Surveillance, initial assessment, and subsequent progress of patients with superficial bladder cancer in a prospective longitudinal study. National Bladder Cancer Collaborative Group A (NBCCGA).

abstract：:Twenty patients with metastatic malignant melanoma were studied with 99mTc-labeled monoclonal antibody (MoAb) Fab fragment (NR-Ml-05) reactive with a high molecular weight (Mr 240,000) melanoma associated antigen. Patients received 40 mg unlabeled irrelevant MoAb (NR-2AD-IgG) and 7.5 mg unlabeled NR-Ml-05 (whole IgG) ...

journal_title：Cancer research

authors： Lamki LM,Zukiwski AA,Shanken LJ,Legha SS,Benjamin RS,Plager CE,Salk DF,Schroff RW,Murray JL

更新日期：1990-02-01 00:00:00

abstract：:This study was undertaken to determine the extent of apoptosis in lung carcinoma and to evaluate it as a prognostic marker. A series of 75 lung carcinomas (47 squamous cell carcinomas, 24 adenocarcinomas, 3 small cell carcinomas, and 1 large cell carcinoma) was analyzed for the extent of apoptosis by using the 3' end-...

journal_title：Cancer research

authors： Törmänen U,Eerola AK,Rainio P,Vähäkangas K,Soini Y,Sormunen R,Bloigu R,Lehto VP,Pääkkö P

更新日期：1995-12-01 00:00:00

abstract：:The chemotherapeutic agent 6-mercaptopurine was previously shown to inhibit the binding of 7r,8t-dihydroxy-9,10t-oxy-7,8,9,10-tetrahydro-benzo(a) pyrene (BPDE-I) to DNA in Chinese hamster ovary cells. Two compounds related to 6-mercaptopurine, 2,6-dithiopurine (DTP) and thiopurinol (TP), have been tested for inhibitio...

journal_title：Cancer research

authors： MacLeod MC,Mann KL,Thai G,Conti CJ,Reiners JJ Jr

更新日期：1991-09-15 00:00:00

abstract：:Four human tumor cell lines were grown in direct contact with the extracellular matrix proteins which had previously been produced by cultured rat smooth muscle cells. The extracellular matrix contained glycoproteins, elastin, and collagen, and its digestion by the tumor cells was followed by the appearance of radioac...

journal_title：Cancer research

authors： Jones PA,DeClerck YA

更新日期：1980-09-01 00:00:00

abstract：:Discoidin domain receptor 1 (DDR1) is a receptor tyrosine kinase activated by various types of collagens and is known to play a role in cell attachment, migration, survival, and proliferation. However, little is known about the molecular mechanism(s) underlying the role of DDR1 in cancer. We report here that DDR1 indu...

journal_title：Cancer research

authors： Das S,Ongusaha PP,Yang YS,Park JM,Aaronson SA,Lee SW

更新日期：2006-08-15 00:00:00

abstract：:Coho salmon (Oncorhynchus kisutch) and chinook salmon (Oncorhynchus tshawytscha) from Lakes Ontario, Michigan, Erie, or Huron were found to suffer epizootics of thyroid hyperplasia and goiters which appeared to have an environmental etiology. There were 13-fold differences in goiter prevalence within the Great Lakes, ...

journal_title：Cancer research

authors： Moccia RD,Leatherland JF,Sonstegard RA

更新日期：1981-06-01 00:00:00

abstract：:An in vitro system was used for investigating transport of rapidly labeled RNA from liver nuclei isolated from control and thioacetamide-treated rats. An enhanced transport was observed in preparations from thioacetamide-treated animals. Analysis of transport at various temperatures indicated that it proceeded as an e...

journal_title：Cancer research

authors： Clawson GA,Koplitz M,Moody DE,Smuckler EA

更新日期：1980-01-01 00:00:00

abstract：:Clinical efficacy of PD-1/PD-L1 targeting relies upon the reactivation of tumor-specific but functionally impaired PD-1+ T cells present before therapy. Thus, analyzing early-stage primary tumors may reveal the presence of T cells that are not yet functionally impaired. In this study, we report that activated (HLA-DR+...

journal_title：Cancer research

authors： Tassi E,Grazia G,Vegetti C,Bersani I,Bertolini G,Molla A,Baldassari P,Andriani F,Roz L,Sozzi G,Pastorino U,Mortarini R,Anichini A

更新日期：2017-02-15 00:00:00

abstract：:Lipid peroxidation is considered a unifying mechanistic pathway through which known risk factors induce renal cell carcinoma (RCC). We hypothesized that genes selected a priori for their role in lipid peroxidation would modify cancer risk. We genotyped 635 single nucleotide polymorphisms (SNP) in 38candidate genes in ...

journal_title：Cancer research

authors： Moore LE,Brennan P,Karami S,Menashe I,Berndt SI,Dong LM,Meisner A,Yeager M,Chanock S,Colt J,Schwartz K,Davis F,Zaridze D,Mattveev V,Janout V,Kollarova H,Bencko V,Navratilova M,Szeszenia-Dabrowska N,Mates D,Holcato

更新日期：2009-10-15 00:00:00

abstract：:Methodology for identifying tumor-associated antigens recognized by T cells has been successfully used to clone antigens from melanoma cells. Similar efforts for nonmelanoma tumors have had limited success with few antigens identified. To identify potentially relevant tumor-associated antigens expressed in renal cell ...

journal_title：Cancer research

authors： Hanada K,Perry-Lalley DM,Ohnmacht GA,Bettinotti MP,Yang JC

更新日期：2001-07-15 00:00:00

abstract：:Invasive breast cancer has a high risk of recurrence to incurable disease and needs improved prognostic and therapeutic tools. Our work combines clinical and molecular analyses to show that the transcriptional repressor HBP1 may be a new target for invasive breast cancer. Previous work indicated that HBP1 regulated pr...

journal_title：Cancer research

authors： Paulson KE,Rieger-Christ K,McDevitt MA,Kuperwasser C,Kim J,Unanue VE,Zhang X,Hu M,Ruthazer R,Berasi SP,Huang CY,Giri D,Kaufman S,Dugan JM,Blum J,Netto G,Wazer DE,Summerhayes IC,Yee AS

更新日期：2007-07-01 00:00:00

abstract：:The mammary carcinoma cell line MFM-223 is characterized by high androgen and low estrogen and progesterone receptor levels. With the dextran charcoal method, androgen binding was determined at 160 fmol/mg protein corresponding to approximately 100,000 binding sites per cell in whole cell binding assays. The estrogen ...

journal_title：Cancer research

authors： Hackenberg R,Lüttchens S,Hofmann J,Kunzmann R,Hölzel F,Schulz KD

更新日期：1991-10-15 00:00:00

abstract：:Melanoma is a disease characterized by lesions that activate ERK. Although 70% of cutaneous melanomas harbor activating mutations in the BRAF and NRAS genes, the alterations that drive tumor progression in the remaining 30% are largely undefined. Vemurafenib, a selective inhibitor of RAF kinases, has clinical utility ...

journal_title：Cancer research

authors： Nissan MH,Pratilas CA,Jones AM,Ramirez R,Won H,Liu C,Tiwari S,Kong L,Hanrahan AJ,Yao Z,Merghoub T,Ribas A,Chapman PB,Yaeger R,Taylor BS,Schultz N,Berger MF,Rosen N,Solit DB

更新日期：2014-04-15 00:00:00

abstract：:A rapid method for the measurement of serum and/or plasma, lipid-associated sialic acid levels has been developed. This test has been applied to 850 human sera of which 670 came from patients with nine categories of malignant disease, 80 from persons with benign disorders, and 100 from normal individuals. Lipid-associ...

journal_title：Cancer research

authors： Katopodis N,Hirshaut Y,Geller NL,Stock CC

更新日期：1982-12-01 00:00:00

abstract：:Adult rat parenchymal hepatocytes in primary culture can be induced to enter into DNA synthesis and mitosis. The optimal conditions for hepatocyte replication are low plating density (less than 10,000 cells/sq cm) and 50% serum from two-thirds partially hepatectomized rats (48 hr after hepatectomy). Approximately 80% ...

journal_title：Cancer research

authors： Michalopoulos G,Cianciulli HD,Novotny AR,Kligerman AD,Strom SC,Jirtle RL

更新日期：1982-11-01 00:00:00

abstract：:We have recently reported a simple and reproducible technique for the purification and rapid expansion of homogeneous populations of large granular lymphocytes expressing a natural killer cell phenotype and high levels of broad antitumor cytotoxic activity [lymphokine-activated killer (LAK) activity]. This technique e...

journal_title：Cancer research

authors： Schwarz RE,Vujanovic NL,Hiserodt JC

更新日期：1989-03-15 00:00:00

abstract：:Mc3 is a murine mAb that is highly effective in treating breast tumors in experimental radioimmunotherapy. Mc3 binds to BA46, a 46-kDa glycoprotein of the human milk fat globule membrane that is also expressed in breast carcinoma cells. We cloned and sequenced cDNAs encoding the variable regions of Mc3 and constructed...

journal_title：Cancer research

authors： Couto JR,Blank EW,Peterson JA,Ceriani RL

更新日期：1995-04-15 00:00:00

abstract：:Nm23-H1 has been identified as a metastasis suppressor gene, but its protein interactions have yet to be understood with any mechanistic clarity. In this study, we evaluated the proteomic spectrum of interactions made by Nm23-H1 in 4T1 murine breast cancer cells derived from tissue culture, primary mammary tumors, and...

journal_title：Cancer research

authors： Marino N,Marshall JC,Collins JW,Zhou M,Qian Y,Veenstra T,Steeg PS

更新日期：2013-10-01 00:00:00

abstract：:The formation and persistence of O6-ethylguanine, O4-ethylthymine, and O2-ethylthymine were quantitated in the genomic DNA of human lymphoblasts exposed to 1.0 mM N-ethyl-N-nitrosourea using immunoslot-blot. The three cell lines used included one which lacks O6-alkylguanine-DNA alkyltransferase, one deficient in nucle...

journal_title：Cancer research

authors： Bronstein SM,Skopek TR,Swenberg JA

更新日期：1992-04-01 00:00:00

abstract：:P-cadherin is normally expressed in the basal layer of squamous epithelia and absent from the healthy intestine and colon. We have previously shown it to be expressed in all inflamed, hyperplastic, and dysplastic intestinal and colonic mucosa. This study aimed to better understand the mechanisms controlling the expres...

journal_title：Cancer research

authors： Milicic A,Harrison LA,Goodlad RA,Hardy RG,Nicholson AM,Presz M,Sieber O,Santander S,Pringle JH,Mandir N,East P,Obszynska J,Sanders S,Piazuelo E,Shaw J,Harrison R,Tomlinson IP,McDonald SA,Wright NA,Jankowski JA

更新日期：2008-10-01 00:00:00

abstract：:The long latency period of cancer would suggest that timely measures to reduce the risk of cancer, such as dietary guidelines to the public, be an integral component of policy on cancer. Although criteria for acceptability of scientific evidence are often defined, judgment its required in interpreting the significance...

journal_title：Cancer research

authors： Palmer S

更新日期：1983-05-01 00:00:00

abstract：:Slow-clearing, tumor-targeting proteins such as monoclonal antibodies typically exhibit high tumor accumulation but low tissue contrast, whereas intermediate-sized proteins such as scFvs show faster clearance but only moderate tumor accumulation. For both, tumor targeting does not seem to improve further above an opti...

journal_title：Cancer research

authors： Zahnd C,Kawe M,Stumpp MT,de Pasquale C,Tamaskovic R,Nagy-Davidescu G,Dreier B,Schibli R,Binz HK,Waibel R,Plückthun A

更新日期：2010-02-15 00:00:00

abstract：:The plasma of dogs afflicted with mammary carcinoma was perfused through chambers bearing Staphylococcus aureus Cowan strain I in an attempt to remove tumor-promoting, immunosuppressive immune complexes from the peripheral blood of these animals. In this canine model of spontaneous mammary carcinoma, reduction of brea...

journal_title：Cancer research

authors： Holohan TV,Phillips TM,Bowles C,Deisseroth A

更新日期：1982-09-01 00:00:00

abstract：:Despite significant advances in cancer precision medicine, a significant hurdle to its broader adoption remains the multitude of variants of unknown significance identified by clinical tumor sequencing and the lack of biologically validated methods to distinguish between functional and benign variants. Here we used fu...

journal_title：Cancer research

authors： Hanrahan AJ,Sylvester BE,Chang MT,Elzein A,Gao J,Han W,Liu Y,Xu D,Gao SP,Gorelick AN,Jones AM,Kiliti AJ,Nissan MH,Nimura CA,Poteshman AN,Yao Z,Gao Y,Hu W,Wise HC,Gavrila EI,Shoushtari AN,Tiwari S,Viale A,Abd

更新日期：2020-10-01 00:00:00

abstract：:The effects of 5-mercapto-2'-deoxyuridine (MUdr) on DNA synthesis in a primary murine spleen lymphocyte culture system stimulated by phytohemagglutinin (PHA) were studied. Inhibition of thymidine incorporation into acid insoluble nucleic acid material was 50% at 0.5 mM MUdR concentration, while inhibition of deoxyurid...

journal_title：Cancer research

authors： Bogyo D,Bardos TJ,Chmielewicz ZF

更新日期：1976-09-01 00:00:00

abstract：:Inactivation of the tumor suppressor p53 through somatic mutations, observed in 50% of human cancers, is one of the leading causes of tumorigenesis. Clinical and experimental evidence also reveals that p53 mutations sometimes occur in tumor-associated fibroblasts, which correlate with an increased rate of metastases a...

journal_title：Cancer research

authors： Guo G,Marrero L,Rodriguez P,Del Valle L,Ochoa A,Cui Y

更新日期：2013-03-15 00:00:00

abstract：:We have isolated a Chinese hamster ovary cell line, designated ADR-1, which exhibits hypersensitivity to a range of drugs which are thought to inhibit the action of the enzyme topoisomerase II. These include anthracyclines, other classes of intercalating agents, and the epipodophyllotoxin, etoposide. No significant se...

journal_title：Cancer research

authors： Robson CN,Hoban PR,Harris AL,Hickson ID

更新日期：1987-03-15 00:00:00

abstract：:The purpose of this study was to determine the effect of route of hepatic administration of drug on the regional pharmacokinetics and systemic exposure of 5-fluorouracil (FUra) and 5-bromo-2-deoxyuridine (BrdUrd). A total of 13 mixed-breed male and female dogs were used in these acute studies. Each dog was administere...

journal_title：Cancer research

authors： Kuan HY,Smith DE,Ensmiger WD,Knol JA,DeRemer SJ,Yang Z,Stetson PL

更新日期：1996-10-15 00:00:00

abstract：:Hereditary renal carcinoma (RC) in the rat, originally reported by Eker in 1954, is an example of a Mendelian dominant predisposition to a specific cancer in an experimental animal. We previously reported that ionizing radiation induces additional tumors in a linear dose-response relationship, suggesting that in heter...

journal_title：Cancer research

authors： Kubo Y,Mitani H,Hino O

更新日期：1994-05-15 00:00:00

abstract：:CD99 is a Mr 32,000 transmembrane molecule that shows a high level of expression on cells of the hemopoietic system as well as on Ewing tumor cells. Within the hematopoietic system, CD99 has been implicated in cell adhesion and cell death, participating in this way in the differentiation of T-cell precursors. In this ...

journal_title：Cancer research

authors： Scotlandi K,Baldini N,Cerisano V,Manara MC,Benini S,Serra M,Lollini PL,Nanni P,Nicoletti G,Bernard G,Bernard A,Picci P

更新日期：2000-09-15 00:00:00