Frequent mutation of Apc gene in rat colon tumors and mucin-depleted foci, preneoplastic lesions in experimental colon carcinogenesis.

abstract：:MicroRNAs are noncoding RNAs that inhibit the expression of their targets in a sequence-specific manner and play crucial roles during oncogenesis. Here we show that microRNA-7 (miR-7) inhibits p21-activated kinase 1 (Pak1) expression, a widely up-regulated signaling kinase in multiple human cancers, by targeting the 3...

journal_title：Cancer research

authors： Reddy SD,Ohshiro K,Rayala SK,Kumar R

更新日期：2008-10-15 00:00:00

abstract：:In a study of human breast carcinomas in short-term organ culture, in which plasminogen activator modulation by estrogen was used as a test of estrogen sensitivity (R. Mira-y-Lopez and L. Ossowski, Cancer Res., 47: 3558-3564, 1987), we found that the number of estrogen and progesterone receptor-positive cancers showin...

journal_title：Cancer research

authors： Mira-y-Lopez R,Ossowski L

更新日期：1990-01-01 00:00:00

abstract：:The detection of high-grade bladder tumors prior to invasion is crucial for a good prognosis. We recently found that the levels of hyaluronic acid (HA), a glycosaminoglycan, are elevated in the urine of bladder cancer patients, and small angiogenic HA fragments are present in the urine of high-grade bladder cancer pat...

journal_title：Cancer research

authors： Pham HT,Block NL,Lokeshwar VB

更新日期：1997-02-15 00:00:00

abstract：:Multi-targeting strategies improve the efficacy of antibody and immunotoxin therapies but have not yet been thoroughly explored for HER2-based cancer treatments. We investigated multi-epitope HER2 targeting to boost photosensitizer immunoconjugate uptake as a way of enhancing photoimmunotherapy. Photoimmunotherapy may...

journal_title：Cancer research

authors： Savellano MD,Pogue BW,Hoopes PJ,Vitetta ES,Paulsen KD

更新日期：2005-07-15 00:00:00

abstract：:ErbB-2 (HER-2/neu) is a transforming oncogene expressed by a substantial fraction of breast cancers, and monoclonal antibody therapy directed toward this antigen is an established treatment modality. However, not all tumors respond, and with a monoclonal antibody directed to a single epitope, there is always the risk ...

journal_title：Cancer research

authors： Park JM,Terabe M,Steel JC,Forni G,Sakai Y,Morris JC,Berzofsky JA

更新日期：2008-03-15 00:00:00

abstract：:The single-dose toxicokinetics of N-nitrosomethyl(2-hydroxyethyl)amine (NMHA) has been characterized in 8-week-old Fischer 344 rats by analysis using high-performance liquid chromatography of serial blood samples. An i.v. bolus dose of 0.6 mumol/kg to male rats revealed biphasic first-order elimination with a terminal...

journal_title：Cancer research

authors： Streeter AJ,Nims RW,Hrabie JA,Heur YH,Keefer LK

更新日期：1989-04-01 00:00:00

abstract：:Cell lines designated SNG-P and SNG-M were established from operation specimens of primary and metastatic regions of human endometrial adenocarcinoma. The cell lines grew well without interruption for over 13 months and were subcultivated more than 65 times. They continue to exhibit stable growth. The cultured cells a...

journal_title：Cancer research

authors： Ishiwata I,Nozawa S,Inoue T,Okumura H

更新日期：1977-06-01 00:00:00

abstract：:Cancer chemotherapy may be improved by increasing antineoplastic drug specificity for tumor cells. We have synthesized a glucuronide prodrug that can be enzymatically converted to an antineoplastic agent at tumor cells that are able to bind beta-glucuronidase-monoclonal antibody conjugates. The glucuronide prodrug BHA...

journal_title：Cancer research

authors： Wang SM,Chern JW,Yeh MY,Ng JC,Tung E,Roffler SR

更新日期：1992-08-15 00:00:00

abstract：:alpha(v)beta(3) integrin was investigated in multiple myeloma in relation to the in vitro osteoclast-like activity of malignant plasma cells. Myeloma cells from patients with skeleton involvement overexpressed alpha(v)beta(3) and produced erosion pits on bone substrates, whereas this effect was not observed by cells f...

journal_title：Cancer research

authors： Tucci M,De Palma R,Lombardi L,Rodolico G,Berrino L,Dammacco F,Silvestris F

更新日期：2009-08-15 00:00:00

abstract：:Loss of DNA mismatch repair (MMR) increases the risk of spontaneous mutations. We sought to determine whether there was an interaction between hypoxia and MMR deficiency that might contribute to the phenomenon of tumor progression. Human colon carcinoma HCT116+ch2 (MMR-deficient) and HCT116+ch3 (MMR-proficient) sublin...

journal_title：Cancer research

authors： Kondo A,Safaei R,Mishima M,Niedner H,Lin X,Howell SB

更新日期：2001-10-15 00:00:00

abstract：:There is a preclinical evidence that the oral administration of d,l-sulforaphane (SFN) can decrease the incidence or burden of early-stage prostate cancer [prostatic intraepithelial neoplasia (PIN)] and well-differentiated cancer (WDC) but not late-stage poorly differentiated cancer (PDC). Because SFN treatment induce...

journal_title：Cancer research

authors： Vyas AR,Hahm ER,Arlotti JA,Watkins S,Stolz DB,Desai D,Amin S,Singh SV

更新日期：2013-10-01 00:00:00

abstract：:Oncogenic activation of the BRAF serine/threonine kinase has been associated with initiation and maintenance of melanoma tumors. As such, development of pharmacologic agents to target RAF proteins or their effector kinases is an area of intense investigation. Here we report the biological properties of GDC-0879, a hig...

journal_title：Cancer research

authors： Hoeflich KP,Herter S,Tien J,Wong L,Berry L,Chan J,O'Brien C,Modrusan Z,Seshagiri S,Lackner M,Stern H,Choo E,Murray L,Friedman LS,Belvin M

更新日期：2009-04-01 00:00:00

abstract：:The process of myeloid differentiation in human promyelocytic leukemia cells (HL-60) is accompanied by the coordinate expression of numerous protooncogenes. To investigate the expression of transforming growth factor alpha (TGF-alpha) in myeloid differentiation, HL-60 cells were induced to differentiate into granulocy...

journal_title：Cancer research

authors： Walz TM,Malm C,Wasteson A

更新日期：1993-01-01 00:00:00

abstract：:Cancer vaccines may have applications in the therapy and prevention of mammary carcinoma. To investigate such applications, we constructed a recombinant adenoviral vaccine expressing a kinase-inactive mutant form of human HER2 and introduced this into BALB/c wild-type (WT) or HER2 transgenic mice. Here, we report cont...

journal_title：Cancer research

authors： Triulzi C,Vertuani S,Curcio C,Antognoli A,Seibt J,Akusjärvi G,Wei WZ,Cavallo F,Kiessling R

更新日期：2010-10-01 00:00:00

abstract：:Although the cyclin-dependent kinases CDK4 and CDK6 play fundamental roles in cancer, the specific pathways and downstream targets by which they exert their tumorigenic effects remain elusive. In this study, we uncover distinct and novel functions for these kinases in regulating tumor formation and metastatic coloniza...

journal_title：Cancer research

authors： Dai M,Boudreault J,Wang N,Poulet S,Daliah G,Yan G,Moamer A,Burgos SA,Sabri S,Ali S,Lebrun JJ

更新日期：2020-12-28 00:00:00

abstract：:The ubiquitous food contaminant cadmium has features of an estrogen mimetic that may promote the development of estrogen-dependent malignancies, such as breast cancer. However, no prospective studies of cadmium exposure and breast cancer risk have been reported. We examined the association between dietary cadmium expo...

journal_title：Cancer research

authors： Julin B,Wolk A,Bergkvist L,Bottai M,Akesson A

更新日期：2012-03-15 00:00:00

abstract：:The notion that nuclear factor-kappaB (NF-kappaB) is a tumor-promoting transcription factor has become a widely accepted dogma in biology. However, recent findings suggest an inhibitory role for NF-kappaB in carcinogenesis and tumorigenesis. Although the tumor suppressor-like effect of NF-kappaB remains to be rigorous...

journal_title：Cancer research

authors： Chen F,Castranova V

更新日期：2007-12-01 00:00:00

abstract：:Low oxygen levels have been shown to promote self-renewal in many stem cells. In tumors, hypoxia is associated with aggressive disease course and poor clinical outcomes. Furthermore, many aggressive tumors have been shown to display gene expression signatures characteristic of human embryonic stem cells (hESC). We now...

journal_title：Cancer research

authors： Mathieu J,Zhang Z,Zhou W,Wang AJ,Heddleston JM,Pinna CM,Hubaud A,Stadler B,Choi M,Bar M,Tewari M,Liu A,Vessella R,Rostomily R,Born D,Horwitz M,Ware C,Blau CA,Cleary MA,Rich JN,Ruohola-Baker H

更新日期：2011-07-01 00:00:00

abstract：:Three Burkitt's lymphoma cell lines were studied for their response to cis-diamminedichloroplatinum(II) (cis-DDP) and L-phenylalanine mustard (L-PAM) with the objective of relating cytotoxicity to DNA cross-linking in human cells. Cytotoxicity was measured by cell proliferation and colony formation assays. DNA interst...

journal_title：Cancer research

authors： Ducore JM,Erickson LC,Zwelling LA,Laurent G,Kohn KW

更新日期：1982-03-01 00:00:00

abstract：:In continuation of earlier studies on murine neoplastic liver lesions, we characterized by histochemical methods the phenotype of hepatocellular adenomas and carcinomas induced by single injections of diethylnitrosamine (1.25, 2.5, or 5.0 micrograms/g of body weight) in 15-day-old C57BL/6 x male C3H F1 mice. The hepat...

journal_title：Cancer research

authors： Hacker HJ,Mtiro H,Bannasch P,Vesselinovitch SD

更新日期：1991-04-01 00:00:00

abstract：:A combination of paclitaxel (Taxol) and mitogen-activated protein/extracellular signal-regulated kinase kinase (MEK/Erk) inhibitor represents a rational new approach to chemotherapy. We performed Affymetrix microarray analysis to understand the global effects of this combination in lung carcinoma. Genes involved in ce...

journal_title：Cancer research

authors： Taxman DJ,MacKeigan JP,Clements C,Bergstralh DT,Ting JP

更新日期：2003-08-15 00:00:00

abstract：:Human bronchial carcinoma is thought to develop through progressive stages from basal cell hyperplasia to squamous metaplasia, dysplasia, carcinoma in situ, and finally invasive cancer. In this study, we used tissue microdissection to examine loss of heterozygosity of chromosomes 3p21, 5q21, and 9p21 at each stage of ...

journal_title：Cancer research

authors： Thiberville L,Payne P,Vielkinds J,LeRiche J,Horsman D,Nouvet G,Palcic B,Lam S

更新日期：1995-11-15 00:00:00

abstract：:Promoter hypermethylation and histone deacetylation are common epigenetic mechanisms implicated in the transcriptional silencing of tumor suppressor genes in human cancer. We treated two immortalized glioma cell lines, T98 and U87, and 10 patient-derived primary glioma cell lines with trichostatin A (TSA), a histone d...

journal_title：Cancer research

authors： Foltz G,Ryu GY,Yoon JG,Nelson T,Fahey J,Frakes A,Lee H,Field L,Zander K,Sibenaller Z,Ryken TC,Vibhakar R,Hood L,Madan A

更新日期：2006-07-01 00:00:00

abstract：:Isothiocyanates exert strong anticarcinogenic effects in a number of animal models of cancer, presumably by modulation of xenobiotic-metabolizing enzymes, such as by inhibition of cytochrome P-450 and/or by induction of phase II detoxifying enzymes. Here, we report that phenethyl isothiocyanate and other structurally ...

journal_title：Cancer research

authors： Yu R,Mandlekar S,Harvey KJ,Ucker DS,Kong AN

更新日期：1998-02-01 00:00:00

abstract：:Allelic loss of chromosome region 3p21.3 occurs early and frequently in non-small-cell lung cancer, and numerous tumor suppressor genes at this locus may be targets of inactivation. Using an incident case series study of non-small-cell lung cancer, we sought to determine the prevalence of loss of heterozygosity (LOH) ...

journal_title：Cancer research

authors： Marsit CJ,Hasegawa M,Hirao T,Kim DH,Aldape K,Hinds PW,Wiencke JK,Nelson HH,Kelsey KT

更新日期：2004-12-01 00:00:00

abstract：:We have pursued our analysis of antigens recognized by autologous cytolytic T lymphocytes (CTLs) on the melanoma cells of patient LB33. This patient enjoys an unusually favorable evolution, which is associated with a strong and sustained antitumor CTL response. We reported previously the analysis of two melanoma cell ...

journal_title：Cancer research

authors： Chiari R,Foury F,De Plaen E,Baurain JF,Thonnard J,Coulie PG

更新日期：1999-11-15 00:00:00

abstract：:Although trastuzumab (Herceptin) has substantially improved the overall survival of patients with mammary carcinomas, even initially well-responding tumors often become resistant. Because natural killer (NK) cell-mediated antibody-dependent cell-mediated cytotoxicity (ADCC) is thought to contribute to the therapeutic ...

journal_title：Cancer research

authors： Reim F,Dombrowski Y,Ritter C,Buttmann M,Häusler S,Ossadnik M,Krockenberger M,Beier D,Beier CP,Dietl J,Becker JC,Hönig A,Wischhusen J

更新日期：2009-10-15 00:00:00

abstract：:Immunotherapy for breast cancer using cytotoxic T cells (CTL) is hindered by the lack of well-characterized breast cancer antigens that are expressed in most breast tumor cells and recognized by CD8+ CTL. A recently described breast tissue differentiation antigen, NY-BR-1, is expressed in >80% breast tumors and elicit...

journal_title：Cancer research

authors： Wang W,Epler J,Salazar LG,Riddell SR

更新日期：2006-07-01 00:00:00

abstract：:EphB4 receptor and its ligand ephrinB2 play an important role in vascular development during embryogenesis. In blood vessels, ephrinB2 is expressed in arterial endothelial cells (EC) and mesenchymal supporting cells, whereas EphB4 is only expressed in venous ECs. Previously, we reported that OP9 stromal cells, which s...

journal_title：Cancer research

authors： Huang X,Yamada Y,Kidoya H,Naito H,Nagahama Y,Kong L,Katoh SY,Li WL,Ueno M,Takakura N

更新日期：2007-10-15 00:00:00

abstract：:The effects on Leydig cell tumorigenesis of surgical cryptorchidy, parabiotic union with a castrate male partner, and a combination on the two procedures as well as of the continuous exposure to a high level of diethylstilbestrol stimulation were studied in the high-tumor Fischer rat. Localized foci of adenomatous hyp...

journal_title：Cancer research

authors： Huseby RA

更新日期：1981-08-01 00:00:00