GPx2 suppression of H2O2 stress links the formation of differentiated tumor mass to metastatic capacity in colorectal cancer.

abstract：:Cells of cloned lines of human squamous lung carcinomas elaborate large glycoproteins that are associated with their tumorigenic potential. Two groups of clones (called Le(a)-X-positive and Le(a)-X-negative) were studied that either do or do not express the Le(a)-X oligosaccharide associated with large glycoproteins a...

journal_title：Cancer research

authors： Stranahan PL,Howard RB,Pfenninger O,Cowen ME,Johnston MR,Pettijohn DE

更新日期：1992-05-15 00:00:00

abstract：:Adriamycin, amsacrine, and etoposide produce protein-associated DNA breaks in numerous cell types. However, in vitro exposure to Adriamycin (0.1-50.0 micrograms/ml) resulted in no detectable DNA cleavage in lymphocytes from patients with B-cell chronic lymphocytic leukemia (CLL) or in either B- or T-lymphocytes from n...

journal_title：Cancer research

authors： Potmesil M,Hsiang YH,Liu LF,Bank B,Grossberg H,Kirschenbaum S,Forlenza TJ,Penziner A,Kanganis D

更新日期：1988-06-15 00:00:00

abstract：:In our previous studies carried out on inbred rats of the Sprague-Dawley strain (L. Gross and Y. Dreyfuss, Proc. Natl. Acad. Sci. USA, 76: 5910-5913, 1979), the tumor incidence was increased following irradiation (150 rads, 5 times, at weekly intervals), from 22 to 93% in females and from 5 to 59% in males. Experiment...

journal_title：Cancer research

authors： Gross L,Dreyfuss Y,Faraggiana T

更新日期：1988-05-01 00:00:00

abstract：:Two opposing clusters of transcription factors (TF) have been associated with the differential risks of estrogen receptor positive or negative breast cancers, but the mechanisms underlying the opposing functions of the two clusters are undefined. In this study, we identified NFIB and YBX1 as novel interactors of the e...

journal_title：Cancer research

authors： Campbell TM,Castro MAA,de Oliveira KG,Ponder BAJ,Meyer KB

更新日期：2018-01-15 00:00:00

abstract：:An in vivo transplantation technique has been developed which can be utilized to determine the reproductive survival of parenchymal hepatocytes exposed either in vitro or in vivo to both physical and chemical genotoxic agents. We have used this assay system to determine the survival of liver cells exposed to sparsely ...

journal_title：Cancer research

authors： Jirtle RL,Michalopoulos G,McLain JR,Crowley J

更新日期：1981-09-01 00:00:00

abstract：:The ability of the phorbol ester tumor promoter 12-O-tetradecanoylphorbol- 13-acetate (TPA) to lead to the activation of cyclic adenosine 3':5'-monophosphate (cAMP)-dependent protein kinase was investigated in three cell lines. In the Reuber H35 hepatoma cells, TPA (1.6 microM) led to an increase in the protein kinase...

journal_title：Cancer research

authors： Byus CV,Trevillyan JM,Cavit LJ,Fletcher WH

更新日期：1983-07-01 00:00:00

abstract：:The molecular mechanisms by which human cancer cells spread to bone are largely unexplored. The process likely involves cell adhesion molecules (CAMs) that are responsible for homophilic and heterophilic cell-cell interactions. One relevant CAM may be the calcium-dependent transmembrane glycoprotein E-cadherin. To inv...

journal_title：Cancer research

authors： Mbalaviele G,Dunstan CR,Sasaki A,Williams PJ,Mundy GR,Yoneda T

更新日期：1996-09-01 00:00:00

abstract：:We have previously shown that mice simultaneously infected with the murine mammary tumor virus (MuMTV) and with certain slow murine leukemia viruses (MLV) have an increased resistance to the pathological effects of both agents. Here we report that milk-transmitted MuMTV also delays the development of the acute erythro...

journal_title：Cancer research

authors： Basolo F,Toniolo A,Bistocchi M,Fontanini G,Squartini F

更新日期：1986-08-01 00:00:00

abstract：:Recent studies have shown that the Bcl-2 protein suppresses programmed cell death or apoptosis induced by a variety of stimuli including chemotherapeutic drugs. Because estrogen promotes the survival of estrogen-dependent breast cancer cells in vivo, we investigated whether estrogen might regulate levels of Bcl-2 gene...

journal_title：Cancer research

authors： Teixeira C,Reed JC,Pratt MA

更新日期：1995-09-01 00:00:00

abstract：:Fps/Fes proteins were among the first members of the protein tyrosine kinase family to be characterized as dominant-acting oncoproteins. Addition of retroviral GAG sequences or other experimentally induced mutations activated the latent transforming potential of Fps/Fes. However, activating mutations in fps/fes had no...

journal_title：Cancer research

authors： Sangrar W,Zirgnibl RA,Gao Y,Muller WJ,Jia Z,Greer PA

更新日期：2005-05-01 00:00:00

abstract：:The availability of purified human recombinant interleukin 2 (IL-2) has enabled clinical trials to test its in vivo effects. We report here the immunological effects of 7 consecutive days of IL-2 treatment given to 25 patients with cancer in a clinical Phase I study. Peripheral blood lymphocytes obtained from patients...

journal_title：Cancer research

authors： Hank JA,Kohler PC,Weil-Hillman G,Rosenthal N,Moore KH,Storer B,Minkoff D,Bradshaw J,Bechhofer R,Sondel PM

更新日期：1988-04-01 00:00:00

abstract：:The Morris hepatocellular carcinoma 7777 is productive of extraordinarily high levels of the oncofetal protein, alpha-fetoprotein. Its chromosome composition was examined in detail since it represents the only near-diploid tumor of such productivity and has been reported to demonstrate a single unusual chromosomal alt...

journal_title：Cancer research

authors： Wolman SR,Cohen TI,Becker FF

更新日期：1977-08-01 00:00:00

abstract：:CTLA4 is a cell surface receptor on T cells that functions as an immune checkpoint molecule to enforce tolerance to cognate antigens. Anti-CTLA4 immunotherapy is highly effective at reactivating T-cell responses against melanoma, which is postulated to be due to targeting CTLA4 on T cells. Here, we report that CTLA4 i...

journal_title：Cancer research

authors： Mo X,Zhang H,Preston S,Martin K,Zhou B,Vadalia N,Gamero AM,Soboloff J,Tempera I,Zaidi MR

更新日期：2018-01-15 00:00:00

abstract：:Although polyamines are well recognized for their critical involvement in cell growth, the cell cycle specificity of this requirement has not yet been characterized with respect to the newly delineated regulatory pathways. We recently reported that polyamine analogues having close structural and functional similaritie...

journal_title：Cancer research

authors： Kramer DL,Vujcic S,Diegelman P,Alderfer J,Miller JT,Black JD,Bergeron RJ,Porter CW

更新日期：1999-03-15 00:00:00

abstract：:Three widely studied cell lines were used to examine the nature of the G1 arrest induced in human tumor cells by ionizing radiation and its relation to p53 status. Cell lines MCF-7 and RKO express wild-type p53, whereas HT29 expresses mutant p53. Exponentially growing cells were irradiated with 6 Gy, and the progressi...

journal_title：Cancer research

authors： Nagasawa H,Li CY,Maki CG,Imrich AC,Little JB

更新日期：1995-05-01 00:00:00

abstract：:Tumor resistance to cytotoxic drugs is one of the main obstacles to successful cancer therapy. Emerging evidence suggests that chemoresistance is promoted by substances released from dead and damaged cells that activate the host repair program orchestrated by Toll-like receptor-4 (TLR4). TLR4 is often overexpressed in...

journal_title：Cancer research

authors： Ran S

更新日期：2015-06-15 00:00:00

abstract：:We studied the clinical and karyotypic features of 50 patients with acute lymphoblastic leukemia, including 33 American and 17 Japanese patients, at two institutions. Clonal chromosome abnormalities were found in 39 of the 50 patients (78%) at diagnosis. Eleven patients had diploidy (N patients). Among the 39 aneuploi...

journal_title：Cancer research

authors： Kaneko Y,Rowley JD,Variakojis D,Chilcote RR,Check I,Sakurai M

更新日期：1982-07-01 00:00:00

abstract：:Genetic alterations that occur in human breast cancers are believed to be of importance for initiation as well as progression of the disease. In order to find a genetic alteration that may be used as a prognostic marker, 82 familial breast carcinomas were analyzed for loss of constitutional heterozygosity at polymorph...

journal_title：Cancer research

authors： Lindblom A,Rotstein S,Skoog L,Nordenskjöld M,Larsson C

更新日期：1993-08-15 00:00:00

abstract：:Oligomerization of the nonreceptor tyrosine kinase c-Abl can activate its transforming potential. Domains mediating oligomerization within the BCR-ABL and TEL-ABL oncoproteins are required for transforming activity, and fusion of inducible dimerization domains to c-Abl can generate chimeric proteins with dimerization-...

journal_title：Cancer research

authors： Fan PD,Cong F,Goff SP

更新日期：2003-02-15 00:00:00

abstract：:Galectin-3, a beta-galactoside binding protein, plays a significant role in cell to extracellular matrix interactions. Despite its extracellular expression, the precise physiological mechanisms that trigger its release from the intracellular milieu have not been characterized. The present analyses were, therefore, don...

journal_title：Cancer research

authors： Zhu WQ,Ochieng J

更新日期：2001-03-01 00:00:00

abstract：:More than 70% of patients survive childhood cancer, but chemotherapy and radiation therapy may cause irreversible impairment of spermatogenesis. To treat infertility secondary to anticancer treatment for childhood cancer, we have developed a procedure to isolate germ cells from leukemic mice by fluorescence-activated ...

journal_title：Cancer research

authors： Fujita K,Tsujimura A,Miyagawa Y,Kiuchi H,Matsuoka Y,Takao T,Takada S,Nonomura N,Okuyama A

更新日期：2006-12-01 00:00:00

abstract：:The association of intrauterine exposure to diethylstilbestrol (DES) and the subsequent development of reproductive tract abnormalities in young women has been well documented. Although the incidence of vaginal adenocarcinoma was low in the exposed population, vaginal adenosis, a nonmalignant abnormality, was quite co...

journal_title：Cancer research

authors： Newbold RR,McLachlan JA

更新日期：1982-05-01 00:00:00

abstract：:ErbB2 and ErbB3, two members of the ErbB family, form a high-affinity heregulin coreceptor that elicits potent mitogenic and transforming signals, and clinical studies indicate that these receptors play an important role in tumor incidence and progression. To determine whether N-glycosylation is involved in the functi...

journal_title：Cancer research

authors： Yokoe S,Takahashi M,Asahi M,Lee SH,Li W,Osumi D,Miyoshi E,Taniguchi N

更新日期：2007-03-01 00:00:00

abstract：:We have studied the effects of partial polyamine depletion, induced by treatment with alpha-difluoromethylornithine (DFMO) on cell cycle phase distributions in five cultured human carcinoma cell lines. We used flow cytometry of cells stained with chromomycin-A3 and computer analysis to measure phase distributions of t...

journal_title：Cancer research

authors： Seidenfeld J,Block AL,Komar KA,Naujokas MF

更新日期：1986-01-01 00:00:00

abstract：:Previous results have suggested that methotrexate (MTX) could interfere with the repair of spontaneous DNA damage. To determine its effects on induced DNA damage, MTX was compared to hydroxyurea and arabinofuranosylcytosine (H/A), a drug combination known to block the DNA polymerase step of excision repair, for its ab...

journal_title：Cancer research

authors： Borchers AH,Kennedy KA,Straw JA

更新日期：1990-03-15 00:00:00

abstract：:Previous studies have shown that among populations with a high rate of consanguinity, there is a significant increase in the prevalence of cancer. Single nucleotide polymorphism (SNP) array data (Affymetrix, 50K XbaI) analysis revealed long regions of homozygosity in genomic DNAs taken from tumor and matched normal ti...

journal_title：Cancer research

authors： Bacolod MD,Schemmann GS,Wang S,Shattock R,Giardina SF,Zeng Z,Shia J,Stengel RF,Gerry N,Hoh J,Kirchhoff T,Gold B,Christman MF,Offit K,Gerald WL,Notterman DA,Ott J,Paty PB,Barany F

更新日期：2008-04-15 00:00:00

abstract：:Radiation resistance poses a major clinical challenge in cancer treatment, but little is known about how microRNA (miR) may regulate this phenomenon. In this study, we used next-generation sequencing to perform an unbiased comparison of miR expression in PC3 prostate cancer cells rendered resistant to fractionated rad...

journal_title：Cancer research

authors： Huang X,Taeb S,Jahangiri S,Emmenegger U,Tran E,Bruce J,Mesci A,Korpela E,Vesprini D,Wong CS,Bristow RG,Liu FF,Liu SK

更新日期：2013-12-01 00:00:00

abstract：:Palytoxin (PTX), one of the most toxic nonprotein molecules known, is cytotoxic at picomolar concentrations against a wide variety of cell types. In contrast to most cytotoxins, PTX exerts its activity extracellularly. A method for targeting PTX to tumor cells is described in which a monoclonal antibody-enzyme conjuga...

journal_title：Cancer research

authors： Bignami GS,Senter PD,Grothaus PG,Fischer KJ,Humphreys T,Wallace PM

更新日期：1992-10-15 00:00:00

abstract：:Human cutaneous fatty acid-binding protein (C-FABP) gene is capable of inducing the metastatic phenotype when overexpressed in nonmetastatic rat Rama 37 cells. However, the mechanism of how it induces metastasis is not clear. Northern and slot blot analyses revealed that expression of the endogenous vascular endotheli...

journal_title：Cancer research

authors： Jing C,Beesley C,Foster CS,Chen H,Rudland PS,West DC,Fujii H,Smith PH,Ke Y

更新日期：2001-06-01 00:00:00

abstract：:Tumor cell-derived selectin ligands mediate contact to the endothelium, platelets, and leukocytes through binding to selectins that facilitates metastasis. Here, we describe the mechanism of how endogenous (non-tumor derived) selectin ligands contribute to metastasis using α(1,3)fucosyltransferase 7 (Fuc-TVII(-/-))-de...

journal_title：Cancer research

authors： Hoos A,Protsyuk D,Borsig L

更新日期：2014-02-01 00:00:00