The DNA N-glycosylase MED1 exhibits preference for halogenated pyrimidines and is involved in the cytotoxicity of 5-iododeoxyuridine.

abstract：:Increasing evidence points to an active stromal involvement in cancer initiation and progression. Cytokines derived from tumor cells are believed to modulate stromal cells to produce growth and angiogenic factors, which in turn provide the tumor with the necessary microenvironment for expansion and invasion. Transform...

journal_title：Cancer research

authors： Verona EV,Elkahloun AG,Yang J,Bandyopadhyay A,Yeh IT,Sun LZ

更新日期：2007-06-15 00:00:00

abstract：:The lysyl oxidase (LOX) gene reverted Ras transformation of NIH 3T3 fibroblasts and tumor formation by gastric cancer cells, which frequently carry mutant RAS genes. The secreted lysyl oxidase proenzyme is processed to a propeptide (LOX-PP) and a functional enzyme (LOX). Unexpectedly, the tumor suppressor activity map...

journal_title：Cancer research

authors： Min C,Yu Z,Kirsch KH,Zhao Y,Vora SR,Trackman PC,Spicer DB,Rosenberg L,Palmer JR,Sonenshein GE

更新日期：2009-08-15 00:00:00

abstract：:Human cancer cell lines are commonly used in basic cancer research to understand the behavior of primary tumors. Aberrations in the DNA methylation patterns are nowadays recognized as a hallmark of the cancer cell. However, no comprehensive study defines the DNA methylation environment present in the established cance...

journal_title：Cancer research

authors： Paz MF,Fraga MF,Avila S,Guo M,Pollan M,Herman JG,Esteller M

更新日期：2003-03-01 00:00:00

abstract：:Interplay between tumor cells and host cells in the tumor microenvironment dictates the development of all cancers. In breast cancer, malignant cells educate host macrophages to adopt a protumorigenic phenotype. In this study, we show how the integrin-regulatory protein kindlin-2 (FERMT2) promotes metastatic progressi...

journal_title：Cancer research

authors： Sossey-Alaoui K,Pluskota E,Bialkowska K,Szpak D,Parker Y,Morrison CD,Lindner DJ,Schiemann WP,Plow EF

更新日期：2017-09-15 00:00:00

abstract：:Busulfan, a bifunctional alkylating agent, is a mainstay of myeloablative preparative regimens before hematopoietic stem cell transplantation. The apparent oral clearance of busulfan expressed relative to body surface area is 2-3-fold higher in children 1-4 years old than it is in adults. The first step in busulfan el...

journal_title：Cancer research

authors： Gibbs JP,Murray G,Risler L,Chien JY,Dev R,Slattery JT

更新日期：1997-12-15 00:00:00

abstract：:The development of mouse models with the endogenous hypoxanthine-guanine phosphoribosyl transferase (hprt) gene and lacI transgene as mutational targets provides an excellent opportunity to compare the mutant frequency (Mf) and types of mutations induced in vivo in different sequence contexts. To this end, a study was...

journal_title：Cancer research

authors： Walker VE,Gorelick NJ,Andrews JL,Craft TR,deBoer JG,Glickman BW,Skopek TR

更新日期：1996-10-15 00:00:00

abstract：:Although mutated forms of ras are not associated with the majority of breast cancers (<5%), there is considerable experimental evidence that hyperactive Ras can promote breast cancer growth and development. Therefore, we determined whether Ras and Ras-responsive signaling pathways were activated persistently in nine w...

journal_title：Cancer research

authors： Eckert LB,Repasky GA,Ulkü AS,McFall A,Zhou H,Sartor CI,Der CJ

更新日期：2004-07-01 00:00:00

abstract：:The transmembrane neural cell adhesion receptor L1 is a Wnt/β-catenin target gene expressed in many tumor types. In human colorectal cancer, L1 localizes preferentially to the invasive front of tumors and when overexpressed in colorectal cancer cells, it facilitates their metastasis to the liver. In this study, we inv...

journal_title：Cancer research

authors： Gavert N,Shvab A,Sheffer M,Ben-Shmuel A,Haase G,Bakos E,Domany E,Ben-Ze'ev A

更新日期：2013-09-15 00:00:00

abstract：:Twenty-four patients suspected of having ovarian carcinoma received i.v. injection with a combination of radiolabeled intact IgG (1 mg) and F(ab')2 fragments (1 mg) of the chimeric monoclonal antibody MOv18, each form labeled with 1.85 MBq 131I or 125I. Laparotomy was performed either 2 or 6 days after injection, and ...

journal_title：Cancer research

authors： Buist MR,Kenemans P,den Hollander W,Vermorken JB,Molthoff CJ,Burger CW,Helmerhorst TJ,Baak JP,Roos JC

更新日期：1993-11-15 00:00:00

abstract：:Genetic differences in metabolism of benzo(a)pyrene (BP) were investigated using cultured epidermal keratinocytes and dermal fibroblasts isolated from four inbred strains of mice: C3H/HeJms and C57BL/6J that are responsive; and DBA/2 and AKR/Jms that are nonresponsive in terms of inducibility of aryl hydrocarbon hydro...

journal_title：Cancer research

authors： Hosomi J,Nemoto N,Kuroki T

更新日期：1983-08-01 00:00:00

abstract：:Human breast cancers include cancer stem cell populations as well as nontumorigenic cancer cells. Breast cancer stem cells have self-renewal capability and are resistant to conventional chemotherapy. miRNAs regulate the expression of many target genes; therefore, dysregulation of miRNAs has been associated with the pa...

journal_title：Cancer research

authors： Park EY,Chang E,Lee EJ,Lee HW,Kang HG,Chun KH,Woo YM,Kong HK,Ko JY,Suzuki H,Song E,Park JH

更新日期：2014-12-15 00:00:00

abstract：:N-Nitrosodibutylamine and its omega-hydroxylated metabolite N-nitrosobutyl(4-hydroxybutyl)amine (NB4HBA) induce tumors in the urine bladder of different animal species through their common urinary metabolite N-nitrosobutyl(3-carboxypropyl)amine (NB3CPA), resulting from the oxidation of the alcoholic group of NB4HBA to...

journal_title：Cancer research

authors： Bonfanti M,Magagnotti C,Bonati M,Fanelli R,Airoldi L

更新日期：1988-07-01 00:00:00

abstract：:Therapeutic strategies targeting DNA repair pathway defects have been widely explored, but often only benefit small numbers of patients. Here we characterized potential predictive biomarkers for treatment with AsiDNA, a novel first-in-class DNA repair inhibitor. We evaluated genetic instability and DNA repair defects ...

journal_title：Cancer research

authors： Jdey W,Thierry S,Popova T,Stern MH,Dutreix M

更新日期：2017-08-15 00:00:00

abstract：:A new DNA precipitation assay used together with the alkali unwinding assay may provide a rapid means of detecting DNA damage in addition to strand breaks based on the relative amount of damage measured by the two assays. X-rays, Adriamycin, 4-nitroquinoline-N-oxide, N-methyl-N'-nitrosoguanidine, bleomycin, RSU 1172, ...

journal_title：Cancer research

authors： Olive PL,Chan AP,Cu CS

更新日期：1988-11-15 00:00:00

abstract：:A quantitative assessment of rate-limiting steps in metastasis has always been challenging because of the difficulty of detecting small tumor cell populations. We have developed a highly sensitive assay for monitoring the metastatic dissemination of human tumor cells in the chick embryo and used this assay to investig...

journal_title：Cancer research

authors： Zijlstra A,Mellor R,Panzarella G,Aimes RT,Hooper JD,Marchenko ND,Quigley JP

更新日期：2002-12-01 00:00:00

abstract：:Colorectal cancer (CRC) has traditionally been classified into two groups: microsatellite stable/low-level instability (MSS/MSI-L) and high-level MSI (MSI-H) groups on the basis of multiple molecular and clinicopathologic criteria. Using methylated in tumor (MINT) markers 1, 2, 12, and 31, we stratified 77 primary CRC...

journal_title：Cancer research

authors： Whitehall VL,Wynter CV,Walsh MD,Simms LA,Purdie D,Pandeya N,Young J,Meltzer SJ,Leggett BA,Jass JR

更新日期：2002-11-01 00:00:00

abstract：:The levels of protooncogene RNA in matched bone marrow and peripheral blood cells obtained from patients with newly diagnosed acute myelogenous leukemia were compared. While the absolute amounts of c-myc RNA in the matched specimens are similar, the levels are not correlated. In contrast, while the levels of c-fos RNA...

journal_title：Cancer research

authors： Preisler HD,Sato H,Li YQ,Stein G,Stein J

更新日期：1987-07-15 00:00:00

abstract：:The incidence, distribution, size, and histopathology of colonic tumors induced by parenteral administration of 1,2-dimethylhydrazine were examined in rats fed a chemically defined fiber-free diet or nutritionally and calorically equivalent diets containing either 4.5 or 9.0% purified cellulose or pectin. This double-...

journal_title：Cancer research

authors： Freeman HJ,Spiller GA,Kim YS

更新日期：1980-08-01 00:00:00

abstract：:Increased sialylation and branching of asparagine-linked oligosaccharides have recently been associated with both neoplastic transformation and the metastatic phenotype. Swainsonine, an inhibitor of Golgi alpha-mannosidase II blocks the synthesis of sialylated tri- and tetraantennary asparagine-linked oligosaccharides...

journal_title：Cancer research

authors： Dennis JW

更新日期：1986-10-01 00:00:00

abstract：:An inbred-strain (C57BL/6) transgenic (Tyr-SV40E) mouse model of ultraviolet radiation (UVR)-induced metastatic cutaneous melanoma was produced without the use of chemical carcinogens and without resulting in other skin malignancies. Expression of this transgene occurs specifically in melanocytic-lineage cells. In unt...

journal_title：Cancer research

authors： Kelsall SR,Mintz B

更新日期：1998-09-15 00:00:00

abstract：:The expression of many genes is altered in colon cancer, but the roles of these genes in carcinogenesis are unclear. Using real-time quantitative PCR, we demonstrated that several genes previously implicated in human colon cancer undergo altered expression in the APC(min) mouse adenomatous polyp, a precursor of cancer...

journal_title：Cancer research

authors： Chen LC,Hao CY,Chiu YS,Wong P,Melnick JS,Brotman M,Moretto J,Mendes F,Smith AP,Bennington JL,Moore D,Lee NM

更新日期：2004-05-15 00:00:00

abstract：:Retinoic acid receptors and retinoid X receptors form heterodimers, bind to retinoic acid response elements, and transactivate the transcription of retinoid-responsive genes. Two synthetic retinoids [4-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-anthracenyl)benzoic acid (TTAB) and 6-(5,6,7,8-tetrahydro-5,5,8,8-tetrameth...

journal_title：Cancer research

authors： Lotan R,Dawson MI,Zou CC,Jong L,Lotan D,Zou CP

更新日期：1995-01-15 00:00:00

abstract：:Physiological cell conditions, such as glucose deprivation and hypoxia, play a role in developing drug resistance in solid tumors. These tumor-specific conditions cause decreased expression of DNA topoisomerase IIalpha (topo IIalpha), rendering cells resistant to topo II-targeted drugs, such as etoposide and doxorubic...

journal_title：Cancer research

authors： Ogiso Y,Tomida A,Lei S,Omura S,Tsuruo T

更新日期：2000-05-01 00:00:00

abstract：:When nitric oxide (NO) is produced at micromolar concentrations, as during inflammation, exposure to surrounding cells is potentially cytotoxic. The NO-dependent signaling pathways that initiate cell death are thought to involve the tumor suppressor protein p53, but the degree to which this factor contributes to NO-in...

journal_title：Cancer research

authors： McLaughlin LM,Demple B

更新日期：2005-07-15 00:00:00

abstract：:In this paper, we describe the role of chemokine receptor CXCR4 activation by its natural ligand, the chemokine stromal cell-derived factor (SDF-1) (CXCL12), in glioblastoma cell growth in vitro. We show that both CXC chemokine receptor 4 (CXCR4) and SDF-1 mRNA are expressed in several human glioblastoma multiforme tu...

journal_title：Cancer research

authors： Barbero S,Bonavia R,Bajetto A,Porcile C,Pirani P,Ravetti JL,Zona GL,Spaziante R,Florio T,Schettini G

更新日期：2003-04-15 00:00:00

abstract：:Urine from 22 patients with a variety of disseminated cancers and from an equivalent number of nonmalignant controls of similar age and sex was tested for the presence of transforming growth factor (TGF) activity as measured by the ability to promote the growth in soft agar of nontransformed indicator cells. Cancer pa...

journal_title：Cancer research

authors： Sherwin SA,Twardzik DR,Bohn WH,Cockley KD,Todaro GJ

更新日期：1983-01-01 00:00:00

abstract：:Metastasis is the main reason for lung cancer-related mortality, but little is known about specific determinants of successful dissemination from primary tumors and metastasis initiation. Here, we show that CD133(+)/CXCR4(+) cancer-initiating cells (CIC) directly isolated from patient-derived xenografts (PDX) of non-s...

journal_title：Cancer research

authors： Bertolini G,D'Amico L,Moro M,Landoni E,Perego P,Miceli R,Gatti L,Andriani F,Wong D,Caserini R,Tortoreto M,Milione M,Ferracini R,Mariani L,Pastorino U,Roato I,Sozzi G,Roz L

更新日期：2015-09-01 00:00:00

abstract：:Shedding of tumor cell gangliosides may contribute to tumor cell escape from host immune destruction. Thus, it would be of interest to block the shedding of these immunosuppressive molecules. To this end, we studied a ceramide analogue, D-threo-1-phenyl-2-decanoylamino-3-morpholino-1-propanol (D-PDMP). D-PDMP is a pot...

journal_title：Cancer research

authors： Li R,Ladisch S

更新日期：1996-10-15 00:00:00

abstract：:Vigorous activity after diagnosis was recently reported to be inversely associated with prostate cancer-specific mortality. However, men with metastatic disease may decrease their activity due to their disease; thus, a causal interpretation is uncertain. We therefore prospectively examined vigorous activity and brisk ...

journal_title：Cancer research

authors： Richman EL,Kenfield SA,Stampfer MJ,Paciorek A,Carroll PR,Chan JM

更新日期：2011-06-01 00:00:00

abstract：:Pancreatic cancer is highly resistant to current chemotherapy agents. We therefore examined the effects of triptolide (a diterpenoid triepoxide) on pancreatic cancer growth and local-regional tumor spread using an orthotopic model of pancreatic cancer. We have recently shown that an increased level of HSP70 in pancrea...

journal_title：Cancer research

authors： Phillips PA,Dudeja V,McCarroll JA,Borja-Cacho D,Dawra RK,Grizzle WE,Vickers SM,Saluja AK

更新日期：2007-10-01 00:00:00