Abstract：
:The HMGA1 protein is a major factor in chromatin architecture and gene control. It plays a critical role in neoplastic transformation. In fact, blockage of HMGA1 synthesis prevents rat thyroid cell transformation by murine transforming retroviruses, and an adenovirus carrying the HMGA1 gene in the antisense orientation induces apoptotic cell death in anaplastic human thyroid carcinoma cell lines, but not in normal thyroid cells. Moreover, both in vitro and in vivo studies have established the oncogenic role of the HMGA1 gene. In this study, to define HMGA1 function in vivo, we examined the consequences of disrupting the Hmga1 gene in mice. Both heterozygous and homozygous mice for the Hmga1-null allele show cardiac hypertrophy due to the direct role of HMGA1 on cardiomyocytic cell growth regulation. These mice also developed hematologic malignancies, including B cell lymphoma and myeloid granuloerythroblastic leukemia. The B cell expansion and the increased expression of the RAG1/2 endonuclease, observed in HMGA1-knockout spleen tissues, might be responsible for the high rate of abnormal IgH rearrangements observed in these neoplasias. Therefore, the data reported here indicate the critical role of HMGA1 in heart development and growth, and reveal an unsuspected antioncogenic potential for this gene in hematologic malignancies.
journal_name
Cancer Resjournal_title
Cancer researchauthors
Fedele M,Fidanza V,Battista S,Pentimalli F,Klein-Szanto AJ,Visone R,De Martino I,Curcio A,Morisco C,Del Vecchio L,Baldassarre G,Arra C,Viglietto G,Indolfi C,Croce CM,Fusco Adoi
10.1158/0008-5472.CAN-05-1889subject
Has Abstractpub_date
2006-03-01 00:00:00pages
2536-43issue
5eissn
0008-5472issn
1538-7445pii
66/5/2536journal_volume
66pub_type
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