MCAM Mediates Chemoresistance in Small-Cell Lung Cancer via the PI3K/AKT/SOX2 Signaling Pathway.

abstract：:Malignant pleural mesothelioma (MPM) is an aggressive malignant tumor that secretes various angiogenic factors. The main inhibitor of plasminogen activators, PAI-1 (SERPINE1), has been implicated in tumor progression and angiogenesis, and high PAI-1 expression has been associated with poor prognosis in MPM patients. I...

journal_title：Cancer research

authors： Takayama Y,Hattori N,Hamada H,Masuda T,Omori K,Akita S,Iwamoto H,Fujitaka K,Kohno N

更新日期：2016-06-01 00:00:00

abstract：:12-O-Tetradecanoylphorbol-13-acetate (TPA) is an effective comitogen in phytohemagglutinin-treated bovine lymphocytes. Concurrent addition of 10(-8) M TPA gives a greater than 6-fold increase in DNA synthesis over cultures treated with the lectin alone. The delayed addition of phorbol ester, relative to the start of t...

journal_title：Cancer research

authors： Kensler TW,Mueller GC

更新日期：1978-03-01 00:00:00

abstract：:The deregulation of several cell cycle-related genes participates in neoplastic transformation. Cell cycle progression is driven by cyclin-dependent kinases, which are positively regulated by association with cyclins and negatively regulated by binding to inhibitory subunits. The activity of cyclin-dependent kinases i...

journal_title：Cancer research

authors： Gasparotto D,Maestro R,Piccinin S,Vukosavljevic T,Barzan L,Sulfaro S,Boiocchi M

更新日期：1997-06-15 00:00:00

abstract：:A sound rationale exists for antibody targeting of the MET receptor tyrosine kinase, but therapeutic agents that can broadly block HGF ligand binding and exon 14-mutated or amplified MET to induce receptor degradation have yet to be reported. Here we report the identification of several MET monoclonal antibodies (mAb)...

journal_title：Cancer research

authors： Yang Y,Mandiyan S,Robinson BS,McMahon G

更新日期：2016-10-01 00:00:00

abstract：:With normal human skin fibroblasts in culture, a transient decrease in queuine modification of tRNA precedes a phorbol ester tumor promoter-induced 5- to 10-fold increase in saturation density. Subsequently, an increase in the queuine content of cellular tRNA (to levels comparable to those in untreated cultures) prece...

journal_title：Cancer research

authors： Elliott MS,Katze JR,Trewyn RW

更新日期：1984-08-01 00:00:00

abstract：:Mutational synergism was examined in Chinese hamster V79 cells exposed to methyl methanesulfonate followed by N-acetoxy-2-acetylaminofluorene (AcAAF) at different time intervals. Treatment with 500 micron methyl methanesulfonate resulted in 95% survival of cloning ability and induced approximately 4 azaguanine-resista...

journal_title：Cancer research

authors： Myhr BC,DiPaolo JA

更新日期：1978-08-01 00:00:00

abstract：:In female nude mice, epidermal growth factor (EGF) was present at a mean concentration of 42.8 +/- 16.9 (SD) ng/mg wet tissue in the submandibular gland and 0.28 +/- 0.13 ng/ml in the plasma. Sialoadenectomy (removal of the submandibular glands) decreased circulating EGF to undetectable levels (less than 0.1 ng/ml). T...

journal_title：Cancer research

authors： Tsutsumi O,Tsutsumi A,Oka T

更新日期：1987-09-01 00:00:00

abstract：:Identification of human melanoma-associated peptide antigens for CTLs has opened unprecedented opportunities for active specific immunotherapy for melanoma with synthetic peptide. We have shown that immunization with a MAGE-1 gene encoded nonapeptide (EADPT-GHSY)-pulsed autologous antigen presenting cell-based vaccine...

journal_title：Cancer research

authors： Hu X,Chakraborty NG,Sporn JR,Kurtzman SH,Ergin MT,Mukherji B

更新日期：1996-06-01 00:00:00

abstract：:In previous studies, we have demonstrated that transferrin-gallium inhibits cellular proliferation by a mechanism whereby cellular iron utilization is impaired. Since indium, a similar class 3A metal, has not been well studied, we examined its effects on cellular iron uptake and cellular proliferation. In these studie...

journal_title：Cancer research

authors： Moran PL,Seligman PA

更新日期：1989-08-01 00:00:00

abstract：:An assay using a bimane derivative has been developed to detect free glutathione (GSH) in individual viable cells by flow cytometry. Monochlorobimane [syn-(ClCH2CH3)-1,5-diazabicycla[3.30]acta-3,6-diene-2,8-dio ne], itself nonfluorescent, reacts with GSH to form a highly fluorescent derivative. High pressure liquid ch...

journal_title：Cancer research

authors： Rice GC,Bump EA,Shrieve DC,Lee W,Kovacs M

更新日期：1986-12-01 00:00:00

abstract：:Prostate-specific membrane antigen (PSMA) is expressed in normal human prostate epithelium and is highly up-regulated in prostate cancer. We previously reported a series of novel small molecule inhibitors targeting PSMA. Two compounds, MIP-1072, (S)-2-(3-((S)-1-carboxy-5-(4-iodobenzylamino)pentyl)ureido)pentanedioic a...

journal_title：Cancer research

authors： Hillier SM,Maresca KP,Femia FJ,Marquis JC,Foss CA,Nguyen N,Zimmerman CN,Barrett JA,Eckelman WC,Pomper MG,Joyal JL,Babich JW

更新日期：2009-09-01 00:00:00

abstract：:The therapeutic potential of cisplatin, one of the most active and widely used anticancer drugs, is severely limited by the occurrence of cellular resistance. In this study, using budding yeast Saccharomyces cerevisiae as a model organism to identify novel drug resistance genes, we found that disruption of the yeast g...

journal_title：Cancer research

authors： Schenk PW,Boersma AW,Brandsma JA,den Dulk H,Burger H,Stoter G,Brouwer J,Nooter K

更新日期：2001-10-01 00:00:00

abstract：:Although it is widely accepted that tumor suppressor genes play an important role in the genesis and progression of human cancer, little is known about genetic events that accumulate during multistage lung carcinogenesis. Thus, to determine a subset of tumor suppressor genes that are involved in the genesis and progre...

journal_title：Cancer research

authors： Shiseki M,Kohno T,Nishikawa R,Sameshima Y,Mizoguchi H,Yokota J

更新日期：1994-11-01 00:00:00

abstract：:A nationwide study of all 3183 female patients with breast cancer in Israel diagnosed over a 7-year period (1960 to 1966) was conducted. Monthly series analysis showed a clear seasonal pattern in the symptomatology of the disease most pronounced in patients younger than 55 years, in all ethnic groups, mainly confined ...

journal_title：Cancer research

authors： Cohen P,Wax Y,Modan B

更新日期：1983-02-01 00:00:00

abstract：:Centrosome amplification is a hallmark of virtually all types of cancers, including solid tumors and hematologic malignancies. Cancer cells with extra centrosomes use centrosome clustering (CC) to allow for successful division. Because normal cells do not rely on this mechanism, CC is regarded as a promising target to...

journal_title：Cancer research

authors： Konotop G,Bausch E,Nagai T,Turchinovich A,Becker N,Benner A,Boutros M,Mizuno K,Krämer A,Raab MS

更新日期：2016-11-15 00:00:00

abstract：:It has been shown in previous studies that a variety of estrogen receptor (ER) beta mRNA transcripts are expressed in human breast cancer cell lines and tumors. To complement the RNA expression studies, we have developed ER-beta-specific antibodies to characterize ER-beta protein expression in breast cancer cell lines...

journal_title：Cancer research

authors： Fuqua SA,Schiff R,Parra I,Friedrichs WE,Su JL,McKee DD,Slentz-Kesler K,Moore LB,Willson TM,Moore JT

更新日期：1999-11-01 00:00:00

abstract：:The metabolic changes in rat hepatoma cell line, AH70 cells, after coculturing with Kupffer cells were visualized using a silicon-intensified target camera and subsequent processing with a computer-assisted digital imaging processor. In cocultured tumor cells, nonactivated Kupffer cells reduced mitochondrial energizat...

journal_title：Cancer research

authors： Kurose I,Miura S,Fukumura D,Yonei Y,Saito H,Tada S,Suematsu M,Tsuchiya M

更新日期：1993-06-01 00:00:00

abstract：:The immune reactivity to partially purified Thomsen-Friedenreich antigen was investigated in patients with lung cancer. The modified method of original leukocyte adherence inhibition test, termed superoxide assay-leukocyte adherence inhibition test, was used to detect the reactivity. The coded peripheral mononuclear c...

journal_title：Cancer research

authors： Ichinose Y,Yagawa K,Kaku M,Hara N,Ohta M

更新日期：1985-09-01 00:00:00

abstract：:Capsaicin (trans-8-methyl-N-vanillyl-6-nonenamide), a natural product of Capsicum species, is known to induce excitation of nociceptive terminals involved in pain perception. Recent studies have also shown that capsaicin not only has chemopreventive properties against certain carcinogens and mutagens but also exerts a...

journal_title：Cancer research

authors： Min JK,Han KY,Kim EC,Kim YM,Lee SW,Kim OH,Kim KW,Gho YS,Kwon YG

更新日期：2004-01-15 00:00:00

abstract：:Murine monoclonal antibodies have been developed against human colorectal tumors using immunogens consisting of extracts from xenografted human colon carcinoma bound to lectin-conjugated agarose beads. Antibodies of the IgG3 isotype were selected from the resulting fusions, since we and other investigators have report...

journal_title：Cancer research

authors： Woodhouse CS,Morgan AC Jr

更新日期：1989-05-15 00:00:00

abstract：:A series of nitrofuran-based compounds were identified as inhibitors of estrogen signaling in a cell-based, high-throughput screen of a diverse library of small molecules. These highly related compounds were subsequently found to inhibit topoisomerase II in vitro at concentrations similar to that required for the inhi...

journal_title：Cancer research

authors： Polycarpou-Schwarz M,Müller K,Denger S,Riddell A,Lewis J,Gannon F,Reid G

更新日期：2007-05-01 00:00:00

abstract：:High expression of VEGFC predicts adverse prognosis in acute myeloid leukemia (AML). We therefore explored VEGFC-targeting efficacy as an AML therapy using a VEGFC mAb. VEGFC antibody therapy enforced myelocytic differentiation of clonal CD34+ AML blasts. Treatment of CD34+ AML blasts with the antibody reduced expansi...

journal_title：Cancer research

authors： Kampen KR,Scherpen FJG,Mahmud H,Ter Elst A,Mulder AB,Guryev V,Verhagen HJMP,De Keersmaecker K,Smit L,Kornblau SM,De Bont ESJM

更新日期：2018-10-15 00:00:00

abstract：:Blood tests to detect circulating tumor cells (CTC) offer great potential to monitor disease status, gauge prognosis, and guide treatment decisions for patients with cancer. For patients with brain tumors, such as aggressive glioblastoma multiforme, CTC assays are needed that do not rely on expression of cancer cell s...

journal_title：Cancer research

authors： Macarthur KM,Kao GD,Chandrasekaran S,Alonso-Basanta M,Chapman C,Lustig RA,Wileyto EP,Hahn SM,Dorsey JF

更新日期：2014-04-15 00:00:00

abstract：:Farnesol (FOH) and other isoprenoid alcohols induce apoptosis in various carcinoma cells and inhibit tumorigenesis in several in vivo models. However, the mechanisms by which they mediate their effects are not yet fully understood. In this study, we show that FOH is an effective inducer of apoptosis in several lung ca...

journal_title：Cancer research

authors： Joo JH,Liao G,Collins JB,Grissom SF,Jetten AM

更新日期：2007-08-15 00:00:00

abstract：:Our recent study found that activation of signal transducer and activator of transcription 3 (Stat3) is up-regulated in human brain metastatic cells and contributes to brain metastasis of melanoma. However, the molecular mechanisms underlying this increased Stat3 activation and effect on brain metastasis are unknown. ...

journal_title：Cancer research

authors： Huang FJ,Steeg PS,Price JE,Chiu WT,Chou PC,Xie K,Sawaya R,Huang S

更新日期：2008-12-01 00:00:00

abstract：:alpha(v)beta(3) integrin was investigated in multiple myeloma in relation to the in vitro osteoclast-like activity of malignant plasma cells. Myeloma cells from patients with skeleton involvement overexpressed alpha(v)beta(3) and produced erosion pits on bone substrates, whereas this effect was not observed by cells f...

journal_title：Cancer research

authors： Tucci M,De Palma R,Lombardi L,Rodolico G,Berrino L,Dammacco F,Silvestris F

更新日期：2009-08-15 00:00:00

abstract：:Ursodeoxycholic acid (UDCA) protects cells from the apoptotic effects of hydrophobic bile acids and some other cytotoxic agents. We observed the opposite result when assessing the effects of UDCA on the apoptotic response to mitochondrial photodamage induced by photodynamic therapy (PDT). Two photosensitizers with pre...

journal_title：Cancer research

authors： Kessel D,Caruso JA,Reiners JJ Jr

更新日期：2000-12-15 00:00:00

abstract：:The effect of type (corn oil or lard) and quantity (5 or 20%) of dietary fat and 1,2-dimethylhydrazine (DMH) on the composition of biliary bile acids, fecal bile acids, and neutral sterols was studied in rats exposed to a given regimen for two generations prior to s.c. treatment with DMH for 20 weeks. Biliary excretio...

journal_title：Cancer research

authors： Reddy BS,Mangat S,Sheinfil A,Weisburger JH,Wynder EL

更新日期：1977-07-01 00:00:00

abstract：:Despite the fact that the local immunological microenvironment shapes the prognosis of colorectal cancer, immunotherapy has shown no benefit for the vast majority of colorectal cancer patients. A better understanding of the complex immunological interplay within the microenvironment is required. In this study, we util...

journal_title：Cancer research

authors： Kather JN,Poleszczuk J,Suarez-Carmona M,Krisam J,Charoentong P,Valous NA,Weis CA,Tavernar L,Leiss F,Herpel E,Klupp F,Ulrich A,Schneider M,Marx A,Jäger D,Halama N

更新日期：2017-11-15 00:00:00

abstract：:Triple-negative breast cancers (TNBC) are especially refractory to treatment due to their negative hormone receptor and ErbB2/HER2 status. Therefore, the identification of cancer-associated deregulated signaling pathways is necessary to develop improved targeted therapies. Here, we show that expression of the ceramide...

journal_title：Cancer research

authors： Heering J,Weis N,Holeiter M,Neugart F,Staebler A,Fehm TN,Bischoff A,Schiller J,Duss S,Schmid S,Korte T,Herrmann A,Olayioye MA

更新日期：2012-06-01 00:00:00