Abstract：
:Tumor hypoxia induces the up-regulation of a gene program associated with angiogenesis, glycolysis, adaptation to pH, and apoptosis via the hypoxia-inducible transcription factors (Hifs) 1 and 2. Disruption of this pathway has been proposed as a cancer therapy. Here, we use short interfering RNAs to compare specific inactivation of Hif-1alpha or Hif-2alpha and show markedly different cell type-specific effects on gene expression and cell migration. Remarkably, among a panel of hypoxia-inducible genes, responses were critically dependent on Hif-1 alpha but not Hif-2 alpha in both endothelial and breast cancer cells but critically dependent on Hif-2 alpha in renal carcinoma cells.
journal_name
Cancer Resjournal_title
Cancer researchauthors
Sowter HM,Raval RR,Moore JW,Ratcliffe PJ,Harris ALsubject
Has Abstractpub_date
2003-10-01 00:00:00pages
6130-4issue
19eissn
0008-5472issn
1538-7445journal_volume
63pub_type
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