Dll4 Blockade in Stromal Cells Mediates Antitumor Effects in Preclinical Models of Ovarian Cancer.

abstract：:XPC protein is a critical DNA damage recognition factor in nucleotide excision repair for which genetic deficiency confers a predisposition to cancer. In this study, we show that XPC has a function that is independent of its canonical function in DNA repair, potentially altering the interpretation of how XPC deficienc...

journal_title：Cancer research

authors： Wang QE,Han C,Zhang B,Sabapathy K,Wani AA

更新日期：2012-02-01 00:00:00

abstract：:One of the major limitations of tumor-specific vaccination is the generation of antigen-loss variants that are able to escape the immune response elicited by a monoantigenic peptide epitope. Here, we report the identification of a new HLA-B*3701-restricted epitope shared by four different members of the MAGE family. P...

journal_title：Cancer research

authors： Tanzarella S,Russo V,Lionello I,Dalerba P,Rigatti D,Bordignon C,Traversari C

更新日期：1999-06-01 00:00:00

abstract：:Checkpoint inhibitors are relatively inefficacious in head and neck cancers, despite an abundance of genetic alterations and a T-cell-inflamed phenotype. One significant barrier to efficacy may be the recruitment of myeloid-derived suppressor cells (MDSC) into the tumor microenvironment. Here we demonstrate functional...

journal_title：Cancer research

authors： Davis RJ,Moore EC,Clavijo PE,Friedman J,Cash H,Chen Z,Silvin C,Van Waes C,Allen C

更新日期：2017-05-15 00:00:00

abstract：:We have studied the effects of low-power-density microwave (MW) radiation (continuous and pulsed wave with average power density of 10 milliwatts/sq cm and range of 5 to 50 milliwatts/sq cm; frequency, 1.0 GHz) on the uptake and action of methotrexate (MTX), the inhibition of DNA synthesis in L1210 murine leukemia cel...

journal_title：Cancer research

authors： Chang BK,Huang AT,Joines WT

更新日期：1980-04-01 00:00:00

abstract：:Successful chemotherapy accounts for both tumor-related factors and host immune response. Compelling evidence suggests that some chemotherapeutic agents can induce an immunogenic type of cell death stimulating tumor-specific immunity. Here, we show that cyclophosphamide (CTX) exerts two types of actions relevant for t...

journal_title：Cancer research

authors： Schiavoni G,Sistigu A,Valentini M,Mattei F,Sestili P,Spadaro F,Sanchez M,Lorenzi S,D'Urso MT,Belardelli F,Gabriele L,Proietti E,Bracci L

更新日期：2011-02-01 00:00:00

abstract：:Effective treatment of malignant carcinomas requires identification of proteins regulating epithelial cell proliferation. To this end, we compared gene expression profiles in murine colonocytes and their c-Myc-transformed counterparts, which possess enhanced proliferative potential. A surprisingly short list of deregu...

journal_title：Cancer research

authors： Thomas-Tikhonenko A,Viard-Leveugle I,Dews M,Wehrli P,Sevignani C,Yu D,Ricci S,el-Deiry W,Aronow B,Kaya G,Saurat JH,French LE

更新日期：2004-05-01 00:00:00

abstract：:Patients diagnosed with leukemia approach their treatment with the hope of cure despite the effect on their quality of life. Some patients will be cured, others will die from treatment, and some will die of their disease. A common theme at the New Directions in Leukemia Research (NDLR 2012) meeting was that cure will ...

journal_title：Cancer research

authors： White DL,Brown AL,D'Andrea RJ,Rice AM

更新日期：2012-09-01 00:00:00

abstract：:Specific inhibitors of mitogen-activated protein kinase/extracellular signal-regulated kinase (ERK) kinase (MEK) have been developed that efficiently inhibit the oncogenic RAF-MEK-ERK pathway. We used a systems-based approach to identify breast cancer subtypes particularly susceptible to MEK inhibitors and to understa...

journal_title：Cancer research

authors： Mirzoeva OK,Das D,Heiser LM,Bhattacharya S,Siwak D,Gendelman R,Bayani N,Wang NJ,Neve RM,Guan Y,Hu Z,Knight Z,Feiler HS,Gascard P,Parvin B,Spellman PT,Shokat KM,Wyrobek AJ,Bissell MJ,McCormick F,Kuo WL,Mills GB,

更新日期：2009-01-15 00:00:00

abstract：:Androgens via their receptor (AR) may play a role in prostate cancer etiology. This study focuses on the inhibitory effects of resveratrol on androgen action in the LNCaP prostate cancer cell line. We found that resveratrol represses different classes of androgen up-regulated genes at the protein or mRNA level includi...

journal_title：Cancer research

authors： Mitchell SH,Zhu W,Young CY

更新日期：1999-12-01 00:00:00

abstract：:Solid human tumors and their surrounding microenvironment are hypothesized to coevolve in a manner that promotes tumor growth, invasiveness, and spread. Mouse models of cancer have focused on genetic changes in the epithelial tumor cells and therefore have not robustly tested this hypothesis. We have recently develope...

journal_title：Cancer research

authors： Wallace JA,Li F,Leone G,Ostrowski MC

更新日期：2011-02-15 00:00:00

abstract：:The ability of the in vitro sister chromatid exchange (SCE) assay to predict in vivo tumor drug sensitivity was investigated using a spontaneous hepatocarcinoma in C3Hf/Kam mice and 3 chemotherapeutic agents: melphalan; cis-platinum; and 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU). For hepatocarcinoma cells grown in m...

journal_title：Cancer research

authors： Tofilon PJ,Basic I,Milas L

更新日期：1985-05-01 00:00:00

abstract：:Plasmacytoid dendritic cells (pDC) are the main producers of a key T-cell-stimulatory cytokine, IFNα, and critical regulators of antiviral immunity. Chronic myeloid leukemia (CML) is caused by BCR-ABL, which is an oncogenic tyrosine kinase that can be effectively inhibited with ABL-selective tyrosine kinase inhibitors...

journal_title：Cancer research

authors： Inselmann S,Wang Y,Saussele S,Fritz L,Schütz C,Huber M,Liebler S,Ernst T,Cai D,Botschek S,Brendel C,Calogero RA,Pavlinic D,Benes V,Liu ET,Neubauer A,Hochhaus A,Burchert A

更新日期：2018-11-01 00:00:00

abstract：:Deleterious mutations of the ubiquitin carboxy-terminal hydrolase BAP1 found in cancers are predicted to encode inactive truncated proteins, suggesting that loss of enzyme function is a primary tumorigenic mechanism. However, many tumors exhibit missense mutations or in-frame deletions or insertions, often outside the...

journal_title：Cancer research

authors： Peng H,Prokop J,Karar J,Park K,Cao L,Harbour JW,Bowcock AM,Malkowicz SB,Cheung M,Testa JR,Rauscher FJ 3rd

更新日期：2018-03-01 00:00:00

abstract：:Similar histologic subtypes of cancers often exhibit different spectrum of genetic and epigenetic alterations. The heterogeneity observed due to lack of consistent and defined alterations affecting a unique set of gene(s) or gene products in cancers derived from a specific tissue, or an organ, pose a challenge in unra...

journal_title：Cancer research

authors： Thiagalingam S

更新日期：2006-08-01 00:00:00

abstract：:The fusion transcript AML1/ETO was detected in the bone marrow of two t(8;21)-negative acute myelogenous leukemia (AML) patients by means of reverse transcription-polymerase chain reaction. This fusion transcript is identical to the one transcribed from the t(8;21) translocation base, as deduced from (a) the size and ...

journal_title：Cancer research

authors： Maruyama F,Yang P,Stass SA,Cork A,Freireich EJ,Lee MS,Chang KS

更新日期：1993-10-01 00:00:00

abstract：:B-cell precursor acute lymphoblastic leukemia (BCP-ALL/B-precursor ALL) is characterized by a high rate of tissue infiltration. The mechanism of BCP-ALL cell extravasation is not fully understood. In the present study, we have investigated the major carrier of carbohydrate selectin ligands in the BCP-ALL cell line NAL...

journal_title：Cancer research

authors： Nonomura C,Kikuchi J,Kiyokawa N,Ozaki H,Mitsunaga K,Ando H,Kanamori A,Kannagi R,Fujimoto J,Muroi K,Furukawa Y,Nakamura M

更新日期：2008-02-01 00:00:00

abstract：:Cancers are initiated as a result of changes that occur in the genome. Identification of gains and losses in the structure and expression of tumor-suppressor genes and oncogenes lies at the root of the understanding of cancer cell biology. Here, we show that the mitogen-activated protein kinase (MAPK) MKK3 suppresses ...

journal_title：Cancer research

authors： MacNeil AJ,Jiao SC,McEachern LA,Yang YJ,Dennis A,Yu H,Xu Z,Marshall JS,Lin TJ

更新日期：2014-01-01 00:00:00

abstract：:Motility related protein-1 (MRP-1) is a transmembrane glycoprotein that is identical to the CD9 antigen. In previous studies, we showed that various types of cultured tumor cells transfected with MRP-1/CD9 cDNA have low motility and diminished metastatic potential to the lung. More recently we used immunohistochemical...

journal_title：Cancer research

authors： Higashiyama M,Taki T,Ieki Y,Adachi M,Huang CL,Koh T,Kodama K,Doi O,Miyake M

更新日期：1995-12-15 00:00:00

abstract：:This study examined the association between 17p allelic loss and p53 gene mutation in a series of 16 esophageal adenocarcinomas arising on a background of Barrett's esophagus. Two highly polymorphic dinucleotide repeat polymorphisms mapping to 17p13 were analyzed to assess the frequency of 17p allelic loss in these tu...

journal_title：Cancer research

authors： Gleeson CM,Sloan JM,McGuigan JA,Ritchie AJ,Russell SE

更新日期：1995-08-01 00:00:00

abstract：:The ErbB2 (Neu) receptor tyrosine kinase is frequently overexpressed in human breast cancers, and this phenotype correlates with a poor clinical prognosis. We examined the effects of the mammalian target of rapamycin inhibitor, rapamycin, on mammary tumorigenesis in transgenic mice bearing an activated ErbB2 (NeuYD) t...

journal_title：Cancer research

authors： Liu M,Howes A,Lesperance J,Stallcup WB,Hauser CA,Kadoya K,Oshima RG,Abraham RT

更新日期：2005-06-15 00:00:00

abstract：:Isoprenoid inhibitors are being evaluated as agents for the treatment of cancer. Their antitumor activity is attributed to inhibition of post-translational modification of Ras, which is crucial for its translocation and attachment to the plasma membrane, and ultimate involvement in signal transduction. However, whethe...

journal_title：Cancer research

authors： Efuet ET,Keyomarsi K

更新日期：2006-01-15 00:00:00

abstract：:Current standard of care for patients with pediatric acute lymphoblastic leukemia (ALL) is mainly effective, with high remission rates after treatment. However, the genetic perturbations that give rise to this disease remain largely undefined, limiting the ability to address resistant tumors or develop less toxic targ...

journal_title：Cancer research

authors： Ding LW,Sun QY,Tan KT,Chien W,Mayakonda A,Yeoh AEJ,Kawamata N,Nagata Y,Xiao JF,Loh XY,Lin DC,Garg M,Jiang YY,Xu L,Lim SL,Liu LZ,Madan V,Sanada M,Fernández LT,Hema Preethi SS,Lill M,Kantarjian HM,Kornblau SM,

更新日期：2017-01-15 00:00:00

abstract：:Fischer X Copenhagen rats bearing Dunning R3327-AT tumors were treated with hematoporphyrin derivative and red light (630 nm from an argon-driven dye laser) alone or in combination with the hypoxic cell radiosensitizer, misonidazole (MISO). In vitro studies had suggested that hypoxia might significantly decrease the c...

journal_title：Cancer research

authors： Gonzalez S,Arnfield MR,Meeker BE,Tulip J,Lakey WH,Chapman JD,McPhee MS

更新日期：1986-06-01 00:00:00

abstract：:Primary solid tumors were mechanically and/or enzymatically disassociated, and the resulting suspensions of single cells and small clumps of cells were seeded onto three different substrates, i.e., tissue culture plastic, rat smooth muscle cells (SMCs), and SMC-derived extracellular matrix. Tests of the relative effec...

journal_title：Cancer research

authors： Bogenmann E,Mark C,Isaacs H,Neustein HB,De Clerck YA,Laug WE,Jones PA

更新日期：1983-03-01 00:00:00

abstract：:Our recent study found that activation of signal transducer and activator of transcription 3 (Stat3) is up-regulated in human brain metastatic cells and contributes to brain metastasis of melanoma. However, the molecular mechanisms underlying this increased Stat3 activation and effect on brain metastasis are unknown. ...

journal_title：Cancer research

authors： Huang FJ,Steeg PS,Price JE,Chiu WT,Chou PC,Xie K,Sawaya R,Huang S

更新日期：2008-12-01 00:00:00

abstract：:Our laboratory has found genomic imprinting of a large genomic domain of human 11p15.5, identifying six imprinted genes within this domain: (a) insulin-like growth factor II (IGF-II), an important autocrine growth factor in a wide variety of malignancies; (b) H19, an untranslated RNA that is a putative growth suppress...

journal_title：Cancer research

authors： Feinberg AP

更新日期：1999-04-01 00:00:00

abstract：:A cloned, virus-producing, tumorigenic, promonocytic leukemia cell line, AC8, derived from an Abelson murine leukemia virus-infected mouse can differentiate in vitro. Differentiated cells, purified from a population containing undifferentiated cells on the basis of expression of the macrophage differentiation antigens...

journal_title：Cancer research

authors： Hines DL

更新日期：1988-04-01 00:00:00

abstract：:A radioimmunoassay for transforming growth factor alpha (TGF-alpha) using synthetic rat sarcoma transforming growth factor and its rabbit polyclonal antibody has been developed. Using radioimmunoassays, the urinary TGF-alpha and epidermal growth factor (EGF) concentrations in 31 patients with hepatocellular carcinoma ...

journal_title：Cancer research

authors： Yeh YC,Tsai JF,Chuang LY,Yeh HW,Tsai JH,Florine DL,Tam JP

更新日期：1987-02-01 00:00:00

abstract：:Genomic imprinting is an epigenetic modification of the gamete or zygote leading to parental origin-specific gene expression in somatic cells of the offspring. We have previously identified a cluster of imprinted genes on human chromosome 11p15.5, a region involved in Beckwith-Wiedemann syndrome, Wilms' tumor, and ova...

journal_title：Cancer research

authors： Lee MP,Feinberg AP

更新日期：1998-03-01 00:00:00

abstract：:The microbial alkaloid staurosporine is a potent but nonselective inhibitor of protein kinases. The derivative CGP 41251 has been shown to exert a high degree of selectivity for inhibition of protein kinase C activity. Both compounds are powerful inhibitors of proliferation of both normal and transformed cells in vitr...

journal_title：Cancer research

authors： Andrejauskas-Buchdunger E,Regenass U

更新日期：1992-10-01 00:00:00