Interstitial deletion of short arm of chromosome 11 limited to Wilms' tumor cells in a patient without aniridia.

Abstract:

:An interstitial deletion of the short arm of a chromosome 11 was found in Wilms' tumor cells of a patient without aniridia. The chromosomes in her peripheral blood lymphocytes were normal. The karyotype of the tumor cells is similar to that reported for the somatic cells of patients with aniridia-Wilms' tumor association. We showed that the same cytogenetic change as that seen in patients with this condition, namely, an interstitial deletion of 11p13, can occur in patients without aniridia as a mutation that is confined to tumor cells.

journal_name

Cancer Res

journal_title

Cancer research

authors

Kaneko Y,Egues MC,Rowley JD

subject

Has Abstract

pub_date

1981-11-01 00:00:00

pages

4577-8

issue

11 Pt 1

eissn

0008-5472

issn

1538-7445

journal_volume

41

pub_type

杂志文章
  • Adaptive therapy.

    abstract::A number of successful systemic therapies are available for treatment of disseminated cancers. However, tumor response is often transient, and therapy frequently fails due to emergence of resistant populations. The latter reflects the temporal and spatial heterogeneity of the tumor microenvironment as well as the evol...

    journal_title:Cancer research

    pub_type: 杂志文章

    doi:10.1158/0008-5472.CAN-08-3658

    authors: Gatenby RA,Silva AS,Gillies RJ,Frieden BR

    更新日期:2009-06-01 00:00:00

  • The putative tumor suppressor gene FHIT at 3p14.2 is rarely affected by loss of heterozygosity in primary human brain tumors.

    abstract::To elucidate the role of the recently identified FHIT gene, located at 3p14.2 in human brain tumor carcinogenesis, a total of 259 tumors were analyzed for loss of heterozygosity (LOH) at microsatellite loci D3S1313, D3S1234, D3S1300, and D3S1481. In primary brain tumors, LOH was detected at a frequency of 8.4% (n = 21...

    journal_title:Cancer research

    pub_type: 杂志文章

    doi:

    authors: Frank S,Müller J,Plaschke J,Hahn M,Hampl J,Hampl M,Pistorius S,Schackert G,Schackert HK

    更新日期:1997-07-01 00:00:00

  • Direct evidence for a role of cyclooxygenase 2-derived prostaglandin E2 in human head and neck xenograft tumors.

    abstract::Both nonsteroidal anti-inflammatory drugs (NSAIDs) and cyclooxygenase (COX) 2-selective inhibitors such as celecoxib are being reported as having potent anticancer activity in laboratory models. Several reports have suggested that the mechanism of action of these agents in reducing tumor volume/burden is unrelated to ...

    journal_title:Cancer research

    pub_type: 杂志文章

    doi:

    authors: Zweifel BS,Davis TW,Ornberg RL,Masferrer JL

    更新日期:2002-11-15 00:00:00

  • Interferon-γ Signaling in Melanocytes and Melanoma Cells Regulates Expression of CTLA-4.

    abstract::CTLA4 is a cell surface receptor on T cells that functions as an immune checkpoint molecule to enforce tolerance to cognate antigens. Anti-CTLA4 immunotherapy is highly effective at reactivating T-cell responses against melanoma, which is postulated to be due to targeting CTLA4 on T cells. Here, we report that CTLA4 i...

    journal_title:Cancer research

    pub_type: 杂志文章

    doi:10.1158/0008-5472.CAN-17-1615

    authors: Mo X,Zhang H,Preston S,Martin K,Zhou B,Vadalia N,Gamero AM,Soboloff J,Tempera I,Zaidi MR

    更新日期:2018-01-15 00:00:00

  • Promotion of angiogenesis by ps20 in the differential reactive stroma prostate cancer xenograft model.

    abstract::Human prostate cancer is associated with a reactive stroma typified by an increase in the proportion of myofibroblast type cells and elevated synthesis of extracellular matrix proteins. Increased vascular density has been identified in the reactive stroma compartment adjacent to both precancerous and cancerous prostat...

    journal_title:Cancer research

    pub_type: 杂志文章

    doi:

    authors: McAlhany SJ,Ressler SJ,Larsen M,Tuxhorn JA,Yang F,Dang TD,Rowley DR

    更新日期:2003-09-15 00:00:00

  • IL-2 costimulation enables statin-mediated activation of human NK cells, preferentially through a mechanism involving CD56+ dendritic cells.

    abstract::Statins are inhibitors of cholesterol biosynthesis and protein prenylation that also have been studied in cancer therapy and chemoprevention. With regard to natural killer (NK) cells, only inhibitory effects of statins such as suppression of granule exocytosis have been reported so far. In this study, we show that sta...

    journal_title:Cancer research

    pub_type: 杂志文章

    doi:10.1158/0008-5472.CAN-10-1968

    authors: Gruenbacher G,Gander H,Nussbaumer O,Nussbaumer W,Rahm A,Thurnher M

    更新日期:2010-12-01 00:00:00

  • IL6 Promotes a STAT3-PRL3 Feedforward Loop via SHP2 Repression in Multiple Myeloma.

    abstract::Overexpression of PRL-3, an oncogenic phosphatase, was identified as a novel cluster in patients with newly diagnosed multiple myeloma. However, the regulation and oncogenic activities of PRL-3 in multiple myeloma warrant further investigation. Here, we report that IL6 activates STAT3, which acts as a direct transcrip...

    journal_title:Cancer research

    pub_type: 杂志文章

    doi:10.1158/0008-5472.CAN-19-0343

    authors: Chong PSY,Zhou J,Lim JSL,Hee YT,Chooi JY,Chung TH,Tan ZT,Zeng Q,Waller DD,Sebag M,Chng WJ

    更新日期:2019-09-15 00:00:00

  • Inhibition of radiation-induced nuclear factor-kappaB activation by an anti-Ras single-chain antibody fragment: lack of involvement in radiosensitization.

    abstract::We have shown previously that the transduction of a number of human tumor cell lines with an adenovirus (AV1Y28) expressing a single-chain antibody fragment (scFv) directed against Ras proteins results in radiosensitization. Because Ras is involved in the regulation of a number of transcription factors, we have determ...

    journal_title:Cancer research

    pub_type: 杂志文章

    doi:

    authors: Russell JS,Raju U,Gumin GJ,Lang FF,Wilson DR,Huet T,Tofilon PJ

    更新日期:2002-04-15 00:00:00

  • Human neural stem cell transplantation ameliorates radiation-induced cognitive dysfunction.

    abstract::Cranial radiotherapy induces progressive and debilitating declines in cognition that may, in part, be caused by the depletion of neural stem cells. The potential of using stem cell replacement as a strategy to combat radiation-induced cognitive decline was addressed by irradiating athymic nude rats followed 2 days lat...

    journal_title:Cancer research

    pub_type: 杂志文章

    doi:10.1158/0008-5472.CAN-11-0027

    authors: Acharya MM,Christie LA,Lan ML,Giedzinski E,Fike JR,Rosi S,Limoli CL

    更新日期:2011-07-15 00:00:00

  • ErbB-2 induces the cyclin D1 gene in prostate epithelial cells in vitro and in vivo.

    abstract::The receptor tyrosine kinase ErbB-2 plays an important role in the regulation of growth factor-induced signal transduction cascades in the epithelium, and ErbB-2 is frequently overexpressed in epithelial tumors. Our previous studies on clinical prostate cancer specimens indicated that ErbB-2 expression was increased i...

    journal_title:Cancer research

    pub_type: 杂志文章

    doi:10.1158/0008-5472.CAN-06-1898

    authors: Casimiro M,Rodriguez O,Pootrakul L,Aventian M,Lushina N,Cromelin C,Ferzli G,Johnson K,Fricke S,Diba F,Kallakury B,Ohanyerenwa C,Chen M,Ostrowski M,Hung MC,Rabbani SA,Datar R,Cote R,Pestell R,Albanese C

    更新日期:2007-05-01 00:00:00

  • Lower heat shock factor activation and binding and faster rate of HSP-70A messenger RNA turnover in heat sensitive human leukemias.

    abstract::Normal bone marrow progenitors and some leukemic cells develop only a limited amount of thermotolerance. Further, once developed, thermotolerance decays at a faster rate than that normally observed in cells of nonhemopoietic origin. Thermotolerance induction and maintenance correlates with reduced levels of expression...

    journal_title:Cancer research

    pub_type: 杂志文章

    doi:

    authors: Mivechi NF,Ouyang H,Hahn GM

    更新日期:1992-12-15 00:00:00

  • Dual inhibition of class IA phosphatidylinositol 3-kinase and mammalian target of rapamycin as a new therapeutic option for T-cell acute lymphoblastic leukemia.

    abstract::Recent investigations have documented that constitutively activated phosphatidylinositol 3-kinase (PI3K)/Akt/mammalian target of rapamycin (mTOR) signaling is a common feature of T-cell acute lymphoblastic leukemia (T-ALL), where it strongly influences growth and survival. These findings lend compelling weight for the...

    journal_title:Cancer research

    pub_type: 杂志文章

    doi:10.1158/0008-5472.CAN-08-4884

    authors: Chiarini F,Falà F,Tazzari PL,Ricci F,Astolfi A,Pession A,Pagliaro P,McCubrey JA,Martelli AM

    更新日期:2009-04-15 00:00:00

  • Reduction in formation and growth of 1,2-dimethylhydrazine-induced aberrant crypt foci in rat colon by docosahexaenoic acid.

    abstract::The effect of intragastric gavage administration of docosahexaenoic acid (DHA) on the formation of 1,2-dimethylhydrazine (DMH)-induced aberrant crypt foci in rat colon was investigated. Male F344 rats were treated three times s.c. with 20 mg/kg of DMH and were given either 0.7 ml of DHA or water intragastrically 5 tim...

    journal_title:Cancer research

    pub_type: 杂志文章

    doi:

    authors: Takahashi M,Minamoto T,Yamashita N,Yazawa K,Sugimura T,Esumi H

    更新日期:1993-06-15 00:00:00

  • Evaluation of the potential role of class II histocompatibility antigen HLA-DR in platelet/tumor cell interaction.

    abstract::It has been reported that HLA-DR is a potent inducer of thrombin generation. Human colorectal cells (GEO, WiDr, DLD-1, and MIP) that lack the constitutive expression of HLA-DR cause platelet aggregation through a thrombin-dependent mechanism. Treatment with recombinant human gamma-interferon induced the expression of ...

    journal_title:Cancer research

    pub_type: 杂志文章

    doi:

    authors: Ferroni P,Guadagni F,Spila A,Martini F,Gazzaniga PP

    更新日期:1994-02-01 00:00:00

  • A new virus in a spontaneous mammary tumor of a rhesus monkey.

    abstract::This study investigated the ultrastructure and development of virus particles detected in a spontaneous mammary tumor of an 8 year old rhesus monkey. During a 3-month period of tumor growth, several biopsies were performed. Thin section electron microscopy of the tumor tissue revealed 2 types of particles: 1) an in...

    journal_title:Cancer research

    pub_type: 杂志文章

    doi:

    authors: Chopra HC,Mason MM

    更新日期:1970-08-01 00:00:00

  • Selective killing of methotrexate-resistant cells carrying amplified dihydrofolate reductase genes.

    abstract::A method for the selective killing of methotrexate (MTX)-resistant cells has been developed. The selection is based on the incorporation of tritiated deoxyuridine into the DNA of MTX-resistant cells but not normal MTX-sensitive cells in the presence of the drug. A Chinese hamster ovary cell mutant that overproduces di...

    journal_title:Cancer research

    pub_type: 杂志文章

    doi:

    authors: Urlaub G,Landzberg M,Chasin LA

    更新日期:1981-05-01 00:00:00

  • Rescue of a biologically active Epstein-Barr virus from nonproducer cells.

    abstract::We recently established an epithelial/hybrid cell line, A2L/AH, by fusion of 8-azaguanine-resistant epithelial cells, Ad-AH, with a nonproducer lymphoblastoid cell line, A2L, using lymphocytes derived from the human nasopharynx transformed with the B95-8 strain of Epstein-Barr virus. The treatment of the parental A2L ...

    journal_title:Cancer research

    pub_type: 杂志文章

    doi:

    authors: Takimoto T,Sato H,Ogura H,Glaser R

    更新日期:1986-04-01 00:00:00

  • The insulin-like growth factor I receptor protects tumor cells from apoptosis in vivo.

    abstract::The role of the insulin-like growth factor I receptor (IGF-IR) in programmed cell death has been investigated in vivo in a biodiffusion chamber, where the extent of cell death could be determined quantitatively. We found that a decrease in the number of IGF-IRs causes massive apoptosis in vivo in several transplantabl...

    journal_title:Cancer research

    pub_type: 杂志文章

    doi:

    authors: Resnicoff M,Abraham D,Yutanawiboonchai W,Rotman HL,Kajstura J,Rubin R,Zoltick P,Baserga R

    更新日期:1995-06-01 00:00:00

  • Immunological basis of close-contact sensitization to osteosarcoma.

    abstract::Normal persons with a history of close contact with cancer patients often given positive responses in tests for specific tumor immunity. The present study was designed to establish the immunological relevance of such reactivity. Leukocyte adherence inhibition analysis was used to test responses of osteosarcoma (OS)-po...

    journal_title:Cancer research

    pub_type: 杂志文章

    doi:

    authors: Powell A,Sloss AM,Makley JT

    更新日期:1979-02-01 00:00:00

  • Phenotypic heterogeneity in cultured human head and neck squamous cell carcinoma lines with low-level methotrexate resistance.

    abstract::Low-level methotrexate (MTX) resistance (less than 20-fold) was induced by gradual selection pressure in four human head and neck squamous cell carcinoma lines established in culture from biopsies of patients not previously treated with MTX. Each parental and resistant line was characterized with respect to MTX uptake...

    journal_title:Cancer research

    pub_type: 杂志文章

    doi:

    authors: Rosowsky A,Wright JE,Cucchi CA,Lippke JA,Tantravahi R,Ervin TJ,Frei E 3rd

    更新日期:1985-12-01 00:00:00

  • Efficient therapeutic gene delivery after systemic administration of a novel polyethylenimine/DNA vector in an orthotopic bladder cancer model.

    abstract::Successful systemic gene therapy has been hindered by vector-related limitations, including toxicity and inefficient gene delivery to tumor cells after i.v. administration. To circumvent these problems, we developed a novel formulation between the polycation polyethyleneimine and DNA that mediates high-level tumor cel...

    journal_title:Cancer research

    pub_type: 杂志文章

    doi:

    authors: Sweeney P,Karashima T,Ishikura H,Wiehle S,Yamashita M,Benedict WF,Cristiano RJ,Dinney CP

    更新日期:2003-07-15 00:00:00

  • Mutations of the bak gene in human gastric and colorectal cancers.

    abstract::The Bcl-2 homologue Bak is a potent inducer of apoptosis. We performed PCR-based single-strand conformational polymorphism and sequencing analysis of the entire coding region of the bak gene (exons 2-6) in 24 primary gastric cancers (6 early-stage and 18 advanced-stage cancers) and 20 primary colorectal cancers (6 ear...

    journal_title:Cancer research

    pub_type: 杂志文章

    doi:

    authors: Kondo S,Shinomura Y,Miyazaki Y,Kiyohara T,Tsutsui S,Kitamura S,Nagasawa Y,Nakahara M,Kanayama S,Matsuzawa Y

    更新日期:2000-08-15 00:00:00

  • Placenta growth factor gene expression is induced by hypoxia in fibroblasts: a central role for metal transcription factor-1.

    abstract::Placenta growth factor (PlGF) is a mitogen for endothelial cells that can potentiate the growth and permeabilizing effects on endothelium of vascular endothelial growth factor. Here we report that hypoxia induces the expression of both PlGF mRNA and protein in immortalized/transformed mouse embryonic fibroblasts (mEFs...

    journal_title:Cancer research

    pub_type: 杂志文章

    doi:

    authors: Green CJ,Lichtlen P,Huynh NT,Yanovsky M,Laderoute KR,Schaffner W,Murphy BJ

    更新日期:2001-03-15 00:00:00

  • Interleukin 4 inhibits stimulation of hepatic lipogenesis by tumor necrosis factor, interleukin 1, and interleukin 6 but not by interferon-alpha.

    abstract::Multiple cytokines stimulate hepatic lipogenesis in rodents. We have previously shown that lipogenic cytokines can be divided into 2 classes by their mechanism of action and their synergistic interactions. We now report the effects of interleukin 4, a cytokine known to inhibit the synthesis and action of other cytokin...

    journal_title:Cancer research

    pub_type: 杂志文章

    doi:

    authors: Grunfeld C,Soued M,Adi S,Moser AH,Fiers W,Dinarello CA,Feingold KR

    更新日期:1991-06-01 00:00:00

  • Signal transducers and activators of transcription mediate fibroblast growth factor-induced vascular endothelial morphogenesis.

    abstract::The fibroblast growth factors (FGF) play diverse roles in development, wound healing, and angiogenesis. The intracellular signal transduction pathways, which mediate these pleiotropic activities, remain incompletely understood. We show here that the proangiogenic factors FGF2 and FGF8b can activate signal transducers ...

    journal_title:Cancer research

    pub_type: 杂志文章

    doi:10.1158/0008-5472.CAN-07-6385

    authors: Yang X,Qiao D,Meyer K,Friedl A

    更新日期:2009-02-15 00:00:00

  • Targeting of miR34a-NOTCH1 axis reduced breast cancer stemness and chemoresistance.

    abstract::Human breast cancers include cancer stem cell populations as well as nontumorigenic cancer cells. Breast cancer stem cells have self-renewal capability and are resistant to conventional chemotherapy. miRNAs regulate the expression of many target genes; therefore, dysregulation of miRNAs has been associated with the pa...

    journal_title:Cancer research

    pub_type: 杂志文章

    doi:10.1158/0008-5472.CAN-14-1140

    authors: Park EY,Chang E,Lee EJ,Lee HW,Kang HG,Chun KH,Woo YM,Kong HK,Ko JY,Suzuki H,Song E,Park JH

    更新日期:2014-12-15 00:00:00

  • Membrane-type 4 matrix metalloproteinase promotes breast cancer growth and metastases.

    abstract::Membrane-type matrix metalloproteinases (MT-MMP) constitute a subfamily of six distinct membrane-associated MMPs. Although the contribution of MT1-MMP during different steps of cancer progression has been well documented, the significance of other MT-MMPs is rather unknown. We have investigated the involvement of MT4-...

    journal_title:Cancer research

    pub_type: 杂志文章

    doi:10.1158/0008-5472.CAN-05-3012

    authors: Chabottaux V,Sounni NE,Pennington CJ,English WR,van den Brûle F,Blacher S,Gilles C,Munaut C,Maquoi E,Lopez-Otin C,Murphy G,Edwards DR,Foidart JM,Noël A

    更新日期:2006-05-15 00:00:00

  • Dominant negative isoform of the Ikaros gene in patients with adult B-cell acute lymphoblastic leukemia.

    abstract::Gene targeting studies in mice have shown that the transcription factor Ikaros plays an essential role in lymphoid development and as a tumor suppressor in T cells, whereas the related gene Aiolos functions as a tumor suppressor in B cells. We analyzed the expression levels of the Ikaros gene family, Ikaros and Aiolos...

    journal_title:Cancer research

    pub_type: 杂志文章

    doi:

    authors: Nakase K,Ishimaru F,Avitahl N,Dansako H,Matsuo K,Fujii K,Sezaki N,Nakayama H,Yano T,Fukuda S,Imajoh K,Takeuchi M,Miyata A,Hara M,Yasukawa M,Takahashi I,Taguchi H,Matsue K,Nakao S,Niho Y,Takenaka K,Shinagawa K,

    更新日期:2000-08-01 00:00:00

  • High fidelity patient-derived xenografts for accelerating prostate cancer discovery and drug development.

    abstract::Standardized and reproducible preclinical models that recapitulate the dynamics of prostate cancer are urgently needed. We established a bank of transplantable patient-derived prostate cancer xenografts that capture the biologic and molecular heterogeneity currently confounding prognostication and therapy development....

    journal_title:Cancer research

    pub_type: 杂志文章

    doi:10.1158/0008-5472.CAN-13-2921-T

    authors: Lin D,Wyatt AW,Xue H,Wang Y,Dong X,Haegert A,Wu R,Brahmbhatt S,Mo F,Jong L,Bell RH,Anderson S,Hurtado-Coll A,Fazli L,Sharma M,Beltran H,Rubin M,Cox M,Gout PW,Morris J,Goldenberg L,Volik SV,Gleave ME,Collins

    更新日期:2014-02-15 00:00:00

  • Human T-cell leukemia virus oncoprotein tax represses nuclear receptor-dependent transcription by targeting coactivator TAX1BP1.

    abstract::Human T-cell leukemia virus type 1 oncoprotein Tax is a transcriptional regulator that interacts with a large number of host cell factors. Here, we report the novel characterization of the interaction of Tax with a human cell protein named Tax1-binding protein 1 (TAX1BP1). We show that TAX1BP1 is a nuclear receptor co...

    journal_title:Cancer research

    pub_type: 杂志文章

    doi:10.1158/0008-5472.CAN-06-3053

    authors: Chin KT,Chun AC,Ching YP,Jeang KT,Jin DY

    更新日期:2007-02-01 00:00:00