Involvement of RNA helicases p68 and p72 in colon cancer.

abstract：:Severe weight loss is associated with many malignant diseases of humans and animals. Avian reticuloendotheliosis viruses (RE viruses) induce runting in experimentally infected chickens. Chickens infected with a replication-competent RE virus, reticuloendotheliosis-associated virus, weighed 30-50% less than control bir...

journal_title：Cancer research

authors： Garry RF,Shackleford GM,Berry LJ,Bose HR Jr

更新日期：1985-10-01 00:00:00

abstract：:Alterations in 5 microsatellite loci were analyzed in tumors from 137 patients with primary non-small cell lung carcinomas that were also genotyped for the Hras1 variable number of tandem repeats (VNTR) locus. Twenty-nine patients (21%) had changes in at least one microsatellite locus. A majority of these cases (24 of...

journal_title：Cancer research

authors： Ryberg D,Lindstedt BA,Zienolddiny S,Haugen A

更新日期：1995-09-15 00:00:00

abstract：:17beta-Hydroxysteroid dehydrogenase type 12 (17beta-HSD12) has been shown to be involved in elongation of very long chain fatty acid (VLCFA) as well as in biosynthesis of estradiol (E2). 17beta-HSD12 expression was also reported in breast carcinomas but its functions have remained unknown. In this study, we examined t...

journal_title：Cancer research

authors： Nagasaki S,Suzuki T,Miki Y,Akahira J,Kitada K,Ishida T,Handa H,Ohuchi N,Sasano H

更新日期：2009-02-15 00:00:00

abstract：:Normal bronchial epithelial cells (NBECs) are at risk for damage from inhaled and endogenous oxidative species and from epoxide metabolites of inhaled polycyclic aromatic hydrocarbons. Epidemiological and in vitro data suggest that interindividual variation in this risk may result from variation in NBEC expression of ...

journal_title：Cancer research

authors： Crawford EL,Khuder SA,Durham SJ,Frampton M,Utell M,Thilly WG,Weaver DA,Ferencak WJ,Jennings CA,Hammersley JR,Olson DA,Willey JC

更新日期：2000-03-15 00:00:00

abstract：:Monoclonal antibodies (MAbs) targeted to glioma-associated antigens may allow the selective delivery of imaging and therapeutic agents to brain tumors; the use of MAb fragments may be a strategy to further improve tumor uptake of such agents relative to normal tissues. In this study, we have examined the in vivo local...

journal_title：Cancer research

authors： Colapinto EV,Humphrey PA,Zalutsky MR,Groothuis DR,Friedman HS,de Tribolet N,Carrel S,Bigner DD

更新日期：1988-10-15 00:00:00

abstract：:Streptavidin (SA)-biotin pretargeted radioimmunotherapy (PRIT) that targets CD20 in non-Hodgkin lymphoma (NHL) exhibits remarkable efficacy in model systems, but SA immunogenicity and interference by endogenous biotin may complicate clinical translation of this approach. In this study, we engineered a bispecific fusio...

journal_title：Cancer research

authors： Green DJ,Frayo SL,Lin Y,Hamlin DK,Fisher DR,Frost SH,Kenoyer AL,Hylarides MD,Gopal AK,Gooley TA,Orozco JJ,Till BG,O'Steen S,Orcutt KD,Wilbur DS,Wittrup KD,Press OW

更新日期：2016-11-15 00:00:00

abstract：:The clinical effects and pharmacokinetics of high-dose uridine were determined in seven patients with advanced-stage cancer and in one healthy volunteer. Uridine was also examined for its effect on 5-fluorouracil toxicity in two patients. Uridine was administered as a 1-hr i.v. infusion at doses of 1 to 12 g/sq m. Pla...

journal_title：Cancer research

authors： Leyva A,van Groeningen CJ,Kraal I,Gall H,Peters GJ,Lankelma J,Pinedo HM

更新日期：1984-12-01 00:00:00

abstract：:Transcriptionally regulated growth-response genes play a pivotal role in the determination of the fate of a cell. p53 is known to transcriptionally regulate genes important in regulating cell growth potential. Using differential reverse transcription-PCR analysis of rat embryo fibroblast cells containing a temperature...

journal_title：Cancer research

authors： Madden SL,Galella EA,Riley D,Bertelsen AH,Beaudry GA

更新日期：1996-12-01 00:00:00

abstract：:Carcinoma cells can transition from an epithelial-to-mesenchymal differentiation state through a process known as epithelial-mesenchymal transition (EMT). The process of EMT is characterized by alterations in the pattern of gene expression and is associated with a loss of cell polarity, an increase in invasiveness, an...

journal_title：Cancer research

authors： Bogachek MV,De Andrade JP,Weigel RJ

更新日期：2015-01-01 00:00:00

abstract：:The Fas receptor ligand FasL regulates immune cell levels by inducing apoptosis of Fas receptor-positive cells. Here, we studied the impact of host FasL on tumor development in mice. Genetically targeting FasL in naïve mice increased myeloid cell populations, but, in marked contrast, it reduced the levels of myeloid-d...

journal_title：Cancer research

authors： Peyvandi S,Buart S,Samah B,Vétizou M,Zhang Y,Durrieu L,Polrot M,Chouaib S,Benihoud K,Louache F,Karray S

更新日期：2015-10-15 00:00:00

abstract：:Prior studies of fluorescence anisotropy (polarization) with diphenylhexatriene in normal and malignant cell populations have shown differences which have been attributed to an altered membrane lipid composition in cancer. We studied fresh tumor cells from patients with diverse lymphoid neoplasms and found a discrete ...

journal_title：Cancer research

authors： Spiegel RJ,Magrath IT,Shutta JA

更新日期：1981-02-01 00:00:00

abstract：:Mutations in RAS proteins occur widely in human cancer. Prompted by the confirmation of KRAS mutation as a predictive biomarker of response to epidermal growth factor receptor (EGFR)-targeted therapies, limited clinical testing for RAS pathway mutations has recently been adopted. We performed a multiplatform genomic a...

journal_title：Cancer research

authors： Janakiraman M,Vakiani E,Zeng Z,Pratilas CA,Taylor BS,Chitale D,Halilovic E,Wilson M,Huberman K,Ricarte Filho JC,Persaud Y,Levine DA,Fagin JA,Jhanwar SC,Mariadason JM,Lash A,Ladanyi M,Saltz LB,Heguy A,Paty PB,Solit

更新日期：2010-07-15 00:00:00

abstract：:Despite its function as an inhibitor of urokinase and tissue-type plasminogen activator (PA), PA inhibitor-1 (PAI-1) has a paradoxical protumorigenic role in cancer, promoting angiogenesis and tumor cell survival. In this review, we summarize preclinical evidence in support of the protumorigenic function of PAI-1 that...

journal_title：Cancer research

authors： Placencio VR,DeClerck YA

更新日期：2015-08-01 00:00:00

abstract：:One hundred eighty-four cases of feline leukemia and lymphoma diagnosed in Boston from 1972 through 1976 were investigated. Fifty-eight % of these cases were lymphoma, and 42% were leukemia. Sixty-seven % of the cats had positive fluorescent antibody tests for circulating feline leukemia virus. The rest (33%) were vir...

journal_title：Cancer research

authors： Francis DP,Cotter SM,Hardy WD Jr,Essex M

更新日期：1979-10-01 00:00:00

abstract：:Mitomycin C (MMC) is an anticancer drug that requires reductive activation to exert its toxicity. MMC is known to cross-link DNA that contributes significantly to the cytotoxicity and consequent cell death. Cytosolic NADPH:quinone oxidoreductase 1 (NQO1) and microsomal enzymes have been shown to mediate MMC-induced DN...

journal_title：Cancer research

authors： Celli CM,Jaiswal AK

更新日期：2003-09-15 00:00:00

abstract：:The present study was designed to determine whether alterations in host metabolism associated with progressive tumor growth were a result of the anorexia frequently observed with cancer or could be attributed to other direct tumor effects. Rates of tyrosine flux, oxidation, and incorporation into protein, as well as f...

journal_title：Cancer research

authors： Kawamura I,Moldawer LL,Keenan RA,Batist G,Bothe A Jr,Bistrian BR,Blackburn GL

更新日期：1982-03-01 00:00:00

abstract：:Lysophosphatidic acid (LPA) and sphingosine-1-phosphate (S1P) are lysophospholipid mediators of diverse cellular processes important for cancer progression. S1P is produced by two sphingosine kinases, SphK1 and SphK2. Expression of SphK1 is elevated in many cancers. Here, we report that LPA markedly enhanced SphK1 mRN...

journal_title：Cancer research

authors： Shida D,Fang X,Kordula T,Takabe K,Lépine S,Alvarez SE,Milstien S,Spiegel S

更新日期：2008-08-15 00:00:00

abstract：:C57BL/6J-Min/+mice (n = 56), heterozygous for a nonsense mutation in the Apc gene, were randomized at weaning to seven groups, including groups treated with piroxicam at 0, 50, 100, and 200 ppm in the AIN93G diet. After only 6 weeks of treatment, intestinal adenomas and aberrant crypt foci were counted, and serum leve...

journal_title：Cancer research

authors： Jacoby RF,Marshall DJ,Newton MA,Novakovic K,Tutsch K,Cole CE,Lubet RA,Kelloff GJ,Verma A,Moser AR,Dove WF

更新日期：1996-02-15 00:00:00

abstract：:Monoclonal antibodies (Mabs) against human ovarian mucinous and serous carcinoma were obtained by the Mab technique. Their reactivities against human tumors were tested by indirect immunofluorescence. One of the Mabs, named 4C7, derived from the spleen cells of mice immunized with mucinous carcinoma line OVA-1, reacte...

journal_title：Cancer research

authors： Tsuji Y,Suzuki T,Nishiura H,Takemura T,Isojima S

更新日期：1985-05-01 00:00:00

abstract：:Estrogen exposure is considered a significant risk factor for breast cancer development. Estrogen receptor (ER) alpha is expressed at low levels in normal epithelia, and its expression is dramatically up-regulated as transformation progresses during mammary hyperplasia and adenocarcinoma development. The mechanism(s) ...

journal_title：Cancer research

authors： Sotgia F,Rui H,Bonuccelli G,Mercier I,Pestell RG,Lisanti MP

更新日期：2006-11-15 00:00:00

abstract：:A murine monoclonal antibody 14.18 specifically recognizes disialoganglioside GD2, the major ganglioside expressed on the surface of human neuroblastoma cells. This monoclonal antibody (Mab) is of immunoglobulin G3 isotype, has an affinity constant (KA) of 3.5 X 10(8) M-1, and reacts preferentially with tumor cells an...

journal_title：Cancer research

authors： Mujoo K,Cheresh DA,Yang HM,Reisfeld RA

更新日期：1987-02-15 00:00:00

abstract：:The objective of this investigation was to throw light on the biological behavior and metabolic regulation of hepatic enzymes of the nonoxidative branch of the pentose phosphate pathway. The activities of transaldolase (EC 2.2.1.2) and trasketolase (EC 2.2.1.1) Were compared in biological conditions that involve modu...

journal_title：Cancer research

authors： Heinrich PC,Morris HP,Weber G

更新日期：1976-09-01 00:00:00

abstract：:Tumorigenesis can arise from inappropriate activation of developmental genes in mature tissues. Here, we show that the developmental regulator Six1 is overexpressed in ovarian carcinoma cell lines (OCC) compared with normal ovarian surface epithelium. As observed in other cancers, Six1 overexpression in OCC leads to i...

journal_title：Cancer research

authors： Behbakht K,Qamar L,Aldridge CS,Coletta RD,Davidson SA,Thorburn A,Ford HL

更新日期：2007-04-01 00:00:00

abstract：:High levels of reactive oxygen species (ROS) present in human prostate epithelia are an important etiologic factor in prostate cancer (CaP) occurrence, recurrence, and progression. Androgen induces ROS production in the prostate by a yet unknown mechanism. Here, to the best of our knowledge, we report for the first ti...

journal_title：Cancer research

authors： Basu HS,Thompson TA,Church DR,Clower CC,Mehraein-Ghomi F,Amlong CA,Martin CT,Woster PM,Lindstrom MJ,Wilding G

更新日期：2009-10-01 00:00:00

abstract：:The effect of hydrocortisone on blood-borne tumor metastasis was studied in an i.v. inoculation experiment with Ehrlich hypotetraploid clone 1, Ehrlich hypotetraploid stock, and Ehrlich hyperdiploid stock tumors. The administration of hydrocortisone before tumor inoculation resulted in increased tumor take, reduced me...

journal_title：Cancer research

authors： Kodama M,Kodama T

更新日期：1975-04-01 00:00:00

abstract：:Homozygous deletion of the methylthioadenosine phosphorylase (MTAP) gene is a frequent event in a wide variety of human cancers and is a possible molecular target for therapy. One potential therapeutic strategy to target MTAP-deleted tumors involves combining toxic purine analogues such as 6'-thioguanine (6TG) or 2'-f...

journal_title：Cancer research

authors： Tang B,Lee HO,An SS,Cai KQ,Kruger WD

更新日期：2018-08-01 00:00:00

abstract：:Some, but not all, epidemiological studies have suggested that dichlorodiphenyltrichloroethane (DDT) may play a role in the development of breast cancer. These investigations have been conducted in countries where this substance has been banned for at least 20 years. We conducted a study in Mexico, a country in which ...

journal_title：Cancer research

authors： López-Carrillo L,Blair A,López-Cervantes M,Cebrián M,Rueda C,Reyes R,Mohar A,Bravo J

更新日期：1997-09-01 00:00:00

abstract：:Autotaxin (ATX) is an exoenzyme that potently induces tumor cell motility, and enhances experimental metastasis and angiogenesis. ATX was shown recently to be identical to serum lysophospholipase D activity, producing lysophosphatidic acid (LPA) from lyso-glycerophospholipids. LPA, itself a strong chemoattractant for ...

journal_title：Cancer research

authors： Clair T,Aoki J,Koh E,Bandle RW,Nam SW,Ptaszynska MM,Mills GB,Schiffmann E,Liotta LA,Stracke ML

更新日期：2003-09-01 00:00:00

abstract：:An estrogen-responsive mouse Leydig cell tumor line (Tumor 124958) has been shown to contain only a low-affinity binder for estradiol in the cytosol fraction. This differed from the putative estrogen receptor in terms of its hormone-binding specificity as well as affinity. In addition, the possibility that an estrogen...

journal_title：Cancer research

authors： Maeda Y,Sato B,Noma K,Kishimoto S,Koizumi K,Aono T,Matsumoto K

更新日期：1983-09-01 00:00:00

abstract：:There are now more than 10 million cancer survivors in the United States. With these numbers, chronic sequelae that result from cancer therapy have become a major health care problem. Although radiation therapy of the brain has improved cancer cure rates, learning disorders and memory deficits are a common consequence...

journal_title：Cancer research

authors： Thotala DK,Hallahan DE,Yazlovitskaya EM

更新日期：2008-07-15 00:00:00