Identification of beta-oncofetal antigen in cervical squamous cancer and its demonstration in neoplastic and normal tissues.

abstract：:Infection of tumor cells by herpes simplex virus 1 (HSV-1) results in cell destruction and production of progeny virion in a process referred to as viral oncolysis. In this study, an HSV-1 mutant (HSV1yCD) was engineered such that the viral ribonucleotide reductase gene is disrupted by sequences encoding yeast cytosin...

journal_title：Cancer research

authors： Nakamura H,Mullen JT,Chandrasekhar S,Pawlik TM,Yoon SS,Tanabe KK

更新日期：2001-07-15 00:00:00

abstract：:Adult rat parenchymal hepatocytes in primary culture can be induced to enter into DNA synthesis and mitosis. The optimal conditions for hepatocyte replication are low plating density (less than 10,000 cells/sq cm) and 50% serum from two-thirds partially hepatectomized rats (48 hr after hepatectomy). Approximately 80% ...

journal_title：Cancer research

authors： Michalopoulos G,Cianciulli HD,Novotny AR,Kligerman AD,Strom SC,Jirtle RL

更新日期：1982-11-01 00:00:00

abstract：:Dendritic epidermal T-cells (DETC) are a unique population of T-cells that reside normally in mouse epidermis and express a gamma delta T-cell receptor. We have reported previously that DETC acquire in culture the capacity to lyse the YAC-1 lymphoma, a conventional target for natural killer cells. The aim of the prese...

journal_title：Cancer research

authors： Kaminski MJ,Cruz PD Jr,Bergstresser PR,Takashima A

更新日期：1993-09-01 00:00:00

abstract：:Active-specific immunotherapy with dendritic cells loaded with peptide derived from the melanoma antigen, gp100, failed to mediate regression of established B16F10 melanoma in normal mice. Dendritic cell vaccination induced activation and subsequent deletion of adoptively transferred naive CD8+ T-cell receptor transge...

journal_title：Cancer research

authors： Wang LX,Li R,Yang G,Lim M,O'Hara A,Chu Y,Fox BA,Restifo NP,Urba WJ,Hu HM

更新日期：2005-11-15 00:00:00

abstract：:[D-Arg1,D-Trp5,7,9,Leu11]Substance P (SP) was identified out of a panel of novel SP analogues as the most potent inhibitor of small cell lung cancer (SCLC) cell growth. This analogue inhibited proliferation of H-510 and H-69 SCLC cells in liquid culture and in semisolid media (IC50, 5 microM). Colony formation stimula...

journal_title：Cancer research

authors： Seckl MJ,Higgins T,Widmer F,Rozengurt E

更新日期：1997-01-01 00:00:00

abstract：:[SP-4-3-(R)]-[1,1-cyclobutanedicarboxylato(2-)](2-methyl-1,4- butane-diamine-N,N')platinum (CI-973) is a cisplatin analogue that is currently in clinical trial. Preclinically, CI-973 retained activity against L1210, P388, K562, and human ovarian carcinoma sublines resistant to cisplatin in vitro. CI-973 also retained ...

journal_title：Cancer research

authors： Elliott WL,Roberts BJ,Howard CT,Leopold WR 3rd

更新日期：1994-08-15 00:00:00

abstract：:Anti-idiotypic monoclonal antibodies (MoAbs) were prepared in a syngeneic system against anti-carcinoembryonic antigen (CEA) MoAb 5B3 (IgG1), which reacted with a carbohydrate moiety on CEA, and MoAb MA208 (IgG1), which reacted with a peptide on CEA. Anti-idiotypic MoAb T3-503 and T4-202 recognized the private idiotyp...

journal_title：Cancer research

authors： Tsujisaki M,Imai K,Tokuchi S,Hanzawa Y,Ishida T,Kitagawa H,Hinoda Y,Yachi A

更新日期：1991-05-15 00:00:00

abstract：:Thyroid-stimulating hormone (TSH) has long been recognized as the major proliferative and functional stimulus for thyroid follicular cells. TSH receptor (TSHR) engagement stimulates the production of cyclic AMP and the subsequent activation of downstream effector molecules, including protein kinase A, S6K1, and Rap1, ...

journal_title：Cancer research

authors： Brewer C,Yeager N,Di Cristofano A

更新日期：2007-09-01 00:00:00

abstract：:Breast carcinomas < or = 1 cm in size (T1a,b) are being detected more frequently as a result of screening. Because traditional prognostic parameters are either lacking (tumor size) or rare (nodal metastases), a marker(s) is needed to identify the subset of patients who could benefit from adjuvant therapy. A retrospect...

journal_title：Cancer research

authors： Tan P,Cady B,Wanner M,Worland P,Cukor B,Magi-Galluzzi C,Lavin P,Draetta G,Pagano M,Loda M

更新日期：1997-04-01 00:00:00

abstract：:Targeting the tyrosine kinase activity of Bcr-Abl is an attractive therapeutic strategy in chronic myeloid leukemia (CML) and in Bcr-Abl-positive acute lymphoblastic leukemia. Whereas imatinib, a selective inhibitor of Bcr-Abl tyrosine kinase, is now used in frontline therapy for CML, second-generation inhibitors of B...

journal_title：Cancer research

authors： Mahon FX,Hayette S,Lagarde V,Belloc F,Turcq B,Nicolini F,Belanger C,Manley PW,Leroy C,Etienne G,Roche S,Pasquet JM

更新日期：2008-12-01 00:00:00

abstract：:Metformin may reduce the progression of head and neck squamous cell carcinoma (HNSCC); however, whether metformin acts by altering the host metabolism or targets cancer-initiating cells remains poorly understood. This gap in knowledge has prevented the stratification of patient populations who are most likely to benef...

journal_title：Cancer research

authors： Wu X,Yeerna H,Goto Y,Ando T,Wu VH,Zhang X,Wang Z,Amornphimoltham P,Murphy AN,Tamayo P,Chen Q,Lippman SM,Gutkind JS

更新日期：2019-09-01 00:00:00

abstract：:The antitumoral effects of oncolytic viruses have generally been limited by inefficient spread of the viruses within infected tumors and by inefficient systemic delivery, particularly in preimmunized hosts. Tumor-selective poxviruses have biological characteristics that may overcome these limitations. Nevertheless, ph...

journal_title：Cancer research

authors： Kirn DH,Wang Y,Liang W,Contag CH,Thorne SH

更新日期：2008-04-01 00:00:00

abstract：:Inherited mutations of the human BRCA2 gene confer increased risks for developing breast, ovarian, and several other cancers. Unlike previously described Brca2 knockout mice that display predominantly embryonic lethal phenotypes, we developed mice with a homozygous germ-line deletion of Brca2 exon 27 that exhibit a mo...

journal_title：Cancer research

authors： McAllister KA,Bennett LM,Houle CD,Ward T,Malphurs J,Collins NK,Cachafeiro C,Haseman J,Goulding EH,Bunch D,Eddy EM,Davis BJ,Wiseman RW

更新日期：2002-02-15 00:00:00

abstract：:Tumor suppressor p53-dependent apoptosis is thought to be one of the most important tumor-suppressive functions in human tumorigenesis. However, whether the major mechanism underlying the p53-dependent apoptosis is transactivation dependent or independent remains unclear. Using 179 mutant p53s with diverse transcripti...

journal_title：Cancer research

authors： Kakudo Y,Shibata H,Otsuka K,Kato S,Ishioka C

更新日期：2005-03-15 00:00:00

abstract：:Distal enhancers have recently emerged as a common mode of gene regulation for several transcription factors, including estrogen and androgen receptors, the two key regulators of breast and prostate cancer major subtypes. Despite the rapid success in genome-wide annotation of estrogen receptor-alpha (ERalpha) binding ...

journal_title：Cancer research

authors： Chan CS,Song JS

更新日期：2008-11-01 00:00:00

abstract：:An animal lectin purified from loach (Misgurnus anguillicaudatus) eggs induced release of cytotoxin from fresh bone marrow cells from mice, although the other lectins tested, wheat germ agglutinin, concanavalin A, and phytohemagglutinin did not. The cytotoxin released from bone marrow cells was a heat-labile protein w...

journal_title：Cancer research

authors： Okutomi T,Nakajima Y,Sakakibara F,Kawauchi H,Yamazaki M

更新日期：1987-01-01 00:00:00

abstract：:In L1210 cells in culture, 3-deazaguanine (DG), a relatively new purine analog, was found to inhibit DNA and protein synthesis but not total RNA synthesis. The effect of the drug on protein synthesis was therefore further examined. Polyadenylic acid-containing RNA synthesis was not decreased by DG treatment, suggestin...

journal_title：Cancer research

authors： Rivest RS,Irwin D,Mandel HG

更新日期：1982-10-01 00:00:00

abstract：:Inhibitors of 5alpha-reductase (SRD5A) that lower intraprostatic levels of dihydrotestosterone (DHT) reduce the overall incidence of prostate cancer (PCa), but there is significant variation in chemopreventive activity between individual men. In seeking molecular alterations that might underlie this variation, we comp...

journal_title：Cancer research

authors： Mostaghel EA,Geng L,Holcomb I,Coleman IM,Lucas J,True LD,Nelson PS

更新日期：2010-02-15 00:00:00

abstract：:The chemopreventive effects of two xanthophylls, astaxanthin (AX) and canthaxanthin (CX) on oral carcinogenesis induced by 4-nitroquinoline 1-oxide (4-NQO) was investigated in male F344 rats. Rats were given 20 ppm of 4-NQO in their drinking water for 8 weeks to induce oral neoplasms or preneoplasms. Animals were fed ...

journal_title：Cancer research

authors： Tanaka T,Makita H,Ohnishi M,Mori H,Satoh K,Hara A

更新日期：1995-09-15 00:00:00

abstract：:Isozymes of carbamyl phosphate synthetase (CPS), CPS I, a mitochondrial enzyme found exclusively in liver and involved in urea synthesis, and of CPS II, a soluble cytoplasmic enzyme widely distributed in animal tissues, were assayed in rat liver and in a series of rat liver neoplasms ranging widely in growth rate and ...

journal_title：Cancer research

authors： Lawson D,Paik WK,Morris HP,Weinhouse S

更新日期：1975-01-01 00:00:00

abstract：:The urokinase-type plasminogen activator (u-PA) was used to study 96 cases of lung adenocarcinoma and 49 cases of lymph node metastatic adenocarcinoma. We made use of the immunohistochemistry of paraffinized samples. u-PA was detected in the cytoplasm of tumor cells, and the number of positive cells was higher in pati...

journal_title：Cancer research

authors： Oka T,Ishida T,Nishino T,Sugimachi K

更新日期：1991-07-01 00:00:00

abstract：:We have examined the ability of ingenol to bind to and activate protein kinase C and to induce similar responses to the phorbol esters in biological systems. The rationale was that ingenol possesses the critical functionalities of the phorbol ester pharmacophore with the exception of the hydrophobic domain; it might t...

journal_title：Cancer research

authors： Hasler CM,Acs G,Blumberg PM

更新日期：1992-01-01 00:00:00

abstract：:Imatinib currently represents the standard treatment in the early chronic phase of chronic myelogenous leukemia (CML), thanks to the high percentage of cytogenetic complete remission achieved, but it is yet unclear to what extent it can eradicate leukemia. Therefore, different vaccination strategies have been suggeste...

journal_title：Cancer research

authors： Volpe G,Cignetti A,Panuzzo C,Kuka M,Vitaggio K,Brancaccio M,Perrone G,Rinaldi M,Prato G,Fava M,Geuna M,Pautasso M,Casnici C,Signori E,Tonon G,Tarone G,Marelli O,Fazio VM,Saglio G

更新日期：2007-06-01 00:00:00

abstract：:Chromosomal passenger complex (CPC) has been demonstrated to be a potential target of cancer therapy by inhibiting Aurora B or survivin in different types of cancer including neuroblastoma. However, chemical inhibition of either Aurora B or survivin does not target CPC specifically due to off-target effects or CPC-ind...

journal_title：Cancer research

authors： Sun M,Veschi V,Bagchi S,Xu M,Mendoza A,Liu Z,Thiele CJ

更新日期：2019-10-01 00:00:00

abstract：:The antiapoptotic protein bcl-2 is found up-regulated in a number of malignant and premalignant skin conditions of keratinocyte origin, but in normal skin, it is expressed at low levels only in interfollicular epidermis. To investigate whether unregulated bcl-2 expression could affect the incidence of epidermal tumors...

journal_title：Cancer research

authors： Rossiter H,Beissert S,Mayer C,Schön MP,Wienrich BG,Tschachler E,Kupper TS

更新日期：2001-05-01 00:00:00

abstract：:Malignant astrocytoma is one of the most deadly primary central nervous system tumors. Although significant progress has been made in understanding the molecular pathways that lead to the development of these tumors in adults, comparatively little analysis has been done in childhood astrocytomas, which are less common...

journal_title：Cancer research

authors： Pollack IF,Finkelstein SD,Burnham J,Holmes EJ,Hamilton RL,Yates AJ,Finlay JL,Sposto R,Children's Cancer Group.

更新日期：2001-10-15 00:00:00

abstract：:The effects of transforming growth factor-beta (TGF beta) on a human colon carcinoma cell line (MOSER) were investigated. TGF beta, at low concentrations (between 0.1 and 1.0 ng/ml), inhibited the proliferation of MOSER cells both in monolayer culture and soft agarose, in a dose-dependent manner. MOSER cells adapted t...

journal_title：Cancer research

authors： Hoosein NM,Brattain DE,McKnight MK,Levine AE,Brattain MG

更新日期：1987-06-01 00:00:00

abstract：:The multistage process of cancer formation is driven by the progressive acquisition of somatic mutations. Replication stress creates genomic instability in mammals. Using a well-defined multistep leukemia model driven by Spi-1/PU.1 overexpression in the mouse and Spi-1/PU.1-overexpressing human leukemic cells, we inve...

journal_title：Cancer research

authors： Rimmelé P,Komatsu J,Hupé P,Roulin C,Barillot E,Dutreix M,Conseiller E,Bensimon A,Moreau-Gachelin F,Guillouf C

更新日期：2010-09-01 00:00:00

abstract：:The involvement of immune response in the resistance of chemically induced stomach cancer was studied in a resistant rat strain (Buffalo) and a sensitive rat strain (ACI). Groups of 10 male Buffalo and ACI rats, 6 weeks of age, were given drinking water with or without N-methyl-N'-nitro-N-nitrosoguanidine (MNNG; 100 m...

journal_title：Cancer research

authors： Oka M,Furihata C,Kitoh K,Yamamoto M,Tatematsu M,Ichinose M,Miki K,Ito T,Sakaki Y,Reske K

更新日期：1998-09-15 00:00:00

abstract：:The fibroblast growth factors (FGF) play diverse roles in development, wound healing, and angiogenesis. The intracellular signal transduction pathways, which mediate these pleiotropic activities, remain incompletely understood. We show here that the proangiogenic factors FGF2 and FGF8b can activate signal transducers ...

journal_title：Cancer research

authors： Yang X,Qiao D,Meyer K,Friedl A

更新日期：2009-02-15 00:00:00