Effect of subcutaneously administered 2,6,10,14-tetramethylpentadecane on plasmacytoma growth.

Abstract:

:2,6,10,14-Tetramethylpentadecane (pristane), s.c. injected simultaneously with plasmacytoma inocula, enhances the transplantability of tumor cells. The effect is dose and time dependent. The enhancement is shown only by plasmacytoma (MOPC-315 and MPC-11) and not by the murine lymphosarcoma and chondrosarcoma tested. Various mechanisms, such as stress and depression of humoral and cellular immunity, have been considered.

journal_name

Cancer Res

journal_title

Cancer research

authors

Platica M,Bojko C,Steiner G,Hollander VP

subject

Has Abstract

pub_date

1980-07-01 00:00:00

pages

2229-33

issue

7

eissn

0008-5472

issn

1538-7445

journal_volume

40

pub_type

杂志文章
  • Flow cytometric analysis of pentakis(aziridino)thiatriazadiphosphorine oxide (SOAz)-induced changes in cell cycle progression of HeLa and HL-60 cells.

    abstract::The treatment of HeLa and HL-60 cells with various concentrations of pentakis(arizidino)thiatriazadiphosphorine oxide results in inhibition of growth and modification of cell cycle distribution. These phenomena were observed at 10(-4) M and 5 X 10(-5) M for HeLa cells and 10(-5) M and 5 X 10(-6) M for HL-60 cells. The...

    journal_title:Cancer research

    pub_type: 杂志文章

    doi:

    authors: Hecquet C,Nafziger J,Ronot X,Marie JP,Adolphe M

    更新日期:1985-02-01 00:00:00

  • Serum level of interleukin 6 as a prognosis factor in metastatic renal cell carcinoma.

    abstract::Interleukin (IL) 6 was measured in the serum of 138 patients with metastatic renal carcinoma before the initiation of IL-2 treatment. IL-6 was detectable in 66 patients with renal cancer (48%) and in only 8 of 70 normal adults (11%). Serum C reactive protein (CRP) and IL-6 levels are correlated, suggesting that IL-6 i...

    journal_title:Cancer research

    pub_type: 杂志文章

    doi:

    authors: Blay JY,Negrier S,Combaret V,Attali S,Goillot E,Merrouche Y,Mercatello A,Ravault A,Tourani JM,Moskovtchenko JF

    更新日期:1992-06-15 00:00:00

  • Cytokines prevent dexamethasone-induced apoptosis via the activation of mitogen-activated protein kinase and phosphatidylinositol 3-kinase pathways in a new multiple myeloma cell line.

    abstract::A new human myeloma cell line, OPM-6, was established from the peripheral blood of a patient with advanced IgG-kappa plasma cell leukemia. Cytogenetic and phenotypic analysis confirmed that the cells were derived from the patient's leukemic cells. Insulin-like growth factor-1 (IGF-1) acts as an autocrine growth factor...

    journal_title:Cancer research

    pub_type: 杂志文章

    doi:

    authors: Ogawa M,Nishiura T,Oritani K,Yoshida H,Yoshimura M,Okajima Y,Ishikawa J,Hashimoto K,Matsumura I,Tomiyama Y,Matsuzawa Y

    更新日期:2000-08-01 00:00:00

  • Hybrid resistance to BALB/c plasmacytomas: F1 hybrid anti-MPC-11 immunological responses correlated with resistance to tumor challenge.

    abstract::BALB/cJ X C57BL/10Sn F1 (hereafter called B10F1) hybrids resist challenge with the BALB/c plasmacytoma, MPC-11, by a radiation-sensitive, silica-insensitive mechanism, whereas BALB/cJ X BALB.B F1 (hereafter called BALB.BF1) hybrids are as susceptible to MPC-11 as are homozygous BALB/c mice themselves. To investigate t...

    journal_title:Cancer research

    pub_type: 杂志文章

    doi:

    authors: Marsili MA,Walker MC,Phillips-Quagliata JM

    更新日期:1986-01-01 00:00:00

  • Cellular heterogeneity in normal and neoplastic human urothelium.

    abstract::Cell suspensions derived from 2 specimens of normal human urothelium and 13 human transitional cell carcinomas were studied by discontinuous density gradient centrifugation. The histochemical and proliferative properties of the fractions were evaluated. In normal urothelium, DNA synthesis was restricted to a subpopula...

    journal_title:Cancer research

    pub_type: 杂志文章

    doi:

    authors: Mackillop WJ,Bizarri JP,Ward GK

    更新日期:1985-09-01 00:00:00

  • Surveillance, initial assessment, and subsequent progress of patients with superficial bladder cancer in a prospective longitudinal study. National Bladder Cancer Collaborative Group A (NBCCGA).

    abstract::Through a bladder cancer surveillance protocol, a sizable population of patients suitable for characterizing the dynamics and patterns of recurrent superficial transitional cell carcinoma has been identified. One hundred thirty-three patients have been followed after their first occurrence of transitional cell carcino...

    journal_title:Cancer research

    pub_type: 杂志文章

    doi:

    authors:

    更新日期:1977-08-01 00:00:00

  • Assessing Lung Cancer Absolute Risk Trajectory based on a Polygenic Risk Model.

    abstract::Lung cancer is the leading cause of cancer death globally. An improved risk stratification strategy can increase efficiency of low-dose computed tomography (LDCT) screening. Here we assessed whether individual's genetic background has clinical utility for risk stratification in the context of LDCT screening. Based on ...

    journal_title:Cancer research

    pub_type: 杂志文章

    doi:10.1158/0008-5472.CAN-20-1237

    authors: Hung RJ,Warkentin MT,Brhane Y,Chatterjee N,Christiani DC,Landi MT,Caporaso NE,Liu G,Johansson M,Albanes D,Le Marchand L,Tardon A,Rennert G,Bojesen SE,Chen C,Field JK,Kiemeney LA,Lazarus P,Zienolddiny S,Lam S,Andre

    更新日期:2021-01-20 00:00:00

  • Induction of p21 by the Wilms' tumor suppressor gene WT1.

    abstract::WT1 encodes a zinc finger transcription factor that is expressed in the developing kidney and the inactivation of which leads to Wilms' tumor, a pediatric kidney cancer. We have recently shown that inducible expression of WT1 in osteosarcoma cells triggers programmed cell death, an effect that is associated with trans...

    journal_title:Cancer research

    pub_type: 杂志文章

    doi:

    authors: Englert C,Maheswaran S,Garvin AJ,Kreidberg J,Haber DA

    更新日期:1997-04-15 00:00:00

  • Chemotherapy with [SP-4-3-(R)]-[1,1-cyclobutanedicarboxylato(2-)](2- methyl-1,4-butanediamine-N,N')platinum (CI-973, NK121) in combination with standard agents against murine tumors in vivo.

    abstract::[SP-4-3-(R)]-[1,1-cyclobutanedicarboxylato(2-)](2-methyl-1,4- butane-diamine-N,N')platinum (CI-973) is a cisplatin analogue that is currently in clinical trial. Preclinically, CI-973 retained activity against L1210, P388, K562, and human ovarian carcinoma sublines resistant to cisplatin in vitro. CI-973 also retained ...

    journal_title:Cancer research

    pub_type: 杂志文章

    doi:

    authors: Elliott WL,Roberts BJ,Howard CT,Leopold WR 3rd

    更新日期:1994-08-15 00:00:00

  • Factors affecting growth and drug sensitivity of mouse mammary tumor lines in collagen gel cultures.

    abstract::A series of mouse mammary tumor subpopulation lines were compared for growth properties and sensitivity to chemotherapeutic drugs when grown as boluses in a collagen gel matrix versus in monolayer culture. Although the cell lines exhibited characteristic rates of bolus expansion in collagen, this growth was not parall...

    journal_title:Cancer research

    pub_type: 杂志文章

    doi:

    authors: Miller BE,Miller FR,Heppner GH

    更新日期:1985-09-01 00:00:00

  • HLA A2601-restricted CTLs recognize a peptide antigen expressed on squamous cell carcinoma.

    abstract::The CD4-CD8+ CTL (KE-4 CTL) cell line against autologous tumor cells was established in a patient with esophageal cancer. This KE-4 CTL recognized a peptide antigen on esophageal and lung squamous cell carcinomas in an HLA A2601-restricted manner, as evaluated by cytotoxicity against a panel of tumor cells, transfecti...

    journal_title:Cancer research

    pub_type: 杂志文章

    doi:

    authors: Nakao M,Yamana H,Imai Y,Toh Y,Toh U,Kimura A,Yanoma S,Kakegawa T,Itoh K

    更新日期:1995-10-01 00:00:00

  • Aberrant expression of photoreceptor-specific calcium-binding protein (recoverin) in cancer cell lines.

    abstract::Cancer-associated retinopathy (CAR) is an ocular manifestation of a paraneoplastic syndrome whereby immunological reactions to retinal antigens aberrantly expressed in tumor cells lead to the degeneration of retinal photoreceptor cells. In our previous study (H. Ohguro et al., Invest. Ophthalmol. Vis. Sci., 40: 82-89,...

    journal_title:Cancer research

    pub_type: 杂志文章

    doi:

    authors: Maeda A,Ohguro H,Maeda T,Wada I,Sato N,Kuroki Y,Nakagawa T

    更新日期:2000-04-01 00:00:00

  • Primary neoplastic transformation in vivo of xenogeneic skin grafts on nude mice.

    abstract::Rabbit skin was infected with Shope papilloma virus and grafted orthotopically to nude mice. Typical Shope rabbit papillomas developed in most of the grafts, but similarly treated nude mouse skin grafts were not altered. These results demonstrated that xenogeneic tissues retained susceptibility to oncogenic agents aft...

    journal_title:Cancer research

    pub_type: 杂志文章

    doi:

    authors: Kreider JW,Bartlett GL,Sharkey FE

    更新日期:1979-01-01 00:00:00

  • Combination chemotherapy in vitro exploiting glutamine metabolism of human glioma and medulloblastoma.

    abstract::The human glioma-derived cell line D-54 MG and the human medulloblastoma-derived cell line TE-671 have been shown to be sensitive in culture to the pharmacological interference with glutamine metabolism by acivicin, 6-diazo-5-oxo-L-norleucine, and methionine sulfoximine. Using as a guide the multiple contributions of ...

    journal_title:Cancer research

    pub_type: 杂志文章

    doi:

    authors: Dranoff G,Elion GB,Friedman HS,Bigner DD

    更新日期:1985-09-01 00:00:00

  • Intraperitoneal immunoconjugates.

    abstract::Intracavitary instillation of radioantibodies has been proposed as therapy for anatomically confined malignant disease. To evaluate this therapeutic strategy, a monoclonal antibody reactive with human transferrin receptor (7D3) was evaluated for localization in a human malignant mesothelioma transplanted i.p. in athym...

    journal_title:Cancer research

    pub_type: 临床试验,杂志文章

    doi:

    authors: Griffin TW,Collins J,Bokhari F,Stochl M,Brill AB,Ito T,Emond G,Sands H

    更新日期:1990-02-01 00:00:00

  • Monocyte-Derived Leukemia-Associated Macrophages Facilitate Extramedullary Distribution of T-cell Acute Lymphoblastic Leukemia Cells.

    abstract::Macrophages play important roles in both physiologic and pathologic processes and arise from successive waves of embryonic and adult hematopoiesis. Monocyte-derived macrophages (MOMF) exert distinct functions under pathologic conditions, and leukemia-associated macrophages (LAM) show considerable diversities in activa...

    journal_title:Cancer research

    pub_type: 杂志文章

    doi:10.1158/0008-5472.CAN-20-0034

    authors: Yang F,Feng W,Wang H,Wang L,Liu X,Wang R,Chen C,Yang X,Zhang D,Ren Q,Zheng G

    更新日期:2020-09-01 00:00:00

  • IgG2a induced by interleukin (IL) 12-producing tumor cell vaccines but not IgG1 induced by IL-4 vaccine is associated with the eradication of experimental metastases.

    abstract::We evaluated whether antibody response correlates with tumor therapy by cytokine gene-modified tumor cell vaccines. To characterize the antibody (Ab) response against a known antigen, colon carcinoma C26 cells and C26 variants engineered to produce interleukin (IL) 12 or IL-4 were further transduced to express the hum...

    journal_title:Cancer research

    pub_type: 杂志文章

    doi:

    authors: Rodolfo M,Melani C,Zilocchi C,Cappetti B,Luison E,Arioli I,Parenza M,Canevari S,Colombo MP

    更新日期:1998-12-15 00:00:00

  • Synchronization of hepatocellular DNA synthesis in regenerating rat liver by continuous infusion of hydroxyurea.

    abstract::Hydroxyurea (HU) inhibited DNA synthesis in the livers of partially hepatectomized rats. After an i.v. infusion of HU begun in the late G1 phase and continued for periods of up to 30 hr, all hepatocytes scheduled to embark on DNA synthesis in a characteristic intralobular sequence during this time interval accumulated...

    journal_title:Cancer research

    pub_type: 杂志文章

    doi:

    authors: Rabes HM,Iseler G,Czichos S,Tuczek HV

    更新日期:1977-04-01 00:00:00

  • The bioreductive prodrug PR-104A is activated under aerobic conditions by human aldo-keto reductase 1C3.

    abstract::PR-104, currently in phase II clinical trials, is a phosphate ester pre-prodrug which is converted in vivo to its cognate alcohol, PR-104A, a prodrug designed to exploit tumor hypoxia. Bioactivation occurs via one-electron reduction to DNA crosslinking metabolites in the absence of oxygen. However, certain tumor cell ...

    journal_title:Cancer research

    pub_type: 杂志文章

    doi:10.1158/0008-5472.CAN-09-3237

    authors: Guise CP,Abbattista MR,Singleton RS,Holford SD,Connolly J,Dachs GU,Fox SB,Pollock R,Harvey J,Guilford P,Doñate F,Wilson WR,Patterson AV

    更新日期:2010-02-15 00:00:00

  • The in vivo expansion rate of properly stimulated transferred CD8+ T cells exceeds that of an aggressively growing mouse tumor.

    abstract::It has been hypothesized that rapidly dividing tumor cells can outpace adoptively transferred antitumor lymphocytes when tumors are large. However, this hypothesis is at odds with clinical observations indicating that bulky tumors can be destroyed by small numbers of adoptively transferred antitumor T cells. We sought...

    journal_title:Cancer research

    pub_type: 杂志文章

    doi:10.1158/0008-5472.CAN-05-1679

    authors: Hwang LN,Yu Z,Palmer DC,Restifo NP

    更新日期:2006-01-15 00:00:00

  • An osteoprotegerin-like peptidomimetic inhibits osteoclastic bone resorption and osteolytic bone disease in myeloma.

    abstract::Multiple myeloma is a B-cell malignancy characterized by the uncontrolled growth of plasma cells in the bone marrow and the development of osteolytic bone disease. Myeloma cells express the receptor activator of nuclear factor kappaB ligand (RANKL), induce RANKL expression in the bone marrow, and down-regulate express...

    journal_title:Cancer research

    pub_type: 杂志文章

    doi:10.1158/0008-5472.CAN-06-1287

    authors: Heath DJ,Vanderkerken K,Cheng X,Gallagher O,Prideaux M,Murali R,Croucher PI

    更新日期:2007-01-01 00:00:00

  • Changes in gene expression following neoplastic transformation of rat myogenic cells.

    abstract::Two malignant sublines, M4 and RMS4 , were previously derived from the recloned L6 line of rat myogenic cells. Comparative studies in tissue culture and inoculation into suckling rats indicated that M4 cells and RMS4 cells may be considered as low-malignant and high-malignant cells, respectively, while L6 cells are no...

    journal_title:Cancer research

    pub_type: 杂志文章

    doi:

    authors: Hillion J,Leibovitch SA,Leibovitch MP,Raymondjean M,Kruh J,Harel J

    更新日期:1984-07-01 00:00:00

  • Unusually high expression of N-acetylglucosaminyltransferase-IVa in human choriocarcinoma cell lines: a possible enzymatic basis of the formation of abnormal biantennary sugar chain.

    abstract::Structural analysis of the sugar chains of human chorionic gonadotropin (hCG) has revealed that abnormal biantennary structures appear specifically on hCG in the urine of choriocarcinoma patients. However, the enzymatic and molecular mechanisms of the biosynthesis of abnormal biantennary sugar chains have not yet been...

    journal_title:Cancer research

    pub_type: 杂志文章

    doi:

    authors: Takamatsu S,Oguri S,Minowa MT,Yoshida A,Nakamura K,Takeuchi M,Kobata A

    更新日期:1999-08-15 00:00:00

  • Towards Greater Inclusion in Cancer Genomics Studies.

    abstract::The study by Jaratlerdsiri and colleagues represents the first whole-genome sequencing study of prostate cancer from men in sub-Saharan Africa. Preliminary findings include a higher tumor mutation burden in these tumors compared with data from other available prostate cancer cohorts. Although larger studies are needed...

    journal_title:Cancer research

    pub_type: 评论,杂志文章

    doi:10.1158/0008-5472.CAN-18-3382

    authors: Huang FW

    更新日期:2018-12-15 00:00:00

  • Search for estrogen receptors in human meningioma tissue sections with a monoclonal antibody against the human estrogen receptor.

    abstract::Meningiomas are rich in progestin receptors, whereas estrogen receptors (ER) are virtually undetectable. The present experiments were performed to evaluate whether the absence of ER from the majority of human meningioma cytosols can be attributed to: occurrence of only a small number of ER-positive cells in an otherwi...

    journal_title:Cancer research

    pub_type: 杂志文章

    doi:

    authors: Blankenstein MA,Berns PM,Blaauw G,Mulder E,Thijssen JH

    更新日期:1986-08-01 00:00:00

  • Chromogranin A restricts drug penetration and limits the ability of NGR-TNF to enhance chemotherapeutic efficacy.

    abstract::NGR-TNF is a derivative of TNF-α that targets tumor blood vessels and enhances penetration of chemotherapeutic drugs. Because of this property, NGR-TNF is being tested in combination with chemotherapy in various phase II and III clinical trials. Here we report that chromogranin A (CgA), a protein present in variable a...

    journal_title:Cancer research

    pub_type: 杂志文章

    doi:10.1158/0008-5472.CAN-11-1273

    authors: Dondossola E,Gasparri AM,Colombo B,Sacchi A,Curnis F,Corti A

    更新日期:2011-09-01 00:00:00

  • Increased amounts of double-stranded RNA in the cytoplasm of rat liver following treatment with carcinogens.

    abstract::Cytoplasmic RNA was isolated from control rats or at 48 hr following carcinogen administration. A significant quantity (0.6%) of double-stranded RNA was present in control preparations, as assessed by digestion with RNase III. Following carcinogen treatment of rats, this percentage increased significantly. The results...

    journal_title:Cancer research

    pub_type: 杂志文章

    doi:

    authors: Clawson GA,Smuckler EA

    更新日期:1982-08-01 00:00:00

  • Neopterin formation and tryptophan degradation by a human myelomonocytic cell line (THP-1) upon cytokine treatment.

    abstract::Determination of neopterin [D-erythro-6-(1',2',3'-trihydroxypropyl)pterin] in body fluids is a powerful diagnostic tool in a variety of diseases in which activation of cellular immune mechanisms is involved, such as certain malignancies, allograft rejection, and autoimmune and infectious diseases. In vitro, neopterin ...

    journal_title:Cancer research

    pub_type: 杂志文章

    doi:

    authors: Werner-Felmayer G,Werner ER,Fuchs D,Hausen A,Reibnegger G,Wachter H

    更新日期:1990-05-15 00:00:00

  • Identification of gene expression patterns in superficial and invasive human bladder cancer.

    abstract::Multiple transcriptional events take place when normal urothelium is transformed into tumor tissue. These can now be monitored simultaneously by the use of oligonucleotide arrays, and expression patterns of superficial and invasive tumors can be established. Single-cell suspensions were prepared from bladder biopsies ...

    journal_title:Cancer research

    pub_type: 杂志文章

    doi:

    authors: Thykjaer T,Workman C,Kruhøffer M,Demtröder K,Wolf H,Andersen LD,Frederiksen CM,Knudsen S,Orntoft TF

    更新日期:2001-03-15 00:00:00

  • Normal bronchial epithelial cell expression of glutathione transferase P1, glutathione transferase M3, and glutathione peroxidase is low in subjects with bronchogenic carcinoma.

    abstract::Normal bronchial epithelial cells (NBECs) are at risk for damage from inhaled and endogenous oxidative species and from epoxide metabolites of inhaled polycyclic aromatic hydrocarbons. Epidemiological and in vitro data suggest that interindividual variation in this risk may result from variation in NBEC expression of ...

    journal_title:Cancer research

    pub_type: 杂志文章

    doi:

    authors: Crawford EL,Khuder SA,Durham SJ,Frampton M,Utell M,Thilly WG,Weaver DA,Ferencak WJ,Jennings CA,Hammersley JR,Olson DA,Willey JC

    更新日期:2000-03-15 00:00:00