Prolyl Hydroxylase 3 Attenuates MCL-1-Mediated ATP Production to Suppress the Metastatic Potential of Colorectal Cancer Cells.

abstract：:The three-dimensional structures of two carcinogens, 7-chloromethyl-12-methylbenz[a]anthracene and 7-chloromethylbenz[ai1anthracene, have been determined by X-ray crystallographic techniques. Both compounds are carcinogenic and are believed to act by alkylating DNA. However, the first has a nonplanar ring system, wher...

journal_title：Cancer research

authors： Glusker JP,Zacharias DE,Carrell HL

更新日期：1976-07-01 00:00:00

abstract：:Triple-negative breast cancer (TNBC) is a highly aggressive, heterogeneous disease with poor prognosis and no effective targeted therapies. EGFR is highly expressed in basal-like TNBC and is considered as a potential therapeutic target. However, EGFR targeting exerts only marginal clinical benefits, possibly due to ac...

journal_title：Cancer research

authors： Verma N,Müller AK,Kothari C,Panayotopoulou E,Kedan A,Selitrennik M,Mills GB,Nguyen LK,Shin S,Karn T,Holtrich U,Lev S

更新日期：2017-01-01 00:00:00

abstract：:The LeY determinant, a difucosylated type 2 blood group-related antigen, is a positional isomer of the Leb blood group antigen and a fucosylated derivative of the LeX antigen. The LeX antigen behaves like an oncodevelopmental tumor-associated antigen in human colon cancer, and extended polyfucosyl LeX antigens are mor...

journal_title：Cancer research

authors： Kim YS,Yuan M,Itzkowitz SH,Sun QB,Kaizu T,Palekar A,Trump BF,Hakomori S

更新日期：1986-11-01 00:00:00

abstract：:Organization of cancer cells into endothelial-like cell-lined structures to support neovascularization and to fuel solid tumors is a hallmark of progression and poor outcome. In triple-negative breast cancer (TNBC), PDGFRβ has been identified as a key player of this process and is considered a promising target for bre...

journal_title：Cancer research

authors： D'Ippolito E,Plantamura I,Bongiovanni L,Casalini P,Baroni S,Piovan C,Orlandi R,Gualeni AV,Gloghini A,Rossini A,Cresta S,Tessari A,De Braud F,Di Leva G,Tripodo C,Iorio MV

更新日期：2016-09-15 00:00:00

abstract：:Hereditary nonpolyposis colorectal cancer is associated with inherited defects in DNA mismatch repair. Clinical variation even in cases with identical predisposing mutations suggests the existence of other factors contributing to the phenotype. We addressed the modifying role of the common A/G polymorphism in exon 4 a...

journal_title：Cancer research

authors： Bala S,Peltomäki P

更新日期：2001-08-15 00:00:00

abstract：:As with many types of cancer, cell motility is an important factor in the progression and metastasis of hepatocellular carcinomas (HCC). HCC is associated with significant fibrosis in the liver. The fibrotic microenvironment in the liver is characterized by an altered composition of the extracellular matrix (ECM) and ...

journal_title：Cancer research

authors： Yang C,Zeisberg M,Lively JC,Nyberg P,Afdhal N,Kalluri R

更新日期：2003-12-01 00:00:00

abstract：:The mechanism of latent membrane protein LMP1 of EBV in inducing cell transformation and tumorigenesis was investigated in Rat-1 fibroblasts. A plasmid encoding a site-specific mutant of LMP1 defective in binding to tumor necrosis factor receptor-associated death domain protein was constructed. This LMP1(TRADD) gene i...

journal_title：Cancer research

authors： He Z,Xin B,Yang X,Chan C,Cao L

更新日期：2000-04-01 00:00:00

abstract：:Organic anion transporting polypeptide 1B3 (OATP1B3, SLCO1B3) is normally expressed in hepatocytes. In this study, we showed frequent overexpression of OATP1B3 in colorectal adenocarcinomas. Quantitative reverse transcription-PCR analysis of 17 colon tumors indicated tumoral overexpression of OATP1B3 by approximately ...

journal_title：Cancer research

authors： Lee W,Belkhiri A,Lockhart AC,Merchant N,Glaeser H,Harris EI,Washington MK,Brunt EM,Zaika A,Kim RB,El-Rifai W

更新日期：2008-12-15 00:00:00

abstract：:The candidate tumor suppressor gene RASSF1A is inactivated in many types of adult and childhood cancers. However, the mechanisms by which RASSF1A exerts its tumor suppressive functions have yet to be elucidated. To this end, we performed a yeast two-hybrid screen to identify novel RASSF1A-interacting proteins in a hum...

journal_title：Cancer research

authors： Dallol A,Agathanggelou A,Fenton SL,Ahmed-Choudhury J,Hesson L,Vos MD,Clark GJ,Downward J,Maher ER,Latif F

更新日期：2004-06-15 00:00:00

abstract：:The class of folate antimetabolites typified by (6R)-dideazatetrahydrofolate (lometrexol, DDATHF) are specific inhibitors of de novo purine synthesis because of potent inhibition of glycinamide ribonucleotide formyltransferase (GART) but do not induce detectable levels of DNA strand breaks. As such, they are a test ca...

journal_title：Cancer research

authors： Bronder JL,Moran RG

更新日期：2002-09-15 00:00:00

abstract：:Ascorbate free radical stimulates the growth of human promyelocytic leukemia cells (HL-60) in the presence of a limited amount of serum (1%) when added to the cells under conditions where it is impermeable. Maximum growth stimulation occurs at concentrations from 5 x 10(-9) to 2 x 10(-8) M. Ascorbate mimicks the stimu...

journal_title：Cancer research

authors： Alcaín FJ,Burón MI,Rodríguez-Aguilera JC,Villalba JM,Navas P

更新日期：1990-09-15 00:00:00

abstract：:We previously reported that both sodium butyrate and trichostatin A (TSA), both of which are known as inhibitors of histone deacetylase, arrest human tumor cells at G1 and G2-M and activate the cyclin-dependent kinase inhibitor, the p21/WAF1/Cip1 gene promoter, through the Sp1 sites. In this study, we identified Sp1 a...

journal_title：Cancer research

authors： Sowa Y,Orita T,Minamikawa-Hiranabe S,Mizuno T,Nomura H,Sakai T

更新日期：1999-09-01 00:00:00

abstract：:The aminoacyl tRNA synthetase complex-interacting multifunctional protein 2 (AIMP2) splice variant designated DX2 is induced by cigarette smoke carcinogens and is often detected in human lung cancer specimens. However, the function of DX2 in lung carcinogenesis is obscure. In this study, we found that DX2 expression w...

journal_title：Cancer research

authors： Oh AY,Jung YS,Kim J,Lee JH,Cho JH,Chun HY,Park S,Park H,Lim S,Ha NC,Park JS,Park CS,Song GY,Park BJ

更新日期：2016-08-15 00:00:00

abstract：:Genomic aberrations on chromosome 8 are common in colon cancer, and are associated with lymph node and distant metastases as well as with disease susceptibility. This prompted us to generate a high-resolution map of genomic imbalances of chromosome 8 in 51 primary colon carcinomas using a custom-designed genomic array...

journal_title：Cancer research

authors： Camps J,Grade M,Nguyen QT,Hörmann P,Becker S,Hummon AB,Rodriguez V,Chandrasekharappa S,Chen Y,Difilippantonio MJ,Becker H,Ghadimi BM,Ried T

更新日期：2008-03-01 00:00:00

abstract：:The cardiotoxic effects of Adriamycin (ADM) were studied utilizing mammalian myocardial cells in culture as a model system. ADM inhibited cell growth and the rhythmic contractions characteristic of these cells. Because a possible involvement of energy metabolism in the action of ADM was suggested previously, the adeny...

journal_title：Cancer research

authors： Seraydarian MW,Artaza L

更新日期：1979-08-01 00:00:00

abstract：:miRNAs that translocate from the nucleus to mitochondria are referred to as mitochondrial microRNAs (mitomiR). mitomiRs have been shown to modulate the translational activity of the mitochondrial genome, yet their role in mitochondrial DNA (mtDNA) transcription remains to be determined. Here we report that the mitomiR...

journal_title：Cancer research

authors： Fan S,Tian T,Chen W,Lv X,Lei X,Zhang H,Sun S,Cai L,Pan G,He L,Ou Z,Lin X,Wang X,Perez MF,Tu Z,Ferrone S,Tannous BA,Li J

更新日期：2019-03-15 00:00:00

abstract：:To understand the involvement of allelic losses and inactivation of tumor suppressor genes for the development of endometrial carcinoma of the uterus (EC), 24 cases of EC were examined for loss of heterozygosity (LOH) using a total of 57 polymorphic DNA markers covering all 23 pairs of chromosomes. LOH was observed at...

journal_title：Cancer research

authors： Okamoto A,Sameshima Y,Yamada Y,Teshima S,Terashima Y,Terada M,Yokota J

更新日期：1991-10-15 00:00:00

abstract：:A hormone-dependent subline of the transplantable rat mammary tumor MTW9 contains binding sites for both prolactin and estrogen. Prolactin binding is saturable (K-d similar to 2 times 10-9 M), hormone specific, and destroyed by proteases. By contrast, an autonomous subline derived from the same parent tumor has lost m...

journal_title：Cancer research

authors： Costlow ME,Buschow RA,Richert NJ,McGuire WL

更新日期：1975-04-01 00:00:00

abstract：:Earlier studies have shown guanine arabinoside (ara-G) is an effective agent against growth of T-cell lines and freshly isolated human T-leukemic cells. However, poor water solubility of ara-G limits clinical use. 2-Amino-6-methoxypurine arabinoside (506U) is a water-soluble prodrug converted to ara-G by adenosine dea...

journal_title：Cancer research

authors： Lambe CU,Averett DR,Paff MT,Reardon JE,Wilson JG,Krenitsky TA

更新日期：1995-08-01 00:00:00

abstract：:Latent prostate tumors are commonly found with similar frequency in many countries and ethnic groups. In contrast, aggressive prostate cancer (PC) is significantly less prevalent among Asian men, where the intake of soy products is very high. High consumption of foods containing soy results in high plasma, urine, and ...

journal_title：Cancer research

authors： Mentor-Marcel R,Lamartiniere CA,Eltoum IE,Greenberg NM,Elgavish A

更新日期：2001-09-15 00:00:00

abstract：:The effect of 17beta-estradiol on an estrogen receptor-positive human breast cancer cell line (MCF-7) was studied. Low concentrations (10(-9) M) of 17beta-estradiol enhanced the rate of cell proliferation; the overall cell cycle time was shortened; and the proportion of cells in the S phase increased. Higher concentra...

journal_title：Cancer research

authors： Weichselbaum RR,Hellman S,Piro AJ,Nove JJ,Little JB

更新日期：1978-08-01 00:00:00

abstract：:Avian erythroblastosis virus strain R (AEV)-transformed, cloned erythroleukemia cells from three different ages of SC strain chickens were analyzed before and after differentiation induced by 1.0 mM butyric acid for expression of chicken fetal antigens (CFAs) and chicken adult antigens (CAAs) and for hemoglobin expres...

journal_title：Cancer research

authors： Nelson CH,Allison JP,Kline K,Sanders BG

更新日期：1982-11-01 00:00:00

abstract：:SNAI2 overexpression appears to be associated with poor prognosis in breast cancer, yet it remains unclear in which breast cancer subtypes this occurs. Here we show that excess SNAI2 is associated with a poor prognosis of luminal B HER2+/ERBB2+ breast cancers in which SNAI2 expression in the stroma but not the epithel...

journal_title：Cancer research

authors： Blanco-Gómez A,Hontecillas-Prieto L,Corchado-Cobos R,García-Sancha N,Salvador N,Castellanos-Martín A,Sáez-Freire MDM,Mendiburu-Eliçabe M,Alonso-López D,De Las Rivas J,Lorente M,García-Casas A,Del Carmen S,Abad-Hernández MDM,C

更新日期：2020-12-01 00:00:00

abstract：:Chemokines play the key role in initiating immune responses by regulating the attraction and homing of immune cells to the lymphoid and nonlymphoid tissues. CXCL14 is a chemokine that in tumors may act as chemoattractant for monocytes and dendritic cells (DC), which may modulate antitumor immune responses in certain c...

journal_title：Cancer research

authors： Song EY,Shurin MR,Tourkova IL,Gutkin DW,Shurin GV

更新日期：2010-06-01 00:00:00

abstract：:Biologically active phorbol ester derivatives displace [3H]phorbol-12, 13-dibutyrate from thioglycollate-elicited mouse peritoneal macrophages in a time-, temperature-, and concentration-dependent manner. Scatchard analysis revealed an apparent Kd of 54.1 nM and 8.0 X 10(5) sites/cell, indicating that these macrophage...

journal_title：Cancer research

authors： Sturm RJ,Smith BM,Lane RW,Laskin DL,Harris LS,Carchman RA

更新日期：1983-10-01 00:00:00

abstract：:Rat mammary carcinomas were induced by directly inserting activated neu or ras genes into in situ rat mammary ductal cells using replication-defective retroviral vectors. neu was over 200 times more potent than ras in inducing rat mammary carcinomas. Ovariectomy 2 days postinfection dramatically reduced the occurrence...

journal_title：Cancer research

authors： Wang B,Kennan WS,Yasukawa-Barnes J,Lindstrom MJ,Gould MN

更新日期：1992-08-01 00:00:00

abstract：:In principle, the inhibition of candidate gain-of-function genes defined through genomic analyses of large patient cohorts offers an attractive therapeutic strategy. In this study, we focused on changes in expression of CD24, a well-validated clinical biomarker of poor prognosis and a driver of tumor growth and metast...

journal_title：Cancer research

authors： Agarwal N,Dancik GM,Goodspeed A,Costello JC,Owens C,Duex JE,Theodorescu D

更新日期：2016-09-01 00:00:00

abstract：:Lung carcinoma cell lines were analyzed in culture and in nude mouse xenograft for both morphological appearance and expression of specific proteins that participate in cross-linked envelope formation during normal squamous cell terminal differentiation. Cross-linked envelope formation, induced by artificial influx of...

journal_title：Cancer research

authors： Levitt ML,Gazdar AF,Oie HK,Schuller H,Thacher SM

更新日期：1990-01-01 00:00:00

abstract：:Transcription factor oncogenes such as GLI and c-MYC are central to the pathogenesis of human tumors. GLI encodes a zinc finger protein that is activated by Sonic Hedgehog signaling. Mutations in this pathway induce GLI expression in basal cell carcinoma, and expression of GLI in mice is sufficient to induce these ski...

journal_title：Cancer research

authors： Louro ID,Bailey EC,Li X,South LS,McKie-Bell PR,Yoder BK,Huang CC,Johnson MR,Hill AE,Johnson RL,Ruppert JM

更新日期：2002-10-15 00:00:00

abstract：:The supply of oxygen and nutrients to solid tumors is inefficient because cancer tissues have an inadequate number of microvessels, thus inducing the selective growth of the most aggressive cancer cells. This explains why many of the factors underlying a poor prognosis are induced in hypoxic/hypoglycemic conditions. A...

journal_title：Cancer research

authors： Raspaglio G,De Maria I,Filippetti F,Martinelli E,Zannoni GF,Prislei S,Ferrandina G,Shahabi S,Scambia G,Ferlini C

更新日期：2010-07-15 00:00:00