Experimental infection of squirrel and marmoset monkeys with attenuated Herpesvirus saimiri.

abstract：:Regulators of differentiated cell fate can offer targets for managing cancer development and progression. Here, we identify Runx2 as a new regulator of epithelial cell fate in mammary gland development and breast cancer. Runx2 is expressed in the epithelium of pregnant mice in a strict temporally and hormonally regula...

journal_title：Cancer research

authors： Owens TW,Rogers RL,Best S,Ledger A,Mooney AM,Ferguson A,Shore P,Swarbrick A,Ormandy CJ,Simpson PT,Carroll JS,Visvader J,Naylor MJ

更新日期：2014-09-15 00:00:00

abstract：:XPC protein is a critical DNA damage recognition factor in nucleotide excision repair for which genetic deficiency confers a predisposition to cancer. In this study, we show that XPC has a function that is independent of its canonical function in DNA repair, potentially altering the interpretation of how XPC deficienc...

journal_title：Cancer research

authors： Wang QE,Han C,Zhang B,Sabapathy K,Wani AA

更新日期：2012-02-01 00:00:00

abstract：:It is known that Wnt-1 signaling inhibits apoptosis by activating beta-catenin/tcf-mediated transcription. Here, we show that blocking Wnt-1 signaling in beta-catenin-deficient mesothelioma cell lines H28 and MS-1 induces apoptotic cell death. Both Wnt-1 small interfering RNA (siRNA) and Dishevelled siRNA induced sign...

journal_title：Cancer research

authors： You L,He B,Uematsu K,Xu Z,Mazieres J,Lee A,McCormick F,Jablons DM

更新日期：2004-05-15 00:00:00

abstract：:We previously demonstrated that mutational inactivation of transforming growth factor beta type II receptors (RIIs) is very common among the 13% of human colon cancers with microsatellite instability. These mutations principally cluster in the BAT-RII polyadenine sequence repeat. Among microsatellite stable (MSS) colo...

journal_title：Cancer research

authors： Grady WM,Myeroff LL,Swinler SE,Rajput A,Thiagalingam S,Lutterbaugh JD,Neumann A,Brattain MG,Chang J,Kim SJ,Kinzler KW,Vogelstein B,Willson JK,Markowitz S

更新日期：1999-01-15 00:00:00

abstract：:Radiolabeled antibodies have produced encouraging remissions in patients with chemotherapy-resistant hematological malignancies; however, the selection of therapeutic radionuclides for clinical trials remains controversial. In this study, we compared the internalization, lysosomal targeting, metabolism, and cellular r...

journal_title：Cancer research

authors： Press OW,Shan D,Howell-Clark J,Eary J,Appelbaum FR,Matthews D,King DJ,Haines AM,Hamann P,Hinman L,Shochat D,Bernstein ID

更新日期：1996-05-01 00:00:00

abstract：:PAX5 is a transcription factor essential for B-cell development. Recently, it has been found as a frequent target of aberrancies in childhood acute lymphoblastic leukemia (ALL; 30% of B cell ALL cases), showing monoallelic loss, point mutations, or chromosomal translocations. The role of these aberrancies is still poo...

journal_title：Cancer research

authors： Fazio G,Palmi C,Rolink A,Biondi A,Cazzaniga G

更新日期：2008-01-01 00:00:00

abstract：:Previously, we identified an amplified gene in a stomach cancer cell line, KATO-III, and designated it K-sam. This gene was later found to be identical with a gene for a receptor tyrosine kinase, bek/FGFR2. One of the characteristics of the K-sam gene is structural diversity of its transcripts; K-sam complementary DNA...

journal_title：Cancer research

authors： Ishii H,Hattori Y,Itoh H,Kishi T,Yoshida T,Sakamoto H,Oh H,Yoshida S,Sugimura T,Terada M

更新日期：1994-01-15 00:00:00

abstract：:Plasmids may have unique advantages as a gene delivery system. However, a major obstacle is the low in vivo transduction efficiency. In this study, an electroporation-based gene transduction approach was taken to study the effect of interleukin (IL)-2 or IL-12 gene transduction on the growth of experimental murine tum...

journal_title：Cancer research

authors： Lohr F,Lo DY,Zaharoff DA,Hu K,Zhang X,Li Y,Zhao Y,Dewhirst MW,Yuan F,Li CY

更新日期：2001-04-15 00:00:00

abstract：:In vivo 31P nuclear magnetic resonance (MR) spectroscopy has shown great promise as a tool for cancer research and the clinical management of solid tumors. It is now possible in some cases to integrate MR spectroscopy with routine MR imaging of the cancer patient, so that tissue identified as tumor on an MR image can ...

journal_title：Cancer research

authors： Steen RG

更新日期：1989-08-01 00:00:00

abstract：:Merkel cell carcinoma (MCC) is a highly malignant neuroendocrine nonmelanoma skin cancer, which is associated with the Merkel cell polyoma virus (MCPyV). Recently, expression of the terminal deoxynucleotidyl transferase (TdT) and the paired box gene 5 (PAX 5) has been consistently reported in the majority of MCCs. We ...

journal_title：Cancer research

authors： Zur Hausen A,Rennspiess D,Winnepenninckx V,Speel EJ,Kurz AK

更新日期：2013-08-15 00:00:00

abstract：:We investigated whether a polymorphism in the cytochrome P450c17alpha gene (CYP17), which is associated with higher endogenous hormone levels, influences the use of hormone replacement therapy (HRT). The study included 749 postmenopausal women ages 44-75 years at baseline randomly selected from a larger multiethnic co...

journal_title：Cancer research

authors： Feigelson HS,McKean-Cowdin R,Pike MC,Coetzee GA,Kolonel LN,Nomura AM,Le Marchand L,Henderson BE

更新日期：1999-08-15 00:00:00

abstract：:A lymphocyte blastogenesis inhibitory factor (LBIF) has been characterized as an immunoregulatory molecule, especially on the T-lymphocyte proliferation. Using fast protein liquid chromatography-purified LBIF, we examined the effect of LBIF on the proliferation of various 18 tumor cell lines in vitro in comparison wit...

journal_title：Cancer research

authors： Sugimura K,Ohno T,Fukuda S,Wada Y,Kimura T,Azuma I

更新日期：1990-01-15 00:00:00

abstract：:2,6,10,14-Tetramethylpentadecane (pristane), s.c. injected simultaneously with plasmacytoma inocula, enhances the transplantability of tumor cells. The effect is dose and time dependent. The enhancement is shown only by plasmacytoma (MOPC-315 and MPC-11) and not by the murine lymphosarcoma and chondrosarcoma tested. V...

journal_title：Cancer research

authors： Platica M,Bojko C,Steiner G,Hollander VP

更新日期：1980-07-01 00:00:00

abstract：:VEGF/vascular permeability factor (VEGF/VPF or VEGF-A) is a pivotal driver of cancer angiogenesis that is a central therapeutic target in the treatment of malignancy. However, little work has been devoted to investigating functions of VEGF that are independent of its proangiogenic activity. Here, we report that VEGF p...

journal_title：Cancer research

authors： Cao Y,E G,Wang E,Pal K,Dutta SK,Bar-Sagi D,Mukhopadhyay D

更新日期：2012-08-15 00:00:00

abstract：:Human bronchial carcinoma is thought to develop through progressive stages from basal cell hyperplasia to squamous metaplasia, dysplasia, carcinoma in situ, and finally invasive cancer. In this study, we used tissue microdissection to examine loss of heterozygosity of chromosomes 3p21, 5q21, and 9p21 at each stage of ...

journal_title：Cancer research

authors： Thiberville L,Payne P,Vielkinds J,LeRiche J,Horsman D,Nouvet G,Palcic B,Lam S

更新日期：1995-11-15 00:00:00

abstract：:Retroviral and transposon-based mutagenesis screens in mice have been useful for identifying candidate cancer genes for some tumor types. However, many of the organs that exhibit the highest cancer rates in humans, including the prostate, have not previously been amenable to these approaches. This study shows for the ...

journal_title：Cancer research

authors： Rahrmann EP,Collier LS,Knutson TP,Doyal ME,Kuslak SL,Green LE,Malinowski RL,Roethe L,Akagi K,Waknitz M,Huang W,Largaespada DA,Marker PC

更新日期：2009-05-15 00:00:00

abstract：:The in vitro cytotoxicities of the four drugs most frequently used for intravesical chemotherapy (Adriamycin, epodyl, mitomycin C, Thiotepa) and epirubicin were compared using monolayers and multicellular tumor spheroids of the human bladder cancer cell line, MGH-U1. Adriamycin and epirubicin were most cytotoxic again...

journal_title：Cancer research

authors： Knuchel R,Hofstadter F,Jenkins WE,Masters JR

更新日期：1989-03-15 00:00:00

abstract：:Batracylin (8-aminoisoindolo [1,2-b]quinazolin-10(12H)-one; NSC320846) is an investigational clinical anticancer agent. Previous animal studies showed activity against solid tumors and Adriamycin-resistant leukemia. We initially sought to test the proposed Top2-mediated DNA cleavage activity of batracylin and identify...

journal_title：Cancer research

authors： Rao VA,Agama K,Holbeck S,Pommier Y

更新日期：2007-10-15 00:00:00

abstract：:A correlation exists between the ability of tumor cells to aggregate platelets and their tendency to metastasize. Tumor cell-induced platelet aggregation (TCIPA) facilitates the embolization of the vasculature with tumor cells and the formation of metastatic foci. It is well documented that matrix metalloproteinases (...

journal_title：Cancer research

authors： Jurasz P,Sawicki G,Duszyk M,Sawicka J,Miranda C,Mayers I,Radomski MW

更新日期：2001-01-01 00:00:00

abstract：:In immunodeficient mice antitumor single-chain Fv (scFv) molecules penetrate tumors rapidly and have rapid serum clearance, leading to excellent tumor:normal organ ratios. However, the absolute quantity of scFv retained in the tumor is low due to rapid serum clearance and monovalent scFv binding. We previously demonst...

journal_title：Cancer research

authors： Nielsen UB,Adams GP,Weiner LM,Marks JD

更新日期：2000-11-15 00:00:00

abstract：:FOXP3 is inactivated in breast cancer cells by a number of mechanisms, including somatic mutations, deletion, and epigenetic silencing. Because the mutation and deletion are usually heterozygous in the cancer samples, it is of interest to determine whether the gene can be induced for the purpose of cancer therapy. Her...

journal_title：Cancer research

authors： Liu Y,Wang Y,Li W,Zheng P,Liu Y

更新日期：2009-07-15 00:00:00

abstract：:Busulfan causes long-lasting defects in the hematopoietic stem cells and in the immune system of mice. We designed studies to determine whether chloramphenicol further damaged the already defective hematopoietic stem cells of mice that were pretreated with busulfan, and we unexpectedly observed that mice given injecti...

journal_title：Cancer research

authors： Robin E,Berman M,Bhoopalam N,Cohen H,Fried W

更新日期：1981-09-01 00:00:00

abstract：:Toll-like receptor (TLR) agonists are considered adjuvants in clinical trials of cancer immunotherapy. Here, we investigated the modulation of gammadelta T cell-mediated tumor cell lysis by TLR ligands. gammadelta T-cell cytotoxicity and granzyme A/B production were enhanced after pretreatment of tumor cells with TLR3...

journal_title：Cancer research

authors： Shojaei H,Oberg HH,Juricke M,Marischen L,Kunz M,Mundhenke C,Gieseler F,Kabelitz D,Wesch D

更新日期：2009-11-15 00:00:00

abstract：:Hypoxia inducible factors (HIF) are critical mediators of the cellular response to decreased oxygen tension and are overexpressed in a number of tumors. Although HIF1alpha and HIF2alpha share a high degree of sequence homology, recent work has shown that the two alpha subunits can have contrasting and tissue-specific ...

journal_title：Cancer research

authors： Bertout JA,Patel SA,Fryer BH,Durham AC,Covello KL,Olive KP,Goldschmidt MH,Simon MC

更新日期：2009-04-01 00:00:00

abstract：:Curcumin, a natural compound, is a well-known chemopreventive agent with potent anticarcinogenic activity in a wide variety of tumor cells. Curcumin inhibits cancer cell proliferation in part by suppressing cyclin D1 and inducing expression of the cyclin-dependent kinase inhibitor p21(Waf1/Cip1). Both p53-dependent an...

journal_title：Cancer research

authors： Choi BH,Kim CG,Bae YS,Lim Y,Lee YH,Shin SY

更新日期：2008-03-01 00:00:00

abstract：:The thymidylate synthase reaction remains an important target for widely used anticancer agents; however, the clinical utility of these drugs is limited by the occurrence of cellular resistance. Despite the considerable amount of information available regarding mechanisms of drug action, the relative significance of d...

journal_title：Cancer research

authors： Tinkelenberg BA,Hansbury MJ,Ladner RD

更新日期：2002-09-01 00:00:00

abstract：:Understanding the intratumoral heterogeneity of hepatocellular carcinoma is instructive for developing personalized therapy and identifying molecular biomarkers. Here we applied whole-exome sequencing to 69 samples from 11 patients to resolve the genetic architecture of subclonal diversification. Spatial genomic diver...

journal_title：Cancer research

authors： Lin DC,Mayakonda A,Dinh HQ,Huang P,Lin L,Liu X,Ding LW,Wang J,Berman BP,Song EW,Yin D,Koeffler HP

更新日期：2017-05-01 00:00:00

abstract：:The i.p. inoculation of C3H mice with 5 times 10-6 cells of a transplantable ovarian carcinoma invariably evokes accumulation of large amounts of ascitic fluid. Histological and pharmacotherapeutic studies indicate that obstruction to peritoneal lymphatic drainage is a key factor in the formation of carcinomatous asci...

journal_title：Cancer research

authors： Feldman GB

更新日期：1975-02-01 00:00:00

abstract：:Liposome formulations of camptothecins have been actively pursued because of the potential for significant pharmacologic advantages from successful drug delivery of this important class of anticancer drugs. We describe nanoliposomal CPT-11, a novel nanoparticle/liposome construct containing CPT-11 (irinotecan) with un...

journal_title：Cancer research

authors： Drummond DC,Noble CO,Guo Z,Hong K,Park JW,Kirpotin DB

更新日期：2006-03-15 00:00:00

abstract：:Cell division cycle 25B (Cdc25B) phosphatase controls entry into mitosis and regulates recovery from G2-M checkpoint-induced arrest. In the present study, we show that exposure of diploid mouse embryonic fibroblasts (MEF) to the ultimate carcinogen anti-benzo(a)pyrene (BP)-7,8-diol-9,10-epoxide (anti-BPDE) resulted in...

journal_title：Cancer research

authors： Srivastava SK,Bansal P,Oguri T,Lazo JS,Singh SV

更新日期：2007-10-01 00:00:00