell lines in comparison with phenotypes of the same lines transfected with histo-blood group A or B genes. A and B gene transfectants, prepared i...

journal_title：Cancer research

authors： Ichikawa D,Handa K,Withers DA,Hakomori S

更新日期：1997-08-01 00:00:00

abstract：:The Na+/I- symporter (NIS) present in the membranes of thyroid cells is responsible for the capacity of the thyroid to concentrate iodide. This allows treatment of thyroid cancers with 131I. We propose to enlarge this therapeutic strategy to nonthyroid tumors by using an adenoviral vector to deliver the NIS gene into ...

journal_title：Cancer research

authors： Boland A,Ricard M,Opolon P,Bidart JM,Yeh P,Filetti S,Schlumberger M,Perricaudet M

更新日期：2000-07-01 00:00:00

abstract：:The cells' ability to proliferate in response to growth factor stimulation is significantly altered during cancer progression. To investigate the mechanisms underlying these alterations in prostate cancer, the role and expression of beta1A integrin and type 1 insulin-like growth factor receptor (IGF-IR), known to cont...

journal_title：Cancer research

authors： Goel HL,Breen M,Zhang J,Das I,Aznavoorian-Cheshire S,Greenberg NM,Elgavish A,Languino LR

更新日期：2005-08-01 00:00:00

abstract：:Emerging evidence supporting the activation of the Akt-mammalian target of rapamycin (mTOR) signaling network in head and neck squamous cell carcinoma (HNSCC) progression has provided the rationale for exploring the therapeutic potential of inhibiting this pathway for HNSCC treatment. Indeed, rapamycin, a clinically r...

journal_title：Cancer research

authors： Amornphimoltham P,Patel V,Leelahavanichkul K,Abraham RT,Gutkind JS

更新日期：2008-02-15 00:00:00

abstract：:Epstein-Barr virus (EBV) is associated with Burkitt lymphoma, nasopharyngeal carcinoma, opportunistic lymphomas in immunocompromised hosts, and a fraction of gastric cancers. Aberrant promoter methylation accompanies human gastric carcinogenesis, though the contribution of EBV to such somatic methylation changes has n...

journal_title：Cancer research

authors： Matsusaka K,Kaneda A,Nagae G,Ushiku T,Kikuchi Y,Hino R,Uozaki H,Seto Y,Takada K,Aburatani H,Fukayama M

更新日期：2011-12-01 00:00:00

abstract：:Immunotherapy based on adoptive transfer of tumor antigen-specific CD8(+) T cell (TC) is generally limited by poor in vivo expansion and tumor infiltration. In this study, we report that activated STAT5 transcription factors (STAT5CA) confer high efficiency on CD8(+) effector T cells (eTC) for host colonization after ...

journal_title：Cancer research

authors： Grange M,Buferne M,Verdeil G,Leserman L,Schmitt-Verhulst AM,Auphan-Anezin N

更新日期：2012-01-01 00:00:00

abstract：:Administration of methylating carcinogens such as methyl methanesulfonate (120 mg/kg), dimethylnitrosamine (5 mg/kg), or methylnitrosourea (80 mg/kg) to rats resulted in an increased ellipticity in circular dichroism spectra and in an enhanced ability to bind ethidium bromide in the liver chromatin. Although shearing ...

journal_title：Cancer research

authors： Nicolini C,Ramanathan R,Kendall F,Murphy J,Parodi S,Sarma DS

更新日期：1976-05-01 00:00:00

abstract：:Hematopoietic progenitor kinase 1 (HPK1) regulates stress responses, proliferation, and apoptosis in hematopoietic cells. In this study, we examined the expression, regulation, and functions of HPK1 in pancreatic ductal adenocarcinomas (PDA). We found that loss of HPK1 protein expression correlated significantly with ...

journal_title：Cancer research

authors： Wang H,Song X,Logsdon C,Zhou G,Evans DB,Abbruzzese JL,Hamilton SR,Tan TH,Wang H

更新日期：2009-02-01 00:00:00

abstract：:We obtained seven monoclonal antibodies (MAb) against a gastric mucin of an ALeb patient. By immunoperoxidase on normal gastric mucosae, two MAbs (3-3A and 2-25 LE) reacted exclusively with the A and Lewis-positive individuals, respectively; the five other MAbs (1-13 M1, 2-11 M1, 2-12 M1, 9-13 M1, and 58 M1) stained t...

journal_title：Cancer research

authors： Bara J,Gautier R,Daher N,Zaghouani H,Decaens C

更新日期：1986-08-01 00:00:00

abstract：:Ras associated with diabetes (Rad) is a Ras-related GTPase that promotes cell growth by accelerating cell cycle transitions. Rad knockdown induced cell cycle arrest and premature senescence without additional cellular stress in multiple cancer cell lines, indicating that Rad expression might be critical for the cell c...

journal_title：Cancer research

authors： Lee I,Yeom SY,Lee SJ,Kang WK,Park C

更新日期：2010-06-01 00:00:00

abstract：:Partial regression in cutaneous malignant melanoma has been reported by a number of observers, albeit not all, to be associated with a relatively poor prognosis; in contrast, a keratoacanthoma, which eventually regresses, does not metastasize. The Hammond effect could explain the possibly poor prognosis of the thin re...

journal_title：Cancer research

authors： Prehn RT

更新日期：1996-03-01 00:00:00

abstract：:Anchorage-independent growth is a hallmark of tumor cells. We compared gene expression profiles of anchored and nonanchored human mammary carcinoma cells to study this phenomenon. In this study, we show that anchorage had striking effects on cell growth and morphology but altered transcript levels from a limited numbe...

journal_title：Cancer research

authors： Goldberg GS,Jin Z,Ichikawa H,Naito A,Ohki M,El-Deiry WS,Tsuda H

更新日期：2001-02-15 00:00:00

abstract：:The cyclin-dependent kinase (Cdk)-associated protein phosphatase (KAP) is a human dual specificity protein phosphatase that dephosphorylates Cdk2 on threonine 160 in a cyclin-dependent manner. To investigate whether mutations of this enzyme occur in hepatocellular carcinoma (HCC), KAP mRNA was analyzed by reverse tran...

journal_title：Cancer research

authors： Yeh CT,Lu SC,Chen TC,Peng CY,Liaw YF

更新日期：2000-09-01 00:00:00

abstract：:PR-104, currently in phase II clinical trials, is a phosphate ester pre-prodrug which is converted in vivo to its cognate alcohol, PR-104A, a prodrug designed to exploit tumor hypoxia. Bioactivation occurs via one-electron reduction to DNA crosslinking metabolites in the absence of oxygen. However, certain tumor cell ...

journal_title：Cancer research

authors： Guise CP,Abbattista MR,Singleton RS,Holford SD,Connolly J,Dachs GU,Fox SB,Pollock R,Harvey J,Guilford P,Doñate F,Wilson WR,Patterson AV

更新日期：2010-02-15 00:00:00

abstract：:Similar histologic subtypes of cancers often exhibit different spectrum of genetic and epigenetic alterations. The heterogeneity observed due to lack of consistent and defined alterations affecting a unique set of gene(s) or gene products in cancers derived from a specific tissue, or an organ, pose a challenge in unra...

journal_title：Cancer research

authors： Thiagalingam S

更新日期：2006-08-01 00:00:00

abstract：:The partial pressure of oxygen (pO2) of FSaII tumors grown in the leg of C3H mice significantly improved when the tumors were heated by immersing the tumor-bearing legs in a water bath at 41.5 degrees C for 60 min. The tumor pO2 also substantially increased when the tumor-bearing mice breathed carbogen (95% O2:5% CO2)...

journal_title：Cancer research

authors： Griffin RJ,Okajima K,Barrios B,Song CW

更新日期：1996-12-15 00:00:00

abstract：:Glioblastomas (GBM) are highly infiltrated by myeloid-derived innate immune cells that contribute to the immunosuppressive nature of the brain tumor microenvironment (TME). CD47 has been shown to mediate immune evasion, as the CD47-SIRPα axis prevents phagocytosis of tumor cells by macrophages and other myeloid cells....

journal_title：Cancer research

authors： Ma D,Liu S,Lal B,Wei S,Wang S,Zhan D,Zhang H,Lee RS,Gao P,Lopez-Bertoni H,Ying M,Li JJ,Laterra J,Wilson MA,Xia S

更新日期：2019-05-15 00:00:00