Using chemopreventive agents to enhance the efficacy of cancer therapy.

Abstract:

:Emerging evidence suggests that cancer preventative agents might be combined with chemotherapy or radiotherapy for the more effective treatment of cancer. Recent studies suggest that genistein and other dietary compounds that prevent cancer may enhance the efficacy of cancer therapeutics by modifying the activity of key cell proliferation and survival pathways, such as those controlled by Akt, nuclear factor-kappaB, and cyclooxygenase-2. In this article, we summarize the findings of recent investigations of chemopreventive agents in combination with cancer treatment regimens.

journal_name

Cancer Res

journal_title

Cancer research

authors

Sarkar FH,Li Y

doi

10.1158/0008-5472.CAN-05-4526

subject

Has Abstract

pub_date

2006-04-01 00:00:00

pages

3347-50

issue

7

eissn

0008-5472

issn

1538-7445

pii

66/7/3347

journal_volume

66

pub_type

杂志文章,评审
  • Phenotypic heterogeneity in cultured human head and neck squamous cell carcinoma lines with low-level methotrexate resistance.

    abstract::Low-level methotrexate (MTX) resistance (less than 20-fold) was induced by gradual selection pressure in four human head and neck squamous cell carcinoma lines established in culture from biopsies of patients not previously treated with MTX. Each parental and resistant line was characterized with respect to MTX uptake...

    journal_title:Cancer research

    pub_type: 杂志文章

    doi:

    authors: Rosowsky A,Wright JE,Cucchi CA,Lippke JA,Tantravahi R,Ervin TJ,Frei E 3rd

    更新日期:1985-12-01 00:00:00

  • Identification of biomarkers modulated by the rexinoid LGD1069 (bexarotene) in human breast cells using oligonucleotide arrays.

    abstract::Retinoids have been found to be promising chemopreventive agents that play an important role in regulating cell growth, differentiation, and apoptosis. The action of retinoids is mediated by retinoid receptors (retinoic acid receptors and retinoid X receptors), which are nuclear transcription factors that, when bound ...

    journal_title:Cancer research

    pub_type: 杂志文章

    doi:10.1158/0008-5472.CAN-05-2515

    authors: Kim HT,Kong G,Denardo D,Li Y,Uray I,Pal S,Mohsin S,Hilsenbeck SG,Bissonnette R,Lamph WW,Johnson K,Brown PH

    更新日期:2006-12-15 00:00:00

  • Lung Tumor Suppressor GPRC5A Binds EGFR and Restrains Its Effector Signaling.

    abstract::GPRC5A is a G-protein-coupled receptor expressed in lung tissue but repressed in most human lung cancers. Studies in Gprc5a(-/-) mice have established its role as a tumor-suppressor function in this setting, but the basis for its role has been obscure. Here, we report that GPRC5A functions as a negative modulator of E...

    journal_title:Cancer research

    pub_type: 杂志文章

    doi:10.1158/0008-5472.CAN-14-2005

    authors: Zhong S,Yin H,Liao Y,Yao F,Li Q,Zhang J,Jiao H,Zhao Y,Xu D,Liu S,Song H,Gao Y,Liu J,Ma L,Pang Z,Yang R,Ding C,Sun B,Lin X,Ye X,Guo W,Han B,Zhou BP,Chin YE,Deng J

    更新日期:2015-05-01 00:00:00

  • Inhibition of nitric oxide synthase induces a selective reduction in tumor blood flow that is reversible with L-arginine.

    abstract::The effect of i.v. administration of the nitric oxide synthase (NOS) inhibitor N(omega)-nitro-L-arginine (L-NNA) on tumor blood flow compared with normal tissue blood flow was studied in anesthetized BD9 rats bearing subcutaneous P22 carcinosarcomas. Blood flow was measured by the tissue uptake of radiolabeled iodoant...

    journal_title:Cancer research

    pub_type: 杂志文章

    doi:

    authors: Tozer GM,Prise VE,Chaplin DJ

    更新日期:1997-03-01 00:00:00

  • Toxicity and antitumor activity of hexamethylmelamine and its N-demethylated metabolites in mice with transplantable tumors.

    abstract::N-Demethylated metabolites of the antineoplastic agent hexamethylmelamine were synthesized, and their toxicities and antitumor activities were determined in vivo. Determinations of the lethal dose for 10% of the male C57BL X DBA/2 F1 (hereafter called BD2F1) mice showed hexamethylmelamine toxicity to be decreased by N...

    journal_title:Cancer research

    pub_type: 杂志文章

    doi:

    authors: Lake LM,Grunden EE,Johnson BM

    更新日期:1975-10-01 00:00:00

  • Expression of cyclooxygenase-2 and inducible nitric oxide synthase in human ovarian tumors and tumor-associated macrophages.

    abstract::This study investigates whether and to what extent cyclooxygenase type-2 (COX-2) and inducible nitric oxide-synthase (iNOS), both known to have an immunosuppressive effect, are expressed in human ovarian tumors. Because COX-2 and iNOS can be expressed by activated macrophages, the presence of tumor-associated macropha...

    journal_title:Cancer research

    pub_type: 杂志文章

    doi:

    authors: Klimp AH,Hollema H,Kempinga C,van der Zee AG,de Vries EG,Daemen T

    更新日期:2001-10-01 00:00:00

  • Interstitial taxol delivered from a biodegradable polymer implant against experimental malignant glioma.

    abstract::Taxol is a novel antitumor agent with demonstrated efficacy against ovarian, breast, and non-small cell lung cancers in Phase II clinical trials, but which has been shown not to cross the blood-brain barrier. To adapt taxol as a therapy for brain tumors, we have incorporated it into a biodegradable polyanhydride matri...

    journal_title:Cancer research

    pub_type: 杂志文章

    doi:

    authors: Walter KA,Cahan MA,Gur A,Tyler B,Hilton J,Colvin OM,Burger PC,Domb A,Brem H

    更新日期:1994-04-15 00:00:00

  • Cellular retinoic acid-binding protein in virus-induced Shope papillomas of rabbit skin.

    abstract::Cellular retinoic acid-binding protein (cRABP) was detected in the cytosol of virus-induced papilloma (Shope) of rabbit skin. The Shope papilloma cRABP showed the same ligand specificity and sedimentation value (2S) as was found in other animal species. The level of cRABP in the papillomatous tissue was significantly ...

    journal_title:Cancer research

    pub_type: 杂志文章

    doi:

    authors: Rattanapanone V,Tashiro S,Tokuda H,Rattanapanone N,Ito Y

    更新日期:1981-04-01 00:00:00

  • Bdp, a new member of a family of DNA-binding proteins, associates with the retinoblastoma gene product.

    abstract::We have cloned a gene, BDP, encoding a protein with homology to the retinoblastoma-binding proteins Rbp1 and Rbp2. It also has homology to DNA-binding proteins such as Bright, a B-cell-specific trans-activator, and the Drosophila melanogaster dead ringer gene product. Like MyoD, Bdp binds to the COOH-terminal region o...

    journal_title:Cancer research

    pub_type: 杂志文章

    doi:

    authors: Numata S,Claudio PP,Dean C,Giordano A,Croce CM

    更新日期:1999-08-01 00:00:00

  • Tumorigenicity of the cyc- variant of the S49 murine lymphoma deficient in the Gs-alpha subunit of adenylate cyclase.

    abstract::S49 cyc- lymphoma cells contain a mutation resulting in loss of a functional guanine nucleotide regulatory protein rendering their adenylate cyclase refractory to most stimuli. S49 wild-type and cyc- clones were used in the present study to investigate the possible association of altered cAMP metabolism with tumorigen...

    journal_title:Cancer research

    pub_type: 杂志文章

    doi:

    authors: Stadel JM,Johnson RK,Mirabelli CK,Powers DA,Sung CM,Faucette LF,McCabe FL,Crooke ST

    更新日期:1988-02-01 00:00:00

  • Modification of serum, pancreatic, and microbial lipase activities by phorbol diesters.

    abstract::The influence of phorbol diesters on the in vitro hydrolysis of diacylglycerols was examined using enzymes from rat serum, porcine pancreas, and Rhizopus delemar. Two main phenomena were observed: 12-O-tetradecanoylphorbol-13-acetate (TPA), when added to the enzyme assay system, stimulated 2- to 3-fold the hydrolysis ...

    journal_title:Cancer research

    pub_type: 杂志文章

    doi:

    authors: Zhang ZC,Cabot MC

    更新日期:1987-01-01 00:00:00

  • A radioresistant variant derived from a human neuroblastoma cell line is less prone to radiation-induced apoptosis.

    abstract::By subjecting radiosensitive human neuroblastoma IMR 32 cells to a regime of fractionated X-irradiation, a radioresistant variant, XRIMR 32, was obtained. Radiation resistance of XRIMR 32 cells was demonstrated by clonogenic and spheroid regrowth delay assays. The XRIMR 32 cultures were phenotypically unstable, with t...

    journal_title:Cancer research

    pub_type: 杂志文章

    doi:

    authors: Russell J,Wheldon TE,Stanton P

    更新日期:1995-11-01 00:00:00

  • Absence of the wild-type allele predicts poor prognosis in adult de novo acute myeloid leukemia with normal cytogenetics and the internal tandem duplication of FLT3: a cancer and leukemia group B study.

    abstract::The FLT3 gene is mutated by an internal tandem duplication (ITD) in 20-25% of adults with acute myeloid leukemia (AML). We studied 82 adults <60 years of age with primary AML and normal cytogenetics, who received uniform high-dose therapy and found FLT3 ITD in 23 (28%) patients. When the 23 FLT3 ITD+ cases were compar...

    journal_title:Cancer research

    pub_type: 杂志文章

    doi:

    authors: Whitman SP,Archer KJ,Feng L,Baldus C,Becknell B,Carlson BD,Carroll AJ,Mrózek K,Vardiman JW,George SL,Kolitz JE,Larson RA,Bloomfield CD,Caligiuri MA

    更新日期:2001-10-01 00:00:00

  • Cdc37 enhances proliferation and is necessary for normal human prostate epithelial cell survival.

    abstract::Cdc37 is a co-chaperone protein that recruits several immature client kinases to Hsp90 for proper folding. Cdc37 up-regulation is a common early event in localized human prostate cancer. Although targeted overexpression in mice leads to prostate epithelial cell hyperplasia, the effect of Cdc37 dysregulation in human p...

    journal_title:Cancer research

    pub_type: 杂志文章

    doi:

    authors: Schwarze SR,Fu VX,Jarrard DF

    更新日期:2003-08-01 00:00:00

  • Identification of the MEK1(F129L) activating mutation as a potential mechanism of acquired resistance to MEK inhibition in human cancers carrying the B-RafV600E mutation.

    abstract::Although targeting the Ras/Raf/MEK pathway remains a promising anticancer strategy, mitogen-activated protein/extracellular signal-regulated kinase (ERK) kinase (MEK) inhibitors in clinical development are likely to be limited in their ability to produce durable clinical responses due to the emergence of acquired drug...

    journal_title:Cancer research

    pub_type: 杂志文章

    doi:10.1158/0008-5472.CAN-10-4351

    authors: Wang H,Daouti S,Li WH,Wen Y,Rizzo C,Higgins B,Packman K,Rosen N,Boylan JF,Heimbrook D,Niu H

    更新日期:2011-08-15 00:00:00

  • MLK3 regulates paxillin phosphorylation in chemokine-mediated breast cancer cell migration and invasion to drive metastasis.

    abstract::MLK3 kinase activates multiple mitogen-activated protein kinases and plays a critical role in cancer cell migration and invasion. In the tumor microenvironment, prometastatic factors drive breast cancer invasion and metastasis, but their associated signaling pathways are not well-known. Here, we provide evidence that ...

    journal_title:Cancer research

    pub_type: 杂志文章

    doi:10.1158/0008-5472.CAN-12-0655

    authors: Chen J,Gallo KA

    更新日期:2012-08-15 00:00:00

  • Expression of epidermal growth factor receptor in human gastric and colonic carcinomas.

    abstract::The expression of epidermal growth factor (EGF) receptor was examined immunohistochemically in a total of 122 gastric and 61 colonic carcinomas, out of which 16 gastric and 8 colonic carcinomas were also examined by 125I-labeled EGF binding analysis and Western blotting. The values of EGF binding were 12.68 +/- 1.98 (...

    journal_title:Cancer research

    pub_type: 杂志文章

    doi:

    authors: Yasui W,Sumiyoshi H,Hata J,Kameda T,Ochiai A,Ito H,Tahara E

    更新日期:1988-01-01 00:00:00

  • Comparison of 1,2-dihydropyrido[3,4-b]pyrazines (1-deaza-7,8-dihydropteridines) with several other inhibitors of mitosis.

    abstract::Several properties of four 1-deaza-7,8-dihydropteridines were compared with those of each other and with those of colchicine, nocodazole, podophyllotoxin, and vincristine. Compound NSC 370147 was more active than the other compounds of this type with respect to inhibition of proliferation of cultured L1210 cells and t...

    journal_title:Cancer research

    pub_type: 杂志文章

    doi:

    authors: Bowdon BJ,Waud WR,Wheeler GP,Hain R,Dansby L,Temple C Jr

    更新日期:1987-03-15 00:00:00

  • Nuclear factor-kappaB activation is involved in LMP1-mediated transformation and tumorigenesis of rat-1 fibroblasts.

    abstract::The mechanism of latent membrane protein LMP1 of EBV in inducing cell transformation and tumorigenesis was investigated in Rat-1 fibroblasts. A plasmid encoding a site-specific mutant of LMP1 defective in binding to tumor necrosis factor receptor-associated death domain protein was constructed. This LMP1(TRADD) gene i...

    journal_title:Cancer research

    pub_type: 杂志文章

    doi:

    authors: He Z,Xin B,Yang X,Chan C,Cao L

    更新日期:2000-04-01 00:00:00

  • Inverse PCR-based RFLP scanning identifies low-level mutation signatures in colon cells and tumors.

    abstract::Detecting the presence and diversity of low-level mutations in human tumors undergoing genomic instability is desirable due to their potential prognostic value and their putative influence on the ability of tumors to resist drug treatment and/or metastasize. However, direct measurement of these genetic alterations in ...

    journal_title:Cancer research

    pub_type: 杂志文章

    doi:10.1158/0008-5472.can-03-3652

    authors: Liu WH,Kaur M,Wang G,Zhu P,Zhang Y,Makrigiorgos GM

    更新日期:2004-04-01 00:00:00

  • Enhanced uptake of a thermally responsive polypeptide by tumor cells in response to its hyperthermia-mediated phase transition.

    abstract::Elastin-like polypeptides (ELPs) composed of a VPGXG repeat undergo a reversible phase transition in aqueous solution. They are hydrophilic and soluble in aqueous solution below their transition temperature (T(t)), but they become hydrophobic and aggregate when the temperature is raised above their T(t). In this study...

    journal_title:Cancer research

    pub_type: 杂志文章

    doi:

    authors: Raucher D,Chilkoti A

    更新日期:2001-10-01 00:00:00

  • PIN1 Maintains Redox Balance via the c-Myc/NRF2 Axis to Counteract Kras-Induced Mitochondrial Respiratory Injury in Pancreatic Cancer Cells.

    abstract::Kras is a decisive oncogene in pancreatic ductal adenocarcinoma (PDAC). PIN1 is a key effector involved in the Kras/ERK axis, synergistically mediating various cellular events. However, the underlying mechanism by which PIN1 promotes the development of PDAC remains unclear. Here we sought to elucidate the effect of PI...

    journal_title:Cancer research

    pub_type: 杂志文章

    doi:10.1158/0008-5472.CAN-18-1968

    authors: Liang C,Shi S,Liu M,Qin Y,Meng Q,Hua J,Ji S,Zhang Y,Yang J,Xu J,Ni Q,Li M,Yu X

    更新日期:2019-01-01 00:00:00

  • Aclacinomycin A stabilizes topoisomerase I covalent complexes.

    abstract::Aclacinomycin A (aclarubicin) is an anthracycline anticancer agent with demonstrated activity against both leukemias and solid tumors. Previous results suggested that a major activity of aclacinomycin A is the inhibition of topoisomerase II catalytic activity. We have applied a yeast system to test whether aclacinomyc...

    journal_title:Cancer research

    pub_type: 杂志文章

    doi:

    authors: Nitiss JL,Pourquier P,Pommier Y

    更新日期:1997-10-15 00:00:00

  • Sensitivity of subpopulations of mouse skin papillomas to malignant conversion by urethane or 4-nitroquinoline N-oxide.

    abstract::Papillomas induced in SENCAR mice by initiation with 7,12-dimethylbenz(a)anthracene and promotion by treatment for 10-12 weeks with 12-O-tetradecanoylphorbol-13-acetate (TPA) convert to malignancy at a low frequency. The rate of malignant conversion can be increased by either (a) promoting with TPA for a shorter durat...

    journal_title:Cancer research

    pub_type: 杂志文章

    doi:

    authors: Hennings H,Shores R,Balaschak M,Yuspa SH

    更新日期:1990-02-01 00:00:00

  • Glioblastoma induces vascular endothelial cells to express telomerase in vitro.

    abstract::Angiogenesis is essential for the growth of solid tumors. We have observed previously that the vascular endothelial cells of astrocytic brain tumors express human telomerase reverse transcriptase (hTERT) mRNA, suggesting a role for telomerase in the angiogenesis of these neoplasms. Here, we used an in vitro model to d...

    journal_title:Cancer research

    pub_type: 杂志文章

    doi:

    authors: Falchetti ML,Pierconti F,Casalbore P,Maggiano N,Levi A,Larocca LM,Pallini R

    更新日期:2003-07-01 00:00:00

  • Continuous culture and soft agarose cloning of multiple human breast carcinoma cell lines in serum-free medium.

    abstract::We tested the ability of a serum-free medium containing insulin, transferrin, 17 beta-estradiol, dexamethasone, triiodothyronine, prostaglandin F2 alpha, and fibronectin (HBCA medium) to support the continuous growth and passage of five human breast carcinoma cell lines on a collagen matrix. Doubling times of the cell...

    journal_title:Cancer research

    pub_type: 杂志文章

    doi:

    authors: Calvo F,Brower M,Carney DN

    更新日期:1984-10-01 00:00:00

  • The Role of Cholesterol in Cancer.

    abstract::The roles played by cholesterol in cancer development and the potential of therapeutically targeting cholesterol homeostasis is a controversial area in the cancer community. Several epidemiologic studies report an association between cancer and serum cholesterol levels or statin use, while others suggest that there is...

    journal_title:Cancer research

    pub_type: 杂志文章,评审

    doi:10.1158/0008-5472.CAN-15-2613

    authors: Kuzu OF,Noory MA,Robertson GP

    更新日期:2016-04-15 00:00:00

  • Suppression of growth of renal carcinoma cells by the von Hippel-Lindau tumor suppressor gene.

    abstract::Clear cell renal carcinomas are most frequently characterized by loss of function of both copies of the von Hippel-Lindau (VHL) disease gene, suggesting that the VHL gene product plays an important role in regulating renal cell proliferation. To directly assess the function of the VHL gene product, we transfected the ...

    journal_title:Cancer research

    pub_type: 杂志文章

    doi:

    authors: Chen F,Kishida T,Duh FM,Renbaum P,Orcutt ML,Schmidt L,Zbar B

    更新日期:1995-11-01 00:00:00

  • Detection of the M(r) 190,000 multidrug resistance protein, MRP, with monoclonal antibodies.

    abstract::MRP is a M(r) 190,000 integral membrane phosphoglycoprotein that is overexpressed in some drug-selected resistant cell lines and has been shown to cause multidrug resistance in transfected cells. Five murine hybridoma cell lines (QCRL-1, QCRL-2, QCRL-3, QCRL-4, and QCRL-6) have been generated which secrete monoclonal ...

    journal_title:Cancer research

    pub_type: 杂志文章

    doi:

    authors: Hipfner DR,Gauldie SD,Deeley RG,Cole SP

    更新日期:1994-11-15 00:00:00

  • Effect of stathmin on the sensitivity to antimicrotubule drugs in human breast cancer.

    abstract::Stathmin is a p53-regulated protein known to influence microtubule dynamics. Because several chemotherapeutic agents used to treat breast cancer alter the dynamic equilibrium of tubulin polymerization, stathmin may play an important role in determining the sensitivity to these drugs. Therefore, we evaluated the effect...

    journal_title:Cancer research

    pub_type: 杂志文章

    doi:

    authors: Alli E,Bash-Babula J,Yang JM,Hait WN

    更新日期:2002-12-01 00:00:00