Abstract：
:Coexpression of epidermal growth factor receptor (EGFR) and c-erbB-2 in 47-68% of ovarian cancer cells indicate their strong association with tumor formation. We examined the effects of simultaneous antisense- or immunosuppression of EGFR and c-erbB-2 expression on the invasive phenotype, aneuploidy, and genotype of cultured human ovarian carcinoma cells (NIH:OVCAR-8). We report here that suppression of both EGFR and c-erbB-2 results in regression of aneuploidy and genomic imbalances in NIH:OVCAR-8 cells, restores a more normal phenotype, and results in a more normal gene expression profile. Combined with cytogenetic analysis, our data demonstrate that the regression of aneuploidy is due to the selective apoptosis of double antisense transfected cells with highly abnormal karyotype.
journal_name
Cancer Resjournal_title
Cancer researchauthors
Pack SD,Alper OM,Stromberg K,Augustus M,Ozdemirli M,Miermont AM,Klus G,Rusin M,Slack R,Hacker NF,Ried T,Szallasi Z,Alper Odoi
10.1158/0008-5472.can-03-1982subject
Has Abstractpub_date
2004-02-01 00:00:00pages
789-94issue
3eissn
0008-5472issn
1538-7445journal_volume
64pub_type
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