Superiority of an acid-labile daunorubicin-monoclonal antibody immunoconjugate compared to free drug.

abstract：:2-Methoxyestradiol (2ME(2)), a physiologic metabolite of 17beta-estradiol (estrogen), has emerged as a promising cancer therapy because of its potent growth-inhibitory and proapoptotic effects on both endothelial and tumor cells. 2ME(2) also suppresses osteoclast differentiation and induces apoptosis of mature osteocl...

journal_title：Cancer research

authors： Cicek M,Iwaniec UT,Goblirsch MJ,Vrabel A,Ruan M,Clohisy DR,Turner RR,Oursler MJ

更新日期：2007-11-01 00:00:00

abstract：:The pharmacokinetics of melphalan following high-dose p.o. administration were determined in 17 patients with various malignancies for the purpose of assessing interpatient and intrapatient pharmacokinetic variability. All patients underwent bone marrow harvest on day -8 (relative to bone marrow reinfusion). On days -...

journal_title：Cancer research

authors： Choi KE,Ratain MJ,Williams SF,Golick JA,Beschorner JC,Fullem LJ,Bitran JD

更新日期：1989-03-01 00:00:00

abstract：:N-Nitrosodibutylamine and its omega-hydroxylated metabolite N-nitrosobutyl(4-hydroxybutyl)amine (NB4HBA) induce tumors in the urine bladder of different animal species through their common urinary metabolite N-nitrosobutyl(3-carboxypropyl)amine (NB3CPA), resulting from the oxidation of the alcoholic group of NB4HBA to...

journal_title：Cancer research

authors： Bonfanti M,Magagnotti C,Bonati M,Fanelli R,Airoldi L

更新日期：1988-07-01 00:00:00

abstract：:Oxidation of the vinyl halide carcinogen and hepatotoxin vinylidene chloride (VDC) by microsomal cytochrome P-450 yields 2,2-dichloroacetaldehyde, 2-chloroacetyl chloride, 2-chloroacetic acid, and 1,1-dichloroethylene oxide. The roles of these metabolites in covalent modification of proteins and reduced glutathione (G...

journal_title：Cancer research

authors： Liebler DC,Meredith MJ,Guengerich FP

更新日期：1985-01-01 00:00:00

abstract：:Malignant changes are often accompanied by alterations in activity and composition of the plasminogen activators (PA). To study the relationship between PA expression and the development of colorectal cancer, we determined urokinase-type plasminogen activator (u-PA) and tissue-type plasminogen activator (t-PA) activit...

journal_title：Cancer research

authors： de Bruin PA,Griffioen G,Verspaget HW,Verheijen JH,Lamers CB

更新日期：1987-09-01 00:00:00

abstract：:microRNAs (miRNA) are small noncoding RNAs that participate in diverse biological processes by suppressing target gene expression. Altered expression of miR-21 has been reported in cancer. To gain insights into its potential role in tumorigenesis, we generated miR-21 knockout colon cancer cells through gene targeting....

journal_title：Cancer research

authors： Wang P,Zou F,Zhang X,Li H,Dulak A,Tomko RJ Jr,Lazo JS,Wang Z,Zhang L,Yu J

更新日期：2009-10-15 00:00:00

abstract：:The DF3 antigen is a member of a family of high-molecular-weight glycoproteins aberrantly expressed in human breast carcinomas. Recent work has described the generation of a monoclonal antibody (MAb), designated DF3-P, that reacts with immature, underglycosylated precursors of DF3 antigen. Immunoperoxidase staining st...

journal_title：Cancer research

authors： Perey L,Hayes DF,Kufe D

更新日期：1992-11-15 00:00:00

abstract：:Delivery of therapeutic agents to the brain and its neoplasms depends on the presence of membrane transport proteins in the blood-brain barrier and in the target cells. The cellular and subcellular localization of these membrane transporters determines the drug accessibility to the brain and its tumors. We therefore a...

journal_title：Cancer research

authors： Bronger H,König J,Kopplow K,Steiner HH,Ahmadi R,Herold-Mende C,Keppler D,Nies AT

更新日期：2005-12-15 00:00:00

abstract：:Picroliv, an iridoid glycoside derived from the plant Picrorhiza kurroa, is used traditionally to treat fever, asthma, hepatitis, and other inflammatory conditions. However, the exact mechanism of its therapeutic action is still unknown. Because nuclear factor-kappaB (NF-kappaB) activation plays a major role in inflam...

journal_title：Cancer research

authors： Anand P,Kunnumakkara AB,Harikumar KB,Ahn KS,Badmaev V,Aggarwal BB

更新日期：2008-11-01 00:00:00

abstract：:Cytochrome P4501B1 is highly active in the bioactivation of polycyclic aromatic hydrocarbons (PAHs) to mutagenic metabolites. The C3H mouse embryo fibroblast cell line, C3H10T1/2, and primary mouse embryo fibroblasts (MEFs) express CYP1B1 as the predominant cytochrome P-450 form. This is constitutively expressed and i...

journal_title：Cancer research

authors： Alexander DL,Eltom SE,Jefcoate CR

更新日期：1997-10-15 00:00:00

abstract：:Eight analogues of 2,5-bis(carboethoxyamino)-3,6-diaziridinyl-1,4-benzoquinone have been synthesized and tested for cytotoxicity against four different leukemic and lymphomic cell lines. For K562 and BSM cells, the toxicity could be correlated with the ease of reduction of the compounds as determined by the one-electr...

journal_title：Cancer research

authors： Dzielendziak A,Butler J,Hoey BM,Lea JS,Ward TH

更新日期：1990-04-01 00:00:00

abstract：:Solid tumors contain a subset of stem-like cells that are resistant to the cytotoxic effects of chemotherapy/radiotherapy, but their susceptibility to cytolytic T lymphocyte (CTL) effector mechanisms has not been well characterized. Using a panel of early-passage human brain tumor stem/initiating cell (BTSC) lines der...

journal_title：Cancer research

authors： Brown CE,Starr R,Martinez C,Aguilar B,D'Apuzzo M,Todorov I,Shih CC,Badie B,Hudecek M,Riddell SR,Jensen MC

更新日期：2009-12-01 00:00:00

abstract：:We demonstrated previously elevated caveolin-1 expression in metastatic mouse and human prostate cancer cells both in vitro and in vivo. In this study, we analyzed its prognostic value for progression of clinically confined human prostate cancer. Immunohistochemical staining with a caveolin-1-specific antibody was per...

journal_title：Cancer research

authors： Yang G,Truong LD,Wheeler TM,Thompson TC

更新日期：1999-11-15 00:00:00

abstract：:The base excision repair protein MED1 (also known as MBD4), an interactor with the mismatch repair protein MLH1, has a central role in the maintenance of genomic stability with dual functions in DNA damage response and repair. MED1 acts as a thymine and uracil DNA N-glycosylase on T:G and U:G mismatches that occur at ...

journal_title：Cancer research

authors： Turner DP,Cortellino S,Schupp JE,Caretti E,Loh T,Kinsella TJ,Bellacosa A

更新日期：2006-08-01 00:00:00

abstract：:Although aberrant microRNA (miRNA) is expressed in different types of human cancer tissues, its pathophysiologic role and the relevance of tumorigenesis and metastasis are still largely unknown. Here, we defined miRNAs involved in cancer metastasis (metastamirs) using an established mouse model for peritoneal dissemin...

journal_title：Cancer research

authors： Takei Y,Takigahira M,Mihara K,Tarumi Y,Yanagihara K

更新日期：2011-02-15 00:00:00

abstract：:It is estimated that familial aggregation and genetic susceptibility play a role in as many as 10% of pancreatic ductal adenocarcinomas. To investigate the role of germ-line mutations in the etiology of pancreatic cancer, we have analyzed samples from patients with pancreatic cancer enrolled in the NFPTR for mutations...

journal_title：Cancer research

authors： Murphy KM,Brune KA,Griffin C,Sollenberger JE,Petersen GM,Bansal R,Hruban RH,Kern SE

更新日期：2002-07-01 00:00:00

abstract：:Calmodulin contents of normal rat liver, host liver [bearing hepatoma 5123t.c.(h)], regenerating liver, and Morris hepatomas 7800, 5123t.c.(h), and 7794A were determined by phosphodiesterase assay and by radioimmunoassay. The calmodulin levels determined by both assays were significantly increased in three hepatomas w...

journal_title：Cancer research

authors： Wei JW,Morris HP,Hickie RA

更新日期：1982-07-01 00:00:00

abstract：:A two-stage genome-wide association study (GWAS) of the Cancer Genetic Markers of Susceptibility (CGEMS) initiative identified single nucleotide polymorphisms (SNP) in 150 regions across the genome that may be associated with prostate cancer (PCa) risk. We filtered these results to identify 43 independent SNPs where t...

journal_title：Cancer research

authors： Hsu FC,Sun J,Wiklund F,Isaacs SD,Wiley KE,Purcell LD,Gao Z,Stattin P,Zhu Y,Kim ST,Zhang Z,Liu W,Chang BL,Walsh PC,Duggan D,Carpten JD,Isaacs WB,Grönberg H,Xu J,Zheng SL

更新日期：2009-04-01 00:00:00

abstract：:Hematogenous carcinoma metastasis is supported by aggregated platelets and leukocytes, forming tumor cell emboli. Early tumor cell-platelet interactions can be mediated by P-selectin binding to tumor cell surface ligands and this process is blocked by heparin. We previously showed that L-selectin deficiency also atten...

journal_title：Cancer research

authors： Läubli H,Stevenson JL,Varki A,Varki NM,Borsig L

更新日期：2006-02-01 00:00:00

abstract：:The pharmacokinetics of UCN-01 after administration as a 72- or 3-h infusion to cancer patients in initial Phase I trials displayed distinctive features that could not have been predicted from preclinical data. The distribution volumes (0.0796-0.158 liters/kg) and the systemic clearance (0.0407-0.252 ml/h/kg) were ext...

journal_title：Cancer research

authors： Fuse E,Tanii H,Kurata N,Kobayashi H,Shimada Y,Tamura T,Sasaki Y,Tanigawara Y,Lush RD,Headlee D,Figg WD,Arbuck SG,Senderowicz AM,Sausville EA,Akinaga S,Kuwabara T,Kobayashi S

更新日期：1998-08-01 00:00:00

abstract：:Fluorescein-labeled dextrans (FITC-D) from 3 to 5000 kDa (Stokes' radii from 1 to 40 nm) were used to study influx from the plasma into the peritoneum and efflux from the peritoneal cavity into the plasma in normal and ascites tumor-bearing mice and in mice whose peritoneal vessels had been rendered hyperpermeable by ...

journal_title：Cancer research

authors： Nagy JA,Herzberg KT,Masse EM,Zientara GP,Dvorak HF

更新日期：1989-10-01 00:00:00

abstract：:Tumor-specific rosette-forming cells reactive to solubilized tumor antigens conjugated to autologous erythrocytes were quantitated by flow cytofluorometry. Leukocytes from a high frequency of the patients (greater than 70%) with squamous cell carcinoma of the head and neck (SQCC) formed rosettes to the conjugated SQCC...

journal_title：Cancer research

authors： Tong AW,Vanderbark AA,Kraybill W,Vetto RM,Burger DR

更新日期：1982-07-01 00:00:00

abstract：:DNA-dependent RNA polymerase A (or 1) was purified from murine myeloma MOPC 21 by diethylaminoethyl Sephadex chromatography. Further separation from DNA polymerases, protein kinase and DNA endonuclease was accomplished by polyriboadenylate-Sepharose affinity chromatography followed by gradient centrifugation. Yields f...

journal_title：Cancer research

authors： Hall SH,Smuckler EA

更新日期：1976-03-01 00:00:00

abstract：:"Self" melanocyte differentiation antigens are potential targets for specific melanoma immunotherapy. Vaccination against murine tyrosinase-related protein (TRP)-1/gp75 was shown recently to cause melanoma rejection, which was accompanied by autoimmune skin depigmentation (vitiligo). To further explore the linkage bet...

journal_title：Cancer research

authors： Bronte V,Apolloni E,Ronca R,Zamboni P,Overwijk WW,Surman DR,Restifo NP,Zanovello P

更新日期：2000-01-15 00:00:00

abstract：:Antibodies to formalin-fixed, syngeneic melanoma cells were prepared in mice, purified by immunoaffinity chromatography, and tested for binding activity to viable melanoma cells. The radiolabeled antibodies detected congruent to 9 X 10(6) melanoma antigenic sites/cell. The calculated average association constant (Ka) ...

journal_title：Cancer research

authors： Winkelhake JL,Elcombe BM,Hodach A

更新日期：1979-08-01 00:00:00

abstract：:Chemotherapy with 4'-O-tetrahydropyranyladriamycin (THP-ADM), a new derivative of Adriamycin, was equally or more effective against several experimental mouse tumors than it was with Adriamycin (ADM). When mice with P388 leukemia were given i.p. injections of THP-ADM or ADM daily for 9 consecutive days, the maximum in...

journal_title：Cancer research

authors： Tsuruo T,Iida H,Tsukagoshi S,Sakurai Y

更新日期：1982-04-01 00:00:00

abstract：:Although obesity is one of the strongest risk factors for esophageal adenocarcinoma (EAC), the molecular mechanisms underlying this association remain unclear. We recently identified 4 EAC-specific master regulator transcription factors (MRTF) ELF3, KLF5, GATA6, and EHF. In the present study, Gene Set Enrichment Analy...

journal_title：Cancer research

authors： Ma S,Zhou B,Yang Q,Pan Y,Yang W,Freedland SJ,Ding LW,Freeman MR,Breunig JJ,Bhowmick NA,Pan J,Koeffler HP,Lin DC

更新日期：2021-01-05 00:00:00

abstract：:Although adoptive transfer of cytotoxic T lymphocytes (CTL) offer a promising cancer therapeutic direction, the generation of antigen-specific CTL from patients has faced difficulty in efficient expansion in ex vivo culture. To resolve this issue, several groups have proposed that induced pluripotent stem cell technol...

journal_title：Cancer research

authors： Maeda T,Nagano S,Ichise H,Kataoka K,Yamada D,Ogawa S,Koseki H,Kitawaki T,Kadowaki N,Takaori-Kondo A,Masuda K,Kawamoto H

更新日期：2016-12-01 00:00:00

abstract：:Rodent biliary glycoprotein (Bgp), also known as C-CAM, has recently been shown to function as a tumor suppressor in colon, prostate, and bladder cancers. This glycoprotein is a member of the carcinoembryonic antigen family and is one of the only proteins in this family to encode either a long (71-73 amino acids) or s...

journal_title：Cancer research

authors： Turbide C,Kunath T,Daniels E,Beauchemin N

更新日期：1997-07-01 00:00:00

abstract：:Multiple myeloma (MM) is a treatable, but incurable, malignancy of plasma cells (PC) in the bone marrow (BM). It represents the final stage in a continuum of PC dyscrasias and is consistently preceded by a premalignant phase termed monoclonal gammopathy of undetermined significance (MGUS). The existence of this well-d...

journal_title：Cancer research

authors： van Nieuwenhuijzen N,Spaan I,Raymakers R,Peperzak V

更新日期：2018-05-15 00:00:00