Effect of host age on the transplantation, growth, and radiation response of EMT6 tumors.

abstract：:Merbarone, a novel DNA topoisomerase II (topo II) inhibitor, differs from teniposide (VM-26) in that it inhibits topo II activities without stabilizing topo II-DNA covalent complexes. Thus, while the cellular effects of VM-26 are the consequences of inhibition of topo II catalytic activities and generation of topo II-...

journal_title：Cancer research

authors： Chen M,Beck WT

更新日期：1995-04-01 00:00:00

abstract：:Cranial radiotherapy induces progressive and debilitating declines in cognition that may, in part, be caused by the depletion of neural stem cells. The potential of using stem cell replacement as a strategy to combat radiation-induced cognitive decline was addressed by irradiating athymic nude rats followed 2 days lat...

journal_title：Cancer research

authors： Acharya MM,Christie LA,Lan ML,Giedzinski E,Fike JR,Rosi S,Limoli CL

更新日期：2011-07-15 00:00:00

abstract：:We have assessed the role of the p53 tumor suppressor gene in cell cycle arrest and cytotoxicity of ionizing radiation in 17 Burkitt's lymphoma and lymphoblastoid cell lines. Cell cycle arrest was assessed by flow cytometry of cells 16 h following irradiation. In addition to the usual G2 arrest, the cell lines exhibit...

journal_title：Cancer research

authors： O'Connor PM,Jackman J,Jondle D,Bhatia K,Magrath I,Kohn KW

更新日期：1993-10-15 00:00:00

abstract：:Virion antigens of feline leukemia virus are associated with HLA antigens in the membrane of human cells infected with the virus. Feline leukemia virus produced by these cells incorporates host membrane antigens into the virion envelope, making the virus susceptible to lysis by antisera directed to HLA or to uninfecte...

journal_title：Cancer research

authors： Azocar J,Essex M

更新日期：1979-09-01 00:00:00

abstract：:Hereditary renal carcinoma (RC) in the rat, originally reported by Eker in 1954, is an example of a Mendelian dominant predisposition to a specific cancer in an experimental animal. We previously reported that ionizing radiation induces additional tumors in a linear dose-response relationship, suggesting that in heter...

journal_title：Cancer research

authors： Kubo Y,Mitani H,Hino O

更新日期：1994-05-15 00:00:00

abstract：:The levels of protooncogene RNA in matched bone marrow and peripheral blood cells obtained from patients with newly diagnosed acute myelogenous leukemia were compared. While the absolute amounts of c-myc RNA in the matched specimens are similar, the levels are not correlated. In contrast, while the levels of c-fos RNA...

journal_title：Cancer research

authors： Preisler HD,Sato H,Li YQ,Stein G,Stein J

更新日期：1987-07-15 00:00:00

abstract：:Effects of breast cancer-associated gene 1 (BRCA1) missense mutations on the function of BRCA1 protein in DNA recombination have been little studied. In this report, we adapted a homology-directed recombination (HDR) assay to analyze the effects of BRCA1 mutations on this function. Using a HeLa-derived cell line with ...

journal_title：Cancer research

authors： Ransburgh DJ,Chiba N,Ishioka C,Toland AE,Parvin JD

更新日期：2010-02-01 00:00:00

abstract：:The steroid hormone 1,25-dihydroxyvitamin D3 [1,25-(OH)2D3] has potential to be used as an antitumor agent, but its clinical application is restricted by the strong calcemic activity. Therefore, new vitamin D3 analogues are developed with increased growth inhibitory and reduced calcemic activity. In the present study,...

journal_title：Cancer research

authors： Vink-van Wijngaarden T,Pols HA,Buurman CJ,van den Bemd GJ,Dorssers LC,Birkenhäger JC,van Leeuwen JP

更新日期：1994-11-01 00:00:00

abstract：:The influence of pretreatment with piperonylbutoxide (PIP) on the biological effects of N-nitrosodiethylamine (DEN) in vivo in Syrian golden hamsters was investigated. PIP pretreatment significantly reduced covalent binding of N-[ethyl-1-14C]DEN to tissue macromolecules in trachea, lung, and liver, while it did not ch...

journal_title：Cancer research

authors： Schuller HM,McMahon JB

更新日期：1985-06-01 00:00:00

abstract：:Heterotopic new bone formation was induced by implanting pieces of demineralized bone matrix in the abdominal wall of 22 growing Sprague-Dawley rats. The animals were divided into three groups and were given, 24 hr after initiation of the bone induction process, a single i.v. injection of methotrexate, 100 or 250 mg/k...

journal_title：Cancer research

authors： Nilsson OS,Bauer FC,Broström LA,Nilsonne U

更新日期：1984-04-01 00:00:00

abstract：:The deleted in colorectal cancer (DCC) gene, a candidate tumor suppressor gene on chromosome 18q21, encodes a neural cell adhesion molecule family protein that is most highly expressed in the nervous system. To address the hypothesis that DCC may play a role in glioma development and/or progression, we examined DCC ex...

journal_title：Cancer research

authors： Reyes-Mugica M,Rieger-Christ K,Ohgaki H,Ekstrand BC,Helie M,Kleinman G,Yahanda A,Fearon ER,Kleihues P,Reale MA

更新日期：1997-02-01 00:00:00

abstract：:Kras is a decisive oncogene in pancreatic ductal adenocarcinoma (PDAC). PIN1 is a key effector involved in the Kras/ERK axis, synergistically mediating various cellular events. However, the underlying mechanism by which PIN1 promotes the development of PDAC remains unclear. Here we sought to elucidate the effect of PI...

journal_title：Cancer research

authors： Liang C,Shi S,Liu M,Qin Y,Meng Q,Hua J,Ji S,Zhang Y,Yang J,Xu J,Ni Q,Li M,Yu X

更新日期：2019-01-01 00:00:00

abstract：:Paclitaxel is a standard-of-care chemotherapy for breast cancer, despite the increasing recognition of its poor effectiveness in the treatment of patients with advanced disease. Here, we report that adenovirus-type 5 E1A-mediated elevation of the miRNA-processing enzyme Dicer is sufficient to enhance paclitaxel sensit...

journal_title：Cancer research

authors： Chang TY,Chen HA,Chiu CF,Chang YW,Kuo TC,Tseng PC,Wang W,Hung MC,Su JL

更新日期：2016-07-01 00:00:00

abstract：:Plasmin is shown to play a crucial role in many pathophysiologic processes primarily through its ability to degrade extracellular matrix (ECM) and/or mobilizing growth factors that are sequestered in the ECM. Cysteine-rich 61 (CCN1) is a matricellular protein of which expression is up-regulated in cancer and various v...

journal_title：Cancer research

authors： Pendurthi UR,Tran TT,Post M,Rao LV

更新日期：2005-11-01 00:00:00

abstract：:Seventeen young women with clinically confirmed mammary dysplasia and six age-matched controls were treated with alpha-tocopherol. Serum samples collected during the luteal phase of each woman at monthly intervals for the 4-month duration of the study were analyzed for serum luteinizing hormone, follicle-stimulating h...

journal_title：Cancer research

authors： Sundaram GS,London R,Margolis S,Wenk R,Lustgarten J,Nair PP,Goldstein P

更新日期：1981-09-01 00:00:00

abstract：:The mitotic kinase Aurora A is an important therapeutic target for cancer therapy. This study evaluated new mechanism-based pharmacodynamic biomarkers in cancer patients in two phase I studies of MLN8054, a small-molecule inhibitor of Aurora A kinase. Patients with advanced solid tumors received MLN8054 orally for 7 c...

journal_title：Cancer research

authors： Chakravarty A,Shinde V,Tabernero J,Cervantes A,Cohen RB,Dees EC,Burris H,Infante JR,Macarulla T,Elez E,Andreu J,Rodriguez-Braun E,Rosello S,von Mehren M,Meropol NJ,Langer CJ,ONeil B,Bowman D,Zhang M,Danaee H,Faron

更新日期：2011-02-01 00:00:00

abstract：:Control rats or rats bearing Morris hepatoma 5123C (intact), 5123C (adrenalectomized), 7794A, 7800, 8999, 9121, or 9618A were fed a purified diet either deficient or adequate for vitamin B6. The concentration of pyridoxal phosphate in the plasma, host livers, and hepatomas was determined, as well as the in vitro rate ...

journal_title：Cancer research

authors： Reynolds RD,Morris HP

更新日期：1979-08-01 00:00:00

abstract：:Estrogen exposure is considered a significant risk factor for breast cancer development. Estrogen receptor (ER) alpha is expressed at low levels in normal epithelia, and its expression is dramatically up-regulated as transformation progresses during mammary hyperplasia and adenocarcinoma development. The mechanism(s) ...

journal_title：Cancer research

authors： Sotgia F,Rui H,Bonuccelli G,Mercier I,Pestell RG,Lisanti MP

更新日期：2006-11-15 00:00:00

abstract：:Regulators of differentiated cell fate can offer targets for managing cancer development and progression. Here, we identify Runx2 as a new regulator of epithelial cell fate in mammary gland development and breast cancer. Runx2 is expressed in the epithelium of pregnant mice in a strict temporally and hormonally regula...

journal_title：Cancer research

authors： Owens TW,Rogers RL,Best S,Ledger A,Mooney AM,Ferguson A,Shore P,Swarbrick A,Ormandy CJ,Simpson PT,Carroll JS,Visvader J,Naylor MJ

更新日期：2014-09-15 00:00:00

abstract：:Elevated tumor cyclooxygenase-2 (COX-2) expression is associated with tumor invasion, metastasis, and poor prognosis in non-small cell lung cancer (NSCLC). Here, we report that COX-2-dependent pathways contribute to the modulation of E-cadherin expression in NSCLC. First, whereas genetically modified COX-2-sense (COX-...

journal_title：Cancer research

authors： Dohadwala M,Yang SC,Luo J,Sharma S,Batra RK,Huang M,Lin Y,Goodglick L,Krysan K,Fishbein MC,Hong L,Lai C,Cameron RB,Gemmill RM,Drabkin HA,Dubinett SM

更新日期：2006-05-15 00:00:00

abstract：:The metabolism of vitamin B6 in McA-RH7777 cells has been characterized with respect to pyridoxal 5'-phosphate (PLP) levels, and the activities of pyridoxine (PN) kinase (EC 2.1.7.35) and pyridoxine 5'-phosphate (PNP) oxidase (EC 1.4.3.5). PLP levels (12.4 +/- 4.4 ng/mg protein) were at the lower end of the range foun...

journal_title：Cancer research

authors： Meisler NT,Thanassi JW

更新日期：1988-03-01 00:00:00

abstract：:Cancers are initiated as a result of changes that occur in the genome. Identification of gains and losses in the structure and expression of tumor-suppressor genes and oncogenes lies at the root of the understanding of cancer cell biology. Here, we show that the mitogen-activated protein kinase (MAPK) MKK3 suppresses ...

journal_title：Cancer research

authors： MacNeil AJ,Jiao SC,McEachern LA,Yang YJ,Dennis A,Yu H,Xu Z,Marshall JS,Lin TJ

更新日期：2014-01-01 00:00:00

abstract：:FoxP3 is a member of the forkhead family of transcription factors critically involved in the development and function of CD25(+) regulatory T cells (Treg). Until recently, FoxP3 expression was thought to be restricted to the T-cell lineage. However, using immunohistochemistry and flow cytometric analysis of human mela...

journal_title：Cancer research

authors： Ebert LM,Tan BS,Browning J,Svobodova S,Russell SE,Kirkpatrick N,Gedye C,Moss D,Ng SP,MacGregor D,Davis ID,Cebon J,Chen W

更新日期：2008-04-15 00:00:00

abstract：:Macrophages play important roles in both physiologic and pathologic processes and arise from successive waves of embryonic and adult hematopoiesis. Monocyte-derived macrophages (MOMF) exert distinct functions under pathologic conditions, and leukemia-associated macrophages (LAM) show considerable diversities in activa...

journal_title：Cancer research

authors： Yang F,Feng W,Wang H,Wang L,Liu X,Wang R,Chen C,Yang X,Zhang D,Ren Q,Zheng G

更新日期：2020-09-01 00:00:00

abstract：:We recently identified the immunoglobulin-CAM CD155/PVR (the poliovirus receptor) as a regulator of cancer invasiveness and glioma migration, but the mechanism through which CD155/PVR controls these processes is unknown. Here, we show that expression of CD155/PVR in rat glioma cells that normally lack this protein enh...

journal_title：Cancer research

authors： Sloan KE,Stewart JK,Treloar AF,Matthews RT,Jay DG

更新日期：2005-12-01 00:00:00

abstract：:Pancreatic ductal adenocarcinoma (PDAC) is characterized by therapeutic resistance for which the basis is poorly understood. Here, we report that the DNA and p53-binding protein ATDC/TRIM29, which is highly expressed in PDAC, plays a critical role in DNA damage signaling and radioresistance in pancreatic cancer cells....

journal_title：Cancer research

authors： Wang L,Yang H,Palmbos PL,Ney G,Detzler TA,Coleman D,Leflein J,Davis M,Zhang M,Tang W,Hicks JK,Helchowski CM,Prasad J,Lawrence TS,Xu L,Yu X,Canman CE,Ljungman M,Simeone DM

更新日期：2014-03-15 00:00:00

abstract：:Monoclonal antibodies (McAbs) to human bladder carcinoma were generated by fusion of NS-1 mouse myeloma cells with spleen cells from BALB/c mice immunized with either cultured human bladder cancer cells or cells obtained from a fresh surgically removed bladder tumor. Four hybridomas which reacted strongly with bladder...

journal_title：Cancer research

authors： Young DA,Prout GR Jr,Lin CW

更新日期：1985-09-01 00:00:00

abstract：:The renal handling of cis-diamminedichloroplatinum (CP) was investigated by measuring the renal clearance of creatinine, inulin, and free platinum in ten cancer patients. Free platinum clearances exceeded the glomerular filtration rate in all time periods. For example, at 1 to 2 hr, the mean clearance of free platinum...

journal_title：Cancer research

authors： Jacobs C,Coleman CN,Rich L,Hirst K,Weiner MW

更新日期：1984-08-01 00:00:00

abstract：:The tumor suppressor protein BRCA1 localizes to sites of DNA double-strand breaks (DSB), promoting repair by homologous recombination through the recruitment of DNA damage repair proteins. In normal cells, homologous recombination largely depends on BRCA1. However, assembly of the pivotal homologous recombination regu...

journal_title：Cancer research

authors： Nakada S,Yonamine RM,Matsuo K

更新日期：2012-10-01 00:00:00

abstract：:Expression of the ectonucleotidase CD73 by tumor cells, stromal cells, and immune cells is associated in cancer with immune suppression. In this study, we investigated the role of CD73 on the activity of the anti-HER2/ErbB2 monoclonal antibody (mAb) trastuzumab. In a prospective, randomized phase III clinical trial ev...

journal_title：Cancer research

authors： Turcotte M,Allard D,Mittal D,Bareche Y,Buisseret L,José V,Pommey S,Delisle V,Loi S,Joensuu H,Kellokumpu-Lehtinen PL,Sotiriou C,Smyth MJ,Stagg J

更新日期：2017-10-15 00:00:00