Increased amounts of double-stranded RNA in the cytoplasm of rat liver following treatment with carcinogens.

abstract：:A transplantable mammary tumor derived from an outgrowth of nodule-like alveolar lesions induced by 7,12-dimethylbenz[a]anthracene in cultures of whole mammary gland was shown to produce a family of somatomedin-like polypeptides when cultured in vitro. Minced mammary tumor tissue as well as monolayer cultures of tumor...

journal_title：Cancer research

authors： Knauer DJ,Iyer AP,Banerjee MR,Smith GL

更新日期：1980-12-01 00:00:00

abstract：:After initially identifying potential biomarkers of radiation exposure through microarray studies of ex vivo irradiated human peripheral white blood cells, we have now measured the in vivo responses of several of these biomarker genes in patients undergoing total body irradiation. Microarray analysis has identified ad...

journal_title：Cancer research

authors： Amundson SA,Grace MB,McLeland CB,Epperly MW,Yeager A,Zhan Q,Greenberger JS,Fornace AJ Jr

更新日期：2004-09-15 00:00:00

abstract：:Mucin-depleted foci (MDF) are microscopic dysplastic lesions induced in the colon of rodents by specific colon carcinogens. Most MDF show Wnt pathway activation, whereas only a subset shows mutations in the Ctnnb1 gene, coding for beta-catenin. Because Apc is a member of the Wnt pathway and the most frequent mutated g...

journal_title：Cancer research

authors： Femia AP,Dolara P,Giannini A,Salvadori M,Biggeri A,Caderni G

更新日期：2007-01-15 00:00:00

abstract：:Palytoxin (PTX), one of the most toxic nonprotein molecules known, is cytotoxic at picomolar concentrations against a wide variety of cell types. In contrast to most cytotoxins, PTX exerts its activity extracellularly. A method for targeting PTX to tumor cells is described in which a monoclonal antibody-enzyme conjuga...

journal_title：Cancer research

authors： Bignami GS,Senter PD,Grothaus PG,Fischer KJ,Humphreys T,Wallace PM

更新日期：1992-10-15 00:00:00

abstract：:Tumor hypoxia induces the up-regulation of a gene program associated with angiogenesis, glycolysis, adaptation to pH, and apoptosis via the hypoxia-inducible transcription factors (Hifs) 1 and 2. Disruption of this pathway has been proposed as a cancer therapy. Here, we use short interfering RNAs to compare specific i...

journal_title：Cancer research

authors： Sowter HM,Raval RR,Moore JW,Ratcliffe PJ,Harris AL

更新日期：2003-10-01 00:00:00

abstract：:Gene expression signatures for a basal-like breast cancer (BLBC) subtype have been associated with poor clinical outcomes, but a molecular basis for this disease remains unclear. Here, we report overexpression of the transcription factor FOXC1 as a consistent feature of BLBC compared with other molecular subtypes of b...

journal_title：Cancer research

authors： Ray PS,Wang J,Qu Y,Sim MS,Shamonki J,Bagaria SP,Ye X,Liu B,Elashoff D,Hoon DS,Walter MA,Martens JW,Richardson AL,Giuliano AE,Cui X

更新日期：2010-05-15 00:00:00

abstract：:Chemoprevention of colorectal cancer using aspirin has been demonstrated in rodents and has been suggested by data from epidemiological studies. The mechanism that accounts for this prevention is unknown, but it is thought to relate to an irreversible inhibition of cyclooxygenase and, subsequently, prostaglandin produ...

journal_title：Cancer research

authors： Subbegowda R,Frommel TO

更新日期：1998-07-01 00:00:00

abstract：:Serial anthropometrics, creatinine-height ratios. serum albumin levels, and elemental balances were compared for cachectic cancer and noncancer patients receiving hyperalimentation. Cancer patients compared unfavorably in all measurements except triceps skinfold increments, which were equal for both groups, suggesting...

journal_title：Cancer research

authors： Nixon DW

更新日期：1982-01-01 00:00:00

abstract：:The underlying mechanism regulating the expression of the cancer stem cell/tumor-initiating cell marker CD133/prominin-1 in cancer cells remains largely unclear, although knowledge of this mechanism would likely provide important biological information regarding cancer stem cells. Here, we found that the inhibition of...

journal_title：Cancer research

authors： Matsumoto K,Arao T,Tanaka K,Kaneda H,Kudo K,Fujita Y,Tamura D,Aomatsu K,Tamura T,Yamada Y,Saijo N,Nishio K

更新日期：2009-09-15 00:00:00

abstract：:Arsenite-induced mitotic abnormalities result in mitotic death in several cancer cell lines. However, how arsenite induces these effects is not known. We have previously shown that arsenite induces mitotic arrest, mitotic abnormalities, and mitotic death in CGL-2 cells. To further delineate the mechanism of action of ...

journal_title：Cancer research

authors： Yih LH,Tseng YY,Wu YC,Lee TC

更新日期：2006-02-15 00:00:00

abstract：:Glycogen synthase kinase 3beta (GSK3beta) is a multifunctional serine/threonine kinase. We showed that the expression of GSK3beta was drastically down-regulated in human cutaneous squamous cell carcinomas and basal cell carcinomas. Due to its negative regulation of many oncogenic proteins, we hypothesized that GSK3bet...

journal_title：Cancer research

authors： Ma C,Wang J,Gao Y,Gao TW,Chen G,Bower KA,Odetallah M,Ding M,Ke Z,Luo J

更新日期：2007-08-15 00:00:00

abstract：:Malignant changes are often accompanied by alterations in activity and composition of the plasminogen activators (PA). To study the relationship between PA expression and the development of colorectal cancer, we determined urokinase-type plasminogen activator (u-PA) and tissue-type plasminogen activator (t-PA) activit...

journal_title：Cancer research

authors： de Bruin PA,Griffioen G,Verspaget HW,Verheijen JH,Lamers CB

更新日期：1987-09-01 00:00:00

abstract：:Transcriptional regulator YAP is activated in multiple human cancers and plays critical roles in tumor initiation, progression, metastasis, and drug resistance. However, therapeutic targeting of the Hippo-YAP pathway has been challenging due to its low druggability and limited knowledge of YAP regulation in cancer. He...

journal_title：Cancer research

authors： Seo J,Kim MH,Hong H,Cho H,Park S,Kim SK,Kim J

更新日期：2019-12-15 00:00:00

abstract：:We report here the use of viral fusogenic membrane glycoproteins (FMGs) as a new class of therapeutic genes for the control of tumor growth. FMGs kill cells by fusing them into large multinucleated syncytia, which die by sequestration of cell nuclei and subsequent nuclear fusion by a mechanism that is nonapoptotic, as...

journal_title：Cancer research

authors： Bateman A,Bullough F,Murphy S,Emiliusen L,Lavillette D,Cosset FL,Cattaneo R,Russell SJ,Vile RG

更新日期：2000-03-15 00:00:00

abstract：:Apoptosis is a mode of cell death that is carefully regulated based on cellular and environmental signals. The ability to modulate the individual cellular machinery and thereby to promote apoptosis is an important strategy in cancer therapy. It has previously been shown that overexpression of the transcription factor ...

journal_title：Cancer research

authors： Hunt KK,Deng J,Liu TJ,Wilson-Heiner M,Swisher SG,Clayman G,Hung MC

更新日期：1997-11-01 00:00:00

abstract：:Small-molecule inhibitors of PARP1/2, such as olaparib, have been proposed to serve as a synthetic lethal therapy for cancers that harbor BRCA1 or BRCA2 mutations. Indeed, in clinical trials, PARP1/2 inhibitors elicit sustained antitumor responses in patients with germline BRCA gene mutations. In hypothesizing that ad...

journal_title：Cancer research

authors： Bajrami I,Frankum JR,Konde A,Miller RE,Rehman FL,Brough R,Campbell J,Sims D,Rafiq R,Hooper S,Chen L,Kozarewa I,Assiotis I,Fenwick K,Natrajan R,Lord CJ,Ashworth A

更新日期：2014-01-01 00:00:00

abstract：:Although altered expression of platelet-derived growth factor (PDGF)-A is a hallmark of many cancers, the importance of pro-PDGF-A conversion to PDGF-A in tumorigenesis and the cognate protease(s) is unknown. Pro-PDGF-A processing occurs at pairs of basic residues, likely involving the proprotein convertases (PCs). In...

journal_title：Cancer research

authors： Siegfried G,Khatib AM,Benjannet S,Chrétien M,Seidah NG

更新日期：2003-04-01 00:00:00

abstract：:The p53 gene has been implicated as a tumor suppressor gene involved in the pathogenesis of lung cancer. Our previous study revealed that the p53 gene is frequently mutated with a distinct nucleotide substitution pattern in small cell lung cancer specimens in Japanese patients. In this study, we examined 30 primary, r...

journal_title：Cancer research

authors： Suzuki H,Takahashi T,Kuroishi T,Suyama M,Ariyoshi Y,Takahashi T,Ueda R

更新日期：1992-02-01 00:00:00

abstract：:Myeloproliferative disorders (MPD) are stem cell-derived clonal diseases arising as a consequence of acquired aberrations in c-ABL, Janus-activated kinase 2 (JAK2), and platelet-derived growth factor receptor (PDGFR) that generate oncogenic fusion tyrosine kinases (FTK), including BCR/ABL, TEL/ABL, TEL/JAK2, and TEL/P...

journal_title：Cancer research

authors： Cramer K,Nieborowska-Skorska M,Koptyra M,Slupianek A,Penserga ET,Eaves CJ,Aulitzky W,Skorski T

更新日期：2008-09-01 00:00:00

abstract：:UV radiation has been shown to play a role in the initiation of human cutaneous melanoma, but its role in the development of malignant melanoma to the metastatic state is not very well defined. Although previous studies have concentrated on the effect of UV-B on the host immune response, the effect of UV-B on the tumo...

journal_title：Cancer research

authors： Singh RK,Gutman M,Reich R,Bar-Eli M

更新日期：1995-08-15 00:00:00

abstract：:TGF-β has limited effects on ovarian cancer cells, but its contributions to ovarian tumor growth might be mediated through elements of the tumor microenvironment. In the present study, we tested the hypothesis that TGF modulates ovarian cancer progression by modulating the contribution of cancer-associated fibroblasts...

journal_title：Cancer research

authors： Yeung TL,Leung CS,Wong KK,Samimi G,Thompson MS,Liu J,Zaid TM,Ghosh S,Birrer MJ,Mok SC

更新日期：2013-08-15 00:00:00

abstract：:Cytosol estradiol receptor from MTW9-D (ovarian dependent) and MTW9-MtT (ovarian independent) rat mammary tumors were fractionated by chromatofocusing, a procedure which separates proteins on an ion-exchange column as a function of isoelectric point. Receptor from MTW9-D usually fractionated as three peaks with mean p...

journal_title：Cancer research

authors： Coufalik AH,Feldman M,Platica M,Toth L,Dreiling D,Hollander VP

更新日期：1983-11-01 00:00:00

abstract：:Bisphosphonate (BP), a specific inhibitor of osteoclasts, has been widely used as a beneficial agent for the treatment of bone metastases in patients with breast cancer. It is well recognized that BP reduces osteolysis by promoting apoptosis in osteoclasts. However, recent animal and human data suggest that BPs not on...

journal_title：Cancer research

authors： Hiraga T,Williams PJ,Mundy GR,Yoneda T

更新日期：2001-06-01 00:00:00

abstract：:CAMA-1 cells, isolated from malignant pleural effusion, are grown in long-term cultures as monolayers. The rate of growth is dependent upon fetal bovine serum and estradiol. These cells also exhibit a dose response to added 17 beta-estradiol with respect to the incorporation of radiolabeled thymidine into cells. The u...

journal_title：Cancer research

authors： Leung BS,Qureshi S,Leung JS

更新日期：1982-12-01 00:00:00

abstract：:The relationship between adenosine deaminase (ADA) and a human membrane thymus leukemia (HTL) antigen-detected by an antithymocyte serum was explored. A freeze-thaw extract of the T-cell-derived cell line, MOLT 4, was applied to an immunoabsorbant column of a rabbit antiserum to calf ADA. The bound MOLT 4 ADA was elut...

journal_title：Cancer research

authors： Dowell BL,Segars JH,Metzgar RS

更新日期：1981-01-01 00:00:00

abstract：:An interstitial deletion of the short arm of a chromosome 11 was found in Wilms' tumor cells of a patient without aniridia. The chromosomes in her peripheral blood lymphocytes were normal. The karyotype of the tumor cells is similar to that reported for the somatic cells of patients with aniridia-Wilms' tumor associat...

journal_title：Cancer research

authors： Kaneko Y,Egues MC,Rowley JD

更新日期：1981-11-01 00:00:00

abstract：:The deregulation of several cell cycle-related genes participates in neoplastic transformation. Cell cycle progression is driven by cyclin-dependent kinases, which are positively regulated by association with cyclins and negatively regulated by binding to inhibitory subunits. The activity of cyclin-dependent kinases i...

journal_title：Cancer research

authors： Gasparotto D,Maestro R,Piccinin S,Vukosavljevic T,Barzan L,Sulfaro S,Boiocchi M

更新日期：1997-06-15 00:00:00

abstract：:A theoretical drawback to alpha-particle therapy with 213Bi is the short range of the particle track coupled with the short half-life of the radionuclide, thereby potentially limiting effective cytotoxicity to rapidly accessible, disseminated individual tumor cells (e.g., as in leukemia). In this work, a prostate carc...

journal_title：Cancer research

authors： Ballangrud AM,Yang WH,Charlton DE,McDevitt MR,Hamacher KA,Panageas KS,Ma D,Bander NH,Scheinberg DA,Sgouros G

更新日期：2001-03-01 00:00:00

abstract：:Neuroblastoma (NB), a common pediatric neoplasm, consists of two main cell populations: neuroblastic/ganglionic cells and Schwann cells. NB tumors with abundant Schwannian stroma display a more benign clinical behavior than stroma-poor tumors. Recent studies suggest that Schwann cells influence NB tumor growth via sec...

journal_title：Cancer research

authors： Chlenski A,Liu S,Crawford SE,Volpert OV,DeVries GH,Evangelista A,Yang Q,Salwen HR,Farrer R,Bray J,Cohn SL

更新日期：2002-12-15 00:00:00

abstract：:We previously found that a high-molecular-weight anticancer agent, polystyrene-co-maleic acid conjugated neocarzinostatin (SMANCS), in which two chains of styrene/maleic acid copolymer are conjugated to the anticancer protein neocarzinostatin (NCS), accumulated more selectively in tumor tissue than in normal tissue an...

journal_title：Cancer research

authors： Kimoto A,Konno T,Kawaguchi T,Miyauchi Y,Maeda H

更新日期：1992-02-15 00:00:00