Caveolin-1, mammary stem cells, and estrogen-dependent breast cancers.

abstract：:Cellular immune competence was found to be impaired in previous studies of patients with malignant brain tumors. In patients with nonneural tumors, we recently found that serum levels of acute-phase proteins were related to immune status as well as to tumor extent. To determine whether the serum proteins in patients w...

journal_title：Cancer research

authors： Weiss JF,Morantz RA,Bradley WP,Chretien PB

更新日期：1979-02-01 00:00:00

abstract：:Endocrine therapies effectively improve the outcomes of patients with estrogen receptor (ER)-positive breast cancer. However, the emergence of drug-resistant tumors creates a core clinical challenge. In breast cancer cells rendered resistant to the antiestrogen fulvestrant, we defined causative mechanistic roles for t...

journal_title：Cancer research

authors： Shibata T,Watari K,Izumi H,Kawahara A,Hattori S,Fukumitsu C,Murakami Y,Takahashi R,Toh U,Ito KI,Ohdo S,Tanaka M,Kage M,Kuwano M,Ono M

更新日期：2017-01-15 00:00:00

abstract：:Inhibition of constitutive active signaling pathways, which are a characteristic phenomenon for many tumors, can be an effective therapeutic strategy. In contrast, oncogenic transcription factors, often activated by mutational events, are in general less amenable to small-molecule inhibition despite their obvious impo...

journal_title：Cancer research

authors： Amstutz R,Wachtel M,Troxler H,Kleinert P,Ebauer M,Haneke T,Oehler-Jänne C,Fabbro D,Niggli FK,Schäfer BW

更新日期：2008-05-15 00:00:00

abstract：:Exposures to carcinogens present in the diet, in cigarette smoke, or in the environment have been associated with increased risk of bladder and colorectal cancer. The aromatic amines and their metabolites, a class of carcinogen implicated in these exposures, can be N- or O-acetylated by the NAT1 and NAT2 enzymes. Acet...

journal_title：Cancer research

authors： Bell DA,Badawi AF,Lang NP,Ilett KF,Kadlubar FF,Hirvonen A

更新日期：1995-11-15 00:00:00

abstract：:HeLa TCRC-1, is a monophenotypic cell line for the production of the carcinoplacental Regan isoenzyme of alkaline phosphatase. It has been previously reported that, when this cell line is grown in immunosuppressed rats, there is an alteration of phenotypic expression in that an isoenzyme that is referred to as oncoamn...

journal_title：Cancer research

authors： Singer RM

更新日期：1976-11-01 00:00:00

abstract：:Whole-genome sequencing studies have recently identified a quarter of cases of the rare childhood brainstem tumor diffuse intrinsic pontine glioma to harbor somatic mutations in ACVR1. This gene encodes the type I bone morphogenic protein receptor ALK2, with the residues affected identical to those that, when mutated ...

journal_title：Cancer research

authors： Taylor KR,Vinci M,Bullock AN,Jones C

更新日期：2014-09-01 00:00:00

abstract：:Imatinib currently represents the standard treatment in the early chronic phase of chronic myelogenous leukemia (CML), thanks to the high percentage of cytogenetic complete remission achieved, but it is yet unclear to what extent it can eradicate leukemia. Therefore, different vaccination strategies have been suggeste...

journal_title：Cancer research

authors： Volpe G,Cignetti A,Panuzzo C,Kuka M,Vitaggio K,Brancaccio M,Perrone G,Rinaldi M,Prato G,Fava M,Geuna M,Pautasso M,Casnici C,Signori E,Tonon G,Tarone G,Marelli O,Fazio VM,Saglio G

更新日期：2007-06-01 00:00:00

abstract：:Loss of susceptibility to apoptosis signals is a crucial step in carcinogenesis. Therefore, sensitization of tumor cells to apoptosis is a promising therapeutic strategy. c-Jun-N-terminal-kinases (JNK) have been implicated in stress-induced apoptosis, but may also contribute to survival signaling. Here we show that CD...

journal_title：Cancer research

authors： Kuntzen C,Sonuc N,De Toni EN,Opelz C,Mucha SR,Gerbes AL,Eichhorst ST

更新日期：2005-08-01 00:00:00

abstract：:Suramin, a polysulfonated naphthylurea widely used in the treatment of trypanosomiasis and onchocerciasis, is currently being investigated as an antitumor agent for the treatment of advanced cancer. Suramin exerts a wide variety of biological effects. We have shown that suramin inhibits cell proliferation and DNA synt...

journal_title：Cancer research

authors： Jindal HK,Anderson CW,Davis RG,Vishwanatha JK

更新日期：1990-12-15 00:00:00

abstract：:The microbial alkaloid staurosporine is a potent but nonselective inhibitor of protein kinases. The derivative CGP 41251 has been shown to exert a high degree of selectivity for inhibition of protein kinase C activity. Both compounds are powerful inhibitors of proliferation of both normal and transformed cells in vitr...

journal_title：Cancer research

authors： Andrejauskas-Buchdunger E,Regenass U

更新日期：1992-10-01 00:00:00

abstract：:Microcephalin (MCPH1) is a BRCA1 COOH terminal (BRCT) domain containing protein involved in the cellular response to DNA damage that has been implicated in autosomal recessive primary microcephaly. MCPH1 is recruited to sites of DNA double-strand breaks by phosphorylated histone H2AX (gammaH2AX), but the mechanism by ...

journal_title：Cancer research

authors： Wu X,Mondal G,Wang X,Wu J,Yang L,Pankratz VS,Rowley M,Couch FJ

更新日期：2009-07-01 00:00:00

abstract：:A truncated retinoblastoma (RB) protein of approximately 94 kDa (RB94), lacking the NH2 -terminal 112 amino acid residues of the full-length RB, has been found to have great efficacy in tumor suppression. This study investigated the role of adenovirus-mediated RB94 (Ad-RB94) gene therapy for human head and neck squamo...

journal_title：Cancer research

authors： Li D,Day KV,Yu S,Shi G,Liu S,Guo M,Xu Y,Sreedharan S,O'Malley BW Jr

更新日期：2002-08-15 00:00:00

abstract：:Infection of the bone marrow-derived mast cell line PB-3c with a retrovirus carrying oncogenic c-Ha-ras or v-Ha-ras reduced the interleukin 3 (IL-3) growth requirement and induced a state of tumorigenicity. In contrast, normal c-Ha-ras had no effect on the IL-3 requirement of this cell line nor did the cells become tu...

journal_title：Cancer research

authors： Imber R,Fabbro D

更新日期：1991-01-15 00:00:00

abstract：:Connexins are tumor suppressors, and human breast connexin 26 (Cx26) and connexin 43 (Cx43) gap junctions are often down-regulated in breast cancer. We previously showed that Cx26 and Cx43 overexpressed in MDA-MB-231 breast cancer cells inhibited tumor growth in vivo but not in two-dimensional cultures. In the current...

journal_title：Cancer research

authors： McLachlan E,Shao Q,Wang HL,Langlois S,Laird DW

更新日期：2006-10-15 00:00:00

abstract：:Urine from 22 patients with a variety of disseminated cancers and from an equivalent number of nonmalignant controls of similar age and sex was tested for the presence of transforming growth factor (TGF) activity as measured by the ability to promote the growth in soft agar of nontransformed indicator cells. Cancer pa...

journal_title：Cancer research

authors： Sherwin SA,Twardzik DR,Bohn WH,Cockley KD,Todaro GJ

更新日期：1983-01-01 00:00:00

abstract：:The mechanism by which gonadotropin-releasing hormone (GnRH) agonists and antagonists inhibit tumor cell growth and proliferation is controversial. Direct mediation of the antitumor effects through the high-affinity GnRH receptors has been questioned because of the low level of expression of receptors on the tumor cel...

journal_title：Cancer research

authors： Kakar SS

更新日期：1998-10-15 00:00:00

abstract：:Host resistance to neoplastic growth and invasiveness is recognized to be an important factor in determining the occurrence, the progress, and the eventual outcome of every cancer illness. The factors involved in host resistance are briefly reviewed, and the relationship between these factors and ascorbic acid metabol...

journal_title：Cancer research

authors： Cameron E,Pauling L,Leibovitz B

更新日期：1979-03-01 00:00:00

abstract：:Chromatin coregulators are important factors in tumorigenesis and cancer progression. ANCCA is an AAA+ ATPase and a bromodomain-containing nuclear coactivator for the estrogen and androgen receptors that is crucial for assembly of chromatin-modifying complexes and proliferation of hormone-responsive cancer cells. In t...

journal_title：Cancer research

authors： Kalashnikova EV,Revenko AS,Gemo AT,Andrews NP,Tepper CG,Zou JX,Cardiff RD,Borowsky AD,Chen HW

更新日期：2010-11-15 00:00:00

abstract：:Epidemiological data have provided clues to the etiological factors involved in large bowel cancer development. High intake of dietary fat tends to promote colon carcinogenesis. Studies in metabolic epidemiology have shown that the high dietary fat affects the metabolic activity of gut bacteria as well as the levels o...

journal_title：Cancer research

authors： Reddy BS

更新日期：1981-09-01 00:00:00

abstract：:Tissue survival responses to ionizing radiation are nonlinear with dose, rather yielding tissue-specific descending curves that impede straightforward analysis of biologic effects. Apoptotic cell death often occurs at low doses, while at clinically relevant intermediate doses, double-strand break misrepair yields mito...

journal_title：Cancer research

authors： Martin ML,Adileh M,Hsu KS,Hua G,Lee SG,Li C,Fuller JD,Rotolo JA,Bodo S,Klingler S,Haimovitz-Friedman A,Deasy JO,Fuks Z,Paty PB,Kolesnick RN

更新日期：2020-03-01 00:00:00

abstract：:Integrin alpha(5)beta(1) is overexpressed on endothelial cells of tumor vessels and is uniformly and rapidly accessible to antibodies in the bloodstream. Here, we determined whether antibodies rapidly gain access to integrin overexpressed on the abluminal (basolateral) surface of endothelial cells through vascular lea...

journal_title：Cancer research

authors： Magnussen A,Kasman IM,Norberg S,Baluk P,Murray R,McDonald DM

更新日期：2005-04-01 00:00:00

abstract：:The first recombinant endostatin that elicited strong antitumor activity was expressed in Escherichia coli and administered as a suspension. Under these conditions, the protein retained its full antiangiogenic activity. Lack of requirement for a folded structure prompted us to investigate antitumor properties of synth...

journal_title：Cancer research

authors： Tjin Tham Sjin RM,Satchi-Fainaro R,Birsner AE,Ramanujam VM,Folkman J,Javaherian K

更新日期：2005-05-01 00:00:00

abstract：:The cells' ability to proliferate in response to growth factor stimulation is significantly altered during cancer progression. To investigate the mechanisms underlying these alterations in prostate cancer, the role and expression of beta1A integrin and type 1 insulin-like growth factor receptor (IGF-IR), known to cont...

journal_title：Cancer research

authors： Goel HL,Breen M,Zhang J,Das I,Aznavoorian-Cheshire S,Greenberg NM,Elgavish A,Languino LR

更新日期：2005-08-01 00:00:00

abstract：:Focal adhesion kinase (FAK) and vascular endothelial growth factor receptor-3 (VEGFR-3) are protein tyrosine kinases that are overexpressed in human cancer and play an important role in survival signaling. In addition to its involvement with cell survival, VEGFR-3 is a primary factor in lymphatic angiogenesis. Because...

journal_title：Cancer research

authors： Garces CA,Kurenova EV,Golubovskaya VM,Cance WG

更新日期：2006-02-01 00:00:00

abstract：:In previous studies, we reported that key antioxidant and DNA repair genes are regulated differently in normal bronchial epithelial cells of lung cancer cases compared with non-lung cancer controls. In an effort to develop a biomarker for lung cancer risk, we evaluated the transcript expressions of 14 antioxidant, DNA...

journal_title：Cancer research

authors： Blomquist T,Crawford EL,Mullins D,Yoon Y,Hernandez DA,Khuder S,Ruppel PL,Peters E,Oldfield DJ,Austermiller B,Anders JC,Willey JC

更新日期：2009-11-15 00:00:00

abstract：:A novel method for high-efficiency and region- controlled in vivo gene transfer was developed by combining in vivo electroporation and intraarterial plasmid DNA injection. A mammalian expression plasmid for the Escherichia coli lacZ gene (driven with a SV40 early promoter) was injected into the internal carotid artery...

journal_title：Cancer research

authors： Nishi T,Yoshizato K,Yamashiro S,Takeshima H,Sato K,Hamada K,Kitamura I,Yoshimura T,Saya H,Kuratsu J,Ushio Y

更新日期：1996-03-01 00:00:00

abstract：:The human promyelocytic leukemia cell line HL-60 and monoblastic leukemia cell line U937 undergo differentiation when induced by lymphokine and cytokine preparations. Growth inhibition, acquisition of immunoglobulin Fc receptors, increased expression of monocyte-related surface antigens, and an increase in lysosomal e...

journal_title：Cancer research

authors： Harris PE,Ralph P,Gabrilove J,Welte K,Karmali R,Moore MA

更新日期：1985-07-01 00:00:00

abstract：:The effects on Leydig cell tumorigenesis of surgical cryptorchidy, parabiotic union with a castrate male partner, and a combination on the two procedures as well as of the continuous exposure to a high level of diethylstilbestrol stimulation were studied in the high-tumor Fischer rat. Localized foci of adenomatous hyp...

journal_title：Cancer research

authors： Huseby RA

更新日期：1981-08-01 00:00:00

abstract：:In the multistep process of metastasis, "anchorage-independent growth," where cancer cells need to survive without cell-substratum interaction, is supposed to be important. In this study, we found that anchorage-independent growth analyzed using the soft agar colony formation assay correlated with hematogeneous intrah...

journal_title：Cancer research

authors： Nakanishi K,Sakamoto M,Yasuda J,Takamura M,Fujita N,Tsuruo T,Todo S,Hirohashi S

更新日期：2002-05-15 00:00:00

abstract：:Factors affecting the expression of carcinoembryonic antigen (CEA) at the surface of in vitro human colon carcinoma cells were determined using 125I-labeled antibodies. Binding of specific anti-CEA antibodies resulted in polar redistribution of CEA, followed by endocytosis of most of the CEA-anti-CEA complexes. These ...

journal_title：Cancer research

authors： Rosenthal KL,Tompkins WA,Rawls WE

更新日期：1980-12-01 00:00:00