Ultrastructural characterization of the retrovirus particles (Sm-MTV) liberated from the mammary tumor cell line (Sm-MT) of a house musk shrew, Suncus murinus (Insectivora).

abstract：:Hypoxia-inducible factor-1alpha (HIF-1alpha) is a master transcription factor that is critical for the regulation of a variety of cellular functions. HIF-1alpha is rapidly degraded under normoxic conditions by ubiquitin-mediated proteasome pathway controlled by the tumor suppressor von Hippel Lindau (VHL). Several rec...

journal_title：Cancer research

authors： Zhang D,Li J,Costa M,Gao J,Huang C

更新日期：2010-01-15 00:00:00

abstract：:The Rb/E2F pathway is deregulated in most human brain tumors, and the finding that loss of E2F1 reduced pituitary tumorigenesis in Rb(+/-) mice suggests that loss of pRb induces brain tumors by activating E2F1. We therefore investigated the role of E2F1 in the development and maintenance of brain cancer using a transg...

journal_title：Cancer research

authors： Olson MV,Johnson DG,Jiang H,Xu J,Alonso MM,Aldape KD,Fuller GN,Bekele BN,Yung WK,Gomez-Manzano C,Fueyo J

更新日期：2007-05-01 00:00:00

abstract：:Sixty % of clones isolated from HeLa cells treated with toxic concentrations of a methylating carcinogen showed increased resistance to the cytotoxicity of N-methyl-N-nitrosourea. D37 values were 6- to 100-fold higher than in the parental cell population. The absence of detectable levels of the repair enzyme O6-methyl...

journal_title：Cancer research

authors： Aquilina G,Hess P,Fiumicino S,Ceccotti S,Bignami M

更新日期：1995-06-15 00:00:00

abstract：:The urokinase-type plasminogen activator receptor (uPAR) has a well-established role in cancer progression, but it has been little studied at earlier stages of cancer initiation. Here, we show that uPAR deficiency in the mouse dramatically reduces susceptibility to the classical two-stage protocol of inflammatory skin...

journal_title：Cancer research

authors： Mazzieri R,Pietrogrande G,Gerasi L,Gandelli A,Colombo P,Moi D,Brombin C,Ambrosi A,Danese S,Mignatti P,Blasi F,D'Alessio S

更新日期：2015-11-15 00:00:00

abstract：:Ataxia-telangiectasia (A-T) is an autosomal recessive syndrome associated with a greatly increased incidence of malignant neoplasms in homozygous affected individuals. Heterozygotes for the gene for A-T are thought to comprise about 1% of the general population and, therefore, it is important to know whether this gene...

journal_title：Cancer research

authors： Swift M,Sholman L,Perry M,Chase C

更新日期：1976-01-01 00:00:00

abstract：:Ovarian cancer is resistant to the antiproliferative effects of transforming growth factor-beta (TGF-beta); however, the mechanism of this resistance remains unclear. We used oligonucleotide arrays to profile 37 undissected, 68 microdissected advanced-stage, and 14 microdissected early-stage papillary serous cancers t...

journal_title：Cancer research

authors： Sunde JS,Donninger H,Wu K,Johnson ME,Pestell RG,Rose GS,Mok SC,Brady J,Bonome T,Birrer MJ

更新日期：2006-09-01 00:00:00

abstract：:Patients with human papillomavirus (HPV+)-associated head and neck cancer (HNC) show significantly improved survival outcome compared with those with HPV-negative (HPV-) tumors. Published data examining this difference offers conflicting results to date. We systematically investigated the radiation sensitivity of all ...

journal_title：Cancer research

authors： Kimple RJ,Smith MA,Blitzer GC,Torres AD,Martin JA,Yang RZ,Peet CR,Lorenz LD,Nickel KP,Klingelhutz AJ,Lambert PF,Harari PM

更新日期：2013-08-01 00:00:00

abstract：:Mucin-depleted foci (MDF) are microscopic dysplastic lesions induced in the colon of rodents by specific colon carcinogens. Most MDF show Wnt pathway activation, whereas only a subset shows mutations in the Ctnnb1 gene, coding for beta-catenin. Because Apc is a member of the Wnt pathway and the most frequent mutated g...

journal_title：Cancer research

authors： Femia AP,Dolara P,Giannini A,Salvadori M,Biggeri A,Caderni G

更新日期：2007-01-15 00:00:00

abstract：:Cloned cell lines derived from the androgen-responsive Shionogi 115 mouse mammary carcinoma, when cultured in the presence of 3.5 X 10(-8) M testosterone, retain their responsiveness to testosterone and 5alpha-dihydrotestosterone and exhibit fibroblast-like morphology; their growth is poorly regulated by cell density....

journal_title：Cancer research

authors： Yates J,King RJ

更新日期：1978-11-01 00:00:00

abstract：:Cyclin G1 was identified as a transcriptional target of p53 that encodes a protein with strong homology to the cyclin family of cell cycle regulators. We show that either ectopically expressed or endogenous cyclin G1 protein is very unstable, undergoes modification with ubiquitin, and is likely degraded by the proteas...

journal_title：Cancer research

authors： Piscopo DM,Hinds PW

更新日期：2008-07-15 00:00:00

abstract：:In order to elucidate the response of mitochondria to the increase in cellular energy demand after hepatectomy, we have examined the effects of partial hepatectomy and hepatic artery ligation on the energy-transducing system of rat liver mitochondria. Specific content of DNA in the mitochondria increased on the first ...

journal_title：Cancer research

authors： Nagino M,Tanaka M,Nishikimi M,Nimura Y,Kubota H,Kanai M,Kato T,Ozawa T

更新日期：1989-09-01 00:00:00

abstract：:Interleukin 2 (IL2) was injected peritumorally and intranodally in 36 patients with unresectable squamous cell carcinoma of the head and neck enrolled in an Eastern Cooperative Oncology Group-sponsored phase Ib trial (EST P-Z388). Groups of 6 patients received escalating doses(200, 2 x 10(3), 2 x 10(4), 2 x 10(5), 2 x...

journal_title：Cancer research

authors： Whiteside TL,Letessier E,Hirabayashi H,Vitolo D,Bryant J,Barnes L,Snyderman C,Johnson JT,Myers E,Herberman RB

更新日期：1993-12-01 00:00:00

abstract：:MicroRNAs are noncoding RNAs that inhibit the expression of their targets in a sequence-specific manner and play crucial roles during oncogenesis. Here we show that microRNA-7 (miR-7) inhibits p21-activated kinase 1 (Pak1) expression, a widely up-regulated signaling kinase in multiple human cancers, by targeting the 3...

journal_title：Cancer research

authors： Reddy SD,Ohshiro K,Rayala SK,Kumar R

更新日期：2008-10-15 00:00:00

abstract：:Spontaneous tumors in urodele amphibians have been considered uncommon, and this resistance has sometimes been associated with the natural regenerative capacity of tissues in such species. This report describes spontaneous, nonpigmented, benign epitheliomas which were found in 44 of 1586 (2.8%) adult newts, Cynops pyr...

journal_title：Cancer research

authors： Pfeiffer CJ,Nagai T,Fujimura M,Tobe T

更新日期：1979-06-01 00:00:00

abstract：:Aberrant promoter hypermethylation and associated gene silencing are epigenetic hallmarks of tumorigenesis. It has been suggested that aberrant DNA methylation can affect the sensitivity of cancers to antineoplastic agents by altering expression of genes critical to drug response. To study this issue, we used bisulfit...

journal_title：Cancer research

authors： Shen L,Kondo Y,Ahmed S,Boumber Y,Konishi K,Guo Y,Chen X,Vilaythong JN,Issa JP

更新日期：2007-12-01 00:00:00

abstract：:We have examined the ability of ingenol to bind to and activate protein kinase C and to induce similar responses to the phorbol esters in biological systems. The rationale was that ingenol possesses the critical functionalities of the phorbol ester pharmacophore with the exception of the hydrophobic domain; it might t...

journal_title：Cancer research

authors： Hasler CM,Acs G,Blumberg PM

更新日期：1992-01-01 00:00:00

abstract：:ZR-75-1, a human breast cancer cell line, has been grown in hormone-supplemented medium without serum. The factors required for optimal growth include 17beta-estradiol, insulin, transferrin, dexamethasone, and L-triiodothyronine. If estradiol, insulin, or L-triiodothyronine is omitted, cells cease division within 7 da...

journal_title：Cancer research

authors： Allegra JC,Lippman ME

更新日期：1978-11-01 00:00:00

abstract：:The comparative metabolism of the enantiomers of cyclo phosphamide and of the racemate has been studied in humans. Four patients were each given, sequentially, the racemate, the (+)-enantiomer, and its (-)-antipode. The plasma levels of parent drug and the urinary output (24 hr) of unchanged drug and of two enzymatica...

journal_title：Cancer research

authors： Jarman M,Milsted RA,Smyth JF,Kinas RW,Pankiewicz K,Stec WJ

更新日期：1979-07-01 00:00:00

abstract：:Down-regulation of gelsolin, an actin-binding protein, is frequently found in several types of transformed cells and tumors. The present study demonstrates that gelsolin protein and RNA were absent or markedly reduced in human breast cancer cell lines relative to "normal" mortal human mammary epithelial cells and beni...

journal_title：Cancer research

authors： Asch HL,Head K,Dong Y,Natoli F,Winston JS,Connolly JL,Asch BB

更新日期：1996-11-01 00:00:00

abstract：:Coexpression of epidermal growth factor receptor (EGFR) and c-erbB-2 in 47-68% of ovarian cancer cells indicate their strong association with tumor formation. We examined the effects of simultaneous antisense- or immunosuppression of EGFR and c-erbB-2 expression on the invasive phenotype, aneuploidy, and genotype of c...

journal_title：Cancer research

authors： Pack SD,Alper OM,Stromberg K,Augustus M,Ozdemirli M,Miermont AM,Klus G,Rusin M,Slack R,Hacker NF,Ried T,Szallasi Z,Alper O

更新日期：2004-02-01 00:00:00

abstract：:While showing promise, vaccination strategies to treat cancer require further optimization. Likely barriers to efficacy involve cancer-associated immunosuppression and peripheral tolerance, which limit the generation of effective vaccine-specific cytotoxic T lymphocytes (CTL). Because CD4(+) T cells improve CTL respon...

journal_title：Cancer research

authors： Ahrends T,Bąbała N,Xiao Y,Yagita H,van Eenennaam H,Borst J

更新日期：2016-05-15 00:00:00

abstract：:The steroid hormone 1,25-dihydroxyvitamin D3 [1,25-(OH)2D3] has potential to be used as an antitumor agent, but its clinical application is restricted by the strong calcemic activity. Therefore, new vitamin D3 analogues are developed with increased growth inhibitory and reduced calcemic activity. In the present study,...

journal_title：Cancer research

authors： Vink-van Wijngaarden T,Pols HA,Buurman CJ,van den Bemd GJ,Dorssers LC,Birkenhäger JC,van Leeuwen JP

更新日期：1994-11-01 00:00:00

abstract：:Mesothelin is a cell-surface tumor-associated antigen expressed in several human cancers. The limited expression of mesothelin on normal tissues and its high expression in many cancers make it an attractive candidate for targeted therapies using monoclonal antibodies, immunoconjugates, and immunotoxins. Mesothelin is ...

journal_title：Cancer research

authors： Zhang Y,Chertov O,Zhang J,Hassan R,Pastan I

更新日期：2011-09-01 00:00:00

abstract：:The majority of patients with colon cancer will develop advanced disease, with the liver being the most common site of metastatic disease. Patients with increased numbers of tumor-infiltrating lymphocytes in primary colon tumors and liver metastases have improved outcomes. However, the molecular factors that could emp...

journal_title：Cancer research

authors： Qiao G,Qin J,Kunda N,Calata JF,Mahmud DL,Gann P,Fu YX,Rosenberg SA,Prabhakar BS,Maker AV

更新日期：2017-04-15 00:00:00

abstract：:Virtually all patients with chronic myelogenous leukemia (CML) express an aberrant protein (p210 Bcr-Abl) that contains NH2-terminal sequences from Bcr fused to COOH-terminal sequences from Abl. In a yeast two-hybrid screen, we have identified TSG101 as a binding partner for Bcr. Because TSG101 is a subunit of the mam...

journal_title：Cancer research

authors： Olabisi OO,Mahon GM,Kostenko EV,Liu Z,Ozer HL,Whitehead IP

更新日期：2006-06-15 00:00:00

abstract：:DNA index and S-phase fraction of 490 primary breast carcinomas were measured by flow cytometry, using paraffin-embedded tissue as a starting point. All patients had involvement of axillary lymph nodes and all were randomized onto one of the Ludwig Breast Cancer Trials I-IV between July 1978 and August 1981. The prese...

journal_title：Cancer research

authors： Hedley DW,Rugg CA,Gelber RD

更新日期：1987-09-01 00:00:00

abstract：:Topotecan (SK&F 104864, hycamptamine, NSC 609699) is believed to exert its cytotoxic effects through inhibition of topoisomerase I, the activity of which recovers rapidly on removal of the drug in vitro. In vivo studies show that the activity of topotecan is schedule dependent, favoring repeated doses. Early human stu...

journal_title：Cancer research

authors： Haas NB,LaCreta FP,Walczak J,Hudes GR,Brennan JM,Ozols RF,O'Dwyer PJ

更新日期：1994-03-01 00:00:00

abstract：:To improve tumor:tissue ratios in immunoscintigraphy, a three-step targeting method has been developed. The reagents used were (a) a radioactive, low molecular weight chelate prepared from ionic gallium and a phenolic polyaminocarboxylic acid, which can be labeled either with the single-photon emitter 67Ga or with the...

journal_title：Cancer research

authors： Schuhmacher J,Klivényi G,Matys R,Stadler M,Regiert T,Hauser H,Doll J,Maier-Borst W,Zöller M

更新日期：1995-01-01 00:00:00

abstract：:Heat stress may enhance the effect of apoptosis-inducing agents in resistant tumor cells. One such agent is the tumor necrosis factor-related apoptosis-inducing ligand (TRAIL), which has attracted intense interest for its ability to induce apoptosis in tumors without affecting nonmalignant cells. We therefore tested w...

journal_title：Cancer research

authors： Pespeni MH,Hodnett M,Abayasiriwardana KS,Roux J,Howard M,Broaddus VC,Pittet JF

更新日期：2007-03-15 00:00:00

abstract：:Cigarette smoking causes cancer and DNA mutations. However, long-term chronic exposure to smoke is believed to be necessary for carcinogenesis. Here, we investigate the relationship between short-term exposure to smoke and the frequency of deletions in the mouse embryo. Deletions and other genome rearrangements are as...

journal_title：Cancer research

authors： Jalili T,Murthy GG,Schiestl RH

更新日期：1998-06-15 00:00:00