Cigarette smoking, asbestos exposure, and malignant mesothelioma.

Abstract:

:In a hospital-based case-control study of 124 (105 male and 19 female) histologically confirmed malignant mesothelioma cases and age- and sex-matched controls, the role of cigarette smoking and the risk of asbestos exposure was investigated. Exposure to asbestos for at least 1 year was likely for 78% of male cases and 16% of female cases, and 90% of males were possibly exposed. Male cases worked predominantly in the ship-building industry, construction, or insulation trades. Elevated risks were found for males employed in asbestos-related industries [odds ratio (OR) 8.1; 95% confidence interval (CI) 4.9-13.5], e.g., shipyards (OR 82.9, 95% CI 25.5-269.1), construction/maintenance (OR 8.3, 95% CI 4.6-14.8), and other asbestos-related jobs (OR 3.2, 95% CI 1.4-7.2), and for males who self-reported exposure to asbestos or insulation (OR 50.9, 95% CI 21.7-119.8). A statistically significant trend was found for the risk of mesothelioma with increasing years employed in non-shipyard asbestos-related occupations. Among women, only one case worked in an asbestos-related industry and two reported domestic contact with asbestos. No association between cigarette smoking and mesothelioma was found for either men or women. We also report the occurrence of mesothelioma in occupations which have not been previously reported.

journal_name

Cancer Res

journal_title

Cancer research

authors

Muscat JE,Wynder EL

subject

Has Abstract

pub_date

1991-05-01 00:00:00

pages

2263-7

issue

9

eissn

0008-5472

issn

1538-7445

journal_volume

51

pub_type

杂志文章
  • Increased levels of human papillomavirus type 16 DNA in a subset of prostate cancers.

    abstract::Whether oncogenic human papilloma viruses (HPVs) are involved in the pathogenesis of prostate cancers has been a subject of great controversy. To clarify the contradictory results of investigations, with the aim of detecting viral nucleic acids in prostate cancers, we have carried out a comparative quantitation of the...

    journal_title:Cancer research

    pub_type: 杂志文章

    doi:

    authors: Serth J,Panitz F,Paeslack U,Kuczyk MA,Jonas U

    更新日期:1999-02-15 00:00:00

  • c-myc-induced apoptosis in polycystic kidney disease is independent of FasL/Fas interaction.

    abstract::Apoptosis is a critical early cellular event in the development of polycystic kidney disease (PKD) in humans and mice. In the SBM transgenic model of PKD, both apoptosis and proliferation are c-myc driven and are independent of p53 and Bcl-2 pathways. On the basis of recent evidence implicating the FasL/Fas pathway in...

    journal_title:Cancer research

    pub_type: 杂志文章

    doi:

    authors: Couillard M,Guillaume R,Tanji N,D'Agati V,Trudel M

    更新日期:2002-04-15 00:00:00

  • The human ribonucleotide reductase subunit hRRM2 complements p53R2 in response to UV-induced DNA repair in cells with mutant p53.

    abstract::Ribonucleotide reductase (RR) is responsible for the de novo conversion of the ribonucleoside diphosphates to deoxyribonucleoside diphosphates, which are essential for DNA synthesis and repair. RR consists of two subunits, hRRM1 and hRRM2. p53R2 is a new RR family member. Because the majority of human tumors possess m...

    journal_title:Cancer research

    pub_type: 杂志文章

    doi:

    authors: Zhou B,Liu X,Mo X,Xue L,Darwish D,Qiu W,Shih J,Hwu EB,Luh F,Yen Y

    更新日期:2003-10-15 00:00:00

  • Inhibition by putrescine of the induction of epidermal ornithine decarboxylase activity and tumor promotion caused by 12-O-tetradecanoylphorbol-13-acetate.

    abstract::The induction of epidermal ornithine decarboxylase (EC 4.1.1.17) (ODC) following topical application of the tumor-promoting agent 12-O-tetradecanoylphorbol-13-acetate (TPA) to mice can be inhibited by topical application of putrescine, the product of the enzyme. The degree of inhibition depended on both the dose and t...

    journal_title:Cancer research

    pub_type: 杂志文章

    doi:

    authors: Weekes RG,Verma AK,Boutwell RK

    更新日期:1980-11-01 00:00:00

  • Combined immunostimulation and conditional cytotoxic gene therapy provide long-term survival in a large glioma model.

    abstract::In spite of preclinical efficacy and recent randomized, controlled studies with adenoviral vectors expressing herpes simplex virus-1 thymidine kinase (HSV1-TK) showing statistically significant increases in survival, most clinical trials using single therapies have failed to provide major therapeutic breakthroughs. Be...

    journal_title:Cancer research

    pub_type: 杂志文章

    doi:10.1158/0008-5472.CAN-04-3434

    authors: Ali S,King GD,Curtin JF,Candolfi M,Xiong W,Liu C,Puntel M,Cheng Q,Prieto J,Ribas A,Kupiec-Weglinski J,van Rooijen N,Lassmann H,Lowenstein PR,Castro MG

    更新日期:2005-08-15 00:00:00

  • Interaction of tomato lycopene and ketosamine against rat prostate tumorigenesis.

    abstract::Prior investigations on the beneficial effect of dietary processed tomato products and lycopene on prostate cancer risk suggested that lycopene may require the presence of other constituents to exert its chemopreventive potential. We investigated whether ketosamines, a group of carbohydrate derivatives present in dehy...

    journal_title:Cancer research

    pub_type: 杂志文章

    doi:10.1158/0008-5472.CAN-08-0108

    authors: Mossine VV,Chopra P,Mawhinney TP

    更新日期:2008-06-01 00:00:00

  • Induction of antigen-specific immune response with use of anti-idiotypic monoclonal antibodies to anti-carcinoembryonic antigen antibodies.

    abstract::Anti-idiotypic monoclonal antibodies (MoAbs) were prepared in a syngeneic system against anti-carcinoembryonic antigen (CEA) MoAb 5B3 (IgG1), which reacted with a carbohydrate moiety on CEA, and MoAb MA208 (IgG1), which reacted with a peptide on CEA. Anti-idiotypic MoAb T3-503 and T4-202 recognized the private idiotyp...

    journal_title:Cancer research

    pub_type: 杂志文章

    doi:

    authors: Tsujisaki M,Imai K,Tokuchi S,Hanzawa Y,Ishida T,Kitagawa H,Hinoda Y,Yachi A

    更新日期:1991-05-15 00:00:00

  • Perivascular cells harboring multiple endocrine neoplasia type 1 alterations are neoplastic cells in angiofibromas.

    abstract::Although neoplasia is caused by clonal proliferation of cells, the resulting tumors are frequently heterogeneous, being composed of both neoplastic and reactive cells. Therefore, identification of tumors as neoplastic processes is frequently obscured. We studied cutaneous angiofibroma, which is a tumor of unknown etio...

    journal_title:Cancer research

    pub_type: 杂志文章

    doi:

    authors: Vortmeyer AO,Böni R,Pack SD,Darling TN,Zhuang Z

    更新日期:1999-01-15 00:00:00

  • Epigenetic Switch between SOX2 and SOX9 Regulates Cancer Cell Plasticity.

    abstract::Cell differentiation within stem cell lineages can check proliferative potential, but nodal pathways that can limit tumor growth are obscure. Here, we report that lung cancer cell populations generate phenotypic and oncogenic plasticity via a switch between differentiation programs controlled by SOX2 and SOX9, thus al...

    journal_title:Cancer research

    pub_type: 杂志文章

    doi:10.1158/0008-5472.CAN-15-3178

    authors: Lin SC,Chou YT,Jiang SS,Chang JL,Chung CH,Kao YR,Chang IS,Wu CW

    更新日期:2016-12-01 00:00:00

  • Differential cytotoxicity and DNA-damaging effects produced in human cells of the Mer+ and Mer- phenotypes by a series of 1-aryl-3-alkyltriazenes.

    abstract::A series of arylalkyltriazenes has been investigated for its differential cytotoxicity towards the HT-29 (Mer+) and BE (Mer-) cell lines and for its ability to cause DNA strand breaks and cross-links. A monomethyltriazene (MMPT) and some hydroxymethyltriazene derivatives capable of generating the monomethyltriazene in...

    journal_title:Cancer research

    pub_type: 杂志文章

    doi:

    authors: Gibson NW,Hartley JA,LaFrance RJ,Vaughan K

    更新日期:1986-10-01 00:00:00

  • Targeted expression of bcl-2 to murine basal epidermal keratinocytes results in paradoxical retardation of ultraviolet- and chemical-induced tumorigenesis.

    abstract::The antiapoptotic protein bcl-2 is found up-regulated in a number of malignant and premalignant skin conditions of keratinocyte origin, but in normal skin, it is expressed at low levels only in interfollicular epidermis. To investigate whether unregulated bcl-2 expression could affect the incidence of epidermal tumors...

    journal_title:Cancer research

    pub_type: 杂志文章

    doi:

    authors: Rossiter H,Beissert S,Mayer C,Schön MP,Wienrich BG,Tschachler E,Kupper TS

    更新日期:2001-05-01 00:00:00

  • Structure-activity relationships of isothiocyanates as mechanism-based inhibitors of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone-induced lung tumorigenesis in A/J mice.

    abstract::A structure-activity relationship study was carried out to identify structural features in arylalkyl and alkyl isothiocyanates that are associated with the inhibitory potency of these compounds against lung tumorigenesis induced in A/J mice by the tobacco-specific nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-buta...

    journal_title:Cancer research

    pub_type: 杂志文章

    doi:

    authors: Jiao D,Eklind KI,Choi CI,Desai DH,Amin SG,Chung FL

    更新日期:1994-08-15 00:00:00

  • Modulation of hypoxia-inducible factor 1alpha expression by the epidermal growth factor/phosphatidylinositol 3-kinase/PTEN/AKT/FRAP pathway in human prostate cancer cells: implications for tumor angiogenesis and therapeutics.

    abstract::Dysregulated signal transduction from receptor tyrosine kinases to phosphatidylinositol 3-kinase (PI3K), AKT (protein kinase B), and its effector FKBP-rapamycin-associated protein (FRAP) occurs via autocrine stimulation or inactivation of the tumor suppressor PTEN in many cancers. Here we demonstrate that in human pro...

    journal_title:Cancer research

    pub_type: 杂志文章

    doi:

    authors: Zhong H,Chiles K,Feldser D,Laughner E,Hanrahan C,Georgescu MM,Simons JW,Semenza GL

    更新日期:2000-03-15 00:00:00

  • Inhibition of initiator-promoter-induced skin tumorigenesis in female SENCAR mice fed a vitamin A-deficient diet and reappearance of tumors in mice fed a diet adequate in retinoid or beta-carotene.

    abstract::Retinoids have chemopreventive activity for epithelial tumors in a variety of systems, including the two-stage tumorigenesis system of mouse skin in which only the promotion stage is inhibited. We asked whether dietary vitamin A deficiency could affect the skin tumorigenic response, prior to major changes in body weig...

    journal_title:Cancer research

    pub_type: 杂志文章

    doi:

    authors: De Luca LM,Shores RL,Spangler EF,Wenk ML

    更新日期:1989-10-01 00:00:00

  • VEGF regulates region-specific localization of perivascular bone marrow-derived cells in glioblastoma.

    abstract::Glioblastoma multiforme (GBM) is characterized by a pathogenic vasculature that drives aggressive local invasion. Recent work suggests that GBM cells recruit bone marrow-derived progenitor cells (BMDC) to facilitate recurrence after radiotherapy, but how this may be achieved is unclear. In this study, we established t...

    journal_title:Cancer research

    pub_type: 杂志文章

    doi:10.1158/0008-5472.CAN-13-3119

    authors: Burrell K,Singh S,Jalali S,Hill RP,Zadeh G

    更新日期:2014-07-15 00:00:00

  • Frequent loss of heterozygosity on chromosomes 1q, 5q, and 17p in human gastric carcinomas.

    abstract::Recently, loss or inactivation of genes at specific chromosomal loci has been considered to be one of the important mechanisms during the development of human tumors. In order to identify tumor suppressor genes for gastric carcinoma, we performed restriction fragment length polymorphism analysis on 48 human gastric ca...

    journal_title:Cancer research

    pub_type: 杂志文章

    doi:

    authors: Sano T,Tsujino T,Yoshida K,Nakayama H,Haruma K,Ito H,Nakamura Y,Kajiyama G,Tahara E

    更新日期:1991-06-01 00:00:00

  • Fatty acid composition transport and metabolism in doxorubicin-sensitive and-resistant rat glioblastoma cells.

    abstract::We have studied the lipid composition and the acyl group composition, transport, and metabolism of doxorubicin-sensitive and -resistant rat glioblastoma cells in monolayer cultures (C6 clone). No difference in lipid composition was evidenced; the acyl group composition was, in contrast, highly modified in resistant ce...

    journal_title:Cancer research

    pub_type: 杂志文章

    doi:

    authors: Vrignaud P,Montaudon D,Londos-Gagliardi D,Robert J

    更新日期:1986-07-01 00:00:00

  • Apoptosis, p53, and tumor cell sensitivity to anticancer agents.

    abstract::A widely held tenet of present day oncology is that tumor cells treated with anticancer agents die from apoptosis, and that cells resistant to apoptosis are resistant to cancer treatment. We suggest, in this review, that this tenet may need to be reexamined for human tumors of nonhematological origin, for two principa...

    journal_title:Cancer research

    pub_type: 杂志文章,评审

    doi:

    authors: Brown JM,Wouters BG

    更新日期:1999-04-01 00:00:00

  • Fes tyrosine kinase expression in the tumor niche correlates with enhanced tumor growth, angiogenesis, circulating tumor cells, metastasis, and infiltrating macrophages.

    abstract::Fes is a protein tyrosine kinase with cell autonomous oncogenic activities that are well established in cell culture and animal models, but its involvement in human cancer has been unclear. Abundant expression of Fes in vascular endothelial cells and myeloid cell lineages prompted us to explore roles for Fes in the tu...

    journal_title:Cancer research

    pub_type: 杂志文章

    doi:10.1158/0008-5472.CAN-10-3757

    authors: Zhang S,Chitu V,Stanley ER,Elliott BE,Greer PA

    更新日期:2011-02-15 00:00:00

  • The original Pathologische Anatomie Leiden-Endothelium monoclonal antibody recognizes a vascular endothelial growth factor binding site within neuropilin-1.

    abstract::For two decades, the antigen recognized by the Pathologische Anatomie Leiden-Endothelium (PAL-E) monoclonal antibody, a standard vascular endothelial cell marker, has remained elusive. Here, we used a combinatorial phage display-based approach ("epitope mapping") to select peptides binding to the original PAL-E antibo...

    journal_title:Cancer research

    pub_type: 杂志文章

    doi:10.1158/0008-5472.CAN-07-2737

    authors: Jaalouk DE,Ozawa MG,Sun J,Lahdenranta J,Schlingemann RO,Pasqualini R,Arap W

    更新日期:2007-10-15 00:00:00

  • Topography of nonneoplastic and neoplastic cells of common origin.

    abstract::The possibility that neoplastic transformation may characteristically alter cell surface morphology prompted a comparison by scanning electron microscopy of nonneoplastic and tumorigenic cell lines from a single clone of mouse embryo cells. Among those studied by scanning electron microscopy, six lines of this clone p...

    journal_title:Cancer research

    pub_type: 杂志文章

    doi:

    authors: Wetzel B,Sanford KK,Fox CH,Jones GM,Westbrook EW,Tarone RE

    更新日期:1977-03-01 00:00:00

  • Role of LIM and SH3 protein 1 (LASP1) in the metastatic dissemination of medulloblastoma.

    abstract::Medulloblastoma is the most common malignant pediatric brain tumor and is one of the leading causes of cancer-related mortality in children. Treatment failure mainly occurs in children harboring metastatic tumors, which typically carry an isochromosome 17 or gain of 17q, a common hallmark of intermediate and high-risk...

    journal_title:Cancer research

    pub_type: 杂志文章

    doi:10.1158/0008-5472.CAN-10-0592

    authors: Traenka C,Remke M,Korshunov A,Bender S,Hielscher T,Northcott PA,Witt H,Ryzhova M,Felsberg J,Benner A,Riester S,Scheurlen W,Grunewald TG,von Deimling A,Kulozik AE,Reifenberger G,Taylor MD,Lichter P,Butt E,Pfister SM

    更新日期:2010-10-15 00:00:00

  • DT-diaphorase as a critical determinant of sensitivity to mitomycin C in human colon and gastric carcinoma cell lines.

    abstract::Mitomycin C (MMC), a known cytotoxic agent, requires cellular enzyme-mediated activation for effective antitumor activity. To study the bioreductive enzymes responsible for MMC activation in tumor cells, we examined the enzyme activities of DT-diaphorase (DTD) and NADPH:cytochrome P-450 reductase in 13 colon and gastr...

    journal_title:Cancer research

    pub_type: 杂志文章

    doi:

    authors: Mikami K,Naito M,Tomida A,Yamada M,Sirakusa T,Tsuruo T

    更新日期:1996-06-15 00:00:00

  • Nuclear distribution of the Ki-67 antigen during the cell cycle: comparison with growth fraction in human breast cancer cells.

    abstract::It has been claimed that the commercially available Ki-67 monoclonal antibody recognizes a nuclear antigen which is solely expressed in cycling cells. Therefore, at present, Ki-67 is increasingly used as a tool in evaluating growth fractions (GFs) of human tumors. Here we describe specific patterns in the expression a...

    journal_title:Cancer research

    pub_type: 杂志文章

    doi:

    authors: van Dierendonck JH,Keijzer R,van de Velde CJ,Cornelisse CJ

    更新日期:1989-06-01 00:00:00

  • Stearoyl CoA Desaturase Regulates Ferroptosis in Ovarian Cancer Offering New Therapeutic Perspectives.

    abstract::Better therapies are urgently needed for ovarian cancer, which is associated with an overall median survival of less than 5 years from diagnosis. In this issue of Cancer Research, Tesfay and colleagues show that stearoyl CoA desaturase (SCD1) is expressed at high levels in different isotypes of ovarian cancer and that...

    journal_title:Cancer research

    pub_type: 评论,杂志文章

    doi:10.1158/0008-5472.CAN-19-2453

    authors: Carbone M,Melino G

    更新日期:2019-10-15 00:00:00

  • Multiomics characterization of low-grade serous ovarian carcinoma identifies potential biomarkers of MEK inhibitor sensitivity and therapeutic vulnerability.

    abstract::Low-grade serous ovarian carcinoma (LGSOC) is a rare tumor subtype with high case fatality rates in patients with metastatic disease. There is a pressing need to develop effective treatments using newly available preclinical models for therapeutic discovery and drug evaluation. Here we use multiomics integration of wh...

    journal_title:Cancer research

    pub_type: 杂志文章

    doi:10.1158/0008-5472.CAN-20-2222

    authors: Shrestha R,Llaurado Fernandez M,Dawson A,Hoenisch J,Volik S,Lin YY,Anderson S,Kim H,Haegert AM,Colborne S,Wong NKY,McConeghy B,Bell RH,Brahmbhatt S,Lee CH,DiMattia GE,Le Bihan S,Morin GB,Collins CC,Carey MS

    更新日期:2021-01-13 00:00:00

  • Aberrant expression of photoreceptor-specific calcium-binding protein (recoverin) in cancer cell lines.

    abstract::Cancer-associated retinopathy (CAR) is an ocular manifestation of a paraneoplastic syndrome whereby immunological reactions to retinal antigens aberrantly expressed in tumor cells lead to the degeneration of retinal photoreceptor cells. In our previous study (H. Ohguro et al., Invest. Ophthalmol. Vis. Sci., 40: 82-89,...

    journal_title:Cancer research

    pub_type: 杂志文章

    doi:

    authors: Maeda A,Ohguro H,Maeda T,Wada I,Sato N,Kuroki Y,Nakagawa T

    更新日期:2000-04-01 00:00:00

  • Metabolism of benzo(a)pyrene by human epithelial cells in vitro.

    abstract::Primary cell cultures derived from human skin epithelium metabolized benzo(a)pyrene to three classes of compounds: phenols, quinones, and dihydrodiols. The relative proportions of metabolites varied according to the skin donor but differed from the pattern of metabolites in rat liver microsome preparations. While appr...

    journal_title:Cancer research

    pub_type: 杂志文章

    doi:

    authors: Fox CH,Selkirk JK,Price FM,Croy RG,Sanford KK,Cottler-Fox M

    更新日期:1975-12-01 00:00:00

  • Biphenotypic sarcomas with myogenic and neural differentiation express the Ewing's sarcoma EWS/FLI1 fusion gene.

    abstract::Accurate diagnosis of primitive childhood sarcomas continues to be a formidable problem because these malignancies generally demonstrate very little morphological evidence of their tissue of origin. One of these tumor classes, the Ewing's sarcoma family of peripheral primitive neuroectodermal tumors (pPNETs), are thou...

    journal_title:Cancer research

    pub_type: 杂志文章

    doi:

    authors: Sorensen PH,Shimada H,Liu XF,Lim JF,Thomas G,Triche TJ

    更新日期:1995-03-15 00:00:00

  • Expression of brain-derived neurotrophic factor and p145TrkB affects survival, differentiation, and invasiveness of human neuroblastoma cells.

    abstract::A large number of poor prognosis neuroblastoma (NB) tumors constitutively express brain-derived neurotrophic factor (BDNF) and variably express the gene for its tyrosine kinase (Trk) receptor TrkB. Good prognosis NB tumors typically express high levels of TrkA mRNA, which encodes the signal transducing receptor for ne...

    journal_title:Cancer research

    pub_type: 杂志文章

    doi:

    authors: Matsumoto K,Wada RK,Yamashiro JM,Kaplan DR,Thiele CJ

    更新日期:1995-04-15 00:00:00