Human in vivo radiation-induced biomarkers: gene expression changes in radiotherapy patients.

abstract：:The role of CD4+ T lymphocytes in antitumor immunity has been largely attributed to providing signals required for the priming of MHC class I-restricted CD8+ cytotoxic T lymphocytes, and CD8+ cytotoxic T lymphocytes are thought to serve as the predominant mediators of tumor killing in vivo. We decided to evaluate the ...

journal_title：Cancer research

authors： Kennedy RC,Shearer MH,Watts AM,Bright RK

更新日期：2003-03-01 00:00:00

abstract：:Aniline of unknown purity has been reported to induce spleen hemangiosarcoma in rats. Aniline has been found to be negative in terms of mutagenicity in both bacteria and yeasts. We have found that both commercial (already rather pure) and repurified aniline are clearly positive to a similar extent in inducing DNA dama...

journal_title：Cancer research

authors： Parodi S,Pala M,Russo P,Zunino A,Balbi C,Albini A,Valerio F,Cimberle MR,Santi L

更新日期：1982-06-01 00:00:00

abstract：:Glucocorticoids are used for the treatment of lymphoid neoplasms, taking advantage of the well-known ability of these compounds to cause apoptosis in lymphoid tissues. Previously, we have shown that dexamethasone, a synthetic glucocorticoid, causes a down-regulation of several antioxidant defense enzymes and proteins,...

journal_title：Cancer research

authors： Tome ME,Baker AF,Powis G,Payne CM,Briehl MM

更新日期：2001-03-15 00:00:00

abstract：:Monoclonal antibody HT462 recognizes a human T-cell leukemia virus type I (HTLV-I)-associated Mr 52,000 glycoprotein (HA-gp52), which is found on the surface of HTLV-infected cells. Whether HA-gp52 is encoded by the virus or by the infected cells has not yet been established. Using monoclonal HT462 in a competitive bi...

journal_title：Cancer research

authors： Robert-Guroff M,Clark JW

更新日期：1985-07-01 00:00:00

abstract：:Metformin, a biguanide widely used in the treatment of type II diabetes, clearly exhibits antineoplastic activity in experimental models and has been reported to reduce cancer incidence in diabetics. There are ongoing clinical trials to evaluate its antitumor properties, which may relate to its fundamental activity as...

journal_title：Cancer research

authors： Gravel SP,Hulea L,Toban N,Birman E,Blouin MJ,Zakikhani M,Zhao Y,Topisirovic I,St-Pierre J,Pollak M

更新日期：2014-12-15 00:00:00

abstract：:Sixteen steroids with different endocrine activities were administered to female rats for 6 or 7 days, in a broad range of doses. Liver growth was recorded by measuring weight and DNA contents and monooxygenase activity by assaying the turnover of five different substrates. According to their effects on these paramete...

journal_title：Cancer research

authors： Schulte-Hermann R,Ochs H,Bursch W,Parzefall W

更新日期：1988-05-01 00:00:00

abstract：:Targeting of steroidogenic enzymes (e.g., abiraterone acetate targeting CYP17A1) has been developed as a novel therapeutic strategy against metastatic castration-resistant prostate cancer (CRPC). However, resistance to steroidal inhibitors inevitably develops in patients, the mechanisms of which remain largely unknown...

journal_title：Cancer research

authors： Xiao L,Wang Y,Xu K,Hu H,Xu Z,Wu D,Wang Z,You W,Ng CF,Yu S,Chan FL

更新日期：2018-05-01 00:00:00

abstract：:B16 melanoma cell variants were used to determine if the metastatic properties of these cells could be correlated to distinct plasma membrane, microsome, and mitochondrial membrane lipid compositions and membrane-bound enzyme activities in high- and low-metastatic cell variants, respectively. The high-metastatic B16-F...

journal_title：Cancer research

authors： Schroeder F,Gardiner JM

更新日期：1984-08-01 00:00:00

abstract：:Tumor-infiltrating lymphocytes (TIL) are potent mediators of an antitumor response. However, their function is attenuated in solid tumors. CD8+ T-cell effector functions, such as cytokine and granzyme production, depend on cytoplasmic Ca2+, which is controlled by ion channels. In particular, Kv1.3 channels regulate th...

journal_title：Cancer research

authors： Chimote AA,Hajdu P,Sfyris AM,Gleich BN,Wise-Draper T,Casper KA,Conforti L

更新日期：2017-01-01 00:00:00

abstract：:The mechanism of in vitro cytotoxicity by tumor necrosis serum (TNS) and a purified fraction was examined using sensitive L-M cells. Cell death was assessed by uptake of the dye trypan blue and/or by release of radiolabeled chromium. Cell killing was time and dose dependent. Cell survival was assessed by counting the ...

journal_title：Cancer research

authors： Kull FC Jr,Cuatrecasas P

更新日期：1981-12-01 00:00:00

abstract：:Normal, viral transformed and tumor-derived cells grown in tissue culture and representing different species were tested for their ability to produce an extracellular tumor angiogenesis factor (TAF). TAF was assayed by measuring the host-mediated vascular response of the chorioallantoic membrane to TAF preparations. A...

journal_title：Cancer research

authors： Klagsbrun M,Knighton D,Folkman J

更新日期：1976-01-01 00:00:00

abstract：:Pancreatic ductal adenocarcinoma (PDAC) remains one of the most lethal cancers largely due to disseminated disease at the time of presentation. Here, we investigated the role and mechanism of action of the metastasis-associated protein anterior gradient 2 (AGR2) in the pathogenesis of pancreatic cancer. AGR2 was induc...

journal_title：Cancer research

authors： Dumartin L,Whiteman HJ,Weeks ME,Hariharan D,Dmitrovic B,Iacobuzio-Donahue CA,Brentnall TA,Bronner MP,Feakins RM,Timms JF,Brennan C,Lemoine NR,Crnogorac-Jurcevic T

更新日期：2011-11-15 00:00:00

abstract：:One of the major problems in the diagnosis of localized prostatic tumors is to predict the aggressiveness of an individual tumor, which is presumably associated with chance to progression. In an attempt to find molecular markers that are specific for aggressive prostatic cancer cells, we compared steady-state mRNA lev...

journal_title：Cancer research

authors： Bussemakers MJ,van de Ven WJ,Debruyne FM,Schalken JA

更新日期：1991-01-15 00:00:00

abstract：:Compelling evidences indicate a key role for regulatory T cells (T(reg)) on the host response to cancer. The Wilms' tumor antigen (WT1) is overexpressed in several human leukemias and thus considered as promising target for development of leukemia vaccine. However, recent studies indicated that the generation of effec...

journal_title：Cancer research

authors： Lehe C,Ghebeh H,Al-Sulaiman A,Al Qudaihi G,Al-Hussein K,Almohareb F,Chaudhri N,Alsharif F,Al-Zahrani H,Tbakhi A,Aljurf M,Dermime S

更新日期：2008-08-01 00:00:00

abstract：:Although immunotherapy based on the adoptive transfer of tumor-specific T lymphocytes has been shown to result in dramatic clinical responses in some patients, the relatively low levels of engraftment and persistence of the adoptively transferred cells may limit these responses in many patients. In an attempt to devel...

journal_title：Cancer research

authors： Charo J,Finkelstein SE,Grewal N,Restifo NP,Robbins PF,Rosenberg SA

更新日期：2005-03-01 00:00:00

abstract：:Malignant pleural mesothelioma (MPM) is an aggressive malignant tumor that secretes various angiogenic factors. The main inhibitor of plasminogen activators, PAI-1 (SERPINE1), has been implicated in tumor progression and angiogenesis, and high PAI-1 expression has been associated with poor prognosis in MPM patients. I...

journal_title：Cancer research

authors： Takayama Y,Hattori N,Hamada H,Masuda T,Omori K,Akita S,Iwamoto H,Fujitaka K,Kohno N

更新日期：2016-06-01 00:00:00

abstract：:With the publishing of the first complete whole genome of a human cancer and its paired normal, we have passed a key milestone in the cancer genome sequencing strategy. The generation of such data will, thanks to technical advances, soon become commonplace. As a significant number of proof-of-concept studies have been...

journal_title：Cancer research

authors： Fox EJ,Salk JJ,Loeb LA

更新日期：2009-06-15 00:00:00

abstract：:Anti-VEGF pathway therapies primarily target immature blood vessels in tumors. However, emerging approaches to combine with targeted therapies impacting the later stages of remodeling and vessel maturation are expected to improve clinical efficacy by expanding the target vessel population. The angiopoietin/Tie ligand/...

journal_title：Cancer research

authors： Gerald D,Chintharlapalli S,Augustin HG,Benjamin LE

更新日期：2013-03-15 00:00:00

abstract：:The pathogenesis of 210Po-induced tumors in the peripheral lung of Syrian golden hamsters has been studied in a serial sacrifice experiment utilizing both plastic (glycol methacrylate) and routine paraffin embedding procedures for lung sections. A rapid progression from hyperplasia of bronchiolar-type cells that appea...

journal_title：Cancer research

authors： Kennedy AR,McGundy RB,Little JB

更新日期：1978-04-01 00:00:00

abstract：:Recently, we have reported that the toxicity of the membrane-active agent valinomycin (VM) can be reduced with maintenance and/or enhancement of its antitumor activity by incorporation in liposomes (S. S. Daoud and Juliano, Cancer Res., 46:5518-5525, 1986). Since the underlying defect(s) in multidrug resistance reside...

journal_title：Cancer research

authors： Daoud SS,Juliano RL

更新日期：1989-05-15 00:00:00

abstract：:Chinese hamster ovary cells were exposed to the sulfhydryl compound cysteamine at different temperatures (5 degrees C, 37 degrees C, 44 degrees C) at concentrations known to generate activated oxygen species. At 37 degrees C, the cellular glutathione (GSH) content increased linearly over the time of drug exposure (2 h...

journal_title：Cancer research

authors： Issels RD,Bourier S,Biaglow JE,Gerweck LE,Wilmanns W

更新日期：1985-12-01 00:00:00

abstract：:Twenty-one tumors from 18 patients (two independent tumors were obtained from each of three patients) with hepatocellular carcinomas were examined for loss of heterozygosity (LOH) at loci on chromosome 13q, using 15 polymorphic nucleotide sequences of microsatellites as genetic markers. The results revealed LOH in a c...

journal_title：Cancer research

authors： Zhang X,Xu HJ,Murakami Y,Sachse R,Yashima K,Hirohashi S,Hu SX,Benedict WF,Sekiya T

更新日期：1994-08-01 00:00:00

abstract：:Genetic alterations that occur in human breast cancers are believed to be of importance for initiation as well as progression of the disease. In order to find a genetic alteration that may be used as a prognostic marker, 82 familial breast carcinomas were analyzed for loss of constitutional heterozygosity at polymorph...

journal_title：Cancer research

authors： Lindblom A,Rotstein S,Skoog L,Nordenskjöld M,Larsson C

更新日期：1993-08-15 00:00:00

abstract：:The aim of this study was to evaluate to what extent tumor necrosis factor alpha (TNF-alpha) and interleukin 1 may explain the development of experimental cancer cachexia. For this purpose, C57BL/6J mice bearing a transplantable low differentiated rapidly growing tumor were passively immunized every other day with rab...

journal_title：Cancer research

authors： Gelin J,Moldawer LL,Lönnroth C,Sherry B,Chizzonite R,Lundholm K

更新日期：1991-01-01 00:00:00

abstract：:Cancer patients and tumor-bearing animals excrete high levels of modified purines and pyrimidines some of which, e.g., N2,N2-dimethylguanosine, can originate only from transfer RNA (tRNA). Until recently, it could not be ascertained whether the high level of excretion of such compounds is due to cell death or specific...

journal_title：Cancer research

authors： Borek E,Baliga BS,Gehrke CW,Kuo CW,Belman S,Troll W,Waalkes TP

更新日期：1977-09-01 00:00:00

abstract：:Emerging studies indicate that DNA damage in cancer cells triggers antitumor immunity, but its intrinsic regulatory mechanism in breast cancer cells remains poorly understood. Here, we show that ZMYND8 is upregulated and inhibits micronucleus formation and DNA damage in breast cancer cells. Loss of ZMYND8 triggered ac...

journal_title：Cancer research

authors： Wang Y,Luo M,Chen Y,Wang Y,Zhang B,Ren Z,Bao L,Wang Y,Wang JE,Fu YX,Luo W,Wang Y

更新日期：2020-11-04 00:00:00

abstract：:Activated leukocyte cell adhesion molecule (ALCAM/CD166/MEMD) could function as a cell surface sensor for cell density, controlling the transition between local cell proliferation and tissue invasion in melanoma progression. We have tested the hypothesis that progressive cell clustering controls the proteolytic cascad...

journal_title：Cancer research

authors： Lunter PC,van Kilsdonk JW,van Beek H,Cornelissen IM,Bergers M,Willems PH,van Muijen GN,Swart GW

更新日期：2005-10-01 00:00:00

abstract：:Initial studies have identified TSP50 as a human testes-specific gene that is demethylated in breast cancer. In this study, we will present new data related to the TSP50 gene. We have found that the TSP50 gene product shares a similar enzymatic structure with many serine proteases. However, the most critical catalytic...

journal_title：Cancer research

authors： Shan J,Yuan L,Xiao Q,Chiorazzi N,Budman D,Teichberg S,Xu HP

更新日期：2002-01-01 00:00:00

abstract：:In our previous studies we showed that motility related protein 1 (MRP-1) is a glycoprotein recognized by mAb M31-15, and that the sequence of MRP-1 is identical to that of CD9, a WBC differentiation antigen. Transfection of MRP-1/CD9 cDNA into cultured nonhematopoietic cells suppresses cell motility. The extent of su...

journal_title：Cancer research

authors： Miyake M,Nakano K,Ieki Y,Adachi M,Huang CL,Itoi S,Koh T,Taki T

更新日期：1995-09-15 00:00:00

abstract：:Low income, poor diet, obesity, and a lack of exercise are interrelated lifestyle factors that can profoundly alter our biologic make up to increase cancer risk, growth, and development. We recently reported a potential mechanistic link between carbohydrate-derived metabolites and cancer, which may provide a biologic ...

journal_title：Cancer research

authors： Turner DP

更新日期：2015-05-15 00:00:00