Identification of biomarkers modulated by the rexinoid LGD1069 (bexarotene) in human breast cells using oligonucleotide arrays.

abstract：:Previously, we had reported that a single i.p. injection of 15 mg cyclophosphamide (CY) per kg cured most mice bearing large MOPC-315 tumors (20 to 25 mm; Day 12 to Day 16 tumors) but rarely cured mice bearing nonpalpable tumors (Day 4 tumors). Also, mice that were not cured if treated with CY, 15 mg/kg, when they had...

journal_title：Cancer research

authors： Mokyr MB,Hengst JC,Dray S

更新日期：1982-03-01 00:00:00

abstract：:Cancers with chromosomal instability (CIN) are held to be aneuploid/polyploid with multiple large-scale gains/deletions, but the processes underlying CIN are unclear and different types of CIN might exist. We investigated colorectal cancer cell lines using array-comparative genomic hybridization (CGH) for copy number ...

journal_title：Cancer research

authors： Gaasenbeek M,Howarth K,Rowan AJ,Gorman PA,Jones A,Chaplin T,Liu Y,Bicknell D,Davison EJ,Fiegler H,Carter NP,Roylance RR,Tomlinson IP

更新日期：2006-04-01 00:00:00

abstract：:Noninvasive, nonmetastatic BW5147 T-lymphoma cells were transfected with the activated human c-Ha-ras oncogene and were examined subsequently for the acquisition of invasive properties in vitro and of metastatic potential in vivo. It was found that several transfectants harboring the ras gene had become invasive in vi...

journal_title：Cancer research

authors： Collard JG,Schijven JF,Roos E

更新日期：1987-02-01 00:00:00

abstract：:Breast cancer stem-like cells (BCSC) have been implicated in tumor growth, metastasis, drug resistance, and relapse but druggable targets in appropriate subsets of this cell population have yet to be identified. Here we identify a fundamental role for the prolyl isomerase Pin1 in driving BCSC expansion, invasiveness, ...

journal_title：Cancer research

authors： Luo ML,Gong C,Chen CH,Lee DY,Hu H,Huang P,Yao Y,Guo W,Reinhardt F,Wulf G,Lieberman J,Zhou XZ,Song E,Lu KP

更新日期：2014-07-01 00:00:00

abstract：:Previously we described a human B-lymphoma xenotransplantation model in which the immunotherapeutic activity of monoclonal antibodies (mAbs), directed against human B-cell antigens, can be studied. An anti-CD19 mAb of IgG2a subclass was therapeutically active by itself in this model, and its efficacy was increased by ...

journal_title：Cancer research

authors： Vuist WM,van Buitenen F,Hekman A,Melief CJ

更新日期：1990-09-15 00:00:00

abstract：:Alternative splicing is an important mechanism for the generation of protein diversity at a post-transcriptional level. Modifications in the splicing patterns of several genes have been shown to contribute to the malignant transformation of different tissue types. In this study, we used the Affymetrix Exon arrays to i...

journal_title：Cancer research

authors： Menghi F,Jacques TS,Barenco M,Schwalbe EC,Clifford SC,Hubank M,Ham J

更新日期：2011-03-15 00:00:00

abstract：:The proto-oncogene MET is aberrantly activated via overexpression or mutation in numerous cancers, making it a prime anticancer molecular target. However, the clinical success of MET-directed tyrosine kinase inhibitors (TKI) has been limited due, in part, to mutations in the MET kinase domain that confer therapeutic r...

journal_title：Cancer research

authors： Miyajima N,Tsutsumi S,Sourbier C,Beebe K,Mollapour M,Rivas C,Yoshida S,Trepel JB,Huang Y,Tatokoro M,Shinohara N,Nonomura K,Neckers L

更新日期：2013-12-01 00:00:00

abstract：:DNA synthesis was studied in mouse ascites sarcoma cells using a permeable cell system. The sarcoma was induced by the Schmidt-Ruppin strain of Rous sarcoma virus. The cells were made permeable to nucleoside triphosphates by treatment with a hypotonic buffer containing 10 mM Tris Cl, 4 mM MgCl2, 1 mM EDTA, and 6 mM 2-...

journal_title：Cancer research

authors： Seki S,Oda T

更新日期：1977-01-01 00:00:00

abstract：:The lymphocytes from some Fanconi's anemia patients appeared to be more radiosensitive than normal as measured by the number of X-ray-(or bleomycin-) induced chromosome aberrations seen following G2 treatment. Fibroblasts from the same patients, however, all showed the same degree of colony survival as normals followi...

journal_title：Cancer research

authors： Duckworth-Rysiecki G,Taylor AM

更新日期：1985-01-01 00:00:00

abstract：:A rat lung cell population had been treated with benzo(a)pyrene, and a set of different epithelial cell lines was derived from it. These cell lines carried either a wild-type or mutant p53 gene and represented grading states of neoplastic development. We demonstrate here that the cells lacking both wild-type p53 allel...

journal_title：Cancer research

authors： Biard DS,Martin M,Rhun YL,Duthu A,Lefaix JL,May E,May P

更新日期：1994-07-01 00:00:00

abstract：:1-Nitropyrene (1-NP) originating from such sources as diesel exhaust emissions and coal combustion fly ash has been detected in the environment. 1-NP, in addition to being both a bacterial and mammalian mutagen, is carcinogenic in rats. The purpose of this study was to quantitate 1-NP metabolism and macromolecular cov...

journal_title：Cancer research

authors： Bond JA,Mauderly JL

更新日期：1984-09-01 00:00:00

abstract：:Based on reports that both human and murine lymphoblastoid cell lines can effect lysis in antibody-dependent (ADCC) and mitogen-induced (MICC) cell-mediated cytotoxicity, 10 human lymphoblastoid cell lines were investigated for their ability to act as effector cells in these lytic reactions. Four cell lines promoted M...

journal_title：Cancer research

authors： Jordan TF,Ferrone S,Pellegrino MA,Dennert G

更新日期：1978-11-01 00:00:00

abstract：:We evaluated the usefulness of L-dopa decarboxylase (DDC) as a tumor marker of neuroendocrine (NE) cell differentiation by measuring its expression in 432 human tumors of diverse types and origins. A subset of these tumors and cell lines derived from them also were studied for expression of two other general NE cell m...

journal_title：Cancer research

authors： Gazdar AF,Helman LJ,Israel MA,Russell EK,Linnoila RI,Mulshine JL,Schuller HM,Park JG

更新日期：1988-07-15 00:00:00

abstract：:The tumor suppressor phosphatase and tensin homologue (PTEN) is involved in cell proliferation, adhesion, and apoptosis. PTEN overexpression in mammary epithelium leads to reduced cell number and impaired differentiation and secretion. In contrast, overexpression of the proto-oncogene Wnt-1 in mammary epithelium leads...

journal_title：Cancer research

authors： Zhao H,Cui Y,Dupont J,Sun H,Hennighausen L,Yakar S

更新日期：2005-08-01 00:00:00

abstract：:The pathogenetic relationship between high-grade prostatic intraepithelial neoplasia (PIN), prostatic carcinoma, and metastases is poorly understood. We used fluorescence in situ hybridization (FISH) with centromere-specific probes for chromosomes 7, 8, 10, 12, and Y to evaluate numeric chromosomal anomalies in PIN (6...

journal_title：Cancer research

authors： Qian J,Bostwick DG,Takahashi S,Borell TJ,Herath JF,Lieber MM,Jenkins RB

更新日期：1995-11-15 00:00:00

abstract：:Recombinant tumor necrosis factor (TNF) stimulates the proliferation of two neuroblastoma cell lines, SKNFI and SKNBE, in both serum-free medium and fetal calf serum-supplemented medium but has no effect in medium without insulin. This effect is very similar with TNF doses ranging from 5 to 500 ng/ml but depends on th...

journal_title：Cancer research

authors： Goillot E,Combaret V,Ladenstein R,Baubet D,Blay JY,Philip T,Favrot MC

更新日期：1992-06-01 00:00:00

abstract：:The apolipoprotein B mRNA editing enzyme catalytic polypeptide-like APOBEC3A and APOBEC3B have emerged as key mutation drivers in cancer. Here, we show that APOBEC3A and APOBEC3B activities impose a unique type of replication stress by inducing abasic sites at replication forks. In contrast to cells under other types ...

journal_title：Cancer research

authors： Buisson R,Lawrence MS,Benes CH,Zou L

更新日期：2017-09-01 00:00:00

abstract：:PD115934 (NSC 366140) is a soluble pyrazoloacridine derivative presently undergoing preclinical toxicology evaluation with the anticipation of Phase I human investigation. The agent displayed both human and murine solid tumor selectivity in vitro in a soft agar disk diffusion assay, relative to its activity against mu...

journal_title：Cancer research

authors： LoRusso P,Wozniak AJ,Polin L,Capps D,Leopold WR,Werbel LM,Biernat L,Dan ME,Corbett TH

更新日期：1990-08-15 00:00:00

abstract：:Mc3 is a murine mAb that is highly effective in treating breast tumors in experimental radioimmunotherapy. Mc3 binds to BA46, a 46-kDa glycoprotein of the human milk fat globule membrane that is also expressed in breast carcinoma cells. We cloned and sequenced cDNAs encoding the variable regions of Mc3 and constructed...

journal_title：Cancer research

authors： Couto JR,Blank EW,Peterson JA,Ceriani RL

更新日期：1995-04-15 00:00:00

abstract：:Two malignant sublines, M4 and RMS4 , were previously derived from the recloned L6 line of rat myogenic cells. Comparative studies in tissue culture and inoculation into suckling rats indicated that M4 cells and RMS4 cells may be considered as low-malignant and high-malignant cells, respectively, while L6 cells are no...

journal_title：Cancer research

authors： Hillion J,Leibovitch SA,Leibovitch MP,Raymondjean M,Kruh J,Harel J

更新日期：1984-07-01 00:00:00

abstract：:Recombinant human gamma-interferon (IFN-gamma) has recently been shown to enhance localization of radiolabeled monoclonal antibodies (MAb) to human colon carcinoma xenografts in athymic mice. The present study investigates the ability of gamma-interferon to enhance radioimmunotherapy of a low carcinoembryonic antigen-...

journal_title：Cancer research

authors： Kuhn JA,Beatty BG,Wong JY,Esteban JM,Wanek PM,Wall F,Buras RR,Williams LE,Beatty JD

更新日期：1991-05-01 00:00:00

abstract：:Slow-clearing, tumor-targeting proteins such as monoclonal antibodies typically exhibit high tumor accumulation but low tissue contrast, whereas intermediate-sized proteins such as scFvs show faster clearance but only moderate tumor accumulation. For both, tumor targeting does not seem to improve further above an opti...

journal_title：Cancer research

authors： Zahnd C,Kawe M,Stumpp MT,de Pasquale C,Tamaskovic R,Nagy-Davidescu G,Dreier B,Schibli R,Binz HK,Waibel R,Plückthun A

更新日期：2010-02-15 00:00:00

abstract：:The relationship between natural cell-mediated cytotoxicity (NCMC) and antibody-dependent cell-mediated cytotoxicity (ADCC) was examined in an Epstein-Barr virus-infected target cell system. The total ADCC reactivity to Epstein-Barr virus-infected target cells varied considerably with different effector cells, indicat...

journal_title：Cancer research

authors： Takasugi M,Mickey MR,Levine PH

更新日期：1982-04-01 00:00:00

abstract：:MTW9, a transplantable mammary tumor in Wistar Furth rats, shows little growth unless host serum prolactin is increased. This study compares the response to ovariectomy of MTW9-MtT, a tumor developed in rats bearing the mammosomatotropic tumor MtTW10 (serum prolactin 500 to 7000 ng/ml) with MTW9-P developed in rats gi...

journal_title：Cancer research

authors： Diamond EJ,Koprak S,Shen SK,Hollander VP

更新日期：1976-01-01 00:00:00

abstract：:Human B-cell tumors have been established in athymic, BALB/c mice using the EBV-positive Burkitt lymphoma cell line Namalwa. One-hundred-one of 104 animals (97%) developed tumors 10-14 days following s.c. injection of a mixture of 20 x 10(6) Namalwa and 5 X 10(6) irradiated human fibrosarcoma (HT-1080) cells. Tumors d...

journal_title：Cancer research

authors： Leonard JE,Johnson DE,Felsen RB,Tanney LE,Royston I,Dillman RO

更新日期：1987-06-01 00:00:00

abstract：:Bone marrow biopsy specimens from patients with myeloma were cultured in either 1 of 2 thin-film culture systems, a controlled environment steady state system or a rocker tube configuration of the system, for periods up to 42 days. Both functional and morphological characteristics of the myeloma cells were well-mainta...

journal_title：Cancer research

authors： Gailani S,McLimans WF,Mundy GR,Nussbaum A,Roholt O,Zeigel R

更新日期：1976-04-01 00:00:00

abstract：:The tumor suppressor protein BRCA1 localizes to sites of DNA double-strand breaks (DSB), promoting repair by homologous recombination through the recruitment of DNA damage repair proteins. In normal cells, homologous recombination largely depends on BRCA1. However, assembly of the pivotal homologous recombination regu...

journal_title：Cancer research

authors： Nakada S,Yonamine RM,Matsuo K

更新日期：2012-10-01 00:00:00

abstract：:Phenobarbital (PB), a classical rodent hepatopromoter, remarkably enhances hepatocarcinogenesis initiated by diethylnitrosamine (DEN) in adult B6C3F1 mice. However, it is also known to strongly inhibit liver tumor development in the B6C3F1 mice initiated with DEN in their infancy. The present study aimed to elucidate ...

journal_title：Cancer research

authors： Lee GH,Ooasa T,Osanai M

更新日期：1998-04-15 00:00:00

abstract：:Chronic inflammation has been hypothesized to be a risk factor for prostate cancer. The Toll-like receptor 4 (TLR4) presents the bacterial lipopolysaccharide (LPS), which interacts with ligand-binding protein and CD14 (LPS receptor) and activates expression of inflammatory genes through nuclear factor-kappaB and mitog...

journal_title：Cancer research

authors： Chen YC,Giovannucci E,Lazarus R,Kraft P,Ketkar S,Hunter DJ

更新日期：2005-12-15 00:00:00

abstract：:Fes is a protein tyrosine kinase with cell autonomous oncogenic activities that are well established in cell culture and animal models, but its involvement in human cancer has been unclear. Abundant expression of Fes in vascular endothelial cells and myeloid cell lineages prompted us to explore roles for Fes in the tu...

journal_title：Cancer research

authors： Zhang S,Chitu V,Stanley ER,Elliott BE,Greer PA

更新日期：2011-02-15 00:00:00